I now have all the textbook content, images, and latest PubMed evidence needed. Let me note regarding "Joshi book" - the library does not contain a book by that specific author, so I'll use the best available authoritative sources (Firestein & Kelley's Rheumatology, Grainger & Allison's Diagnostic Radiology, Goldman-Cecil Medicine) along with the latest evidence.
Ankylosing Spondylitis (AS) - Physiotherapy Assessment & Management
1. DEFINITION & OVERVIEW
Ankylosing Spondylitis (AS) is a chronic, progressive, seronegative inflammatory spondyloarthropathy primarily affecting the axial skeleton (sacroiliac joints and spine). The hallmark is sacroiliitis and enthesitis, with progressive ossification and potential fusion of the spine - the classic "bamboo spine."
- Part of the broader Axial Spondyloarthritis (AxSpA) spectrum
- Most common in HLA-B27 positive young males (15-35 years)
- Male : Female ratio = 3:1
- Strong genetic component - heritability >95%; >90% of white AS patients carry HLA-B27
2. PATHOPHYSIOLOGY
- Inflammation begins at entheses (tendon/ligament insertion points into bone)
- Primary sites: sacroiliac joints → lumbar spine → thoracic → cervical
- Inflammation at Sharpey fibres (annulus fibrosus insertion = Romanus lesions - "shiny corners" on X-ray)
- Progressive ossification → syndesmophyte formation → eventual vertebral fusion
- Driven by IL-17/IL-23 pathway and HLA-B27-mediated immune dysregulation
3. CLINICAL FEATURES
Symptoms
| Feature | Description |
|---|
| Inflammatory back pain | Insidious onset before age 40, >3 months duration |
| Morning stiffness | >1 hour, improves with activity, worsens with rest |
| Night pain | Wakes patient from sleep in second half of night |
| Sacroiliac pain | Deep buttock pain, may alternate sides |
| Peripheral arthritis | Hips (2nd most common joint), shoulders, knees |
| Enthesitis | Achilles tendinitis, plantar fasciitis common |
| Fatigue | Major complaint in active disease |
Extra-articular Manifestations
| System | Feature |
|---|
| Eyes | Acute anterior uveitis (25-40%) - painful red eye |
| Heart | Aortitis, aortic regurgitation, conduction defects |
| Lungs | Upper lobe fibrosis, reduced chest expansion |
| Gut | Inflammatory bowel disease (60% subclinical gut inflammation) |
| Kidneys | IgA nephropathy |
| Skin | Psoriasis |
4. DIAGNOSTIC CRITERIA
Modified New York Criteria (1984) - Still used for Radiographic AS
Clinical criteria:
- Low back pain ≥3 months, improved with exercise, not relieved by rest
- Limitation of lumbar spine motion in both sagittal and frontal planes
- Limitation of chest expansion relative to normal values for age and sex
Radiological criterion:
- Bilateral sacroiliitis grade ≥2 OR unilateral sacroiliitis grade 3-4
Definite AS = radiological criterion + at least 1 clinical criterion
ASAS Classification Criteria (2009) - For AxSpA (includes non-radiographic)
- Age of onset <45 years + chronic back pain ≥3 months + EITHER:
- Sacroiliitis on imaging (MRI/X-ray) + ≥1 SpA feature, OR
- HLA-B27 positive + ≥2 other SpA features
5. INVESTIGATIONS & IMAGING
Laboratory
| Test | Finding |
|---|
| HLA-B27 | Positive in >90% |
| ESR, CRP | Elevated in active disease |
| Seronegative | RF and ANA negative |
| Full blood count | Mild normocytic anaemia |
Imaging Findings
MRI of Sacroiliac Joints (earliest detection):
Fig. 1 - MRI of SIJ in AS: T1 (A) shows erosion with joint space loss (arrows). T2 fat-suppressed (B) shows extensive subchondral oedema indicating disease activity. - Grainger & Allison's Diagnostic Radiology
X-ray - Bamboo Spine:
Fig. 2 - Bamboo Spine: (A) Bridging vertical syndesmophytes around intervertebral discs (arrows). (B) Complete bony fusion of sacroiliac joints bilaterally. - Grainger & Allison's Diagnostic Radiology
X-ray - Romanus Lesions (Shiny Corners):
Fig. 3 - Lateral X-ray showing Romanus lesions (sclerotic "shiny corners") and bridging syndesmophytes in established AS. - Grainger & Allison's Diagnostic Radiology
MRI - Costovertebral Joint Involvement:
Fig. 4 - STIR sagittal MRI showing oedema within costovertebral joints at multiple thoracic levels in AS. - Grainger & Allison's Diagnostic Radiology
PART A: PHYSIOTHERAPY ASSESSMENT
6. SUBJECTIVE ASSESSMENT
Patient Profile
- Age, sex, occupation, activity level, hand dominance
Chief Complaint
- Location: sacral / lumbar / thoracic / cervical / peripheral joints
- Duration, onset (insidious in AS)
- Character of pain: dull/aching, inflammatory type
History of Present Illness - Key Questions
- Does pain improve with activity and worsen with rest? (inflammatory = YES)
- Morning stiffness - duration? (>1 hour = significant)
- Night pain - wakes from sleep?
- Family history of AS / psoriasis / IBD / uveitis?
- Eye symptoms - red, painful eye? (anterior uveitis)
- Bowel symptoms? (IBD association)
- Skin rash (psoriasis)?
- Previous investigations - HLA-B27 result, X-rays, MRI?
Functional History
- ADL limitations: dressing, bathing, getting in/out of car
- Work: sedentary vs physical; time off work
- Sleep position and quality
- Exercise and sport participation
Yellow Flags (Psychosocial)
- Fear of movement (kinesiophobia)
- Depression / anxiety (common in AS)
- Work satisfaction
- Social support
7. OBJECTIVE ASSESSMENT
A. Postural Observation
Classic AS posture (late/advanced disease):
- Flattening of lumbar lordosis (loss of lumbar curve)
- Increased thoracic kyphosis ("question mark" posture)
- Forward head posture (chin protrusion)
- Reduced cervical lordosis
- Hip and knee flexion contractures (in severe cases)
- Reduced overall height due to spinal compression
B. Spinal Range of Motion
Modified Schober's Test (Lumbar Flexion)
- Mark a point 5 cm below and 10 cm above the L5-S1 junction (PSIS level)
- Ask patient to bend forward maximally
- Normal: distance increases by ≥5 cm (i.e., from 15 cm to ≥20 cm)
- In AS: <4 cm increase = significantly restricted
| Measurement | Normal | Mild Restriction | Severe Restriction |
|---|
| Schober's increase | ≥5 cm | 3-4 cm | <2 cm |
Cervical Rotation
- Normal: 70-90° each side
- AS: progressively reduced (measure with goniometer)
Tragus-to-Wall Distance
- Patient stands with heels and back against wall, chin horizontal
- Measure distance from tragus to wall
- Normal: 0 cm (tragus touches wall)
- In AS: increased distance indicates cervical/thoracic kyphosis progression
- Grading: mild <10 cm, moderate 10-15 cm, severe >15 cm
Occiput-to-Wall Distance
- Same position as above
- Normal: 0 cm (occiput touches wall)
- In AS: >0 cm indicates thoracic kyphosis / cervical involvement
Lateral Flexion
- Stand with feet together, measure finger-floor distance on both sides
- Normal: >10 cm drop on each side
C. Chest Expansion Measurement
Critical assessment in AS - costovertebral joint involvement reduces breathing
Technique:
- Patient standing, arms at side
- Place tape measure at 4th intercostal space (nipple level in men)
- Measure at full expiration and full inspiration
- Normal: ≥5 cm difference
- In AS: <2.5 cm = significantly restricted (costovertebral ankylosis)
Note: Reduced chest expansion in AS shifts breathing to diaphragmatic pattern
D. BASMI - Bath AS Metrology Index (5 measures)
The BASMI is the gold-standard physiotherapy measurement tool for AS mobility.
| Measure | Technique | Score 0 (normal) | Score 2 (severe) |
|---|
| Cervical Rotation | Goniometer at top of head | ≥70° | <20° |
| Tragus-to-Wall | Heels against wall, measure | <15 cm | >30 cm |
| Lumbar Flexion (Modified Schober) | 5+10 cm mark, flex forward | ≥4 cm | <2 cm |
| Lateral Lumbar Flexion | Finger-floor distance change | >10 cm | <5 cm |
| Intermalleolar Distance | Supine, spread legs maximally | >100 cm | <70 cm |
BASMI Score: 0 = normal mobility, 10 = severely restricted
E. Neurological Examination (when indicated)
- Usually normal in AS (unlike IVDP)
- Cervical myelopathy may develop in late-stage cervical involvement
- Check: upper and lower limb power, sensation, reflexes
- Check for cauda equina syndrome in late AS (rare - spinal arachnoiditis)
F. Peripheral Joint & Hip Assessment
- Hip ROM (flexion, extension, abduction, rotation) - hip is 2nd most involved
- Thomas test for hip flexor contracture
- FABER / FADIR test
- Active and passive knee, ankle ROM
G. Special Tests for Sacroiliac Joint
| Test | Technique | Positive |
|---|
| FABER (Patrick's) Test | Figure-4 position, pressure on knee | Groin/SI pain |
| Gaenslen's Test | One leg off table, apply pelvic rotation stress | SI pain |
| Sacral Compression Test | Side-lying, compress sacrum downward | SI pain |
| Distraction Test | Supine, push both ASIS outward | SI pain |
| Posterior Shear (Thigh Thrust) | Supine, 90° hip flex, compress downward | SI pain |
Note: Diagnostic value of SI joint tests individually is limited; a cluster of ≥3 positive tests has better diagnostic accuracy.
H. Respiratory Assessment
- Breathing pattern (thoracic vs diaphragmatic)
- Respiratory rate
- Spirometry / peak flow (if available) - restrictive pattern in advanced AS
- Oxygen saturation
I. Standardised Outcome Measures
| Tool | What It Measures | Frequency |
|---|
| BASDAI (Bath AS Disease Activity Index) | 6 questions on fatigue, pain, morning stiffness (0-10) | Every 3 months |
| BASFI (Bath AS Functional Index) | 10 ADL questions (0-10) | Every 3 months |
| BASMI (Bath AS Metrology Index) | 5 physical mobility measures (0-10) | Every 6 months |
| ASDAS (AS Disease Activity Score) | Combines BASDAI + CRP/ESR | Clinic visits |
| BASGI (Bath AS Global Index) | Patient's global health status | Each visit |
| ASQoL (AS Quality of Life) | 18-item QoL questionnaire | Every 6 months |
| VAS / NPRS | Pain intensity | Each visit |
| HADS | Hospital Anxiety and Depression Scale | Initial + 6-monthly |
| 6-Minute Walk Test | Aerobic capacity / functional endurance | Every 3 months |
PART B: PHYSIOTHERAPY MANAGEMENT
10. GOALS OF PHYSIOTHERAPY
- Reduce pain and inflammation
- Maintain or improve spinal and peripheral mobility
- Prevent or slow postural deformity (kyphosis, forward head)
- Maintain chest expansion and respiratory function
- Strengthen postural and core muscles
- Improve aerobic fitness and endurance
- Optimise function and ADLs
- Prevent complications (fractures, contractures)
- Maintain quality of life and mental wellbeing
11. PHASE-BASED MANAGEMENT
PHASE 1 - Active / Flare Phase
Goals: Reduce inflammation, maintain joint mobility, prevent stiffening
Positioning & Rest
- Rest in prone or supine on firm mattress with only one pillow (prevents kyphosis)
- Avoid: soft mattresses, fetal position sleeping, prolonged sitting
- Sleeping on a firm mattress in a supine/prone position maintains spine in extension
- Encourage frequent position changes (every 20-30 min)
Hydrotherapy / Aquatic Therapy
- Warm water (34-36°C) reduces pain, facilitates movement
- Buoyancy reduces joint loading
- Highly recommended for flare periods
Electrotherapy
| Modality | Parameters | Purpose |
|---|
| TENS | 80-100 Hz continuous | Pain gate mechanism |
| IFT | 4000 Hz carrier, 80-150 Hz | Deep pain relief |
| SWD (pulsed) | Pulsed mode only in active inflammation | Reduce inflammation, muscle spasm |
| Ultrasound | 1 MHz, pulsed 1:4, 0.5-1.0 W/cm² | Anti-inflammatory at entheses |
| Hot packs | 20 min to paravertebral muscles | Reduce morning stiffness |
| Cryotherapy | 10-15 min in acute flare | Reduce swelling if peripheral joints involved |
Gentle ROM Exercises (even during flare)
- Key principle in AS: DO NOT STOP EXERCISING even during flare
- Gentle active range of motion exercises within pain limits
- Axial extension postures preferred
PHASE 2 - Subacute / Maintenance Phase
Goals: Restore full mobility, strengthen, maintain extension posture
1. Postural Re-education
The most important ongoing management goal - prevent the "question mark" posture.
Daily Postural Activities:
- Wall stand: Stand with heels, buttocks, shoulders, and head touching the wall - hold 10 min daily
- Prone lying: 20-30 minutes per day minimum - counteracts kyphotic tendency
- Chin tuck exercises: Gently tuck chin to correct forward head posture
- Check posture at mirror regularly
2. Spinal Mobility Exercises
A. Lumbar Spine:
| Exercise | Technique | Sets/Reps |
|---|
| Pelvic tilts | Flatten lumbar spine, posterior tilt | 10 x 3 |
| Cat-camel stretch | On all-fours, alternate flex/extend spine | 10 x 3 |
| Knee-to-chest | Single and double knee to chest | 10 x 3 |
| Lateral flexion stretch | Standing, side-bend both directions | 10 x 3 |
| Lumbar rotation | Supine hook-lying, knees fall to sides | 10 x 3 |
| Extension over roll | Lie over foam roll to extend thoracolumbar spine | 5-10 min |
B. Thoracic Spine:
| Exercise | Technique |
|---|
| Thoracic extension over chair | Lean back over chair back to extend thoracic spine |
| Thoracic rotation (seated) | Seated, rotate trunk maximally each side |
| Doorway stretch | Arms on doorframe, lean forward (thoracic extension) |
| Foam roller extension | Thoracic spine extended over foam roller at each level |
C. Cervical Spine:
| Exercise | Technique |
|---|
| Chin tucks | Gently retract chin (cervical retraction) |
| Cervical rotation | Turn head maximally each side |
| Lateral flexion | Ear toward shoulder each side |
| Extension | Gently look up to ceiling |
| Cervical nodding | Gentle flexion/extension of upper cervical |
⚠️ Caution: In advanced cervical AS with ankylosis, avoid high-velocity cervical manipulation - risk of spinal fracture is high in a rigid spine.
3. Chest Expansion & Breathing Exercises
Critical in AS - prevents restrictive lung disease
| Exercise | Technique | Reps |
|---|
| Deep diaphragmatic breathing | Supine or sitting, belly breathing, 5 sec inhale | 10-15 x 3 |
| Lateral costal breathing | Hands on lateral ribs, expand laterally on inhale | 10 x 3 |
| Pursed lip breathing | Exhale through pursed lips, 2:4 inhale:exhale ratio | 10 x 3 |
| Sniff breathing | Quick forceful nasal inhalations to expand thorax | 5 x 5 |
| Incentive spirometry | Use if available | Each session |
| Upper chest expansion | Deep breath with shoulder elevation and arms raised | 10 x 3 |
Chest expansion target: Try to improve by 0.5-1 cm per assessment period
4. Core Stabilisation & Strengthening
Sequence (same as IVDP rehab but specific to AS posture correction):
| Level | Exercise | Focus |
|---|
| Basic | Abdominal hollowing, pelvic floor activation | TrA + multifidus co-contraction |
| Intermediate | Bridge, bird-dog, dead bug | Global core + hip extensors |
| Advanced | Plank (modified first), single-leg bridge | Full core integration |
| Postural | Prone on elbows (sphinx position) | Thoracolumbar extension |
5. Hip & Peripheral Joint Exercises
- Hip flexor stretching (Thomas stretch) - very important in AS
- Hip extension strengthening (gluteus maximus)
- Hip abductor strengthening (gluteus medius)
- Hamstring stretching
- Achilles tendon stretching (enthesitis prevention)
6. Aerobic / Cardiovascular Exercise
Evidence (Zhang et al., 2025 - 20 RCTs, 1670 patients) confirms exercise therapy significantly improves BASDAI, BASFI, BASMI, VO₂peak, 6MWT, pain and fatigue in axSpA.
| Activity | Benefits | Notes |
|---|
| Swimming (backstroke) | Best overall - maintains spine extension, chest expansion, aerobic fitness | Preferred in AS |
| Walking | Low impact, maintains mobility | 30-45 min/day |
| Cycling (upright) | Aerobic fitness | Avoid forward-leaning position |
| Tai Chi | Balance, flexibility, mobility, mental wellbeing | Evidence for AS |
| Nordic walking | Trunk extension, aerobic | Poles encourage extension |
Swimming is the exercise of choice in AS - water resistance provides strengthening, buoyancy reduces loading, and backstroke promotes thoracic extension.
7. ASAS/EULAR Recommended Exercise Approach (2022 Guidelines)
Based on
Ortolan et al., 2023 - systematic review informing ASAS/EULAR 2022 guidelines:
- Supervised exercise is more effective than home exercise alone
- Land-based exercise is effective for disease activity and function
- Aquatic therapy shows benefits for pain, function, and wellbeing
- Combination of flexibility + muscle strength exercise has the largest effect on spinal mobility
- Adding aerobic exercise to flexibility + strength shows the largest effect on function (Boudjani et al., 2023)
PHASE 3 - Long-term Maintenance & Prevention
Goals: Prevent deformity progression, maintain gains, lifelong exercise habit
Home Exercise Programme (HEP) - Daily Routine Recommended
| Time of Day | Activity | Duration |
|---|
| Morning (after hot shower/bath) | Mobility exercises (spinal, hip, chest) | 20-30 min |
| Afternoon | Aerobic exercise (swimming, walking) | 30-45 min |
| Evening | Posture correction, stretching, breathing | 15 min |
| Sleeping | Prone or supine on firm mattress, one pillow | All night |
Ergonomics & Daily Living Advice
- Sleeping: Firm mattress, supine or prone, only one pillow (avoid cervical flexion)
- Sitting: Upright chair with lumbar support, avoid slouching, get up every 30 min
- Driving: Adjust seat, use neck rest; caution with driving if cervical rotation is severely restricted
- Lifting: Hip hinge technique, avoid spinal flexion with loading
- Work: Alternate sitting/standing, consider sit-stand desk
- Avoid: Contact sports, activities with fall/collision risk (fragile fused spine prone to fracture)
Group Exercise / Spa Therapy
- Group hydrotherapy spa programmes (balneotherapy) - strong evidence in AS
- Social support component improves adherence
- Royal National Hospital for Rheumatic Diseases (RNHRD) Bath protocol widely used
12. MULTIDISCIPLINARY MANAGEMENT (Physiotherapy Role)
| Team Member | Role |
|---|
| Physiotherapist | Assessment, exercise prescription, manual therapy, electrotherapy, education |
| Rheumatologist | NSAIDs, DMARDs, biologics (TNF-inhibitors, IL-17 inhibitors) |
| Occupational Therapist | ADL modification, splinting, aids/adaptations |
| Psychologist | Pain management, depression, CBT |
| Orthopaedic Surgeon | Hip replacement, spinal osteotomy (severe deformity) |
13. MEDICAL MANAGEMENT (context for physiotherapists)
| Drug Class | Examples | Relevance to PT |
|---|
| NSAIDs (first line) | Indomethacin, naproxen, diclofenac | Reduce inflammation - exercise during NSAID cover more effective |
| TNF Inhibitors | Adalimumab, etanercept, infliximab | Dramatic symptom relief - patients more able to exercise |
| IL-17 Inhibitors | Secukinumab, ixekizumab | Effective alternative to TNF inhibitors |
| DMARDs | Sulfasalazine (peripheral joints only) | Limited benefit for axial disease |
Key point for PT students: In AS, biologics alone without exercise do not prevent deformity. Exercise is essential alongside medication for optimal outcomes.
14. PROGNOSIS
- Early diagnosis + aggressive physiotherapy + medications = best outcomes
- Most patients maintain reasonable function for decades
- Risk of severe kyphosis and ankylosis with delayed/no treatment
- Spinal fracture risk is high in advanced ankylosis (even with trivial trauma)
- Life expectancy near normal with proper management
15. EVIDENCE SUMMARY
| Study | Key Finding |
|---|
| Zhang et al., 2025 (PMID 38942347) - 20 RCTs, 1670 patients | Exercise therapy significantly improved BASDAI (-0.78), BASFI (-0.49), BASMI (-0.49), pain, fatigue, and VO₂peak in axSpA |
| Boudjani et al., 2023 (PMID 36369692) - Meta-analysis | Flexibility + strength programs = largest effect on mobility (BASMI); adding aerobic = largest effect on function (BASFI) |
| Ortolan et al., 2023 (PMID 36261247) - ASAS/EULAR guideline review | Supervised exercise superior to home exercise; land + aquatic therapy both effective; supports comprehensive exercise prescription in AS |
| Yu et al., 2026 (PMID 41797767) - Latest 2026 systematic review | Exercise prescription RCTs confirm multimodal exercise (aerobic + flexibility + strength) as standard of care in axSpA |
Note on "Joshi Book": The library does not contain a specific physiotherapy textbook by Joshi. The content above is drawn from Firestein & Kelley's Textbook of Rheumatology (2-Volume Set), Grainger & Allison's Diagnostic Radiology, Goldman-Cecil Medicine, and the latest PubMed systematic reviews (2022-2026). If your institution uses a specific Joshi physiotherapy textbook (e.g., "Joshi's Physiotherapy" or similar Indian textbook), the clinical content above aligns with standard physiotherapy textbook curricula - feel free to map the concepts accordingly.