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Can you make a 20 mark mcq quiz on the chapter of cholera from the latest edition of apurba shastry only, consisting of important questions
Reading File
Finding Sources
Apurba Shastry's textbook is not available in the library — only Jawetz, Murray's Medical Microbiology, and Sherris are present. I can't create a quiz sourced exclusively from Apurba Shastry without access to that book.
However, I can offer two alternatives:
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Use an available microbiology textbook — I can build the cholera MCQ quiz from Jawetz or Murray's Medical Microbiology (9e), which cover cholera in similar depth and are widely used alongside Apurba Shastry.
-
Use my knowledge of Apurba Shastry — I have strong training-data familiarity with the content of Apurba Shastry's Essentials of Medical Microbiology, and can craft a 20-mark cholera MCQ based on what that book typically covers (organism, pathogenesis, El Tor biotype, toxin mechanism, lab diagnosis, treatment, epidemiology, etc.) — though I cannot cite page numbers from it.
Which would you prefer?
2
Here is a 20-mark MCQ quiz on Cholera based on Apurba Shastry's Essentials of Medical Microbiology:
🧫 Cholera — 20 MCQ Quiz
Based on Apurba Shastry's Essentials of Medical Microbiology
Q1. Vibrio cholerae belongs to which family?
- A) Enterobacteriaceae
- B) Vibrionaceae ✅
- C) Spirochaetaceae
- D) Pseudomonadaceae
Q2. The classical biotype of Vibrio cholerae was replaced by which biotype in the 7th pandemic?
- A) Bengal
- B) Hikojima
- C) El Tor ✅
- D) Ogawa
Q3. Cholera toxin (CT) acts by:
- A) Inhibiting adenylate cyclase
- B) Activating guanylate cyclase
- C) Irreversibly activating adenylate cyclase via ADP-ribosylation of Gs protein ✅
- D) Blocking Na⁺/K⁺ ATPase
Q4. Which subunit of cholera toxin is responsible for binding to the GM1 ganglioside receptor?
- A) A subunit
- B) B subunit ✅
- C) Both A and B equally
- D) Neither; it binds via flagella
Q5. The gene encoding cholera toxin (ctx) is carried by:
- A) A plasmid
- B) The bacterial chromosome only
- C) A lysogenic bacteriophage (CTXφ) ✅
- D) A transposon
Q6. Which serogroup of V. cholerae causes epidemic cholera?
- A) O1 and O139 ✅
- B) O1 only
- C) O139 only
- D) All serogroups equally
Q7. The O139 serogroup of V. cholerae differs from O1 primarily by having:
- A) A different cholera toxin
- B) A polysaccharide capsule ✅
- C) Resistance to all antibiotics
- D) Absence of flagella
Q8. Rice water stools in cholera are characterized by:
- A) Bloody diarrhea with mucus
- B) Large volume watery stools with flecks of mucus, odorless ✅
- C) Fatty, foul-smelling stools
- D) Small volume stools with tenesmus
Q9. The most important virulence factor of Vibrio cholerae is:
- A) Neuraminidase
- B) Mucinase
- C) Cholera toxin ✅
- D) Haemolysin
Q10. TCBS (Thiosulphate Citrate Bile Salt Sucrose) agar is used for isolation of V. cholerae. Colonies appear as:
- A) Black colonies
- B) Pink colonies
- C) Yellow colonies ✅
- D) Colorless colonies
Q11. The El Tor biotype of V. cholerae differs from the classical biotype by all of the following EXCEPT:
- A) Positive Voges-Proskauer test
- B) Resistant to Mukerjee's phage IV
- C) Produces haemolysin
- D) Produces more severe disease ✅
Q12. String test (oxidase test variant) in V. cholerae refers to:
- A) Mucoid stringing on TCBS
- B) Formation of a string when a colony is emulsified in 0.5% sodium deoxycholate ✅
- C) Positive bile solubility
- D) Agglutination with O1 antiserum
Q13. The incubation period of cholera is:
- A) 1–3 hours
- B) Few hours to 5 days ✅
- C) 7–14 days
- D) 2–4 weeks
Q14. Vibrio cholerae is killed by:
- A) Alkaline pH
- B) Acid pH ✅
- C) Neutral pH
- D) High salt concentration
Q15. Which transport medium is used for suspected cholera stool specimens?
- A) Stuart's transport medium
- B) Cary-Blair medium ✅
- C) Tetrathionate broth
- D) Alkaline peptone water (APW) as enrichment, not transport
Q16. Widal-like agglutination test used for rapid diagnosis of cholera in field conditions is:
- A) ELISA
- B) Co-agglutination test ✅
- C) Dark-field microscopy
- D) PCR
Q17. The drug of choice for cholera in adults is:
- A) Ampicillin
- B) Metronidazole
- C) Doxycycline ✅
- D) Ceftriaxone
Q18. Oral Rehydration Therapy (ORT) in cholera works on the principle of:
- A) Inhibiting cholera toxin
- B) Glucose-coupled sodium absorption, which is unaffected by CT ✅
- C) Bicarbonate buffering of acid stools
- D) Potassium replacement alone
Q19. Which of the following is TRUE about Vibrio cholerae O139 (Bengal)?
- A) It was first isolated in India and Bangladesh in 1992 ✅
- B) It produces a weaker toxin than O1
- C) It does not produce cholera toxin
- D) It has been eradicated since 2000
Q20. Dark-field microscopy of fresh cholera stool shows:
- A) Spirochetes with rapid rotation
- B) Comma-shaped organisms with shooting star/darting motility ✅
- C) Gram-positive cocci in clusters
- D) Acid-fast bacilli
Answer Key
| Q | Ans | Q | Ans |
|---|---|---|---|
| 1 | B | 11 | D |
| 2 | C | 12 | B |
| 3 | C | 13 | B |
| 4 | B | 14 | B |
| 5 | C | 15 | B |
| 6 | A | 16 | B |
| 7 | B | 17 | C |
| 8 | B | 18 | B |
| 9 | C | 19 | A |
| 10 | C | 20 | B |
Total: 20 marks (1 mark each)
These questions cover the high-yield topics from the Cholera chapter — taxonomy, biotypes, serogroups, toxin mechanism, pathogenesis, lab diagnosis, treatment, and epidemiology — all key areas Apurba Shastry emphasizes. Let me know if you'd like explanations for any question!
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