You are a medical research assistant. Your task is to extract comprehensive information about SYSTEMIC CORTICOSTEROIDS from two sources: SOURCE 1: The attached PDF file at path: /home/daytona/workspace/attachments/3a9dc0c8-b367-41d3-8c9f-cfa79c59c8f0/wolvertonComprehensive Dermatologic Drug Therapy 3ed.pdf First read the PDF skill at /home/daytona/skills/pdf/SKILL.md to learn how to extract text from PDFs. Then extract all content about systemic corticosteroids/systemic steroids from the Wolverton textbook PDF. SOURCE 2: Query the medical library database for content about systemic corticosteroids from Fitzpatrick's, Rook's, Bolognia, and Andrews textbooks. Use query_library_db to search. Here are the SQL queries to run: 1. First check available books: SELECT isbn, title, speciality FROM v_book_overview LIMIT 20; 2. Search headings for systemic corticosteroids: SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'systemic corticosteroids' ORDER BY rank LIMIT 15; 3. Search paragraphs for systemic steroids content: SELECT book_title, section_heading, '/textbooks/' || block_file_path AS file_path, line_start, line_end, snippet(paragraphs_fts, 0, '>>>', '<<<', '...', 50) as snippet FROM paragraphs_fts WHERE paragraphs_fts MATCH '"systemic corticosteroids" AND dermatology' ORDER BY rank LIMIT 10; 4. Search for corticosteroid mechanisms: SELECT book_title, section_heading, '/textbooks/' || block_file_path AS file_path, line_start, line_end, snippet(paragraphs_fts, 0, '>>>', '<<<', '...', 50) as snippet FROM paragraphs_fts WHERE paragraphs_fts MATCH 'corticosteroid mechanism action anti-inflammatory' ORDER BY rank LIMIT 10; 5. Search for corticosteroid side effects: SELECT book_title, section_heading, '/textbooks/' || block_file_path AS file_path, line_start, line_end, snippet(paragraphs_fts, 0, '>>>', '<<<', '...', 50) as snippet FROM paragraphs_fts WHERE paragraphs_fts MATCH 'corticosteroid adverse effects side effects' ORDER BY rank LIMIT 10; After getting the file paths and line numbers from the database, use read_file to read the actual content (100 lines at a time with offset/limit). Extract all relevant content. Return a VERY DETAILED structured summary covering: 1. All book titles found in the library 2. Full content about systemic corticosteroids from each source including: - Classification and types of systemic steroids used in dermatology - Mechanisms of action (genomic and non-genomic) - Pharmacokinetics - Indications in dermatology - Dosing regimens (pulse, alternate day, tapering) - Adverse effects (short-term and long-term) - Contraindications - Drug interactions - Monitoring parameters - Specific conditions: pemphigus, SLE, dermatomyositis, atopic dermatitis, etc. - HPA axis suppression - Any tables, figures, or special boxes mentioned 3. All exact quotes and page references where possible 4. File paths and line numbers for all content retrieved This will be used to create a comprehensive dermatology resident study note.

You are a medical research assistant. Search PubMed for recent evidence on systemic corticosteroids in dermatology. Run the following PubMed searches and return the results: 1. pubmed_search(query='"systemic corticosteroids" AND dermatology', pub_types=["Systematic Review", "Meta-Analysis"], date_range_years=5, max_results=5) 2. pubmed_search(query='corticosteroids AND pemphigus treatment', pub_types=["Systematic Review", "Meta-Analysis"], date_range_years=5, max_results=3) 3. pubmed_search(query='prednisone pulse therapy dermatology', date_range_years=5, max_results=3) 4. pubmed_search(query='corticosteroid adverse effects skin monitoring', pub_types=["Review"], date_range_years=3, max_results=3) 5. Also do a web_search for: "systemic corticosteroids dermatology 2024 guidelines" to find any recent guidelines. For each result found, provide: - Title - Authors - Journal, Year - PMID - Key findings relevant to systemic steroids in dermatology - Evidence tier Return all results in a structured format that can be incorporated into a comprehensive dermatology resident study note on systemic corticosteroids.

"systemic corticosteroids" AND dermatology

corticosteroids AND pemphigus treatment

prednisone pulse therapy dermatology

corticosteroid adverse effects skin monitoring

systemic corticosteroids dermatology 2024 guidelines

PMID: 35769474

PMID: 36893848

PMID: 38420865

PMID: 38960026

PMID: 40032232

python3 << 'EOF' from pypdf import PdfReader import os pdf_path = "/home/dayton…

PMID: 37901249

PMID: 38282607

PMID: 38812522

https://link.springer.com/article/10.1007/s00403-025-04502-6

python3 << 'EOF' from pypdf import PdfReader pdf_path = "/home/daytona/workspac…

mkdir -p /home/daytona/workspace/systemic-steroids-note