A detailed medical flowchart poster titled "Pre-Eclampsia: Pathophysiology & Management" with color-coded sections. Section 1 (top, blue background): "NORMAL PREGNANCY" showing Arachidonic Acid → Cyclo-oxygenase → PGI2/PGE2 → Vasodilation + Uteroplacental blood flow. Also shows VEGF + Nitric Oxide → Vascular refractoriness. Angiotensinase inactivates Angiotensin-II. Section 2 (middle-left, orange/red background): "TRIGGER: Failed Trophoblast Invasion" with arrow pointing right showing: Spiral arteries fail to remodel beyond decidua-myometrial junction → Vasoconstriction → Decreased placental blood flow. Section 3 (center, red background): Large box "ENDOTHELIAL DYSFUNCTION + VASOSPASM" with two columns: Left - PRO-VASOCONSTRICTORS: TXA2 (thromboxane), Angiotensin-II, Endothelin-1, Cytokines (TNF-α, IL-6), Oxidative stress (ROS), sFlt-1/Endoglin (anti-angiogenic) Right - LOST VASODILATORS: ↓ PGI2, ↓ Nitric Oxide, ↓ VEGF, ↓ PLGF Section 4 (bottom, split into 5 color-coded organ boxes): 1. KIDNEYS (yellow): Glomerular endotheliosis → ↓GFR 25% → Oliguria → Proteinuria → Cortical necrosis 2. LIVER (green): Periportal hemorrhagic necrosis → Subcapsular hematoma → ↑AST/ALT → HELLP 3. BRAIN (purple): Vasospasm → PRES → Seizures/Eclampsia → Cerebral edema 4. PLACENTA (pink): ↓ Blood flow → IUGR → Fetal jeopardy 5. BLOOD (maroon): Thrombocytopenia → DIC → Microangiopathic hemolysis Section 5 (bottom right, teal): "HELLP SYNDROME" box: H=Hemolysis, EL=Elevated Liver enzymes, LP=Low Platelets (<100,000/mm³). Labs: AST/ALT >70 IU/L, LDH >600 IU/L, Bilirubin >1.2 mg/dL Section 6 (far bottom, green): "MANAGEMENT" steps: 1) MgSO4 antiseizure prophylaxis, 2) Assess maternal+fetal status, 3) Corticosteroids if <34 weeks, 4) Delivery (usually C-section), 5) ICU monitoring, 6) Platelet transfusion if <50,000/mm³ Use bold text, clear arrows, icons for each organ, bright distinct colors per section, and a clean professional medical education style.