I now have excellent content from Harrison's and Kaplan & Sadock's. Let me compile a comprehensive guide.
How to Study ECG
Why a Systematic Approach Matters
The most common errors in ECG interpretation are errors of omission — missing something because you didn't look for it. Every expert source, from Harrison's to Kaplan & Sadock's, agrees: always follow a fixed sequence, every single time.
Step 1 — Understand the Basics First
Before reading any ECG, you need to know what the waveforms represent:
| Component | Meaning |
|---|
| P wave | Atrial depolarization |
| QRS complex | Ventricular depolarization |
| T wave | Ventricular repolarization |
| U wave | After-repolarization (origin debated) |
| PR interval | AV conduction time (P start → QRS start) |
| QRS interval | Ventricular conduction time |
| QT interval | Total ventricular electrical activity |
| ST segment | Between QRS end and T wave start |
Paper basics:
- Small box = 0.04 sec (horizontal) / 0.1 mV (vertical)
- Large box = 0.2 sec (5 small boxes)
- Standard ECG = 10 seconds long
Step 2 — The 14-Parameter Systematic Checklist
From Harrison's Principles of Internal Medicine (22nd ed.), analyze every ECG in this order:
- Standardization & technical features — Is it calibrated? Any lead misplacement? Artifacts?
- Rhythm — Regular or irregular? P before every QRS?
- Heart rate — Calculate using one of two methods (see below)
- PR interval / AV conduction — Normal: 0.12–0.20 sec (3–5 small boxes)
- QRS interval — Normal: <0.12 sec (<3 small boxes)
- QT/QTc interval — Prolonged QTc >440 ms (men), >460 ms (women)
- Mean QRS electrical axis — Use Leads I and aVF
- P waves — Morphology, presence, regularity
- QRS voltages — High (hypertrophy) or low (effusion, obesity, emphysema)
- Precordial R-wave progression — Should grow V1 → V5
- Abnormal Q waves — Suggests prior infarction
- ST segments — Elevation or depression
- T waves — Inversion, flattening, peaking
- U waves — Prominent in hypokalemia, bradycardia
Always compare with previous ECGs — this is invaluable.
— Harrison's Principles of Internal Medicine, p. 1919
Step 3 — Calculating Heart Rate
Method 1 — "Rate by squares" (regular rhythms):
Count large boxes between two R waves → divide 300 by that number.
- Example: 4 large boxes between R waves → 300 ÷ 4 = 75 bpm
Method 2 — "QRS count" (irregular rhythms like AF):
Count all QRS complexes on the 10-second strip → multiply by 6.
- Example: 10 complexes × 6 = 60 bpm
Step 4 — Determine the Axis
- Normal axis: −30° to +90°
- Use Lead I (0°) and aVF (90°) — they are perpendicular to each other
- Both upright → normal axis
- Left axis deviation (LAD): Lead I up, aVF down — seen in LVH (from chronic hypertension)
- Right axis deviation (RAD): Lead I down, aVF up — seen in RVH, pulmonary HTN, congenital disease
Step 5 — Classify the Rhythm
Approach rhythms by two questions:
- Narrow or wide QRS?
- Narrow (<0.12 sec) = supraventricular origin (follows normal conduction)
- Wide (≥0.12 sec) = ventricular origin OR aberrant conduction
- Regular or irregular?
- Regularly irregular → recurring pattern (e.g., Wenckebach)
- Irregularly irregular → completely disorganized (e.g., atrial fibrillation — no clear P waves)
Step 6 — Key ST/T Wave Patterns to Know
| Finding | Think of |
|---|
| ST elevation | STEMI, pericarditis, early repolarization, LV aneurysm |
| ST depression | Subendocardial ischemia, digoxin effect |
| T-wave inversion | Ischemia, PE, subarachnoid hemorrhage, myocarditis |
| Peaked T waves | Hyperkalemia (or hyperacute STEMI) |
| Prolonged QT | Drugs, hypokalemia, hypomagnesemia, congenital syndromes |
| Wide QRS | Bundle branch block, ventricular rhythm, hyperkalemia |
Repolarization (ST-T) is an active, ATP-dependent process — making it especially susceptible to ischemia.
— Kaplan & Sadock's Comprehensive Textbook of Psychiatry, p. 6825
How to Build Proficiency — Practical Tips
- Read ECGs daily — volume is everything. Free resources include ECG Wave-Maven (Harvard's self-assessment library) and Lifeinthefastlane.com.
- Use a fixed sequence every time — don't skip steps, even on "obvious" tracings.
- Start with normal — read 50+ normal ECGs before focusing on abnormal ones.
- Learn by pattern recognition — LBBB, RBBB, AF, STEMI, AV blocks each have a visual gestalt.
- Correlate with clinical context — age, sex, symptoms, and medications change interpretation dramatically.
- Reference textbooks:
- Goldberger's Clinical Electrocardiography: A Simplified Approach (10th ed., 2024) — the classic beginner's book
- Harrison's Principles of Internal Medicine (22nd ed.) — Chapter 247 for ECG basics
- Braunwald's Heart Disease — for advanced/cardiology-level detail
Sources
- Harrison's Principles of Internal Medicine, 22nd ed., Chapter 247, p. 1919
- Kaplan & Sadock's Comprehensive Textbook of Psychiatry, pp. 6824–6826