Hey, explain me about the concept of fibrinolysis, you know. It is the final step where the clot is dissolved when the vessel got healed, right? So, this concept, explain me and what all are the testables through this concept in the USMLE Step 1. I want a topper-like notes, like useful for step 1.

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I now have all the high-yield information needed from multiple authoritative sources. Let me compile the comprehensive USMLE Step 1 notes on fibrinolysis.

Fibrinolysis — USMLE Step 1 High-Yield Notes

The Big Picture

Fibrinolysis is the enzymatic dissolution of a fibrin clot after tissue repair. It is the counter-regulatory system to coagulation — just as thrombin is the master enzyme of coagulation, plasmin is the master enzyme of fibrinolysis. The two systems are activated in parallel during vascular injury, keeping each other in balance.

Your correction is partially right — fibrinolysis is activated during clot formation (not only after healing), to limit clot growth from the start, and then continues to dissolve the clot as the wound heals.

Core Pathway (The One Diagram You Must Know)

Fibrinolytic System — Activators and Inhibitors

Katzung's Basic and Clinical Pharmacology, 16e — The fibrinolytic system with pharmacologic modulators

Step-by-Step Mechanism

1. Plasminogen → Plasmin (The Key Conversion)

Component	Role
Plasminogen	Inactive zymogen (precursor), circulates in blood
tPA (tissue plasminogen activator)	Primary physiologic activator; released by endothelial cells
uPA (urokinase-type PA)	Second activator; mainly drives extravascular fibrinolysis (inflammatory contexts)
Plasmin	Active serine protease; digests fibrin

tPA cleaves the Arg560–Val561 bond of plasminogen → generates active two-chain plasmin
Endothelial cells synthesize and release both tPA and uPA
tPA predominates under most physiologic conditions
The catalytic efficiency of tPA activation of plasminogen increases >300-fold in the presence of fibrin — this is why plasmin is generated on the clot surface, not diffusely in blood

— Goodman & Gilman's Pharmacological Basis of Therapeutics; Katzung's Basic and Clinical Pharmacology 16e

2. Why Is Fibrinolysis "Fibrin-Specific"? (Kringle Domains — HIGH YIELD)

Plasminogen and plasmin both have kringle domains — loop-like structures near their amino termini that bind to exposed lysine residues on fibrin
This anchors both plasminogen and tPA onto the clot surface → forms a ternary complex (fibrin + plasminogen + tPA) → massively accelerates plasmin generation locally
As plasmin begins degrading fibrin, it exposes new carboxy-terminal lysine residues → even more plasminogen and tPA binding → positive feedback loop of clot dissolution
Plasmin bound to fibrin is protected from circulating α₂-antiplasmin (its inhibitor) because the kringle domains are occupied
Result: plasmin acts only on the clot, not on circulating fibrinogen — "fibrin-specific"

⚠️ This specificity is lost at pharmacologic doses of tPA (alteplase) — too much plasmin overwhelms the inhibitory controls → systemic lytic state → bleeding risk

— Goodman & Gilman's; Harrison's Internal Medicine 22e

3. What Does Plasmin Actually Degrade?

Substrate	Product	Clinical Significance
Cross-linked fibrin (clot)	D-dimer + fibrin degradation products (FDPs)	D-dimer is diagnostic for DVT/PE, DIC
Fibrinogen (in systemic lysis)	Fibrinogen degradation products (FDPs)	Seen in DIC, thrombolytic overdose
Coagulation factors (at high doses)	Degraded V, VIII	Bleeding risk with thrombolytics

D-dimer is produced only when plasmin acts on cross-linked fibrin (Factor XIIIa-stabilized clot) — not from fibrinogen alone. This is its diagnostic value.

— Harrison's Internal Medicine 22e

Regulatory Inhibitors (The Brakes on the System)

Inhibitor	What It Inhibits	Notes
PAI-1 (plasminogen activator inhibitor-1)	tPA and uPA	Major inhibitor of plasminogen activators; synthesized by endothelial cells; rapidly clears tPA from blood
PAI-2	tPA and uPA (lesser extent)	Prominent in pregnancy
α₂-antiplasmin (α₂-plasmin inhibitor)	Plasmin	Major inhibitor of free plasmin; binds kringle domain 1 then blocks active site; overwhelmed by therapeutic tPA doses
TAFI (Thrombin-Activatable Fibrinolysis Inhibitor)	Removes C-terminal lysines from fibrin	Limits plasminogen/tPA binding; thrombin + thrombomodulin activates it
Factor XIIIa	Indirectly (cross-links α₂-antiplasmin to fibrin)	Prevents premature clot lysis

PAI-1 is the key reason tPA exerts little effect on circulating plasminogen in the absence of fibrin — tPA is rapidly neutralized before it can act systemically
α₂-antiplasmin is the main circulating safety net that mops up any plasmin that escapes the clot

— Goodman & Gilman's; Katzung 16e; Harrison's 22e

Pharmacology (Thrombolytics/Fibrinolytics) — HIGH YIELD

Drugs That ACTIVATE Fibrinolysis

Drug	Mechanism	Fibrin-Specific?	Notes
Alteplase (tPA, rt-PA)	Recombinant tPA → activates plasminogen	Yes (at physiologic doses)	Drug of choice for ischemic stroke (within 4.5 hrs), STEMI if no PCI available
Reteplase (rPA)	Recombinant tPA variant	Yes	Double bolus IV; used in STEMI
Tenecteplase (TNK-tPA)	Engineered tPA variant	Yes	Single weight-based bolus; longer half-life; used in STEMI
Streptokinase	Bacterial protein; binds plasminogen → forms an activator complex	No (non-fibrin-specific)	Systemic lytic state; antigenic (↑ antibodies, allergic reactions); cannot re-use
Urokinase (uPA)	Directly converts plasminogen → plasmin	No	Used for catheter-directed thrombolysis
Anistreplase	Streptokinase + plasminogen complex	No	Older agent

Drug That INHIBITS Fibrinolysis

Drug	Mechanism	Use
Aminocaproic acid (ε-aminocaproic acid)	Lysine analogue → blocks kringle domains → prevents plasminogen/tPA binding to fibrin	Hemostasis after surgery, hemophilia bleeds, post-tonsillectomy bleeding
Tranexamic acid (TXA)	Same mechanism as aminocaproic acid (lysine analogue)	Trauma, surgical bleeding, heavy menstrual bleeding

Mnemonic: Aminocaproic acid = Anti-fibrinolytic — it occupies the lysine-binding sites so plasminogen cannot attach to fibrin.

— Katzung 16e; Lippincott Pharmacology; Goodman & Gilman's

Contraindications to Thrombolytics (Step 1 Favorite)

Absolute contraindications:

Prior intracranial hemorrhage (any time)
Ischemic stroke within 3 months (except acute stroke being treated, <4.5 hrs)
Suspected aortic dissection
Active internal bleeding (not menses)
Significant closed-head trauma/facial trauma within 3 months
SBP >180 or DBP >110 at presentation (severe uncontrolled hypertension)

Clinical Scenarios and Lab Findings

D-Dimer

Elevated D-dimer = evidence of fibrin clot formation AND lysis → used to rule OUT DVT/PE (high sensitivity, low specificity)
D-dimer is elevated in: DVT/PE, DIC, post-surgery, pregnancy, malignancy, infection
D-dimer is NOT elevated with just thrombocytopenia or with fibrinogen degradation (needs cross-linked fibrin)

DIC (Disseminated Intravascular Coagulation)

Pathologic activation of BOTH coagulation AND fibrinolysis simultaneously
Labs: ↑ PT, ↑ aPTT, ↑ D-dimer, ↑ FDPs, ↓ fibrinogen, ↓ platelets
Causes: sepsis, trauma, obstetric emergencies (abruptio placentae, amniotic fluid embolism), malignancy
Treat the underlying cause — DIC is often fatal if the underlying process cannot be controlled

Bleeding Complication of Thrombolytics

At pharmacologic doses, plasmin degrades Factors V and VIII in addition to fibrin → impairs thrombin generation → bleeding
Also dissolves fibrin in hemostatic plugs (normal wound seals) → more bleeding risk
Hemorrhage is the major adverse effect of all fibrinolytic drugs

USMLE Step 1 High-Yield Testable Points Summary

Concept	Testable Fact
Plasminogen activator	tPA (physiologic); released by endothelial cells
Kringle domains	Bind lysine on fibrin → clot specificity → protected from α₂-antiplasmin
Major inhibitor of plasmin	α₂-antiplasmin
Major inhibitor of tPA	PAI-1
D-dimer	Product of cross-linked fibrin degradation; rules out DVT/PE
FDPs without D-dimer	From fibrinogen degradation only (not cross-linked fibrin)
DIC labs	↑ PT, ↑ aPTT, ↑ D-dimer, ↓ fibrinogen, ↓ platelets, schistocytes on smear
Streptokinase	Antigenic, non-fibrin-specific, cannot re-administer
Aminocaproic acid / TXA	Lysine analogues → antifibrinolytic
Alteplase contraindications	Hemorrhagic stroke ever; ischemic stroke <3 months; aortic dissection
Fibrin specificity at high tPA doses	LOST → systemic lytic state → bleeding
Positive feedback in lysis	Partial fibrin degradation exposes more lysine residues → more plasmin binding
TAFI	Thrombin-activatable fibrinolysis inhibitor; removes lysines → slows lysis
Factor XIIIa role	Cross-links fibrin AND cross-links α₂-antiplasmin to fibrin → protects clot from early lysis

Memory Map

VESSEL INJURY
    ↓
Coagulation cascade → Thrombin → Fibrin clot (Factor XIIIa cross-links it)
    ↓ (simultaneously)
Endothelial cells release tPA
    ↓
tPA + Plasminogen bind to FIBRIN (via kringle-lysine interaction)
    → Ternary complex → Plasmin (locally generated, fibrin-specific)
    ↓
Plasmin degrades cross-linked fibrin → D-DIMER + FDPs
    ↓
Clot dissolves; vessel patent again

INHIBITORS:
  PAI-1 → blocks tPA/uPA
  α₂-antiplasmin → blocks free plasmin
  TAFI → removes lysines from fibrin (limits plasmin binding)
  Aminocaproic acid / TXA → occupy lysine binding sites (drugs)

Sources: Katzung's Basic and Clinical Pharmacology 16e | Goodman & Gilman's Pharmacological Basis of Therapeutics | Harrison's Principles of Internal Medicine 22e | Lippincott Illustrated Reviews: Pharmacology | Medical Physiology (Boron & Boulpaep)

Step 1 topper like hy and short including everything

Fibrinolysis — Step 1 Topper Notes ⚡

THE MASTER EQUATION

Plasminogen  ──[tPA / uPA]──►  PLASMIN  ──►  Fibrin  ──►  D-dimer + FDPs
                                    ▲
                          (on clot surface only)

KEY PLAYERS — One Line Each

Player	What It Is	One-liner
Plasminogen	Inactive zymogen	Circulates in blood; activated ON the fibrin clot
tPA	Tissue plasminogen activator	Made by endothelium; main physiologic activator
uPA (urokinase)	Urokinase-type PA	Extravascular fibrinolysis; inflammatory states
Plasmin	Active serine protease	The actual "clot dissolver"
PAI-1	Plasminogen activator inhibitor-1	Blocks tPA/uPA → made by endothelium
α₂-antiplasmin	Plasmin inhibitor	Destroys free plasmin; can't reach clot-bound plasmin
TAFI	Thrombin-activatable fibrinolysis inhibitor	Removes lysines from fibrin → slows lysis

WHY PLASMIN IS CLOT-SPECIFIC (Most Tested Concept)

Plasminogen and tPA both have kringle domains → bind lysine residues on fibrin
Forms ternary complex: Fibrin + Plasminogen + tPA → plasmin generated locally
Plasmin on fibrin surface = kringle domains occupied = α₂-antiplasmin CANNOT bind = protected
Partial digestion of fibrin exposes MORE C-terminal lysines → positive feedback → faster lysis
Free plasmin (escapes clot) → instantly killed by α₂-antiplasmin

High-dose tPA (pharmacologic) → overwhelms PAI-1 and α₂-antiplasmin → clot specificity LOST → systemic lysis → BLEEDING

PRODUCTS OF FIBRINOLYSIS

Product	Source	Significance
D-dimer	Plasmin on cross-linked fibrin (Factor XIIIa-stabilized)	Diagnoses active clot formation + lysis (DVT/PE, DIC)
FDPs (fibrin/fibrinogen degradation products)	Plasmin on fibrin OR fibrinogen	Less specific; elevated in DIC, liver disease

D-dimer requires cross-linked fibrin → needs Factor XIIIa to have acted first → not elevated from fibrinogen breakdown alone

DRUGS — THE WHOLE TABLE

🔴 Pro-Fibrinolytic (Thrombolytics) — "Clot Busters"

Drug	Mechanism	Fibrin-Specific?	Key Facts
Alteplase (tPA)	Recombinant tPA	✅ Yes	Stroke (≤4.5 hrs), STEMI, massive PE
Reteplase	tPA variant	✅ Yes	Double IV bolus; STEMI
Tenecteplase (TNK)	Engineered tPA	✅ Yes	Single weight-based bolus; STEMI
Streptokinase	Bacterial → forms plasminogen-activator complex	❌ No	Antigenic → allergic rxn; can't re-use (antibodies); systemic lysis
Urokinase	Directly converts plasminogen → plasmin	❌ No	Catheter-directed thrombolysis

🟢 Anti-Fibrinolytic (Hemostatics) — "Clot Protectors"

Drug	Mechanism	Uses
Aminocaproic acid	Lysine analogue → blocks kringle domains → no plasminogen binding to fibrin	Post-op bleeding, hemophilia, tonsillectomy
Tranexamic acid (TXA)	Same mechanism	Trauma, surgery, heavy periods

Both are competitive inhibitors of plasminogen/plasmin binding to fibrin — they occupy the lysine-binding sites

CONTRAINDICATIONS TO THROMBOLYTICS (Absolute)

Prior intracranial hemorrhage (ever)
Ischemic stroke within 3 months (except: treating acute stroke <4.5 hrs)
Suspected aortic dissection
Active internal bleeding (not menses)
Severe uncontrolled HTN (SBP >180 / DBP >110)
Recent significant head/face trauma (<3 months)

DIC — THE PATHOLOGIC EXTREME

Both coagulation AND fibrinolysis go haywire simultaneously

Lab	Value	Why
PT / aPTT	↑	Clotting factors consumed
Fibrinogen	↓	Consumed + degraded by plasmin
Platelets	↓	Consumed in microthrombi
D-dimer	↑↑	Massive clot lysis
FDPs	↑↑	Fibrin/fibrinogen degradation
Smear	Schistocytes	RBCs sheared by fibrin strands

Causes: Sepsis, trauma, obstetric emergencies (abruption, amniotic fluid embolism, retained products), malignancy (esp. AML-M3 / APL)

Treatment: Treat underlying cause — if uncontrolled, often fatal

D-DIMER CLINICAL USE

Situation	D-dimer
Suspected DVT/PE (low pre-test probability)	If negative → rules OUT (high sensitivity)
DIC	↑↑ (with ↓ fibrinogen, ↓ platelets)
Post-surgery / pregnancy / cancer	False positive (↑ but not diagnostic)
Fibrinogenolysis only (no cross-linked fibrin)	Normal D-dimer, elevated FDPs only

RAPID-FIRE HY FACTS

tPA made by → endothelial cells
tPA cleared rapidly from blood by → PAI-1
Fibrin specificity mechanism → kringle domains + lysine residues
tPA efficiency on fibrin vs. alone → >300× faster on fibrin surface
Factor XIIIa does TWO things: ① cross-links fibrin strands ② cross-links α₂-antiplasmin onto fibrin (prevents early lysis)
TAFI activated by → thrombin + thrombomodulin complex
Streptokinase → antigenic → cannot re-administer (neutralizing antibodies)
Bleeding from thrombolytics → plasmin degrades Factors V and VIII → impairs future thrombin generation
Aminocaproic acid = anti-fibrinolytic → lysine analogue (same as TXA)
D-dimer = specifically from Factor XIIIa cross-linked fibrin degradation

ONE-LINER SUMMARY

tPA (from endothelium) converts plasminogen → plasmin on fibrin surface (via kringle-lysine binding); plasmin digests cross-linked fibrin → D-dimer; free plasmin is killed by α₂-antiplasmin; tPA is killed by PAI-1; drugs mimicking tPA = thrombolytics; drugs blocking lysine binding = antifibrinolytics.

Can you make a time table daily to solve questions of complete u world starting from today till june 30

Asking for Preferences

Here's your complete plan:

UWorld Step 1 Complete Timetable

May 19 → June 30 | Sundays Off

The Numbers

Stat	Value
Total questions	3,658
Total days (May 19 – Jun 30)	43 days
Sundays off (May 25, Jun 1, 8, 15, 22, 29)	6 days
Active study days	37 days
Questions/day needed	3658 ÷ 37 = ~99 Qs/day
Target: 100 Qs/day	Finishes entire bank with buffer

Daily Schedule (8–9 hrs/day)

Time	Activity	Duration
8:00–8:30 AM	Morning review — yesterday's marked/incorrect	30 min
8:30–10:30 AM	Block 1 — 40 Qs (Timed)	2 hrs
10:30–11:30 AM	Review Block 1 explanations deeply	1 hr
11:30–1:30 PM	Block 2 — 40 Qs (Timed)	2 hrs
1:30–2:30 PM	Lunch break	1 hr
2:30–3:30 PM	Review Block 2 explanations	1 hr
3:30–4:30 PM	Block 3 — 20 Qs (Tutor mode)	1 hr
4:30–5:15 PM	Review Block 3 + make notes	45 min
5:15–6:00 PM	Rapid-fire revision — FA/Sketchy/Anki on today's topics	45 min

80 Qs timed + 20 Qs tutor = 100 Qs/day with full review each day

Subject Allocation by Week

Based on your qbank breakdown (heaviest subjects first):

Week	Dates	Subjects	Total Qs
Week 1	May 19–24	Pathology (819 Qs) — Part 1	~600
Week 2	May 26–31	Pathology finish (219) + Pharmacology start (331)	~550
Week 3	Jun 2–7	Pharmacology finish (219) + Pathophysiology start (231)	~450
Week 4	Jun 9–14	Pathophysiology finish (257) + Anatomy (308)	~565
Week 5	Jun 16–21	Microbiology (348) + Behavioral Science start (154)	~500
Week 6	Jun 23–28	Behavioral Sci finish (100) + Physiology (268) + Biochemistry (159)	~527
Final push	Jun 29–30	Immunology (132) + Biostatistics (121) + Genetics (107) + Embryology (75) + Histology (29)	~464

Week-by-Week Daily Breakdown

WEEK 1 — May 19–24 | Pathology

Day	Date	Focus	Qs
Mon	May 19	Pathology — Cell injury, Inflammation, Neoplasia	100
Tue	May 20	Pathology — Cardiovascular	100
Wed	May 21	Pathology — Pulmonary	100
Thu	May 22	Pathology — GI + Hepatobiliary	100
Fri	May 23	Pathology — Renal + Endocrine	100
Sat	May 24	Pathology — Heme/Onc + MSK	100
Sun	May 25	OFF	—

WEEK 2 — May 26–31 | Pathology + Pharmacology

Day	Date	Focus	Qs
Mon	May 26	Pathology — Neuro + Repro (finish)	100
Tue	May 27	Pathology — Remaining + Review weak areas	119
Wed	May 28	Pharmacology — Autonomic + CNS drugs	100
Thu	May 29	Pharmacology — Cardiovascular drugs	100
Fri	May 30	Pharmacology — Antimicrobials	100
Sat	May 31	Pharmacology — Endocrine + Chemo drugs	100
Sun	Jun 1	OFF	—

WEEK 3 — Jun 2–7 | Pharmacology + Pathophysiology

Day	Date	Focus	Qs
Mon	Jun 2	Pharmacology — Remaining (finish)	~150
Tue	Jun 3	Pathophysiology — Cardio	100
Wed	Jun 4	Pathophysiology — Pulm + Renal	100
Thu	Jun 5	Pathophysiology — GI + Endocrine	100
Fri	Jun 6	Pathophysiology — Neuro + Heme	100
Sat	Jun 7	Pathophysiology — Remaining (finish)	~88
Sun	Jun 8	OFF	—

WEEK 4 — Jun 9–14 | Anatomy

Day	Date	Focus	Qs
Mon	Jun 9	Anatomy — Head & Neck	100
Tue	Jun 10	Anatomy — Upper limb + Lower limb	100
Wed	Jun 11	Anatomy — Thorax + Abdomen	100
Thu	Jun 12	Anatomy — finish (8 Qs leftover) + Microbiology — Bacteria	100
Fri	Jun 13	Microbiology — Viruses	100
Sat	Jun 14	Microbiology — Fungi + Parasites	100
Sun	Jun 15	OFF	—

WEEK 5 — Jun 16–21 | Microbiology + Behavioral Science

Day	Date	Focus	Qs
Mon	Jun 16	Microbiology — Remaining + Behavioral Sci start	100
Tue	Jun 17	Behavioral Science — Epidemiology + Ethics	100
Wed	Jun 18	Behavioral Science — finish + Physiology start	100
Thu	Jun 19	Physiology — Cardio + Pulm	100
Fri	Jun 20	Physiology — Renal + GI	100
Sat	Jun 21	Physiology — Neuro + Endocrine (finish)	68
Sun	Jun 22	OFF	—

WEEK 6 — Jun 23–28 | Biochemistry + Small Subjects

Day	Date	Focus	Qs
Mon	Jun 23	Biochemistry — Metabolism + Molecular bio	100
Tue	Jun 24	Biochemistry — finish (59) + Immunology start	100
Wed	Jun 25	Immunology — finish (32 leftover) + Biostatistics	100
Thu	Jun 26	Biostatistics — finish (21) + Genetics	100
Fri	Jun 27	Genetics — finish (7) + Embryology	100
Sat	Jun 28	Embryology — finish + Histology (29) + Spillover/Review	~54
Sun	Jun 29	OFF	—

FINAL 1 DAY — Jun 30

Day	Date	Activity
Mon	Jun 30	Full comprehensive review — All marked questions + weak subjects. Do a mixed 40Q timed block to simulate real test feel.

Rules for Review (Non-Negotiable)

Never skip explanations — read every explanation, even for correct answers
Mark aggressively — if you're not 100% sure, mark it
Wrong answer notebook — one line per wrong answer: "Q topic → Why I was wrong → Correct concept"
Saturday = light day — fewer new Qs, more review of the week's weak spots
Sunday = full off — your brain needs it

Weekly Check-In Targets

End of Week	Qs Completed	% Done
May 24	~600	16%
May 31	~1,219	33%
Jun 7	~1,757	48%
Jun 14	~2,357	64%
Jun 21	~2,957	81%
Jun 28	~3,511	96%
Jun 30	3,658	100% ✅

Bottom line: 100 Qs/day, 6 days/week, 37 active days = entire UWorld done with 1 full review day left. Stick to the 80 timed + 20 tutor split so you build speed AND understand concepts simultaneously.

Wait today is april 13 2026 make from tomorrow

UWorld Step 1 Complete Timetable

April 14 → June 30, 2026 | Sundays Off

The Numbers

Stat	Value
Total questions	3,658
Total days (Apr 14 – Jun 30)	78 days
Sundays off (Apr 19, 26, May 3, 10, 17, 24, 31, Jun 7, 14, 21, 28)	11 days
Active study days	67 days
Questions/day needed	3658 ÷ 67 = ~55 Qs/day
Target: 60 Qs/day	Finishes bank with ~5 days buffer for revision

Great news — you have a very comfortable timeline. 60 Qs/day is very doable in 8–9 hrs, leaving significant time for deep review, notes, and Anki/FA alongside each subject.

Daily Schedule (8–9 hrs/day)

Time	Activity	Duration
8:00–8:30 AM	Morning review — previous day's marked/incorrect Qs	30 min
8:30–10:00 AM	Block 1 — 40 Qs (Timed mode)	1.5 hrs
10:00–11:15 AM	Deep review of Block 1 explanations + notes	1 hr 15 min
11:15–11:30 AM	Short break	15 min
11:30–12:30 PM	Block 2 — 20 Qs (Tutor mode)	1 hr
12:30–1:30 PM	Lunch break	1 hr
1:30–2:30 PM	Review Block 2 + update wrong answer log	1 hr
2:30–4:30 PM	First Aid / Sketchy / Pathoma — parallel reading of today's subject	2 hrs
4:30–5:30 PM	Anki / Flashcard review (new + due cards)	1 hr
5:30–6:00 PM	Plan tomorrow, review weak points	30 min

40 timed + 20 tutor = 60 Qs/day with full deep review + resource reading every day

Subject Allocation Plan

Subject	Qs	Days Needed @ 60/day
Pathology	819	~14 days
Pharmacology	550	~9 days
Pathophysiology	488	~8 days
Anatomy	308	~5 days
Microbiology	348	~6 days
Behavioral Science	254	~4 days
Physiology	268	~4 days
Biochemistry	159	~3 days
Immunology	132	~2 days
Biostatistics	121	~2 days
Genetics	107	~2 days
Embryology	75	~1 day
Histology	29	~1 day
TOTAL	3,658	~61 days → done by ~Jun 18

Leaves Jun 19–30 (12 days) purely for revision of wrong/marked questions

Full Week-by-Week Schedule

WEEK 1 — Apr 14–19 | Pathology: Foundations

Day	Date	Subject Focus	Qs
Mon	Apr 14	Pathology — Cell injury, Apoptosis, Necrosis	60
Tue	Apr 15	Pathology — Inflammation (acute + chronic)	60
Wed	Apr 16	Pathology — Tissue repair, Wound healing	60
Thu	Apr 17	Pathology — Neoplasia (basics, carcinogenesis)	60
Fri	Apr 18	Pathology — Hematologic neoplasms (leukemia/lymphoma)	60
Sat	Apr 19	Pathology — Vascular pathology	60
Sun	Apr 19	OFF ☀️	—

WEEK 2 — Apr 21–26 | Pathology: Organ Systems

Day	Date	Subject Focus	Qs
Mon	Apr 21	Pathology — Cardiovascular	60
Tue	Apr 22	Pathology — Pulmonary	60
Wed	Apr 23	Pathology — GI (esophagus → small bowel)	60
Thu	Apr 24	Pathology — GI (colon, liver, pancreas)	60
Fri	Apr 25	Pathology — Renal	60
Sat	Apr 26	Pathology — Endocrine	60
Sun	Apr 26	OFF ☀️	—

WEEK 3 — Apr 28 – May 3 | Pathology: Finish + Pharmacology Start

Day	Date	Subject Focus	Qs
Mon	Apr 28	Pathology — MSK + Derm	60
Tue	Apr 29	Pathology — Neuro + Repro (finish Pathology ✅)	60
Wed	Apr 30	Pharmacology — Autonomic nervous system	60
Thu	May 1	Pharmacology — CNS drugs (antidepressants, antipsychotics)	60
Fri	May 2	Pharmacology — CNS drugs (antiepileptics, anesthesia, opioids)	60
Sat	May 3	Pharmacology — Cardiovascular drugs (antihypertensives, antiarrhythmics)	60
Sun	May 3	OFF ☀️	—

WEEK 4 — May 5–10 | Pharmacology: Finish

Day	Date	Subject Focus	Qs
Mon	May 5	Pharmacology — Cardiovascular (statins, anticoagulants, antiplatelets)	60
Tue	May 6	Pharmacology — Antimicrobials Part 1 (cell wall, protein synthesis)	60
Wed	May 7	Pharmacology — Antimicrobials Part 2 (quinolones, antifungals, antivirals)	60
Thu	May 8	Pharmacology — Endocrine drugs (insulin, thyroid, steroids)	60
Fri	May 9	Pharmacology — Chemotherapy + Immunosuppressants (finish Pharmacology ✅)	60
Sat	May 10	Pathophysiology — Cardiovascular	60
Sun	May 10	OFF ☀️	—

WEEK 5 — May 12–17 | Pathophysiology

Day	Date	Subject Focus	Qs
Mon	May 12	Pathophysiology — Pulmonary	60
Tue	May 13	Pathophysiology — Renal (AKI, CKD, acid-base)	60
Wed	May 14	Pathophysiology — GI + Hepatobiliary	60
Thu	May 15	Pathophysiology — Endocrine	60
Fri	May 16	Pathophysiology — Hematology (anemias, coagulation)	60
Sat	May 17	Pathophysiology — Neuro + Repro (finish Pathophysiology ✅)	60
Sun	May 17	OFF ☀️	—

WEEK 6 — May 19–24 | Microbiology

Day	Date	Subject Focus	Qs
Mon	May 19	Microbiology — Bacteriology Part 1 (Gram +ve)	60
Tue	May 20	Microbiology — Bacteriology Part 2 (Gram –ve, atypicals)	60
Wed	May 21	Microbiology — Virology (DNA viruses, RNA viruses)	60
Thu	May 22	Microbiology — Mycology + Parasitology	60
Fri	May 23	Microbiology — Remaining (finish Microbiology ✅)	60
Sat	May 24	Anatomy — Head & Neck	60
Sun	May 24	OFF ☀️	—

WEEK 7 — May 26–31 | Anatomy + Behavioral Science

Day	Date	Subject Focus	Qs
Mon	May 26	Anatomy — Upper limb + Lower limb	60
Tue	May 27	Anatomy — Thorax + Abdomen	60
Wed	May 28	Anatomy — Neuroanatomy (finish Anatomy ✅)	60
Thu	May 29	Behavioral Science — Biostatistics/Epidemiology within BS	60
Fri	May 30	Behavioral Science — Ethics, Development, Psychiatry	60
Sat	May 31	Behavioral Science — finish (finish Behavioral Science ✅)	60
Sun	May 31	OFF ☀️	—

WEEK 8 — Jun 2–7 | Physiology + Biochemistry

Day	Date	Subject Focus	Qs
Mon	Jun 2	Physiology — Cardiovascular + Pulmonary	60
Tue	Jun 3	Physiology — Renal + GI	60
Wed	Jun 4	Physiology — Neuro + Endocrine (finish Physiology ✅)	60
Thu	Jun 5	Biochemistry — Metabolism (glycolysis, TCA, FA)	60
Fri	Jun 6	Biochemistry — Molecular biology + Nutrition (finish Biochemistry ✅)	60
Sat	Jun 7	Immunology — Innate + Adaptive immunity	60
Sun	Jun 7	OFF ☀️	—

WEEK 9 — Jun 9–14 | Small Subjects: Finish All

Day	Date	Subject Focus	Qs
Mon	Jun 9	Immunology — finish (finish Immunology ✅)	72
Tue	Jun 10	Biostatistics — Full (finish Biostatistics ✅)	60
Wed	Jun 11	Genetics — Full (finish Genetics ✅)	60
Thu	Jun 12	Embryology + Histology — Full (finish both ✅)	60
Fri	Jun 13	🎉 QBANK COMPLETE — Mixed weak subject review block	60
Sat	Jun 14	Revision Day 1 — All Incorrect Qs (252 total) Part 1	60
Sun	Jun 14	OFF ☀️	—

WEEK 10 — Jun 16–21 | Pure Revision

Day	Date	Activity	Qs
Mon	Jun 16	Revision — Incorrect Qs Part 2	60
Tue	Jun 17	Revision — All Marked Qs (65 total) + Omitted Part 1	60
Wed	Jun 18	Revision — Omitted Qs Part 2 (259 total)	60
Thu	Jun 19	Revision — Omitted Qs finish + Mixed timed block (simulate exam)	60
Fri	Jun 20	Mixed timed block — Pathology + Pharmacology (highest yield)	60
Sat	Jun 21	Mixed timed block — Micro + Physio + Biochem	60
Sun	Jun 21	OFF ☀️	—

FINAL WEEK — Jun 23–30 | Power Revision

Day	Date	Activity
Mon	Jun 23	Weak subject deep dive (whatever scored lowest)
Tue	Jun 24	Mixed 60Q timed block — all subjects random
Wed	Jun 25	Behavioral Science + Biostatistics revision (pure memorization)
Thu	Jun 26	Pharmacology rapid review — mechanisms + side effects only
Fri	Jun 27	Pathology rapid review — classic findings + buzzwords
Sat	Jun 28	Full 40Q timed mock block — exam simulation
Sun	Jun 28	OFF ☀️
Mon	Jun 29	Final review — only your flagged/wrong answer notebook
Tue	Jun 30	Light day — No new Qs. Only read notes. Rest. Sleep early.

Progress Checkpoints

Checkpoint	Date	Qs Done	% Complete
End Week 1	Apr 19	~360	10%
End Week 2	Apr 26	~720	20%
End Week 4	May 10	~1,440	39%
End Week 6	May 24	~2,160	59%
End Week 8	Jun 7	~2,880	79%
Qbank complete	Jun 13	~3,658	100% ✅
Jun 30	Jun 30	Revision done	Ready 🎯

Golden Rules

Never skip explanations — read every one, even when correct
Wrong answer log — one line: Topic → Why wrong → Correct concept
Timed mode always for the 40Q block — builds exam stamina
Read First Aid alongside each subject as you do UWorld
Sundays = full off — no guilt, your brain consolidates on rest days
If you miss a day — don't try to catch up with 120 Qs next day; just resume normally

Can you make a pdf please

Writing File

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  <!-- HEADER -->
  <div class="header">
    <h1>UWorld USMLE Step 1 — Complete Timetable</h1>
    <p>Personalized schedule to complete the entire question bank with full revision</p>
    <div>
      <span class="badge">📅 Apr 14 – Jun 30, 2026</span>
      <span class="badge">📚 3,658 Questions</span>
      <span class="badge">⏰ 8–9 hrs/day</span>
      <span class="badge">🗓 Sundays Off</span>
    </div>
  </div>

  <!-- STATS -->
  <h2>The Numbers</h2>
  <div class="stats-grid">
    <div class="stat-card">
      <div class="num">3,658</div>
      <div class="label">Total Questions</div>
    </div>
    <div class="stat-card">
      <div class="num">67</div>
      <div class="label">Study Days</div>
    </div>
    <div class="stat-card">
      <div class="num">60</div>
      <div class="label">Questions/Day</div>
    </div>
    <div class="stat-card" style="background: linear-gradient(135deg, #059669, #047857);">
      <div class="num">~12</div>
      <div class="label">Revision Days Left</div>
    </div>
  </div>

  <div class="tip-box">
    💡 <strong>Great news:</strong> With 78 days available and only 67 needed to finish the bank, you have a comfortable <strong>~12 full days of pure revision</strong> (Jun 19–30) after completing all questions.
  </div>

  <!-- SUBJECT BREAKDOWN -->
  <h2>Subject Allocation</h2>
  <table>
    <thead>
      <tr>
        <th>Subject</th>
        <th>Questions</th>
        <th>Days @ 60/day</th>
        <th>Scheduled Weeks</th>
      </tr>
    </thead>
    <tbody>
      <tr><td><span class="subj-badge subj-path">Pathology</span></td><td>819</td><td>~14 days</td><td>Week 1–3 (Apr 14–29)</td></tr>
      <tr><td><span class="subj-badge subj-pharm">Pharmacology</span></td><td>550</td><td>~9 days</td><td>Week 3–4 (Apr 30 – May 9)</td></tr>
      <tr><td><span class="subj-badge subj-physio">Pathophysiology</span></td><td>488</td><td>~8 days</td><td>Week 4–5 (May 10–17)</td></tr>
      <tr><td><span class="subj-badge subj-micro">Microbiology</span></td><td>348</td><td>~6 days</td><td>Week 6 (May 19–24)</td></tr>
      <tr><td><span class="subj-badge subj-anat">Anatomy</span></td><td>308</td><td>~5 days</td><td>Week 6–7 (May 24–28)</td></tr>
      <tr><td><span class="subj-badge subj-behav">Behavioral Science</span></td><td>254</td><td>~4 days</td><td>Week 7 (May 29–31)</td></tr>
      <tr><td><span class="subj-badge subj-physio">Physiology</span></td><td>268</td><td>~4 days</td><td>Week 8 (Jun 2–4)</td></tr>
      <tr><td><span class="subj-badge subj-bioc">Biochemistry</span></td><td>159</td><td>~3 days</td><td>Week 8 (Jun 5–6)</td></tr>
      <tr><td><span class="subj-badge subj-immun">Immunology</span></td><td>132</td><td>~2 days</td><td>Week 8–9 (Jun 7–9)</td></tr>
      <tr><td><span class="subj-badge subj-small">Biostatistics</span></td><td>121</td><td>~2 days</td><td>Week 9 (Jun 10)</td></tr>
      <tr><td><span class="subj-badge subj-small">Genetics</span></td><td>107</td><td>~2 days</td><td>Week 9 (Jun 11)</td></tr>
      <tr><td><span class="subj-badge subj-small">Embryology</span></td><td>75</td><td>~1 day</td><td>Week 9 (Jun 12)</td></tr>
      <tr><td><span class="subj-badge subj-small">Histology</span></td><td>29</td><td>~1 day</td><td>Week 9 (Jun 12)</td></tr>
      <tr style="background:#f0f4f8; font-weight:700;"><td><strong>TOTAL</strong></td><td><strong>3,658</strong></td><td><strong>~61 days</strong></td><td><strong>Done by ~Jun 13</strong></td></tr>
    </tbody>
  </table>

  <!-- DAILY SCHEDULE -->
  <h2>Daily Schedule (8–9 Hours)</h2>
  <table>
    <thead>
      <tr><th>Time</th><th>Activity</th><th>Duration</th></tr>
    </thead>
    <tbody>
      <tr><td>8:00 – 8:30 AM</td><td>Morning review — previous day's marked &amp; incorrect Qs</td><td>30 min</td></tr>
      <tr class="complete-row"><td>8:30 – 10:00 AM</td><td>⏱ Block 1 — 40 Questions (TIMED mode)</td><td>1.5 hrs</td></tr>
      <tr><td>10:00 – 11:15 AM</td><td>Deep review of Block 1 explanations + make notes</td><td>1 hr 15 min</td></tr>
      <tr><td>11:15 – 11:30 AM</td><td>☕ Short break</td><td>15 min</td></tr>
      <tr class="complete-row"><td>11:30 AM – 12:30 PM</td><td>📖 Block 2 — 20 Questions (TUTOR mode)</td><td>1 hr</td></tr>
      <tr><td>12:30 – 1:30 PM</td><td>🍽 Lunch break</td><td>1 hr</td></tr>
      <tr><td>1:30 – 2:30 PM</td><td>Review Block 2 + update wrong answer log</td><td>1 hr</td></tr>
      <tr><td>2:30 – 4:30 PM</td><td>First Aid / Sketchy / Pathoma — parallel reading of today's subject</td><td>2 hrs</td></tr>
      <tr><td>4:30 – 5:30 PM</td><td>Anki / Flashcard review (new cards + due cards)</td><td>1 hr</td></tr>
      <tr><td>5:30 – 6:00 PM</td><td>Plan tomorrow, review weak points</td><td>30 min</td></tr>
      <tr style="background:#f0f4f8; font-weight:700;"><td colspan="2"><strong>Total: 40 Timed + 20 Tutor = 60 Qs/day with full review</strong></td><td><strong>~8.5 hrs</strong></td></tr>
    </tbody>
  </table>

  <!-- WEEKLY TIMETABLE -->
  <h2>Week-by-Week Schedule</h2>

  <div class="week-header">WEEK 1 — Apr 14–19 | Pathology: Foundations</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr><td>Monday</td><td>Apr 14</td><td><span class="subj-badge subj-path">Pathology</span> Cell injury, Apoptosis, Necrosis</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Tuesday</td><td>Apr 15</td><td><span class="subj-badge subj-path">Pathology</span> Inflammation (acute + chronic)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Wednesday</td><td>Apr 16</td><td><span class="subj-badge subj-path">Pathology</span> Tissue repair, Wound healing</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Thursday</td><td>Apr 17</td><td><span class="subj-badge subj-path">Pathology</span> Neoplasia basics, Carcinogenesis, Tumor markers</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Friday</td><td>Apr 18</td><td><span class="subj-badge subj-path">Pathology</span> Hematologic neoplasms (Leukemia/Lymphoma)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Saturday</td><td>Apr 19</td><td><span class="subj-badge subj-path">Pathology</span> Vascular pathology</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>Apr 20</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 2 — Apr 21–26 | Pathology: Organ Systems</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr><td>Monday</td><td>Apr 21</td><td><span class="subj-badge subj-path">Pathology</span> Cardiovascular</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Tuesday</td><td>Apr 22</td><td><span class="subj-badge subj-path">Pathology</span> Pulmonary</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Wednesday</td><td>Apr 23</td><td><span class="subj-badge subj-path">Pathology</span> GI — Esophagus to Small Bowel</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Thursday</td><td>Apr 24</td><td><span class="subj-badge subj-path">Pathology</span> GI — Colon, Liver, Pancreas</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Friday</td><td>Apr 25</td><td><span class="subj-badge subj-path">Pathology</span> Renal</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Saturday</td><td>Apr 26</td><td><span class="subj-badge subj-path">Pathology</span> Endocrine</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>Apr 27</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 3 — Apr 28 – May 3 | Pathology Finish + Pharmacology Start</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr><td>Monday</td><td>Apr 28</td><td><span class="subj-badge subj-path">Pathology</span> MSK + Dermatology</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Tuesday</td><td>Apr 29</td><td><span class="subj-badge subj-path">Pathology</span> Neuro + Repro — ✅ PATHOLOGY COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Wednesday</td><td>Apr 30</td><td><span class="subj-badge subj-pharm">Pharmacology</span> Autonomic Nervous System</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Thursday</td><td>May 1</td><td><span class="subj-badge subj-pharm">Pharmacology</span> CNS drugs (Antidepressants, Antipsychotics)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Friday</td><td>May 2</td><td><span class="subj-badge subj-pharm">Pharmacology</span> CNS drugs (Antiepileptics, Anesthesia, Opioids)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Saturday</td><td>May 3</td><td><span class="subj-badge subj-pharm">Pharmacology</span> Cardiovascular drugs (Antihypertensives, Antiarrhythmics)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>May 4</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 4 — May 5–10 | Pharmacology Finish + Pathophysiology Start</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr><td>Monday</td><td>May 5</td><td><span class="subj-badge subj-pharm">Pharmacology</span> Cardiovascular (Statins, Anticoagulants, Antiplatelets)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Tuesday</td><td>May 6</td><td><span class="subj-badge subj-pharm">Pharmacology</span> Antimicrobials Part 1 (Cell wall, Protein synthesis)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Wednesday</td><td>May 7</td><td><span class="subj-badge subj-pharm">Pharmacology</span> Antimicrobials Part 2 (Quinolones, Antifungals, Antivirals)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Thursday</td><td>May 8</td><td><span class="subj-badge subj-pharm">Pharmacology</span> Endocrine drugs (Insulin, Thyroid, Steroids)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Friday</td><td>May 9</td><td><span class="subj-badge subj-pharm">Pharmacology</span> Chemotherapy + Immunosuppressants — ✅ PHARMACOLOGY COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Saturday</td><td>May 10</td><td><span class="subj-badge subj-physio">Pathophysiology</span> Cardiovascular</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>May 11</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 5 — May 12–17 | Pathophysiology</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr><td>Monday</td><td>May 12</td><td><span class="subj-badge subj-physio">Pathophysiology</span> Pulmonary</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Tuesday</td><td>May 13</td><td><span class="subj-badge subj-physio">Pathophysiology</span> Renal (AKI, CKD, Acid-base)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Wednesday</td><td>May 14</td><td><span class="subj-badge subj-physio">Pathophysiology</span> GI + Hepatobiliary</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Thursday</td><td>May 15</td><td><span class="subj-badge subj-physio">Pathophysiology</span> Endocrine</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Friday</td><td>May 16</td><td><span class="subj-badge subj-physio">Pathophysiology</span> Hematology (Anemias, Coagulation)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Saturday</td><td>May 17</td><td><span class="subj-badge subj-physio">Pathophysiology</span> Neuro + Repro — ✅ PATHOPHYSIOLOGY COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>May 18</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 6 — May 19–24 | Microbiology</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr><td>Monday</td><td>May 19</td><td><span class="subj-badge subj-micro">Microbiology</span> Bacteriology Part 1 (Gram +ve organisms)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Tuesday</td><td>May 20</td><td><span class="subj-badge subj-micro">Microbiology</span> Bacteriology Part 2 (Gram –ve, Atypicals)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Wednesday</td><td>May 21</td><td><span class="subj-badge subj-micro">Microbiology</span> Virology (DNA viruses + RNA viruses)</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Thursday</td><td>May 22</td><td><span class="subj-badge subj-micro">Microbiology</span> Mycology + Parasitology</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Friday</td><td>May 23</td><td><span class="subj-badge subj-micro">Microbiology</span> Remaining Qs — ✅ MICROBIOLOGY COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Saturday</td><td>May 24</td><td><span class="subj-badge subj-anat">Anatomy</span> Head &amp; Neck</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>May 25</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 7 — May 26–31 | Anatomy + Behavioral Science</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr><td>Monday</td><td>May 26</td><td><span class="subj-badge subj-anat">Anatomy</span> Upper limb + Lower limb</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Tuesday</td><td>May 27</td><td><span class="subj-badge subj-anat">Anatomy</span> Thorax + Abdomen</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Wednesday</td><td>May 28</td><td><span class="subj-badge subj-anat">Anatomy</span> Neuroanatomy — ✅ ANATOMY COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Thursday</td><td>May 29</td><td><span class="subj-badge subj-behav">Behavioral Sci</span> Biostatistics/Epidemiology + Ethics</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Friday</td><td>May 30</td><td><span class="subj-badge subj-behav">Behavioral Sci</span> Development, Psychiatry, Social determinants</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Saturday</td><td>May 31</td><td><span class="subj-badge subj-behav">Behavioral Sci</span> Remaining Qs — ✅ BEHAVIORAL SCIENCE COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>Jun 1</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 8 — Jun 2–7 | Physiology + Biochemistry + Immunology Start</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr><td>Monday</td><td>Jun 2</td><td><span class="subj-badge subj-physio">Physiology</span> Cardiovascular + Pulmonary</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Tuesday</td><td>Jun 3</td><td><span class="subj-badge subj-physio">Physiology</span> Renal + GI</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Wednesday</td><td>Jun 4</td><td><span class="subj-badge subj-physio">Physiology</span> Neuro + Endocrine — ✅ PHYSIOLOGY COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Thursday</td><td>Jun 5</td><td><span class="subj-badge subj-bioc">Biochemistry</span> Metabolism (Glycolysis, TCA, Fatty acids)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Friday</td><td>Jun 6</td><td><span class="subj-badge subj-bioc">Biochemistry</span> Molecular biology + Nutrition — ✅ BIOCHEMISTRY COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr><td>Saturday</td><td>Jun 7</td><td><span class="subj-badge subj-immun">Immunology</span> Innate immunity + Adaptive immunity</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>Jun 8</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 9 — Jun 9–14 | Finish All Subjects 🎉</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Subject / Focus</th><th>Qs</th></tr></thead>
    <tbody>
      <tr class="complete-row"><td>Monday</td><td>Jun 9</td><td><span class="subj-badge subj-immun">Immunology</span> Remaining Qs — ✅ IMMUNOLOGY COMPLETE</td><td><span class="qs-badge">72</span></td></tr>
      <tr class="complete-row"><td>Tuesday</td><td>Jun 10</td><td><span class="subj-badge subj-small">Biostatistics</span> Full subject — ✅ BIOSTATISTICS COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Wednesday</td><td>Jun 11</td><td><span class="subj-badge subj-small">Genetics</span> Full subject — ✅ GENETICS COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Thursday</td><td>Jun 12</td><td><span class="subj-badge subj-small">Embryology</span> + <span class="subj-badge subj-small">Histology</span> — ✅ BOTH COMPLETE</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="complete-row"><td>Friday</td><td>Jun 13</td><td>🎉 <strong>ENTIRE QBANK COMPLETE</strong> — Mixed weak subject review block</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="revision-row"><td>Saturday</td><td>Jun 14</td><td>📝 REVISION DAY 1 — All Incorrect Qs (252 total) Part 1</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>Jun 15</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">WEEK 10 — Jun 16–21 | Pure Revision</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Activity</th><th>Qs</th></tr></thead>
    <tbody>
      <tr class="revision-row"><td>Monday</td><td>Jun 16</td><td>📝 Revision — Incorrect Qs Part 2 (finish all 252)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="revision-row"><td>Tuesday</td><td>Jun 17</td><td>📝 Revision — All Marked Qs (65) + Omitted Qs Part 1</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="revision-row"><td>Wednesday</td><td>Jun 18</td><td>📝 Revision — Omitted Qs Part 2 (259 total)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="revision-row"><td>Thursday</td><td>Jun 19</td><td>📝 Omitted Qs finish + Mixed timed block (simulate exam)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="revision-row"><td>Friday</td><td>Jun 20</td><td>⏱ Mixed timed block — Pathology + Pharmacology (highest yield)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="revision-row"><td>Saturday</td><td>Jun 21</td><td>⏱ Mixed timed block — Micro + Physio + Biochem</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>Jun 22</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
    </tbody>
  </table>

  <div class="week-header">FINAL WEEK — Jun 23–30 | Power Revision + Exam Prep</div>
  <table>
    <thead><tr><th>Day</th><th>Date</th><th>Activity</th><th>Qs</th></tr></thead>
    <tbody>
      <tr class="revision-row"><td>Monday</td><td>Jun 23</td><td>📉 Weak subject deep dive (whatever scored lowest)</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="revision-row"><td>Tuesday</td><td>Jun 24</td><td>⏱ Mixed 60Q timed block — all subjects random</td><td><span class="qs-badge">60</span></td></tr>
      <tr class="revision-row"><td>Wednesday</td><td>Jun 25</td><td>📊 Behavioral Science + Biostatistics rapid revision (memorization focus)</td><td><span class="qs-badge">40</span></td></tr>
      <tr class="revision-row"><td>Thursday</td><td>Jun 26</td><td>💊 Pharmacology rapid review — mechanisms + side effects only</td><td><span class="qs-badge">40</span></td></tr>
      <tr class="revision-row"><td>Friday</td><td>Jun 27</td><td>🔬 Pathology rapid review — classic findings + buzzwords</td><td><span class="qs-badge">40</span></td></tr>
      <tr class="revision-row"><td>Saturday</td><td>Jun 28</td><td>⏱ Final 40Q FULL TIMED MOCK — exam simulation (strict conditions)</td><td><span class="qs-badge">40</span></td></tr>
      <tr class="sunday-row"><td>Sunday</td><td>Jun 29</td><td>☀️ REST DAY — No studying</td><td>—</td></tr>
      <tr class="revision-row"><td>Monday</td><td>Jun 30</td><td>✏️ Light day — Wrong answer notebook only. NO new Qs. Sleep early.</td><td>—</td></tr>
    </tbody>
  </table>

  <!-- PROGRESS CHECKPOINTS -->
  <h2>Progress Checkpoints</h2>
  <div class="checkpoint-grid">
    <div class="checkpoint-card">
      <div class="date">Apr 19 (End Wk 1)</div>
      <div class="pct">~10%</div>
      <div class="qs-done">~360 Qs done</div>
    </div>
    <div class="checkpoint-card">
      <div class="date">Apr 26 (End Wk 2)</div>
      <div class="pct">~20%</div>
      <div class="qs-done">~720 Qs done</div>
    </div>
    <div class="checkpoint-card">
      <div class="date">May 3 (End Wk 3)</div>
      <div class="pct">~29%</div>
      <div class="qs-done">~1,080 Qs done</div>
    </div>
    <div class="checkpoint-card">
      <div class="date">May 10 (End Wk 4)</div>
      <div class="pct">~39%</div>
      <div class="qs-done">~1,440 Qs done</div>
    </div>
    <div class="checkpoint-card">
      <div class="date">May 17 (End Wk 5)</div>
      <div class="pct">~49%</div>
      <div class="qs-done">~1,800 Qs done</div>
    </div>
    <div class="checkpoint-card">
      <div class="date">May 24 (End Wk 6)</div>
      <div class="pct">~59%</div>
      <div class="qs-done">~2,160 Qs done</div>
    </div>
    <div class="checkpoint-card">
      <div class="date">May 31 (End Wk 7)</div>
      <div class="pct">~69%</div>
      <div class="qs-done">~2,520 Qs done</div>
    </div>
    <div class="checkpoint-card">
      <div class="date">Jun 7 (End Wk 8)</div>
      <div class="pct">~79%</div>
      <div class="qs-done">~2,880 Qs done</div>
    </div>
    <div class="checkpoint-card done">
      <div class="date">Jun 13 (End Wk 9)</div>
      <div class="pct">100% ✅</div>
      <div class="qs-done">3,658 Qs — BANK DONE</div>
    </div>
  </div>

  <!-- GOLDEN RULES -->
  <h2>Golden Rules (Non-Negotiable)</h2>
  <ul class="rules-list">
    <li data-num="1"><strong>Never skip explanations</strong> — read every one, even when you got the answer correct. The explanation teaches more than the question.</li>
    <li data-num="2"><strong>Wrong answer log</strong> — one line per wrong answer: <em>Topic → Why I was wrong → Correct concept.</em> Review every Saturday.</li>
    <li data-num="3"><strong>Timed mode for the 40Q block always</strong> — builds exam stamina and time management from day one.</li>
    <li data-num="4"><strong>Read First Aid in parallel</strong> — open the relevant FA section after every UWorld block. UWorld explains; FA consolidates.</li>
    <li data-num="5"><strong>Sundays = full off</strong> — no guilt, no "just a few cards." Your brain consolidates memory during rest.</li>
    <li data-num="6"><strong>If you miss a day</strong> — do NOT try to catch up with 120 Qs the next day. Just resume the normal 60. Consistency beats bingeing.</li>
    <li data-num="7"><strong>Mark aggressively</strong> — if you're not 100% certain, mark it. Your marked list is your personal high-yield review set.</li>
  </ul>

  <!-- FOOTER -->
  <div class="footer">
    <p>UWorld USMLE Step 1 Timetable &nbsp;|&nbsp; Apr 14 – Jun 30, 2026 &nbsp;|&nbsp; 3,658 Questions &nbsp;|&nbsp; 60 Qs/day &nbsp;|&nbsp; Generated by Orris</p>
    <p style="margin-top:4px;">To save as PDF: Open in browser → File → Print → Save as PDF (A4, margins: default)</p>
  </div>

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The PDF includes everything — color-coded weekly tables, subject breakdown, daily schedule, progress checkpoints, golden rules, and Sunday rest days clearly marked in yellow. Green rows = subject completion milestones, purple rows = revision days.

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