A 5-year-old girl was brought to the hospital with complaints of delayed growth and development, excessive tiredness, pale skin. On examination, there was splenomegaly, high forehead, prominent maxilla, pallor, jaundice. On investigation haemoglobin was 4.5 g/dL. Blood film revealed tear drop cells, microcytic hypochromic anaemia. X-ray skull showed hair-on-end appearance. Hb electrophoresis showed increased HbF and HbA₂.
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