Here is a complete, structured overview of the Types of Fever as taught in clinical medicine:
Types of Fever
Definition
Fever (pyrexia) is a body temperature above the normal range (36-37.2°C / 97-99°F). The hypothalamus acts as a thermostat; when pyrogens (exogenous such as bacterial LPS, or endogenous such as IL-1, IL-6, TNF-alpha) raise the set point, the body generates heat through vasoconstriction and shivering to reach this new level.
The mechanism: Pyrogens --> macrophage activation --> release of IL-1, PGE2 --> hypothalamic set point raised --> fever.
Fever is distinct from hyperthermia, where body temperature rises uncontrolled without a raised hypothalamic set point (e.g., heatstroke, malignant hyperthermia, NMS).
Body temperatures under different conditions - Guyton & Hall Textbook of Medical Physiology
A. Classification by Temperature Degree
| Grade | Temperature |
|---|
| Low-grade fever | 37.3 - 38°C (99.1 - 100.4°F) |
| Moderate fever | 38 - 39°C (100.4 - 102.2°F) |
| High fever | 39 - 40°C (102.2 - 104°F) |
| Hyperpyrexia | >41°C (>105.8°F) - medical emergency |
B. Classification by Fever Pattern (Most Important Clinically)
The pattern of fever charted over time on a temperature chart provides diagnostic clues. This is the most commonly tested classification in surgery and medicine.
1. Continuous (Sustained) Fever
- Temperature remains elevated throughout the day with diurnal variation of less than 1°C (i.e., never touches normal)
- Does NOT touch the normal baseline
- Examples: Lobar pneumonia, typhoid fever (classical), urinary tract infection, rickettsial infections
- Temperature typically 39-40°C throughout
2. Remittent Fever
- Temperature remains elevated throughout the day but diurnal variation exceeds 1°C
- Still does NOT touch normal baseline
- The most common type of fever seen in clinical practice
- Examples: Typhoid fever (more commonly), infective endocarditis, viral fevers, most bacterial infections
3. Intermittent Fever
- Temperature rises above normal and then comes down to normal (or below normal) every day
- The key feature: temperature touches the normal baseline between spikes
- Sub-types based on periodicity:
- Quotidian - fever spike every 24 hours (daily) - seen in Plasmodium falciparum malaria (also some cases of P. vivax), pyogenic abscesses
- Tertian - fever every 48 hours (3rd day cycle) - seen in P. vivax and P. ovale malaria
- Quartan - fever every 72 hours (4th day cycle) - seen in P. malariae malaria
4. Hectic (Septic / Swinging) Fever
- A very wide diurnal variation in temperature (>2°C), with the fever going very high and then coming down to normal or subnormal
- Usually accompanied by rigors (when rising) and profuse sweating (when falling)
- Characteristic of pyogenic (pus-forming) infections
- Examples: Pyogenic abscesses (liver abscess, subphrenic abscess), bacteraemia/septicaemia, tuberculosis (miliary or cavitating), infective endocarditis
5. Relapsing (Periodic) Fever
- Fever present for several days, followed by an afebrile period of several days, then fever returns
- Also called "undulant fever"
- Examples:
- Borrelia infections (relapsing fever) - fever lasts 3-6 days, then 7 days afebrile, then recurs
- Brucellosis (undulant fever) - classic undulating pattern
- Malaria (if untreated, can relapse)
- Hodgkin's lymphoma (Pel-Ebstein fever - a specific type of relapsing pattern)
6. Pel-Ebstein Fever
- A specific relapsing pattern: days to weeks of high fever alternating with days to weeks of normal temperature
- Classically described in Hodgkin's lymphoma
- Considered pathognomonic (though now recognized as uncommon even in Hodgkin's)
7. Inverse (Reverse) Fever
- Temperature is higher in the morning than in the evening
- The reverse of the normal diurnal pattern (normally, body temp is lowest in early morning and highest in late afternoon)
- Examples: Miliary tuberculosis, gram-negative septicaemia, liver abscess (occasionally)
C. Classification by Duration
| Type | Duration | Examples |
|---|
| Acute fever | <7 days | Viral URTI, malaria, UTI |
| Sub-acute fever | 7-21 days | Typhoid fever, brucellosis |
| Chronic / prolonged fever | >3 weeks | Tuberculosis, infective endocarditis, malignancy |
| Pyrexia of Unknown Origin (PUO) | >3 weeks, documented >38.3°C on multiple occasions, no diagnosis after 1 week of hospital investigation | TB, lymphoma, connective tissue diseases, occult infections |
D. Special / Named Fever Patterns
| Name | Disease |
|---|
| Saddle-back (biphasic) fever | Dengue fever - initial fever 3-5 days, brief remission, then second rise |
| Camel-back fever | Brucellosis |
| Undulant fever | Brucellosis |
| Pel-Ebstein fever | Hodgkin's lymphoma |
| Quotidian fever | P. falciparum malaria, JIA (systemic juvenile idiopathic arthritis) |
| Autumn fever | Leptospirosis |
E. Fever in the Surgical Context (Post-operative Fever)
Per Bailey and Love's Short Practice of Surgery (28e), about 40% of patients develop pyrexia after major surgery. The causes follow a classic time-based pattern remembered as the "5 W's":
| Post-op Day | Cause | Mnemonic |
|---|
| Day 1-2 | Wind - Atelectasis, chest infection | W |
| Day 3-5 | Water - Urinary tract infection | W |
| Day 4-6 | Wound - Surgical site infection | W |
| Day 5-7 | Walking - Deep vein thrombosis | W |
| Day 7+ | Wonder drugs - Drug fever, transfusion reaction | W |
Non-infective causes include: DVT, transfusion reactions, wound haematomas, atelectasis, and drug reactions.
F. Fever vs. Hyperthermia - Key Distinction
| Feature | Fever | Hyperthermia |
|---|
| Hypothalamic set point | Raised | Normal |
| Cause | Pyrogens (infection, inflammation) | Heat gain exceeds heat loss |
| Response to antipyretics | Yes - NSAIDs/paracetamol work | No - antipyretics ineffective |
| Examples | Infections, malignancy, autoimmune | Heatstroke, malignant hyperthermia, NMS |
| Treatment | Treat underlying cause + antipyretics | Cooling measures primarily |
Malignant hyperthermia (triggered by inhalational anaesthetics/suxamethonium), Neuroleptic Malignant Syndrome (NMS - from antipsychotics), and Serotonin Syndrome are important drug-induced hyperthermic states in the surgical and psychiatric contexts. (Bradley and Daroff's Neurology, p. 1058)
Sources:
- Guyton and Hall Textbook of Medical Physiology - Chapter 74 (Body Temperature Regulation and Fever)
- Bradley and Daroff's Neurology in Clinical Practice - Chapter 50 (Fever and Hyperthermia)
- Bailey and Love's Short Practice of Surgery, 28e - Chapter 24 (Post-operative fever)