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Viral Exanthems in the Emergency Department
What Is a Viral Exanthem?
A viral exanthem is a skin eruption (rash) that occurs as a manifestation of a systemic viral infection. The rash may result from:
- Direct viral infection of skin cells (e.g., VZV, HSV)
- Secondary immune/inflammatory response following viraemia (e.g., parvovirus B19, measles)
- Toxic effect of viral proteins on cutaneous vasculature
An enanthem is the corresponding mucosal eruption (e.g., Koplik spots in measles, oral ulcers in HFMD) — often preceding the cutaneous rash and providing the key diagnostic clue.
"The rash follows a viremia and is accompanied by fever." — Medical Microbiology 9e
ED Approach to Fever + Rash
Step 1 — Is This Child/Patient Sick or Not Sick?
First priority: ABC assessment + age-appropriate vital signs.
| RED FLAGS — Admit / Urgent Action | Reassuring Features |
|---|
| High fever + petechiae/purpura → meningococcaemia | Well-appearing child |
| Haemodynamic instability | Rash appearing as fever resolves (roseola pattern) |
| Mucosal involvement + skin peeling → SJS/TEN | No mucosal involvement |
| Widespread blistering + Nikolsky sign | Localised or centrifugal spread |
| Immunocompromised host | Vaccinated child |
| Pregnant woman exposed to rubella/parvovirus | Normal WBC; benign prodrome |
| Non-blanching rash | Blanching rash |
| Altered consciousness | Interactive, playful |
Step 2 — Describe the Rash
| Morphology | Key causes |
|---|
| Maculopapular (morbilliform) | Measles, rubella, roseola, EBV, enteroviruses, drugs |
| Vesicular | Varicella, HSV, HFMD, zoster |
| Petechial/purpuric | Meningococcaemia, dengue, EBV, rickettsial |
| Scarlatiniform | Scarlet fever (Group A Strep), Kawasaki |
| Reticular/lacy | Erythema infectiosum (parvovirus B19) |
Step 3 — Distribution of Spread
| Starting location | Condition |
|---|
| Face → trunk → extremities | Measles, rubella, erythema infectiosum |
| Trunk → arms → face | Roseola, scarlet fever |
| Extremities (palms, soles, oral) | HFMD |
| Centripetal (trunk-heavy) | Varicella |
Step 4 — Isolation Precautions in the ED
| Disease | Transmission | Isolation |
|---|
| Measles | Airborne | Airborne (negative pressure room) |
| Varicella | Airborne + contact | Airborne + contact |
| Rubella | Droplet | Droplet |
| Roseola, HFMD | Contact/droplet | Contact |
| Erythema infectiosum | Droplet | Droplet (only if immunocompromised or pregnant exposure) |
Classic Viral Exanthems
1. MEASLES (Rubeola) — First Disease
Causative agent: Measles virus (Paramyxovirus); notifiable disease
Transmission: Airborne; highly contagious (R₀ = 12–18)
Incubation: 7–18 days
Clinical Features
Prodrome (3–4 days):
- High fever (may reach 40°C)
- The 3 Cs: Cough, Coryza (runny nose), Conjunctivitis
- Photophobia
- Child appears toxic/ill
Pathognomonic enanthem:
- Koplik spots — bluish-white/grey "grains of salt" on an erythematous base on the buccal mucosa, appearing 1–2 days before the rash
Exanthem:
- Begins on the face and behind the ears → spreads cephalocaudally to trunk → extremities over 3–4 days
- Erythematous, maculopapular, confluent in high-density areas
- Lasts 4–7 days; fades in the order it appeared (branny desquamation may follow)
- Blanches on pressure initially
Koplik spots — tiny bluish-white macules on erythematous buccal mucosa, opposite the molars
Measles: Koplik spots + confluent maculopapular rash spreading from face to trunk and extremities
Diagnosis
- Clinical (Koplik spots + 3 Cs + rash)
- Confirmatory: Measles IgM serology or RT-PCR (nasopharyngeal swab, urine) — mandatory as notifiable disease
ED Management
- Supportive: Antipyretics (paracetamol/ibuprofen), hydration, eye care
- Vitamin A — reduces morbidity and mortality; WHO recommends for all children with measles:
- <6 months: 50,000 IU × 2 days
- 6–11 months: 100,000 IU × 2 days
- ≥12 months: 200,000 IU × 2 days
- Airborne isolation immediately on suspicion
- No specific antiviral
- Notify public health authorities
Complications
- Pneumonia (most common cause of death)
- Encephalitis (~1 in 1000)
- Otitis media
- Keratoconjunctivitis → corneal ulceration
- Subacute sclerosing panencephalitis (SSPE) — years later
- Immunosuppression ("immune amnesia") for weeks–months
2. RUBELLA (German Measles) — Third Disease
Causative agent: Rubella virus (Togavirus)
Transmission: Droplet; notifiable disease
Incubation: 14–21 days
Clinical Features
Prodrome (1–5 days) — milder than measles:
- Low-grade fever, malaise, headache
- Lymphadenopathy — tender, posterior auricular, occipital, and posterior cervical nodes (highly characteristic)
- Mild coryza and conjunctivitis
Enanthem:
- Forchheimer spots — small, red petechiae on the soft palate (non-specific but suggestive)
Exanthem:
- Begins on face → spreads to trunk → extremities within 24–48 hours (faster than measles)
- Pink-red, discrete maculopapules; rarely confluent
- Less pronounced than measles; may not appear at all in some patients
- Lasts only 3 days ("3-day measles")
- No cephalocaudal desquamation
Rubella: fine, blanching maculopapular rash; rapid cephalocaudal spread; milder than measles
Diagnosis
- Clinical (lymphadenopathy pattern + 3-day rash)
- Confirmatory: Rubella IgM or RT-PCR
- Crucially important in pregnant women — congenital rubella syndrome risk
ED Management
- Supportive only; no antiviral
- Droplet precautions
- Most important action: Identify contact with pregnant women → notify public health; check maternal immune status
- Congenital rubella syndrome: deafness, cataracts, cardiac defects, microcephaly if infection in first trimester
3. ROSEOLA INFANTUM (Exanthem Subitum) — Sixth Disease
Causative agent: Human Herpesvirus 6 (HHV-6) or HHV-7
Transmission: Droplet/contact
Incubation: 10–15 days
Age: 6 months to 3 years (virtually all children are seropositive by age 2)
Clinical Features — Classic Pattern
Phase 1 — High Fever (3–5 days):
- Abrupt onset high fever (39–40°C) with no obvious source
- Child may appear relatively well between febrile peaks
- Febrile seizures in ~10–15% (most common cause of febrile seizures in this age group)
- Mild coryza, lymphadenopathy, mild pharyngitis
- Nagayama spots — erythematous papules on soft palate/uvula
Phase 2 — Rash appears as fever BREAKS:
- Characteristic: fever defervesces → rash appears (fever rarely returns)
- Small, discrete, pale-pink macules and papules; some with surrounding blanching halos
- Begins on trunk → spreads to neck, arms, face (centrifugal)
- Lasts 1–3 days then disappears without desquamation
Roseola: pale-pink macules on trunk and proximal limbs, appearing only after the high fever resolves
Key ED Teaching Point
The rash of roseola is a reassuring sign — it signals that the fever is over and the illness is resolving.
Diagnosis
- Entirely clinical — the pattern of high fever → defervescence → rash is pathognomonic
- Rarely: HHV-6 PCR or serology if uncertain
ED Management
- Supportive: Antipyretics (paracetamol/ibuprofen), hydration, reassurance
- Febrile seizure management if required (benzodiazepines acutely; reassure parents)
- No antiviral needed in immunocompetent children
- Contact precautions (mild)
4. ERYTHEMA INFECTIOSUM — Fifth Disease
Causative agent: Parvovirus B19
Transmission: Respiratory droplet
Incubation: 4–14 days
Peak: 5–14 years; also affects adults
Clinical Features — Three Phases
Phase 1 (1 week before rash):
- Mild prodrome: low-grade fever, malaise, headache, myalgia
- Child is most contagious at this stage (viraemic phase)
Phase 2 — "Slapped Cheek" face:
- Bright red, bilateral malar erythema ("slapped cheeks")
- Perioral pallor preserved (circumoral sparing)
- Child is no longer contagious once rash appears
Phase 3 — Lacy/Reticular Body Rash:
- Spreads to trunk and extremities as a lacy, reticular, net-like erythema
- May wax and wane over 1–3 weeks, exacerbated by sun, heat, exercise
- May be mildly pruritic
Parvovirus B19: bilateral slapped-cheek erythema with perioral sparing and lacy reticular rash on trunk/arms
Fine lacy/net-like reticular erythema on the forearm — characteristic of phase 3 parvovirus B19 infection
ED Special Concerns
| Population | Risk | Action |
|---|
| Pregnant women | Hydrops fetalis (especially 1st/2nd trimester) | Notify obstetrician; parvovirus B19 IgM/IgG; fetal US |
| Sickle cell / haemolytic anaemia | Aplastic crisis (transient red cell aplasia) — severe anaemia | FBC urgently; may need transfusion |
| Immunocompromised | Chronic anaemia from persistent infection | IV immunoglobulin (IVIG) |
| Arthritis | Adults (especially women) develop symmetric polyarthritis | Symptomatic; NSAIDs |
Diagnosis
- Clinical in children (slapped cheek + lacy rash)
- Parvovirus B19 IgM (acute); IgG (past exposure/immunity)
- PCR for viraemia (immunocompromised, aplastic crisis)
ED Management
- Supportive for healthy children — reassurance, antipyretics
- Do NOT use corticosteroids (rash will worsen when stopped)
- Screen all contacts — identify pregnant women or haematologically vulnerable individuals
5. VARICELLA (Chickenpox) — Second Disease
Causative agent: Varicella-Zoster Virus (VZV, HHV-3)
Transmission: Airborne + direct contact with vesicle fluid
Incubation: 10–21 days
Contagious: From 2 days before rash until all lesions crusted
Clinical Features
Prodrome (1–2 days):
- Fever, malaise, headache, anorexia
Exanthem — The Classic Triad:
- Pruritic rash (often severe)
- "Dew drop on a rose petal" — clear vesicles on an erythematous base
- Lesions at multiple stages simultaneously (macule → papule → vesicle → pustule → crust)
Distribution: Starts on trunk (centripetal) → face, scalp → proximal extremities; spares palms/soles (unlike HFMD)
Crops of new lesions appear over 3–5 days
Varicella: centripetal vesicular rash with all stages (macule, papule, vesicle, crust) present simultaneously
Diagnosis
- Clinical in most cases
- Confirmatory (if needed): VZV PCR from vesicle swab; DFA of vesicle scraping
ED Management
Healthy children (mild):
- Supportive: antipyretics (paracetamol — NOT aspirin, risk of Reye's syndrome), calamine lotion, antihistamines for pruritus, trim fingernails
- Airborne + contact isolation
- No antivirals needed in healthy children <12 years with uncomplicated disease
Antivirals indicated (oral acyclovir 80 mg/kg/day ÷ 4 doses, max 3200 mg/day):
- Adults and adolescents (≥12 years) — reduce duration and severity
- Children with skin/pulmonary conditions (e.g., eczema, asthma on steroids)
- Immunocompromised patients → IV acyclovir (10 mg/kg IV q8h)
- Neonates with maternal varicella within 5 days before or 2 days after delivery → IV acyclovir
Post-exposure prophylaxis:
- VZIG (Varicella-Zoster Immune Globulin) — for susceptible immunocompromised, pregnant women, neonates
Complications
| Complication | Risk group |
|---|
| Bacterial superinfection (Group A Strep, Staph) — most common | All |
| Varicella pneumonia | Adults, immunocompromised, smokers |
| Encephalitis / cerebellitis | Children (cerebellitis more common, benign) |
| Haemorrhagic varicella | Immunocompromised |
| Reye's syndrome | If aspirin given |
| Neonatal varicella (severe/fatal) | Perinatal exposure |
6. HAND, FOOT AND MOUTH DISEASE (HFMD)
Causative agents: Coxsackievirus A16, A6, A10; Enterovirus A71
Transmission: Faecal-oral, contact, droplet
Incubation: 3–5 days
Season: Late summer / early autumn
Age: <10 years; commonest <5 years
Clinical Features
Prodrome (12–36 hours):
- Low-grade fever, malaise, anorexia, sore mouth, cough
Enanthem (often first):
- Painful oral ulcers — shallow, grey-yellow erosions on an erythematous base on the tongue, buccal mucosa, hard and soft palate, tonsillar pillars, uvula
- May precede skin lesions
Exanthem:
- Small oval/elliptical vesicles (2–5 mm) on erythematous base — long axis parallel to skin creases
- Distribution: palms, soles, dorsum of feet and hands (acral); also oral, perianal, buttocks, elbows, knees
- May be asymptomatic or painful
- Lesions crust within 7–10 days
If only oral involvement → termed herpangina
Atypical HFMD (Coxsackievirus A6):
- More widespread; involves trunk, face, extremities
- May mimic varicella or eczema herpeticum
Hand, foot and mouth disease: thin-walled vesicles on palms and soles + oral vesicles/ulcers — pathognomonic distribution
HFMD: discrete erythematous vesicles with peripheral halo on the dorsal foot
Diagnosis
- Clinical (distribution is pathognomonic)
- PCR if enterovirus 71 suspected (CNS complications)
ED Management
- Supportive: adequate hydration (oral ulcers reduce intake), oral analgesics (paracetamol, ibuprofen)
- Topical oral anaesthetics (viscous lidocaine in older children/adults) for mucosal pain
- Contact precautions
- Enterovirus 71: watch for neurological complications — aseptic meningitis, encephalitis, pulmonary oedema (rare but potentially fatal); consider lumbar puncture if CNS signs
Complications
- Dehydration from poor oral intake
- Nail loss (onychomadesis) — weeks later
- EV71-associated: meningitis, encephalitis, pulmonary oedema
7. INFECTIOUS MONONUCLEOSIS (EBV)
Causative agent: Epstein-Barr virus (EBV)
Age: Adolescents and young adults
Clinical Features
- Triad: Fever + exudative pharyngitis + lymphadenopathy (posterior cervical)
- Splenomegaly (50%)
- Rash in 5–15% spontaneously
- Ampicillin/amoxicillin rash — 80–100% of EBV patients given aminopenicillins develop a widespread maculopapular rash within days → this is NOT true penicillin allergy
ED Note
- Avoid aminopenicillins
- Avoid contact sports (splenomegaly → splenic rupture risk)
Comparison Table — Classic Viral Exanthems
| Disease | Agent | Age | Prodrome | Enanthem | Rash start | Rash type | Duration | Contagious |
|---|
| Measles | Paramyxovirus | Any | 3–4d; 3Cs, high fever | Koplik spots | Face → trunk → limbs | Maculopapular, confluent | 4–7d | Before rash to day 4 |
| Rubella | Togavirus | Any | 1–5d; mild; lymphadenopathy | Forchheimer spots | Face → trunk | Discrete macules | 3d | 7d before to 7d after |
| Roseola | HHV-6/7 | 6mo–3yr | 3–5d HIGH fever | Nagayama spots | Trunk → arms (as fever breaks) | Pale-pink macules | 1–3d | Fever phase |
| Fifth Disease | Parvovirus B19 | 5–14yr; adults | 1wk; mild | None | Face (slapped cheek) → lacy body | Reticular/lacy | Wks (waxing) | Before rash (viraemic) |
| Varicella | VZV | Any | 1–2d | None (mild) | Trunk → head → limbs | Vesicular, all stages | 5–7d | 2d before → all crusted |
| HFMD | Coxsackie/EV | <10yr | 12–36h; mouth pain | Oral ulcers | Palms/soles/oral | Oval vesicles (acral) | 7–10d | During illness |
ED Management Summary
Universal Principles
- Isolate early — correct precautions (airborne vs droplet vs contact)
- Identify high-risk contacts — pregnant women, immunocompromised, neonates
- Notify public health for notifiable diseases (measles, rubella)
- Avoid aspirin in children with viral illness (Reye's syndrome)
- Do not prescribe corticosteroids for viral rashes (masking, worsening)
- Do not label aminopenicillin rash in EBV as true penicillin allergy
Specific Treatments
| Disease | Specific Treatment |
|---|
| Measles | Vitamin A; supportive |
| Rubella | Supportive only; urgent for pregnant contact |
| Roseola | Supportive; febrile seizure management |
| Fifth disease | Supportive; IVIG in immunocompromised; transfusion in aplastic crisis |
| Varicella | Acyclovir in high-risk groups; VZIG post-exposure |
| HFMD | Supportive; watch EV71 for CNS |
When to Admit from ED
| Indication | Condition |
|---|
| Haemodynamic instability, petechiae, purpura | Meningococcaemia, rickettsial, dengue |
| Aplastic crisis with anaemia | Parvovirus B19 in sickle cell |
| Varicella pneumonia, encephalitis | VZV |
| Immunocompromised with severe viral rash | Any VZV, HSV disseminated |
| Poor oral intake / dehydration | Severe HFMD/herpangina |
| EV71 neurological signs | HFMD with CNS involvement |
| Neonate with maternal varicella exposure | Neonatal VZV — IV acyclovir |
Sources: Medical Microbiology 9e (9780323673228) | SAEM Pediatric EM Curriculum: Dermatology (Updated July 2024) | Primary Care Dermatology Society — Viral Exanthems | Tintinalli's Emergency Medicine (9781260019933)