Assessing Stomach Pain and Cramps
"Stomach pain and cramps" is a very broad presentation — the cause and urgency differ enormously depending on details I don't have yet (age, sex, duration, exact location, associated symptoms, medical history). Here's a framework to work through, plus what would sharpen the differential.
Key questions to narrow it down
- Location: epigastric, periumbilical, RLQ/RUQ/LLQ/LUQ, diffuse/generalized, suprapubic
- Onset and duration: sudden vs. gradual, acute (hours-days) vs. chronic/recurrent (weeks-months)
- Character: crampy/colicky (comes in waves) vs. constant/sharp vs. burning
- Associated symptoms: fever, vomiting, diarrhea or constipation, blood in stool/vomit, bloating, jaundice, urinary symptoms, weight loss
- Modifying factors: relation to meals, bowel movements, menstrual cycle (if female), medications (NSAIDs, antibiotics)
- Age: causes and risk of serious pathology shift a lot with age
Common causes by pattern
- Crampy, periumbilical or diffuse pain with diarrhea/nausea - gastroenteritis (viral most common), food poisoning, IBS
- Epigastric burning, worse/better with food - peptic ulcer disease, gastritis, GERD. Per Harrison's Principles of Internal Medicine, dyspepsia that becomes constant or radiates to the back can suggest a penetrating ulcer, while sudden severe generalized pain raises concern for perforation - Harrison's Principles of Internal Medicine, 22E.
- RLQ pain, worsening, with fever/anorexia - appendicitis (surgical emergency)
- RUQ colicky pain after fatty meals - biliary colic/cholecystitis
- Crampy pain with bloating, altered bowel habits, relieved by defecation, chronic/recurrent - irritable bowel syndrome (a common cause of "cramps")
- Lower abdominal/pelvic cramping in a woman - dysmenorrhea, ovarian cyst, PID, ectopic pregnancy (must rule out if any possibility of pregnancy)
- Diffuse colicky pain with constipation/distension - bowel obstruction
- Flank-to-groin colicky pain - renal colic (kidney stone)
Red flags that warrant urgent evaluation
From Rosen's Emergency Medicine and Harrison's, seek urgent/emergency care if there is:
- Sudden onset of severe, generalized, or "board-like" abdominal pain (possible perforation)
- Pain with rigidity, guarding, or rebound tenderness
- Fever with abdominal pain
- Persistent vomiting, inability to keep fluids down
- Blood in vomit or stool, or black/tarry stools
- Unintentional weight loss
- Signs of GI bleeding or hypovolemia (tachycardia, dizziness, pallor)
- Pain in an older adult: presentations are often deceptively subtle in the elderly (lack of guarding/rebound despite serious pathology), and this group carries a higher risk of a surgical abdomen and death - ROSEN's Emergency Medicine, Concepts and Clinical Practice. Also, in older adults (especially women), abdominal pain alone can be the presenting symptom of acute coronary syndrome rather than chest pain.
- Any possibility of pregnancy with lower abdominal pain (rule out ectopic)
What generally helps in the meantime (if no red flags)
- Clear fluids, small bland meals (BRAT-type diet), rest
- Avoid NSAIDs, alcohol, caffeine, and fatty/spicy foods until cause is clear
- OTC antispasmodics or simethicone for gas/cramping if no contraindication
- Track symptoms: timing relative to meals/bowel movements, stool character, temperature
Could you share a few more specifics — the patient's age/sex, how long this has been going on, exact location of pain, and whether there's fever, vomiting, diarrhea, or blood involved? That would let me point to a much more specific differential and appropriate next steps (or clarify if this needs urgent in-person evaluation now).
Recent literature check: a 2025 review on POCUS for acute abdominal pain (PMID: 41023565) and a 2025 review on chronic abdominal pain approaches (PMID: 41134173) are consistent with the textbook framework above — no contradicting updates found.