Karma (Drug Action) as per Sharangdhara Samhita, Purva Khanda, Chapter 4 - Clinical Explanation
Before the individual karmas, Sharangdhara Samhita defines Karma itself:
Nirukti (Definition):
संयोगे च विभागे च कारणं क्रियामार्गतम् ॥
"Samyoge cha vibhage cha karanam kriya-margatam"
Meaning: The inherent factor in a dravya (substance) that is responsible for bringing about association (samyoga) or dissociation (viyoga) of doshas/dhatus is called Karma. In simple terms, Karma is the therapeutic action of a drug - the cause (karma) produces an effect (kriya), as Charaka also states: "yat karoti kriyam tat karma."
Sharangdhara, in Purva Khanda 4th chapter, enumerates the drug actions (karmas) with their laksana (defining shloka), guna-rasa-virya-vipaka, and examples. Below is each karma with its shloka and clinical correlation.
1. Deepana (Digestive Stimulant)
पच्यशेषामं वह्निहानिं च दीपनं तथा क्रमशः । शा. सं. पू. ४
Meaning: The karma that enhances or stimulates Agni (Jatharagni, Bhutagni, Dhatvagni) without itself digesting the undigested food is Deepana.
Properties: Guna - Ushna, Tikshna, Laghu; Rasa - Katu, Tikta; Vipaka - Katu; Virya - Ushna. E.g. all spices (Shunthi, Maricha, Pippali). Apavada (exception) - Ghrita, Musta.
Clinical correlation: Orexigenic/appetite-stimulant action - increases salivary, gastric, biliary and pancreatic secretions, improves gastric motility and emptying. Used clinically for anorexia and sluggish digestion.
2. Pachana (Digestant)
पचत्यामं न वह्निं च कुर्यात् एवं तु पाचनम् । शा. सं. पू. ४
Meaning: A drug that digests Ama (undigested/toxic metabolic product) without stimulating Agni is called Pachana (unlike Deepana, which stimulates Agni but does not itself digest Ama).
Properties: Guna - Ushna, Tikshna, Laghu; Rasa - Katu, Lavan, Tikta, Amla; Vipaka - Katu; Virya - Ushna. E.g. Musta, Ushira, Parpataka, Chandana, Shunthi.
Clinical correlation: Improves digestion of retained/incompletely digested food, carminative and mild antimicrobial action on gut flora, reduces fermentation/flatulence. Useful in dyspepsia, malabsorption support, and functional GI disorders. Deepana-Pachana together = digestive stimulant + carminative + prokinetic + cholagogue action.
3. Sanshodhana (Purification/Elimination)
स्थानान् बहिः नयेत् ऊर्ध्वं अधो वा मलसंचयम्।
देहे संशोधनं तत् स्यात् देवदाली फलं यथा ॥ शा. सं. पू. खं. ४/९
Meaning: That karma which expels the accumulated (vitiated) doshas out of the body, either upward or downward, from their site of location, is Sanshodhana. Example: Devadali fruit.
Charaka classifies Shodhana into Vamana, Virechana, Shirovirechana and Niruha Basti; Sushruta describes Kapha-shodhana (Urdhvabhagahara), Pitta-shodhana (Adhobhagahara), Kapha-Pitta shodhana (Ubhayabhagahara) and Nasya.
Properties: Bhuta - Prithvi, Aap, Vayu, Agni; Guna - Ushna, Tikshna, Laghu, Sukshma, Sara, Vishada; Rasa - Madhura, Amla, Katu, Tikta, Lavana; Virya - Ushna or Sheeta. E.g. Devadali, Madanaphala, Katutumbi (exception: Chitraka).
Clinical correlation: Corresponds to Panchakarma detoxification - Vamana (emesis), Virechana (purgation), Basti (enema), Nasya, Raktamokshana. Restores homeostasis, reduces inflammatory mediators, improves tissue drug-responsiveness, and has a preventive/curative role in chronic disease.
4. Sanshamana (Pacification)
न शोधयति न श्लेष्ट्रं समान् दोषान् तथा अशोधन्।
समीकरोति विषमान् शमनं तत् यथा अमृता ॥ शा. सं. पू. ४/२-३
Meaning: The karma that neither expels nor obstructs the doshas already in balance, but pacifies/normalizes the vitiated doshas in situ is Shamana. Example: Amrita (Guduchi).
Sushruta assigns Shamana drugs to Akasha Mahabhuta and divides them into Vatashamana, Pittashamana and Kaphashamana.
Properties: Rasa, Vipaka, Virya - all types possible (depends on which dosha is being pacified via viruddha guna).
Clinical correlation: Equivalent to conservative/symptomatic pharmacological management - anti-inflammatory, analgesic, antipyretic, antimicrobial, immunomodulatory action plus diet/lifestyle correction. Preferred in mild-moderate disease or in patients unfit for shodhana (purification).
5. Chedana (Cutting/Disintegrating)
श्लिष्टान् कफादिकान् दोषान् उन्मूलयति यत् बलात्।
छेदनं तथा क्षारा मरिचानि शिलाजतु ॥ (भा. प्र. ६/२२३; शा. सं. पू. खं. ४/९)
Meaning: A drug that forcefully disintegrates and uproots the adhered Kapha-adi doshas from the srotas (channels) is called Chedana. It must (i) act on adhered doshas, (ii) separate/disunite them, (iii) uproot them quickly, and (iv) uproot them forcefully. E.g. Kshara, Marica, Shilajatu.
Clinical correlation: Correlates with mucolytic, fibrinolytic, anti-biofilm, anti-adhesive and debriding action. Clinically useful in thick-sputum chronic bronchitis, chronic sinusitis with tenacious mucus, and debridement of chronic (dushta) wounds.
6. Lekhana (Scraping)
धातुनां लानवा देहस्य विशेषेण लेखनं च यत्।
लेखनं तद् यथा क्षौद्रं निरमं षुण्ठं वचा यवा ॥ शा. सं. पू. ४/१०
Meaning: That karma which dries up the dhatus (especially Kapha, Meda, Mamsa) and scrapes away mala, producing a leaner body, is Lekhana. E.g. Vacha, Darvi, Madhu, Ushnodaka, Yava, Shilajit, Gomutra, Triphala, Rasanjana (Musta is an exception, being Sheeta-virya yet doing Lekhana).
Properties: Guna - Ushna, Ruksha, Laghu, Khara, Vishada; Rasa - Lavana, Tikta, Kashaya; Vipaka - Katu; Virya - Ushna.
Clinical correlation: Correlates with lipolytic, hypolipidemic, anti-atherosclerotic and metabolic-regulating actions - reduces body fat, lowers cholesterol/triglycerides, improves insulin sensitivity. Distinguished from Chedana: Lekhana reduces excess fat/tissue overgrowth, Chedana breaks adherent pathological masses.
7. Grahi (Absorbent/Binding)
दीपनं पाचनं यत् स्याद् आर्द्रत्वात् वा शोषकम्।
ग्राही तत् च यथा शुण्ठी जीरक गजपिप्पली ॥ शा. सं. पू. ४/११-१२
Meaning: A drug that does Deepana and Pachana and, by virtue of Ushna guna, absorbs excess intestinal moisture (drava-shoshana) is Grahi. E.g. Shunthi, Jiraka, Gajapippali, Chavya.
Sushruta considers Grahi drugs Vayu-mahabhuta predominant. Adhamalla subdivides Grahi into (a) Pakwagrahi (Sitasangrahi/Stambhana) and (b) Amagrahi (Ushnasangrahi/true Grahi) - the latter first digests Ama (needs Dipana-Pachana) before drying excess fluid.
Clinical correlation: Antidiarrheal/anti-secretory/gut-absorbent action - increases water and electrolyte absorption, improves mucosal integrity. Useful in chronic non-infectious diarrhea, Grahani roga (malabsorption/IBS-like states), and the recovery phase of gastroenteritis after Ama has been digested.
8. Stambhana (Arresting/Astringent)
रौक्ष्यात् शैत्यात् कषायत्वात् लघुपाकात् च यद् भवेत्।
वातकृत् स्तम्भनं तत् स्यात् यथा वस्तक टुण्टुकौ ॥ शा. सं. पू. ४/१२
Meaning: That karma which, by virtue of Rukshata (dryness), Shita (coldness), Kashaya rasa (astringency) and Laghu paka, obstructs/checks abnormal movement (of doshas or fluids) is Stambhana. E.g. Vastaka (Vasa), Tuntuka.
Properties: Bhuta - Prithvi & Vayu; Guna - Sheeta, Manda, Ruksha, Sthira, Laghu; Rasa - Kashaya; Vipaka - Katu; Virya - Sheeta.
Clinical correlation: Hemostatic/astringent/anti-secretory/anti-exudative action - promotes vasoconstriction and clot formation, precipitates tissue proteins. Used in Atisara (diarrhea), Raktapitta (bleeding disorders), Raktapradara (menorrhagia), hyperhidrosis, Shwetapradara (leucorrhoea) and excessive wound discharge. (Distinct from Grahi: Grahi is used in Ama state, Stambhana in Nirama/clean state; Grahi acts mainly on GI tract, Stambhana across multiple systems.)
9. Madakari (Intoxicating)
बुद्धिं तमोगुणं लुम्पति यत् द्रव्यं मदकारि तद् उच्यते।
तमो गुण प्रधानं च यथा मद्यं सुरादिकम् ॥ शा. सं. पू. ४/२१-२२
Meaning: A dravya predominant in Tamoguna which hampers the mental faculties (Medha, Dhriti, Smriti, Mati, Pratipatti) is called Madakari. E.g. Madya/Sura (alcoholic drinks), Ahiphena (opium), Bhanga (cannabis).
Properties: Guna - Tama, Ushna, Tikshna, Sukshma, Laghu, Ruksha, Vyavayi, Vikasi; Rasa - Amla, Katu, Tikta; Vipaka - Amla; Virya - Ushna.
Clinical correlation: Correlates with CNS depressant/psychoactive drugs - used for sedation before procedures, analgesia, anxiolysis, anaesthesia (under medical supervision). Excessive/inappropriate use causes dependence, cognitive impairment, respiratory depression, and overdose toxicity - important teaching point for narcotic/sedative pharmacology.
10. Pramathi (Agitating/Churning)
निजवीर्येण यद् द्रव्यं स्रोतोभ्यो दोषसंचयम्।
निरसयति प्रमाथी स्यात् तथा मरिचं वचा ॥ शा. सं. पू. ४/२३-२४
Meaning: A dravya that, by its own potency (virya), forcibly removes the accumulated doshas from the srotas (channels) is Pramathi. E.g. Marica, Vacha, Pippali, Chitraka, Haritaki, Shilajit. The root "math" means to churn/dislodge adherent doshas (chiefly Kapha).
Properties: Guna - Tikshna, Ushna, Laghu, Sukshma, Chala; Rasa - Katu; Vipaka - Katu; Virya - Ushna.
Clinical correlation: Mucolytic/expectorant/decongestant/channel-clearing action - liquefies thick mucus, relieves obstruction. Useful in chronic cough, bronchitis, bronchial asthma with thick sputum, chronic sinusitis, and Kapha-dominant obstructive disorders.
11. Vikasi (Loosening/Dissolving)
विकासी विकसन् इव धातुबन्धान् विमोक्षयेत्।
संधिबन्धान् शिथिलान् करोति हि विकासी तत् ॥ शा. सं. पू. ४/२०-२१
Meaning: Vikasi is that karma which, like something "blooming open," loosens the bonds of dhatus and dissolves the compactness of joints (dhatu-sandhi-bandhana), rendering them loose/mobile, and mobilizes the doshas. Affects Dhatu and Ojas. E.g. Kramuka (Areca catechu), Kodrava (Paspalum scrobiculatum).
Clinical correlation: Correlates with smooth-muscle relaxation, vasodilation, altered vascular permeability. Used in Kapha disorders (chronic cough, asthma, sinusitis), and importantly in Purva Karma (pre-purification procedure) to mobilize deep-seated doshas from Shakha (peripheral tissue) to Koshtha (GI tract) before Vamana/Virechana/Basti.
12. Rasayana (Rejuvenation)
रसायनं च तद् ज्ञेयं यत् जरा व्याधिनाशनम्।
यथा अमृता हरिद्रा च गुग्गुलुः हरीतकी ॥ शा. सं. पू. ४/२३
Meaning: That which destroys Jara (ageing) and Vyadhi (disease) is Rasayana. E.g. Haritaki, Amrita (Guduchi), Rudanti, Guggulu.
Charaka defines it further: "lābhopāyo hi śastānām rasādīnām rasāyanam" (C.Chi.1.1/8) - Rasayana is the means of obtaining excellence of Rasa and the other dhatus.
Benefits (from Charaka, cited in text): Dirghayu (longevity), Tarunam vayaha (preserved youth), Jara-vidhwamsi (destroys ageing), Brihmana (nourishment), Vrishya, Deha-bala, Indriya-bala, Chakshushya, Smriti-medhakara, Prabha, Varna, Swara, Kanti.
Properties/examples: Amrita, Haritaki, Guggulu.
Clinical correlation: Geroprotective, immunomodulatory, antioxidant, adaptogenic, neuroprotective and restorative action. Clinically applied in geriatric care, immunity enhancement, post-illness rehabilitation, cognitive support (as Medhya Rasayana), chronic metabolic disease (diabetes, dyslipidemia), degenerative joint disease, reproductive and cardiovascular support, hepatoprotection, and as adjunctive supportive care during chemo/radiotherapy.
13. Vajikarana (Aphrodisiac)
यद् द्रव्यं वेतश्च स्त्रीषु हर्षां वाजीकरं च तत्।
यथा नागबलादिः स्याद् बीजं च कल्पकाञ्जनम् ॥ शा. सं. पू. ४/१४-१५
Meaning: That which imparts sexual vigour like a horse (vaji) and induces pleasure/vigor in intercourse with women is Vajikarana. E.g. Nagabala, Kapikacchu, Ashwagandha, Musali, Shatavari, Shilajit.
The text subdivides Vajikarana drugs (per Chakrapani, Ch.Chi.2-4/51) into:
- Shukrajanana - spermatogenic agents (e.g. Masha)
- Shukrarechana - ejaculatory enhancers/neuro-stimulants (e.g. Shankalpa)
- Shukravrishya-karana - comprehensive rejuvenators/aphrodisiacs (e.g. Ksheera)
Clinical correlation: Correlates with reproductive medicine - androgenic/hormonal modulation, spermatogenic action (improves count, motility, morphology), aphrodisiac action via CNS/hormonal pathways, antioxidant protection of spermatozoa, and nitric-oxide mediated erectile support. Applied clinically in male infertility (oligospermia, asthenozoospermia, teratozoospermia, OAT syndrome), sexual dysfunction (low libido, ED, premature ejaculation), female infertility, and preconception care (Garbhasthapana).
14. Medhya (Nootropic/Cognitive Enhancer)
Medhya refers to drugs that promote Dhi/Buddhi (intellect), Smriti (memory), and Dhriti (retention/mental stability). E.g. Brahmi, Shankhapushpi, Mandukaparni, Yashtimadhu.
Clinical correlation: Correlates with nootropic, neuroprotective, cholinergic, anxiolytic and antioxidant action - modulates acetylcholine, serotonin, dopamine, GABA; supports synaptic plasticity and neurogenesis. Applied clinically in memory impairment, learning disorders, neurodegenerative disease (Alzheimer's, Parkinson's, dementia), psychiatric disorders (anxiety, depression, insomnia), post-stroke cognitive rehabilitation, paediatric conditions (ADHD, ASD - supportive), epilepsy (adjunct), geriatric cognitive decline, and chronic stress/mental fatigue.
Summary Table
| Karma | Core Action | Key Shloka Reference | Clinical Analogy |
|---|
| Deepana | Kindles Agni | Sha.Sam.Pu.4 | Appetiser/carminative |
| Pachana | Digests Ama | Sha.Sam.Pu.4 | Digestive enzyme aid |
| Sanshodhana | Expels doshas | Sha.Sam.Pu.Kh.4/9 | Detox (Panchakarma) |
| Sanshamana | Pacifies doshas | Sha.Sam.Pu.4/2-3 | Symptomatic Rx |
| Chedana | Disintegrates adhered doshas | Sha.Sam.Pu.Kh.4/9 | Mucolytic/debridement |
| Lekhana | Scrapes dhatu/mala | Sha.Sam.Pu.4/10 | Lipolytic/hypolipidemic |
| Grahi | Absorbs fluid, binds stool | Sha.Sam.Pu.4/11-12 | Antidiarrheal/absorbent |
| Stambhana | Arrests flow | Sha.Sam.Pu.4/12 | Hemostatic/astringent |
| Madakari | Intoxicates | Sha.Sam.Pu.4/21-22 | CNS depressant |
| Pramathi | Churns out doshas | Sha.Sam.Pu.4/23-24 | Expectorant/decongestant |
| Vikasi | Loosens dhatu bonds | Sha.Sam.Pu.4/20-21 | Muscle relaxant/vasodilator |
| Rasayana | Anti-ageing, nourishing | Sha.Sam.Pu.4/23 | Geroprotective/antioxidant |
| Vajikarana | Aphrodisiac | Sha.Sam.Pu.4/14-15 | Reproductive/fertility support |
| Medhya | Cognitive enhancer | (Ch.Su. context) | Nootropic |
A note on the source: the shlokas above are drawn directly from your uploaded document, which cites Sharangdhara Samhita Purva Khanda chapter 4 (verses roughly 9-24) along with cross-references to Charaka and Sushruta Samhita for supporting definitions. If you want, I can go deeper into any single karma (e.g., a fuller commentary from Adhamalla/Kashirama's tika, or a comparison table with specific drug dravyas and their rasa-panchaka) - just tell me which one.