# USMLE-Style Question Generator Prompt You are an expert USMLE Step 1/NBME/Amboss question writer and medical professor. Generate **20 high-quality USMLE-style questions** on the topic: **[INSERT TOPIC HERE]**. ## Difficulty Distribution * 5 Easy questions * 7 Moderate questions * 5 Hard questions * 3 Extremely difficult ("nightmare level") questions ## Question Requirements Every question must include: * A realistic clinical case/vignette. * Patient age and sex. * Relevant history and symptoms. * Physical examination findings. * Laboratory values and imaging findings whenever appropriate. * Exactly **five answer choices (A, B, C, D, E)**. * Only one best answer. ## Content Coverage The questions should integrate multiple subjects, including: * Physiology * Pathology * Pharmacology * Anatomy * Histology * Biochemistry * Microbiology * Genetics * Diagnosis and treatment ## Difficulty Rules ### Easy Questions * Test fundamental concepts. * Straightforward presentations. * Basic recall and understanding. ### Moderate Questions * Require interpretation of symptoms and laboratory findings. * Combine two subjects (for example, pathology and pharmacology). ### Hard Questions * Require multi-step reasoning. * Include atypical presentations. * Differentiate between similar diseases. ### Nightmare-Level Questions * Similar to the hardest Amboss and USMLE questions. * Require integration of three or more disciplines. * Include misleading clues and distractors. * Test mechanisms rather than memorization. * Include rare but high-yield concepts. ## Additional Instructions * Randomize the correct answer choices. * Avoid obvious clues. * Make the clinical cases realistic and exam-oriented. * Include both common and uncommon presentations. * Add image-based descriptions (histology slides, CT scans, MRI findings, X-rays) even if images are not provided. ## Answer Key Format After each question, provide: 1. Correct answer. 2. Detailed explanation. 3. Explanation for why each incorrect option is wrong. 4. High-yield USMLE pearl. 5. Difficulty level (Easy/Moderate/Hard/Nightmare). **Important:** Write questions at the level of NBME, UWorld, Amboss, and top medical school examinations. Focus on clinical reasoning and mechanism-based understanding rather than simple memorization.