I now have comprehensive material from Harrison's, Medical Physiology, and Miller's Anesthesia, plus excellent images. Here is a complete ECG learning guide:
π ECG Learning Guide
Sources: Harrison's Principles of Internal Medicine 22e, Medical Physiology (Boron & Boulpaep), Miller's Anesthesia 10e
1. What is an ECG?
An electrocardiogram (ECG) is a surface recording of the electrical potential differences generated by the heart. It reflects every step of the cardiac conduction cycle β from the sinoatrial (SA) node firing to ventricular repolarization.
2. The ECG Paper & Calibration
ECG paper has two grids:
| Box size | Time | Voltage |
|---|
| Small box (1 mm) | 0.04 s | 0.1 mV |
| Large box (5 mm) | 0.20 s | 0.5 mV |
5 large boxes = 1 second.
Quick heart rate formula: Rate = 300 Γ· (number of large boxes in R-R interval)
- 1 box β 300 bpm | 2 β 150 | 3 β 100 | 4 β 75 | 5 β 60 | 6 β 50
3. The Normal ECG Waveform
The Wiggers diagram below shows exactly how the ECG waveform relates to mechanical events of the cardiac cycle:
Miller's Anesthesia β Electrical and mechanical events during a single cardiac cycle
The Waves Explained
| Wave/Interval | Represents | Normal Duration |
|---|
| P wave | Atrial depolarization (SA node β atria) | < 0.12 s (3 small boxes) |
| PR interval | AV node conduction delay | 0.12β0.20 s (3β5 small boxes) |
| QRS complex | Ventricular depolarization | < 0.12 s (3 small boxes) |
| ST segment | Ventricular plateau (early repolarization) | Isoelectric (flat) |
| T wave | Ventricular repolarization | Upright in I, II, V2βV6 |
| QT interval | Total ventricular action potential | Varies with rate (QTc < 0.44 s) |
| U wave | Papillary muscle / slow repolarization | Small, same direction as T |
Key physiology:
- The P wave = SA node fires β impulse travels through atria via internodal tracts
- The PR interval = deliberate AV node delay (gives ventricles time to fill)
- The QRS = depolarization down the His bundle β left and right bundle branches β Purkinje fibers β ventricular myocardium
- The T wave = ventricular repolarization (note: depolarization is QβS; repolarization is T)
(Medical Physiology, Box 21-2)
4. The 12-Lead System
A standard ECG uses 10 electrodes to create 12 views of the heart.
Precordial (Chest) Lead Positions
| Lead | Position |
|---|
| V1 | 4th intercostal space, right sternal border |
| V2 | 4th intercostal space, left sternal border |
| V3 | Between V2 and V4 |
| V4 | 5th intercostal space, midclavicular line |
| V5 | Anterior axillary line (same level as V4) |
| V6 | Midaxillary line (same level as V4) |
Limb Leads & What They "See"
| Lead Group | Leads | Wall of Heart |
|---|
| Inferior | II, III, aVF | Inferior wall (RCA territory) |
| Lateral | I, aVL, V5, V6 | Lateral wall (LCx territory) |
| Anterior | V1βV4 | Anterior wall (LAD territory) |
| Reciprocal | aVR | Global β expected to be negative |
5. Systematic Interpretation β The 14-Step Approach
(Harrison's Principles of Internal Medicine 22e)
Always analyze in this order to avoid errors of omission:
- Standardization / calibration (1 mV = 10 mm? Any artifacts or lead misplacement?)
- Rhythm (regular/irregular? P before every QRS?)
- Heart rate (use the 300-rule above)
- PR interval (AV conduction β normal 0.12β0.20 s)
- QRS interval (< 0.12 s = narrow = normal; β₯ 0.12 s = wide = bundle branch block)
- QT / QTc interval (prolonged QT β torsades risk)
- Mean QRS electrical axis (normal β30Β° to +90Β°)
- P waves (size, shape, duration)
- QRS voltages (high = LVH; low = pericardial effusion/obesity)
- Precordial R-wave progression (should grow from V1βV5)
- Abnormal Q waves (> 1 small box wide or > ΒΌ R height = pathological)
- ST segments (elevation or depression)
- T waves (inversion, hyperacute changes)
- U waves (prominent in hypokalemia)
Always compare with previous ECGs β this is invaluable.
6. Heart Rate & Rhythm
Normal Sinus Rhythm vs Atrial Fibrillation
Normal Sinus Rhythm: Regular R-R intervals, P wave before every QRS, rate 60β100 bpm.
Atrial Fibrillation: Irregularly irregular rhythm, no discernible P waves, fibrillatory baseline, variable R-R intervals.
7. AV Blocks (Heart Blocks)
| Block | ECG Finding | Clinical Significance |
|---|
| 1st degree | PR interval > 0.20 s (5 small boxes), every P conducts | Usually benign |
| 2nd degree Mobitz I (Wenckebach) | PR progressively lengthens until a QRS is dropped | AV node disease; often reversible |
| 2nd degree Mobitz II | Constant PR, then sudden dropped QRS | His-Purkinje disease; needs pacing |
| 3rd degree (complete) | P waves and QRS complexes completely dissociated; separate independent rates | Medical emergency; pacemaker required |
8. ST Changes β Ischemia & Infarction
STEMI (ST-Elevation MI)
STEMI criteria (from Tintinalli's Emergency Medicine):
- β₯ 1 mm ST elevation in β₯ 2 contiguous limb leads, OR
- β₯ 2 mm ST elevation in β₯ 2 contiguous precordial leads
Localization by leads:
| Leads with STE | Infarct Location | Culprit Artery |
|---|
| V1βV4 | Anterior | LAD |
| V1βV6 + I, aVL | Anterolateral | Proximal LAD |
| II, III, aVF | Inferior | RCA (or LCx) |
| I, aVL, V5βV6 | Lateral | LCx |
| Posterior (tall R in V1βV2, ST depression) | Posterior | RCA/LCx |
Reciprocal changes (ST depression in opposite leads) strongly support true STEMI.
9. Key Intervals at a Glance
Normal ECG Intervals
ββββββββββββββββββββββββββββββββββββββββββββββββββββββ
β PR interval: 0.12 β 0.20 s β
β QRS duration: < 0.12 s β
β QT interval: 0.35 β 0.44 s (rate-dependent) β
β QTc (Bazett): < 0.44 s (men) / < 0.46 s (women)β
β Normal axis: β30Β° to +90Β° β
β Heart rate: 60 β 100 bpm β
ββββββββββββββββββββββββββββββββββββββββββββββββββββββ
10. Common Patterns Summary
| Pattern | Key ECG Feature |
|---|
| Normal sinus rhythm | Regular, PβQRSβT, rate 60β100 |
| Sinus bradycardia | Same as above, rate < 60 |
| Sinus tachycardia | Same as above, rate > 100 |
| Atrial fibrillation | Irregularly irregular, no P waves |
| Atrial flutter | Regular sawtooth P waves at ~300/min, 2:1 or 4:1 block |
| SVT (AVNRT) | Narrow QRS tachycardia, P waves hidden in/after QRS |
| VT | Wide QRS tachycardia (β₯ 0.12 s), AV dissociation |
| VF | Chaotic, no identifiable complexes β cardiac arrest |
| LBBB | Wide QRS, dominant S in V1, broad notched R in V5βV6 |
| RBBB | Wide QRS, RSR' (rabbit ears) in V1 |
| LVH | Sokolow-Lyon: S(V1) + R(V5 or V6) > 35 mm |
| Hyperkalaemia | Peaked T waves β wide QRS β sine wave pattern |
| Long QT | QTc > 440 ms β risk of torsades de pointes |
| Pericarditis | Diffuse saddle-shaped ST elevation, PR depression |
Learning Resources
- Life in the Fast Lane ECG Library β free, case-based, comprehensive
- ECG Wave-Maven (Harvard BIDMC) β 1000+ practice ECGs with answers
- ACLS Medical Training ECG Basics β beginner-friendly overview
- Harrison's Principles of Internal Medicine 22e, Chapter 247 β The Electrocardiogram
- Medical Physiology (Boron & Boulpaep), Chapter 21 β Box 21-2
Start with rhythm and rate, then work through the 14 steps systematically. Pattern recognition comes with practice β aim to read at least 5β10 ECGs daily using a free online library like ECG Wave-Maven.