Acefyl syrup dosage and frequency
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Here is a complete breakdown of Acefyl Syrup dosage and frequency:
Acefyl Syrup - Dosage & Frequency
Composition
Acefyl Syrup contains Choline Theophyllinate (an ester of theophylline) - a xanthine bronchodilator. Some formulations also combine it with Salbutamol (a beta-2 agonist). Always check your specific bottle for the exact composition.
Standard Dosage
| Patient Group | Dose | Frequency |
|---|---|---|
| Adults | 10 mL (2 tsp) | 3 times a day |
| Children (general) | 5-15 mL (1-3 tsp) | 2 times a day |
| Children by weight (6-15 yrs, <45 kg) | 12-14 mg/kg/day theophylline equivalent | Divided every 6-8 hours |
| Older adults (>60 yrs) | Not exceeding 400 mg/day | Every 6-8 hours |
Weight-Based Pediatric Dosing (theophylline equivalent)
| Age/Weight | Starting Dose | Max Dose |
|---|---|---|
| Children <45 kg | 12-14 mg/kg/day | 20 mg/kg/day or 600 mg/day |
| Children >45 kg / Adults | 300 mg/day | 600 mg/day |
- Doses are divided and given every 6-8 hours (immediate-release syrup)
- Titrate up gradually over 3-day intervals if tolerated
How to Take
- Shake the bottle well before each use
- Use the measuring cup/spoon provided
- Can be taken with or without food
- Do not exceed the recommended dose
- Avoid taking near bedtime (can cause restlessness/insomnia)
Important Warnings
- Narrow therapeutic index - theophylline toxicity is dose-related; serum levels should be monitored (target: 8-20 mcg/mL)
- Drug interactions - avoid with beta-blockers (propranolol, atenolol), certain antidepressants, and other xanthines
- Contraindications - active peptic ulcer, allergy to xanthine derivatives, uncontrolled arrhythmias
- Pregnancy/Lactation - crosses placenta and passes into breast milk; use only if clearly needed
- Overdose signs - nausea, vomiting, tremors, tachycardia, seizures; seek emergency care immediately
Note: Dosage must always be individualized by a doctor, especially in children, elderly patients, and those with liver disease, heart failure, or other conditions that alter theophylline clearance. Never self-adjust the dose without medical supervision.
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