albumin globulin ratio reversal causes cirrhosis chronic liver disease
Reversal of the albumin:globulin ratio, meaning A:G < 1, is classically seen in:
Chronic liver disease/cirrhosis: reduced albumin synthesis with increased immunoglobulins
Multiple myeloma and other gammopathies
Chronic infections and autoimmune/inflammatory conditions may also cause it
If this is a single-best-answer question, the usual answer is cirrhosis of liver. The medical text also specifically notes A:G reversal in multiple myeloma.
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