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Atherosclerosis according to harshmohan text

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The library doesn't have Harsh Mohan's textbook directly. However, it has Robbins & Kumar Pathology (which covers similar content as Harsh Mohan's Pathology — both are pathology textbooks covering the same topics). Let me search comprehensively using both Robbins books plus the pathology-specific content on atherosclerosis.
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Now let me also get the morphology/plaque content from the earlier section, and also fetch the key images:
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I now have comprehensive content. Let me fetch the key images to include in the answer:
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Atherosclerosis (as given in standard pathology text content equivalent to Harsh Mohan) can be summarized like this:

Definition

Atherosclerosis is an intimal lesion of large and medium arteries characterized by formation of an atheromatous plaque with:
  • Fibrous cap
  • Lipid-rich necrotic core (cholesterol, cholesterol esters, debris)
  • Inflammatory cells, smooth muscle cells, extracellular matrix, and often calcification.
Book source used: Robbins, Cotran & Kumar Pathologic Basis of Disease, p. 466-475

Important risk factors

Non-modifiable

  • Increasing age
  • Male sex
  • Family history/genetic predisposition

Modifiable

  • Hyperlipidemia (especially high LDL, low HDL)
  • Hypertension
  • Cigarette smoking
  • Diabetes mellitus
  • Inflammation-related/metabolic contributors
Book source: Robbins, Cotran & Kumar Pathologic Basis of Disease, p. 467-468

Pathogenesis (response-to-injury hypothesis)

  1. Endothelial injury/dysfunction (from HTN, hyperlipidemia, smoking, turbulent flow, etc.)
  2. Increased permeability and LDL entry into intima
  3. Oxidation/modification of LDL
  4. Monocyte adhesion and migration, macrophage formation
  5. Foam cell formation (macrophages + SMC uptake lipid)
  6. Cytokine-mediated inflammation and smooth muscle migration/proliferation
  7. ECM deposition (collagen) forming fibrous cap
  8. Lipid necrotic core enlarges, calcification may occur
  9. Progression to stable or vulnerable plaque
Book source: Robbins, Cotran & Kumar Pathologic Basis of Disease, p. 468-470

Morphology

  • Fatty streak: early flat yellow lesion composed of foam cells
  • Fibrofatty atheromatous plaque: raised intimal lesion with cap + necrotic core
  • Complicated plaque: rupture/erosion, hemorrhage, thrombosis, calcification
Book source: Robbins, Cotran & Kumar Pathologic Basis of Disease, p. 471-474

Clinical effects/complications

  • Chronic stenosis causing ischemia (classically significant at ~70-75% cross-sectional narrowing in coronaries)
  • Acute plaque rupture/erosion causing thrombosis and infarction (MI/stroke)
  • Atheroembolism
  • Aneurysm formation due to medial weakening
Major outcomes:
  • Myocardial infarction
  • Cerebral infarction (stroke)
  • Aortic aneurysm
  • Peripheral vascular disease
Book source: Robbins, Cotran & Kumar Pathologic Basis of Disease, p. 472-475
If you want, I can also give this in exact exam format used in MBBS (definition, etiopathogenesis, morphology, complications) in 2-page answer style.
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