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Ezetimide minti wagwlanl Rivaroxaban Cropidogrel/ Aspirin Ranolazine Sindenafil Beta-2 agonist LAMA LABA unsulin=au hypes PPAR-gamma DPP4 inhibitor Methimazole Mifepristone Alpha-glucosidase inhibitor Pioglitazone Metolazone LMWH UFH Beta blocker Fibrates. Make notes on this drugs in pharmacologic way using katzung

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All 21 drugs are covered above. A few clarifications on your list:
  • "Minti wagwlanl" - interpreted as Niacin (the classic "flushing" drug; if you meant something else, let me know)
  • "Unsulin = au hypes" - interpreted as Insulin and hypoglycemics (insulin types covered)
  • "Sindenafil" = Sildenafil (covered)
  • "Cropidogrel" = Clopidogrel (covered)
Key Pearls to Remember:
  1. Ezetimibe works at NPC1L1 (brush border); undergoes enterohepatic recirculation; 20% LDL reduction
  2. Rivaroxaban MUST be taken with food at therapeutic doses (≥15 mg); anti-Xa activity monitored when needed
  3. Clopidogrel is a prodrug requiring CYP2C19 - PPIs reduce its activation; genetic polymorphisms cause "resistance"
  4. Ranolazine blocks late INa (not HR/BP) - unique mechanism; QTc prolongation risk; CYP3A4 substrate
  5. Sildenafil + nitrates = ABSOLUTE contraindication (fatal hypotension via dual cGMP elevation)
  6. LABAs must NEVER be used without ICS in asthma
  7. LAMA (tiotropium) is the cornerstone bronchodilator in COPD
  8. DPP-4 inhibitors are glucose-dependent → very low hypoglycemia risk; linagliptin needs no renal dose adjustment
  9. Methimazole is preferred over PTU except in first trimester, thyroid storm, and PTU-intolerance
  10. Mifepristone blocks both PR and GR; used for medical abortion AND Cushing's syndrome
  11. Metolazone works in renal failure (unlike HCTZ) - synergizes powerfully with loop diuretics
  12. UFH preferred over LMWH in severe renal failure and when rapid reversal is needed (protamine fully reverses)
  13. HIT - stop ALL heparin (UFH and LMWH) immediately; switch to direct thrombin inhibitor (argatroban)
  14. Fibrates activate PPARα (not PPARγ) - primary use is severe hypertriglyceridemia; avoid gemfibrozil + statin combination
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