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Nutrition assessment and targets
- Nutrition-risk screening: NRS-2002, NUTRIC
- Limits of albumin, prealbumin, and other traditional markers
- Energy estimation: indirect calorimetry or 25-30 kcal/kg/day
- Protein targets: generally 1.2-2.0 g/kg/day
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Enteral nutrition (EN): initiation and route
- Early EN within 24-48 hours when oral intake is inadequate
- EN preferred over PN where feasible
- Gastric versus post-pyloric feeding
- Hemodynamic stability and vasopressor considerations
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Dose and advancement of EN
- Trophic versus full feeding
- High-risk and severely malnourished patients
- Refeeding-syndrome precautions
- Protein provision
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Monitoring EN and preventing complications
- Gastric residual volumes
- Aspiration-risk reduction
- Feeding protocols
- Diarrhea and EN intolerance
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Formula selection and adjuncts
- Standard polymeric formulas
- Specialty, immune-modulating, fiber-containing, peptide formulas
- Probiotics, antioxidants, trace elements, and glutamine
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Parenteral nutrition (PN)
- When to start exclusive PN
- Supplemental PN timing
- Hypocaloric PN, glucose targets, IV lipid emulsions
- Transition from PN to EN
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Condition-specific nutrition
- Acute respiratory failure
- Acute kidney injury and CRRT
- Liver disease
- Acute pancreatitis
- Trauma, TBI, open abdomen, and burns
- Sepsis
- Postoperative ICU care
- Chronic critical illness
- Obesity
- End-of-life care
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Feed early, preferably through the gut. In critically ill adults unable to eat adequately, EN is generally started within 24-48 hours, once resuscitation is complete and the patient is hemodynamically stable. EN is preferred to PN when the GI tract can be used.
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Assess nutrition risk rather than relying on albumin. Albumin and prealbumin mainly reflect inflammation in the ICU and do not reliably measure nutritional status. NRS-2002 and NUTRIC help identify people most likely to benefit from early, more complete nutrition.
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Do not overfeed. Use indirect calorimetry if available. Otherwise, use a predictive equation or roughly 25-30 kcal/kg/day in typical critically ill adults. Ensure protein is assessed independently, usually 1.2-2.0 g/kg/day.
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Use protocols and avoid unnecessary feed interruption. Routine gastric residual volume monitoring is not recommended. If GRVs are used, do not stop feeds for a GRV below 500 mL without other signs of intolerance. Prevent avoidable NPO periods around procedures.
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PN is reserved for situations where EN is not feasible or insufficient. For low-risk patients, withhold exclusive PN during the first week. In high-risk or severely malnourished patients where EN cannot be given, PN may begin early. Consider supplemental PN after 7-10 days if EN remains below 60% of energy/protein needs.
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Important safety points: Withhold EN in uncontrolled hemodynamic instability; monitor for refeeding syndrome, electrolyte disturbance, aspiration risk, hyperglycemia, and intolerance. Do not use routine glutamine supplementation in critical illness.
The 2016 document is the source PDF. ASPEN issued a focused 2022 update for five foundational ICU nutrition questions, so some recommendations should be interpreted alongside the newer
ASPEN guideline update. The update found insufficient high-quality evidence for several questions, including higher versus lower energy or protein doses, to replace all 2016 suggestions.