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Detailed Care Plan: Alcohol Dependency Syndrome (Alcohol Use Disorder)
Sources: Maudsley Prescribing Guidelines in Psychiatry (15th ed), Kaplan & Sadock's Synopsis of Psychiatry, Goldman-Cecil Medicine, The Washington Manual of Medical Therapeutics, Tintinalli's Emergency Medicine
1. PATIENT ASSESSMENT
1.1 History Taking
- Full drinking history: amount per day (units), duration, pattern of use
- Last drink taken (time/date)
- Previous withdrawal episodes - seizures, delirium tremens (DTs)
- Previous detoxification attempts (community vs inpatient)
- Concurrent substance use (benzodiazepines, opioids, illicit drugs)
- Medical comorbidities (liver disease, epilepsy, diabetes, cardiovascular disease)
- Psychiatric comorbidities (depression, anxiety, PTSD)
- Social history: housing stability, employment, social support, caring responsibilities
- Pregnancy status (if applicable)
1.2 Standardized Screening & Severity Tools
| Tool | Purpose | Action Threshold |
|---|
| AUDIT (Alcohol Use Disorders Identification Test) | Screening & severity | Score ≥20 = likely needs pharmacologically assisted withdrawal |
| SADQ (Severity of Alcohol Dependence Questionnaire) | Dependence severity | Score >30 = severe; inpatient detox required |
| CIWA-Ar (Clinical Institute Withdrawal Assessment - Revised) | Monitor withdrawal severity | Score >10 = assisted withdrawal needed |
| SAWS (Short Alcohol Withdrawal Scale) | Self-complete withdrawal monitoring | Score >12 = assisted withdrawal needed |
1.3 Physical Examination
- Vital signs: pulse, BP, temperature, respiratory rate
- Signs of chronic liver disease (jaundice, spider naevi, palmar erythema, ascites)
- Neurological examination (tremor, gait, peripheral neuropathy, cognitive function)
- Signs of malnutrition
- Skin for injection sites if polysubstance use suspected
1.4 Investigations
- FBC, U&E, LFTs, coagulation (INR/PT), glucose
- Magnesium and phosphate levels
- Blood alcohol level (BAC)
- Urine drug screen
- ECG (especially if disulfiram or other cardiac-risk medications planned)
- CT head (if head injury suspected or severe cognitive impairment)
- Thiamine/B12/folate levels if available
2. NURSING DIAGNOSES / PROBLEM LIST
- Risk of alcohol withdrawal seizures - related to CNS hyperexcitability following cessation
- Risk of delirium tremens - related to severe dependence and abrupt withdrawal
- Fluid and electrolyte imbalance - related to vomiting, diaphoresis, poor oral intake
- Nutritional deficit - related to thiamine deficiency, poor dietary intake, malabsorption
- Disturbed sensory perception - related to alcoholic hallucinosis or DTs
- Ineffective coping - related to alcohol use as maladaptive strategy
- Risk of injury - related to altered mental status, falls, autonomic instability
- Social isolation / impaired social functioning - related to dependence
- Knowledge deficit - regarding effects of alcohol and available treatment
3. ACUTE WITHDRAWAL MANAGEMENT
3.1 Withdrawal Timeline (Kaplan & Sadock's Synopsis of Psychiatry)
| Stage | Symptoms | Onset After Last Drink |
|---|
| Mild | Tremulousness, agitation, anxiety, sweating, nausea, tachycardia, hypertension | 3-12 hours (peak 24-48 hrs) |
| Moderate | Perceptual disturbances, hallucinations (auditory/visual), heightened irritability | 8-48 hours |
| Severe | Generalized tonic-clonic seizures | 12-48 hours |
| Life-threatening | Delirium tremens: tremulousness + hallucinations + agitation + confusion + autonomic hyperactivity | 48-72 hours (up to 14 days) |
Note: DTs complicates 5-10% of alcohol withdrawal cases and carries mortality up to 15% if untreated. - The Washington Manual
3.2 Setting: Community vs Inpatient
Community detoxification is appropriate when:
- A supervising carer is available (ideally 24 hours/day)
- Agreed treatment plan with patient, carer, and GP
- Contingency plan in place
- Patient can collect medication daily and be reviewed regularly
- Psychosocial support is accessible
Inpatient detoxification is required when:
- Regular consumption >30 units/day
- SADQ score >30 (severe dependence)
- History of seizures or delirium tremens
- Current benzodiazepine use alongside alcohol
- Polysubstance misuse
- Pregnancy
- Patient is homeless or lacks social support
- Previous failed community detoxification
- Concurrent acute medical illness
(Maudsley Prescribing Guidelines, 15th ed)
3.3 Pharmacological Management of Withdrawal
First-line: Benzodiazepines
Long-acting benzodiazepines (e.g., diazepam, chlordiazepoxide) are the treatment of choice. A meta-analysis confirmed that long-acting benzodiazepines significantly reduce seizures de novo.
| Clinical Situation | Drug & Dose |
|---|
| Mild-moderate withdrawal | Chlordiazepoxide 25-50 mg PO q6-8h (max 300 mg/day), then taper; OR diazepam - symptom-triggered |
| Severe withdrawal / seizures / DTs | Diazepam 10 mg IV every 5-20 min OR lorazepam IV 2-4 mg every 15-20 min until symptom control |
| Hepatic failure | Oxazepam 15-30 mg PO q6-8h (renally excreted, preferred over hepatically cleared drugs) |
| DTs | Medical emergency - transfer to hospital (high dependency setting); requires larger benzodiazepine doses and caution with antipsychotics |
Seizures: Antiepileptic drugs (AEDs) are NOT routinely indicated for typical alcohol withdrawal seizures. However:
- Long-acting benzodiazepine is recommended as prophylaxis in those with previous seizure history
- Carbamazepine loading may be used in patients with untreated epilepsy or seizures despite adequate benzodiazepine loading
- Phenytoin is ineffective for alcohol withdrawal seizures
Monitoring: Use CIWA-Ar or SAWS at regular intervals throughout detoxification. Monitor vital signs frequently.
3.4 Nutritional / Vitamin Replacement
This is a mandatory component of every alcohol withdrawal care plan.
| Vitamin | Route & Dose | Indication |
|---|
| Thiamine (B1) | 100-500 mg IM/IV first, then 100 mg PO daily | All patients; prevents/treats Wernicke's encephalopathy |
| Multivitamins (with folic acid) | PO daily | Correct nutritional deficits |
| Magnesium sulphate | IV/PO if hypomagnesaemic | Reduces seizure risk; commonly deficient |
| Thiamine BEFORE glucose | Critical sequence | If hypoglycaemia present, give thiamine FIRST to prevent precipitating Wernicke's |
Wernicke's encephalopathy is an acute neuropsychiatric emergency caused by thiamine deficiency in alcohol dependence - secondary to both reduced dietary intake AND reduced absorption. Do not delay thiamine replacement. - Maudsley Prescribing Guidelines
3.5 Fluid & Electrolyte Management
- Maintain IV access
- Monitor and correct: hypomagnesaemia, hypokalaemia, hypoglycaemia
- Maintain adequate hydration, especially if fever, diaphoresis, and vomiting are present
4. ONGOING MEDICAL CARE (POST-DETOXIFICATION)
4.1 Pharmacotherapy for Relapse Prevention
Three medications are FDA-approved for alcohol use disorder in the United States:
| Drug | Dose | Mechanism | Notes |
|---|
| Naltrexone (oral) | 50 mg/day | Opioid receptor antagonist; reduces euphoria and craving | Contraindicated if opioid-dependent or hepatic failure; monitor LFTs |
| Naltrexone (injectable, Vivitrol) | 380 mg IM every 4 weeks | As above, improved compliance | Only after tolerating oral naltrexone for ≥1 week; effective in severe AUD |
| Acamprosate | 666 mg TDS (333 mg TDS if CrCl 30-50 mL/min; avoid if CrCl <30) | GABA-ergic/anti-glutamate; reduces craving in abstinence | Minimal side effects (diarrhea); safe in liver disease; not opioid interaction |
| Disulfiram | Supervised use only | Inhibits alcohol dehydrogenase - causes aversion reaction (flushing, vomiting) | Effective only in highly motivated, supervised patients; potentially dangerous |
Additional agents:
- Gabapentin 1200 mg/day in divided doses - reduces heavy drinking, helps with withdrawal-related insomnia
- Topiramate - evidence supports reduction in drinking
- Combination of naltrexone + acamprosate may be more effective than either alone
- Combination with behavioral interventions improves outcomes further
(Goldman-Cecil Medicine, Washington Manual)
5. PSYCHOSOCIAL INTERVENTIONS
These are key components of any alcohol dependency care plan and must run alongside pharmacotherapy.
- Motivational Interviewing (MI) - explore ambivalence and build intrinsic motivation for change
- Cognitive Behavioral Therapy (CBT) - identify triggers, develop coping strategies, relapse prevention
- 12-Step Facilitation - Alcoholics Anonymous (AA), encourages peer support and abstinence
- SMART Recovery - science-based self-help alternative to 12-step programmes
- Brief interventions - for less severe cases in primary care settings (FRAMES model)
- Couples/family therapy - addresses relationship dynamics that perpetuate use
- Social skills training - rebuilding life skills and social functioning
6. COMPLICATION MONITORING & PREVENTION
| Complication | Signs to Monitor | Prevention/Management |
|---|
| Delirium Tremens | Agitation, confusion, autonomic instability, fever | Adequate benzodiazepine cover; inpatient monitoring |
| Wernicke's Encephalopathy | Confusion, ophthalmoplegia, ataxia (triad) | Thiamine IV/IM prophylactically |
| Korsakoff's Syndrome | Anterograde amnesia, confabulation | Prevent via adequate thiamine; long-term management |
| Alcoholic hepatitis/cirrhosis | Jaundice, coagulopathy, ascites | LFT monitoring; hepatology referral |
| Alcoholic peripheral neuropathy | Distal sensory loss, pain, weakness | Thiamine, B12 supplementation |
| Hypoglycaemia | Sweating, confusion, reduced consciousness | Regular glucose monitoring; IV dextrose + thiamine |
| Aspiration pneumonia | Reduced GCS, fever, cough | Positioning, airway management |
7. NURSING INTERVENTIONS (INPATIENT)
| Priority | Intervention | Rationale |
|---|
| Hourly/2-hourly | Vital signs monitoring | Detect autonomic instability early |
| Every shift | CIWA-Ar or SAWS scoring | Guide PRN benzodiazepine dosing |
| Ongoing | Safety monitoring, call bell in reach, bed rails up, low bed | Prevent falls (confusion, ataxia) |
| Daily | Weight, fluid balance chart | Monitor hydration and nutritional status |
| With every meal | Encourage oral nutrition, thiamine before food/glucose | Correct deficiencies |
| Continuous | Therapeutic relationship - non-judgemental, empathetic approach | Reduces shame, improves engagement |
| PRN | Antiemetics (e.g., metoclopramide) for nausea/vomiting | Improve oral intake and medication adherence |
| On admission | Blood glucose check, ECG, bloods | Baseline safety |
8. DISCHARGE PLANNING & COMMUNITY SUPPORT
- Structured follow-up with GP or addiction specialist within 1-2 weeks
- Prescription of relapse prevention medication (naltrexone or acamprosate) with clear instructions
- Referral to community alcohol services / Drug and Alcohol Team
- Continued psychosocial support (CBT, group therapy, AA/SMART Recovery)
- Written relapse prevention plan including identified triggers and crisis contacts
- Consideration of assertive outreach if chaotic lifestyle or previous disengagement
- Safeguarding review if children in household
- Occupational therapy referral if cognitive impairment or functional decline
- Peer mentoring / recovery coaching where available
9. EXPECTED OUTCOMES / GOALS OF CARE
| Timeframe | Goal |
|---|
| Short-term (0-7 days) | Safe withdrawal; prevention of seizures and DTs; correction of nutritional deficiencies; stabilization of vital signs |
| Medium-term (1-4 weeks) | Engagement with relapse prevention pharmacotherapy; participation in psychosocial programmes; restored nutritional status |
| Long-term (3-12 months) | Sustained reduction or abstinence from alcohol; improved social functioning; prevention of relapse; management of comorbid physical and mental health conditions |
10. SPECIAL CONSIDERATIONS
- Pregnancy: Inpatient detox mandatory; fetal monitoring required; avoid benzodiazepines where possible or use with extreme caution
- Liver failure: Use oxazepam (not diazepam/chlordiazepoxide); avoid naltrexone; acamprosate is safer
- Elderly patients: Require inpatient detox; higher risk of falls, delirium, and polypharmacy interactions; lower starting doses
- Comorbid depression/anxiety: Treat after 2-4 weeks of abstinence (many symptoms resolve); SSRIs if persistent
- Opioid comorbidity: Naltrexone is contraindicated; buprenorphine or methadone for opioid component; acamprosate for alcohol component
Key references: Maudsley Prescribing Guidelines in Psychiatry (15th ed) | Goldman-Cecil Medicine | Kaplan & Sadock's Synopsis of Psychiatry | Washington Manual of Medical Therapeutics | Tintinalli's Emergency Medicine