Textbook guidance emphasizes early antimicrobial therapy when indicated, deciding whether the incision needs opening, obtaining pathogen identification, and narrowing treatment after cultures. Organ-space infections need both microbiologic diagnosis and drainage/source control. Mulholland and Greenfield's Surgery, 7e, p. 507.
For prevention, guideline-based measures include correct timing of perioperative prophylactic antibiotics, clipper rather than razor hair removal when needed, glucose control, and normothermia. Routine continuation of prophylactic antibiotics after incision closure is generally not recommended, including merely because a drain remains in place, per the
CDC SSI guideline. Recent reviews continue to support appropriate antibiotic prophylaxis rather than indiscriminate postoperative courses, including a
2024 systematic review.