Here is the complete stepwise escalation of PPH management, structured from first-line conservative measures through to definitive surgical intervention.
Stepwise Escalation of PPH Management
PPH = blood loss ≥500 mL after vaginal delivery or ≥1000 mL after caesarean, with signs of haemodynamic compromise within 24 hours.
STEP 0 — Simultaneous Resuscitation (All Steps)
Runs in parallel throughout ALL stages:
- Call for help — activate multidisciplinary team (obstetrician, anaesthesiologist, midwife, haematologist)
- 2 large-bore IV cannulae
- Oxygen by face mask; monitoring — BP, pulse, SpO₂, urine output (Foley catheter)
- IV crystalloid resuscitation; initiate massive transfusion protocol (MTP) if ongoing loss
- Blood products — packed red cells : FFP : platelets in 1:1:1 ratio (MTP); early FFP shown to improve outcomes
- Fibrinogen — low fibrinogen predicts severe haemorrhage and developing DIC; replace with cryoprecipitate/fibrinogen concentrate
- Bloods — FBC, coagulation screen (PT, APTT, fibrinogen), cross-match, U&E, TEG/ROTEM if available
- Tranexamic acid (TXA) 1g IV — give as early as possible once PPH diagnosed; repeat 1g if bleeding continues after 30 min or restarts within 24h (WOMAN trial — reduces death from bleeding, most effective within 3 hours)
— Creasy & Resnik's Maternal-Fetal Medicine, p. 1732–1734
STEP 1 — First-Line Uterotonics + Uterine Massage
(Uterine atony — most common cause, 80%)
A. Oxytocin (FIRST-LINE)
- 20–50 units in 1L crystalloid IV infusion — titrate to maintain contractions
- Do NOT give as IV bolus — causes severe hypotension and vasodilation
- If no IV access: 10 units IM
B. Bimanual uterine compression/massage
- One hand compresses anterior uterine wall via the vagina (fist)
- Other hand massages posterior uterus through the abdominal wall
- Sustained firm pressure — do not massage vigorously downward (risk of uterine inversion)
— Roberts & Hedges' Clinical Procedures in Emergency Medicine, p. 1367
STEP 2 — Second-Line Uterotonics
(If oxytocin + massage inadequate after 15–20 min)
| Drug | Dose | Key Cautions |
|---|
| Methylergonovine (Ergometrine) | 0.2 mg IM | Avoid in hypertension, preeclampsia, pulmonary HTN, ischaemic heart disease |
| Carboprost (PGF₂α / Hemabate) | 0.25 mg IM, repeat q15 min (max 8 doses / 2 mg total) | Avoid in severe asthma; give antiemetics; increases pulmonary artery pressure |
| Misoprostol (PGE₁) | 800–1000 µg PR or buccal (single dose) | Fewest contraindications; useful when no IV access |
Multiple uterotonics may be combined simultaneously. — Creasy & Resnik's, p. 1733
STEP 3 — Intrauterine Tamponade
(If uterotonics fail — before moving to surgery)
- Bakri balloon (or BT-Cath, Sengstaken-Blakemore) — inflate with 300–500 mL saline
- Uterine gauze packing — sterile gauze tightly packed into uterine cavity
- Success rates reported up to 91% for balloon tamponade
- Allows time for resuscitation, transfer to theatre, or interventional radiology
- Can be used as a "test of tamponade" — if bleeding stops, surgical intervention may be avoided
— Grainger & Allison's Diagnostic Radiology / PPH Algorithm, p. 2067; Roberts & Hedges', p. 1368
STEP 4 — Surgical Intervention
(If tamponade fails or bleeding is uncontrolled)
4a. Uterine compression sutures (uterus-preserving)
- B-Lynch suture — brace suture compresses the uterus longitudinally; highly effective for atony
- Hayman suture, Cho suture — alternatives
- Applied when abdomen is already open (caesarean) or at laparotomy
4b. Devascularisation (stepwise ligation)
Proceed in order if compression sutures fail:
- Uterine artery ligation bilaterally (O'Leary sutures) — reduces uterine blood flow by ~90%
- Utero-ovarian ligament ligation
- Internal iliac (hypogastric) artery ligation — technically demanding; reduces pulse pressure to pelvis
4c. Interventional Radiology — Uterine Artery Embolisation (UAE)
- Not first-line, but not a last resort — should be used before hysterectomy if available and patient is haemodynamically stable enough for transfer
- Bilateral uterine artery embolisation using Gelfoam via femoral artery approach
- Preserves uterus and fertility
- Recurrent bleeding can be treated with repeat embolisation
— Grainger & Allison's, p. 2067–2068
4d. REBOA (Resuscitative Endovascular Balloon Occlusion of the Aorta)
- Balloon catheter inserted via femoral artery into the aorta
- Acts as internal aortic occlusion to control haemorrhage while definitive treatment is arranged
- Useful in haemodynamically unstable patients with massive haemorrhage (e.g. abnormal placentation)
— Creasy & Resnik's, p. 1734
STEP 5 — Peripartum Hysterectomy (Definitive)
(Last resort — life-saving)
- Indicated when all conservative and surgical measures have failed
- Total or subtotal (supracervical) hysterectomy — subtotal is faster and preferred in unstable patients
- Mandatory for placenta accreta/percreta that cannot be managed conservatively
- Associated with significant morbidity but is life-saving
- Audit of peripartum hysterectomy rate is used to measure PPH protocol effectiveness
STEP 6 — Concurrent Management of Coagulopathy
(Runs alongside all steps once DIC develops)
| Problem | Treatment |
|---|
| Ongoing blood loss | Packed red cells (target Hb >8 g/dL) |
| Coagulopathy / prolonged PT | Fresh frozen plasma (FFP) |
| Fibrinogen <2 g/L | Cryoprecipitate or fibrinogen concentrate |
| Platelets <50 × 10⁹/L | Platelet transfusion |
| Hyperfibrinolysis | Tranexamic acid 1g IV (repeat if needed) |
| Refractory bleeding | Recombinant Factor VIIa (off-label, last resort) |
Use TEG/ROTEM for real-time guided component therapy if available. — Creasy & Resnik's, p. 1734
Summary Ladder
STEP 0 ── Resuscitate + TXA 1g IV (ALWAYS CONCURRENT)
│
STEP 1 ── Oxytocin IV infusion + Bimanual uterine massage
│ ↓ fails
STEP 2 ── Add Ergometrine / Carboprost / Misoprostol
│ ↓ fails
STEP 3 ── Intrauterine balloon tamponade (Bakri)
│ ↓ fails
STEP 4 ── Surgery:
└─ 4a: Compression sutures (B-Lynch)
└─ 4b: Uterine / internal iliac artery ligation
└─ 4c: UAE (interventional radiology)
└─ 4d: REBOA (haemodynamic instability)
│ ↓ fails
STEP 5 ── Peripartum hysterectomy (definitive)
Key principles:
- Steps 0–1 are simultaneous and immediate — never delayed
- Steps may be skipped or combined depending on clinical severity and resources
- Uterine-preserving options should always be attempted before hysterectomy in women who desire future fertility
- Multidisciplinary coordination is mandatory from STEP 0 onwards