🟦 THYROID GLAND - Colorful Notes (Vishram Singh Style)

const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");

// ── Fetch all images ──────────────────────────────────────────────────────────
const imageUrls = [
  "https://cdn.orris.care/cdss_images/2ec58523e023bd33efeb9ba12b34b76158eb9fa16b3ce47605088bd30921c13e.png", // anterior+cross view
  "https://cdn.orris.care/cdss_images/19be9b2bd67c8c5988f6b6824b31cf9145e5beaa01c0bb55873c22d25abeb182.png", // vasculature anterior
  "https://cdn.orris.care/cdss_images/8112f3e87edcb29f118fef612e489630e3c8386c93dcbfd8d7be79250ab9c8a0.png", // posterior + parathyroids
  "https://cdn.orris.care/cdss_images/2fb6e4f63998fbbbb982c4887d732b2db9ac3d4d35c7cc9d74cc61710f1ded02.png", // histology
];

const imgs = JSON.parse(
  execSync(
    `node /home/daytona/skills/shared/scripts/fetch_images.js ${imageUrls.map(u => `"${u}"`).join(" ")}`
  ).toString()
);

const IMG_ANATOMY   = imgs[0].base64;
const IMG_VASC      = imgs[1].base64;
const IMG_POSTERIOR = imgs[2].base64;
const IMG_HISTO     = imgs[3].base64;

// ── Palette ───────────────────────────────────────────────────────────────────
const C = {
  darkTeal:   "0D3B4F",   // dominant dark bg
  teal:       "1A6B7C",
  midTeal:    "2A8FA4",
  accent:     "F7B731",   // golden yellow accent
  accentRed:  "E05252",
  accentGreen:"3BB36A",
  accentPurp: "9B59B6",
  white:      "FFFFFF",
  lightGray:  "EEF4F6",
  textDark:   "1A2E35",
  textMid:    "2C5364",
};

// ── Helpers ───────────────────────────────────────────────────────────────────
function darkBg(slide) {
  slide.addShape("rect", { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.darkTeal }, line: { color: C.darkTeal } });
}
function lightBg(slide) {
  slide.addShape("rect", { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.lightGray }, line: { color: C.lightGray } });
}
function accentBar(slide, color) {
  slide.addShape("rect", { x: 0, y: 0, w: 10, h: 0.08, fill: { color: color || C.accent }, line: { color: color || C.accent } });
}
function bottomBar(slide, color) {
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}
function slideNumber(slide, n) {
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}
function sectionPill(slide, label, color, x, y) {
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  slide.addText(label.toUpperCase(), { x, y, w: label.length * 0.11 + 0.4, h: 0.28, fontSize: 7.5, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
}
function cardBox(slide, x, y, w, h, fillColor, borderColor) {
  slide.addShape("rect", {
    x, y, w, h,
    fill: { color: fillColor || C.white },
    line: { color: borderColor || C.midTeal, width: 1.5 },
    shadow: { type: "outer", color: "000000", blur: 5, offset: 2, angle: 135, opacity: 0.1 },
  });
}

// ── Presentation ──────────────────────────────────────────────────────────────
const pres = new pptxgen();
pres.layout  = "LAYOUT_16x9";
pres.title   = "Thyroid Gland – Anatomy & Pathology";
pres.author  = "Orris Medical";
pres.subject = "Medical Education";

// =============================================================================
// SLIDE 1 – TITLE
// =============================================================================
{
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  sl.addShape("rect", { x: 6.5, y: 0, w: 0.4, h: 5.625, fill: { color: C.accent }, line: { color: C.accent } });

  // Anatomy image on right panel
  sl.addImage({ data: IMG_ANATOMY, x: 6.85, y: 0.3, w: 3.0, h: 5.0, transparency: 10 });

  // Title
  sl.addText("THYROID GLAND", {
    x: 0.4, y: 0.7, w: 6.0, h: 1.1,
    fontSize: 38, bold: true, color: C.white, align: "left",
    fontFace: "Calibri", charSpacing: 3,
  });
  sl.addText("Anatomy, Histology & Pathology", {
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    fontSize: 17, bold: false, color: C.accent, align: "left", fontFace: "Calibri",
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  // Divider line
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  // Subtitle bullets
  sl.addText([
    { text: "🔵  Location & Relations", options: { breakLine: true } },
    { text: "🔴  Blood Supply & Lymphatics", options: { breakLine: true } },
    { text: "🟢  Embryology & Histology", options: { breakLine: true } },
    { text: "🟡  Hormones & Physiology", options: { breakLine: true } },
    { text: "🟣  Pathology & Clinical Notes", options: { breakLine: false } },
  ], {
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    fontSize: 13, color: "CCECF5", align: "left", fontFace: "Calibri", lineSpacingMultiple: 1.4,
  });

  // Bottom label
  sl.addText("Ref: Gray's Anatomy for Students • Junqueira's Histology • Vishram Singh Style", {
    x: 0.4, y: 5.25, w: 6.0, h: 0.28, fontSize: 7.5, color: "7AABB8", italic: true, align: "left",
  });
  bottomBar(sl, C.accent);
}

// =============================================================================
// SLIDE 2 – OVERVIEW: LOCATION & SHAPE
// =============================================================================
{
  const sl = pres.addSlide();
  lightBg(sl);
  accentBar(sl, C.midTeal);

  // Header
  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: C.darkTeal }, line: { color: C.darkTeal } });
  sl.addText("LOCATION & SHAPE", {
    x: 0.3, y: 0, w: 7, h: 0.75, fontSize: 20, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });
  sectionPill(sl, "Anatomy", C.midTeal, 7.5, 0.22);

  // Main anatomy image
  sl.addImage({ data: IMG_ANATOMY, x: 5.3, y: 0.9, w: 4.5, h: 4.5 });

  // Key facts cards
  const facts = [
    { label: "Shape", val: "Butterfly / H-shaped", color: C.midTeal },
    { label: "Weight", val: "25–30 g (adult)", color: C.teal },
    { label: "Isthmus", val: "Crosses 2nd–3rd tracheal rings", color: C.accentGreen },
    { label: "Compartment", val: "Visceral compartment of neck", color: C.accentPurp },
    { label: "Lobes", val: "Two lateral lobes + isthmus", color: C.accentRed },
  ];
  facts.forEach((f, i) => {
    const yy = 0.9 + i * 0.78;
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    sl.addShape("rect", { x: 0.25, y: yy, w: 0.22, h: 0.65, fill: { color: f.color }, line: { color: f.color } });
    sl.addText(f.label.toUpperCase(), { x: 0.55, y: yy + 0.05, w: 4.4, h: 0.22, fontSize: 9, bold: true, color: f.color, fontFace: "Calibri" });
    sl.addText(f.val, { x: 0.55, y: yy + 0.28, w: 4.4, h: 0.28, fontSize: 11, color: C.textDark, fontFace: "Calibri" });
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}

// =============================================================================
// SLIDE 3 – RELATIONS
// =============================================================================
{
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  lightBg(sl);
  accentBar(sl, C.accentRed);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: C.darkTeal }, line: { color: C.darkTeal } });
  sl.addText("ANATOMICAL RELATIONS", {
    x: 0.3, y: 0, w: 7, h: 0.75, fontSize: 20, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });
  sectionPill(sl, "Relations", C.accentRed, 7.5, 0.22);

  // Three columns
  const cols = [
    {
      title: "ANTERIOR", color: C.midTeal,
      items: ["Skin + superficial fascia", "Platysma muscle", "Investing deep fascia", "Sternohyoid muscle", "Sternothyroid muscle", "Omohyoid muscle", "Pretracheal fascia"],
    },
    {
      title: "POSTERIOR", color: C.accentRed,
      items: ["Trachea & esophagus", "Parathyroid glands (×4)", "Recurrent laryngeal nerves", "Longus colli muscle"],
    },
    {
      title: "LATERAL", color: C.accentGreen,
      items: ["Common carotid artery", "Internal jugular vein", "Vagus nerve (CN X)", "(All in carotid sheath)"],
    },
  ];

  cols.forEach((col, ci) => {
    const xx = 0.25 + ci * 3.25;
    sl.addShape("rect", { x: xx, y: 0.9, w: 3.1, h: 0.38, fill: { color: col.color }, line: { color: col.color } });
    sl.addText(col.title, { x: xx, y: 0.9, w: 3.1, h: 0.38, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    cardBox(sl, xx, 1.28, 3.1, col.items.length * 0.47 + 0.2, C.white, col.color);
    col.items.forEach((item, ii) => {
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        { text: "▸ ", options: { color: col.color, bold: true } },
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      });
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  // Bottom note
  sl.addShape("rect", { x: 0.25, y: 4.95, w: 9.5, h: 0.45, fill: { color: "FFF3CD" }, line: { color: C.accent, width: 1.5 } });
  sl.addText("⚠ Berry's Ligament: Thickening of pretracheal fascia attaching thyroid to cricoid cartilage — RLN passes in close relation!", {
    x: 0.35, y: 4.97, w: 9.3, h: 0.4, fontSize: 9.5, color: C.textDark, fontFace: "Calibri", bold: false,
  });

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// =============================================================================
// SLIDE 4 – BLOOD SUPPLY
// =============================================================================
{
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  sl.addText("BLOOD SUPPLY", {
    x: 0.3, y: 0, w: 7, h: 0.75, fontSize: 20, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });
  sectionPill(sl, "Vasculature", C.accent, 7.5, 0.22);

  // Vasculature diagram image
  sl.addImage({ data: IMG_VASC, x: 5.3, y: 0.85, w: 4.5, h: 4.5 });

  // Arteries section
  sl.addShape("rect", { x: 0.25, y: 0.85, w: 4.8, h: 0.35, fill: { color: C.accentRed }, line: { color: C.accentRed } });
  sl.addText("ARTERIES", { x: 0.25, y: 0.85, w: 4.8, h: 0.35, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  const arteries = [
    { name: "Superior thyroid a.", origin: "1st branch of ext. carotid", note: "→ anterior + posterior glandular branches" },
    { name: "Inferior thyroid a.", origin: "Thyrocervical trunk (subclavian)", note: "→ also supplies parathyroids; crosses RLN!" },
    { name: "Thyroid ima a.", origin: "Brachiocephalic trunk / Aorta", note: "Inconstant (~3%); ascends on anterior trachea" },
  ];
  arteries.forEach((a, i) => {
    const yy = 1.25 + i * 0.87;
    cardBox(sl, 0.25, yy, 4.8, 0.78, "FFF5F5", C.accentRed);
    sl.addText(a.name, { x: 0.4, y: yy + 0.04, w: 4.5, h: 0.28, fontSize: 11, bold: true, color: C.accentRed, fontFace: "Calibri" });
    sl.addText(`Origin: ${a.origin}`, { x: 0.4, y: yy + 0.28, w: 4.5, h: 0.22, fontSize: 9.5, color: C.textMid, fontFace: "Calibri" });
    sl.addText(a.note, { x: 0.4, y: yy + 0.5, w: 4.5, h: 0.22, fontSize: 9, italic: true, color: C.teal, fontFace: "Calibri" });
  });

  // Veins
  sl.addShape("rect", { x: 0.25, y: 3.86, w: 4.8, h: 0.32, fill: { color: C.teal }, line: { color: C.teal } });
  sl.addText("VEINS", { x: 0.25, y: 3.86, w: 4.8, h: 0.32, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
  cardBox(sl, 0.25, 4.18, 4.8, 0.9, "F0F8FF", C.teal);
  sl.addText([
    { text: "Superior thyroid vein", options: { bold: true, color: C.teal } },
    { text: "  →  Internal jugular vein\n", options: { color: C.textDark } },
    { text: "Middle thyroid vein", options: { bold: true, color: C.teal } },
    { text: "  →  Internal jugular vein\n", options: { color: C.textDark } },
    { text: "Inferior thyroid veins", options: { bold: true, color: C.teal } },
    { text: "  →  Right & Left brachiocephalic veins", options: { color: C.textDark } },
  ], { x: 0.4, y: 4.22, w: 4.55, h: 0.82, fontSize: 10, fontFace: "Calibri", lineSpacingMultiple: 1.4 });

  slideNumber(sl, 4); bottomBar(sl, C.accent);
}

// =============================================================================
// SLIDE 5 – VENOUS DRAINAGE, LYMPHATICS & RLN (posterior view)
// =============================================================================
{
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  lightBg(sl);
  accentBar(sl, C.accentGreen);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: C.darkTeal }, line: { color: C.darkTeal } });
  sl.addText("LYMPHATICS & RECURRENT LARYNGEAL NERVE", {
    x: 0.3, y: 0, w: 9, h: 0.75, fontSize: 18, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });
  sectionPill(sl, "Nerves & Lymphatics", C.accentGreen, 7.3, 0.22);

  // Posterior diagram
  sl.addImage({ data: IMG_POSTERIOR, x: 5.4, y: 0.85, w: 4.3, h: 4.55 });

  // Lymphatics box
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  sl.addText("LYMPHATIC DRAINAGE", { x: 0.25, y: 0.9, w: 4.85, h: 0.35, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
  const lymph = ["Pre-laryngeal nodes (Delphian node)", "Pre-tracheal nodes", "Para-tracheal nodes", "Deep cervical nodes (below omohyoid)"];
  lymph.forEach((l, i) => {
    sl.addText([
      { text: "🟢 ", options: { color: C.accentGreen } },
      { text: l, options: { color: C.textDark } },
    ], { x: 0.4, y: 1.3 + i * 0.37, w: 4.55, h: 0.35, fontSize: 10.5, fontFace: "Calibri" });
  });

  // RLN box
  cardBox(sl, 0.25, 3.0, 4.85, 1.95, "FFF0F5", C.accentRed);
  sl.addShape("rect", { x: 0.25, y: 3.0, w: 4.85, h: 0.35, fill: { color: C.accentRed }, line: { color: C.accentRed } });
  sl.addText("RECURRENT LARYNGEAL NERVE", { x: 0.25, y: 3.0, w: 4.85, h: 0.35, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
  const rlnItems = [
    "Right RLN: loops around right subclavian artery",
    "Left RLN: loops around arch of aorta",
    "Both ascend in tracheo-esophageal groove",
    "Pass deep to posteromedial lobe of thyroid",
    "Injury → Hoarseness (unilateral) / Stridor (bilateral)",
  ];
  rlnItems.forEach((r, i) => {
    sl.addText([
      { text: "⚠ ", options: { color: C.accentRed } },
      { text: r, options: { color: C.textDark } },
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  });

  slideNumber(sl, 5); bottomBar(sl, C.accentGreen);
}

// =============================================================================
// SLIDE 6 – EMBRYOLOGY
// =============================================================================
{
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  darkBg(sl);
  accentBar(sl, C.accentPurp);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: "1A2A40" }, line: { color: "1A2A40" } });
  sl.addText("EMBRYOLOGICAL DEVELOPMENT", {
    x: 0.3, y: 0, w: 9, h: 0.75, fontSize: 20, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });

  // Timeline / flow
  const steps = [
    { label: "Floor of Pharynx", desc: "Median endodermal thickening between 1st & 2nd pouches", color: C.accentPurp },
    { label: "Foramen Cecum", desc: "Site of origin at tongue base (junction of ant 2/3 & post 1/3)", color: C.midTeal },
    { label: "Thyroglossal Duct", desc: "Path of descent — passes ANTERIOR to hyoid bone", color: C.accent },
    { label: "Final Position", desc: "Anterior to trachea in root of neck", color: C.accentGreen },
  ];
  steps.forEach((s, i) => {
    const xx = 0.3 + i * 2.38;
    sl.addShape("rect", { x: xx, y: 0.95, w: 2.15, h: 0.38, fill: { color: s.color }, line: { color: s.color } });
    sl.addText(s.label, { x: xx, y: 0.95, w: 2.15, h: 0.38, fontSize: 10, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    sl.addShape("rect", { x: xx, y: 1.33, w: 2.15, h: 1.0, fill: { color: "0D3B4F" }, line: { color: s.color, width: 1.5 } });
    sl.addText(s.desc, { x: xx + 0.07, y: 1.38, w: 2.0, h: 0.92, fontSize: 9.5, color: "CCECF5", fontFace: "Calibri", valign: "middle" });
    if (i < 3) {
      sl.addText("→", { x: xx + 2.15, y: 1.0, w: 0.22, h: 0.28, fontSize: 16, bold: true, color: C.accent, align: "center" });
    }
  });

  // Anomalies table
  sl.addShape("rect", { x: 0.3, y: 2.55, w: 9.4, h: 0.32, fill: { color: C.accentPurp }, line: { color: C.accentPurp } });
  sl.addText("DEVELOPMENTAL ANOMALIES", { x: 0.3, y: 2.55, w: 9.4, h: 0.32, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  const anomalies = [
    { cond: "Thyroglossal Duct Cyst", feat: "Most common midline cyst; moves with swallowing AND tongue protrusion; Rx: Sistrunk's operation (excise central hyoid)" },
    { cond: "Lingual Thyroid", feat: "Failure of descent; remains at tongue base; may be the only functioning thyroid tissue" },
    { cond: "Ectopic Thyroid", feat: "Arrested anywhere along descent path" },
    { cond: "Pyramidal Lobe", feat: "Present in ~50%; extends superiorly from isthmus (remnant of thyroglossal duct)" },
    { cond: "Thyroglossal Fistula", feat: "Persistent duct opening onto skin; often secondary to infected cyst" },
  ];
  anomalies.forEach((a, i) => {
    const yy = 2.92 + i * 0.49;
    const bg = i % 2 === 0 ? "0D3B4F" : "112840";
    sl.addShape("rect", { x: 0.3, y: yy, w: 9.4, h: 0.46, fill: { color: bg }, line: { color: "1F5068" } });
    sl.addShape("rect", { x: 0.3, y: yy, w: 2.6, h: 0.46, fill: { color: "112840" }, line: { color: "1F5068" } });
    sl.addText(a.cond, { x: 0.38, y: yy + 0.03, w: 2.45, h: 0.38, fontSize: 10, bold: true, color: C.accentPurp, fontFace: "Calibri", valign: "middle" });
    sl.addText(a.feat, { x: 3.0, y: yy + 0.03, w: 6.6, h: 0.38, fontSize: 9.5, color: "D0E8F0", fontFace: "Calibri", valign: "middle" });
  });

  slideNumber(sl, 6); bottomBar(sl, C.accentPurp);
}

// =============================================================================
// SLIDE 7 – HISTOLOGY
// =============================================================================
{
  const sl = pres.addSlide();
  lightBg(sl);
  accentBar(sl, C.accentGreen);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: C.darkTeal }, line: { color: C.darkTeal } });
  sl.addText("HISTOLOGY OF THE THYROID GLAND", {
    x: 0.3, y: 0, w: 9, h: 0.75, fontSize: 20, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });
  sectionPill(sl, "Histology", C.accentGreen, 7.5, 0.22);

  // Histology image
  sl.addImage({ data: IMG_HISTO, x: 5.35, y: 0.85, w: 4.4, h: 3.5 });

  // Follicular cells
  cardBox(sl, 0.25, 0.9, 4.85, 1.95, "F0FFF4", C.accentGreen);
  sl.addShape("rect", { x: 0.25, y: 0.9, w: 4.85, h: 0.35, fill: { color: C.accentGreen }, line: { color: C.accentGreen } });
  sl.addText("FOLLICULAR CELLS (THYROCYTES)", { x: 0.25, y: 0.9, w: 4.85, h: 0.35, fontSize: 10.5, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
  const folItems = [
    "Simple epithelium surrounding colloid-filled lumen",
    "Active gland → tall columnar; Inactive → squamous",
    "Apical: Golgi, secretory granules, lysosomes, microvilli",
    "Basal: rich RER (protein synthesis)",
    "Function: Synthesize T3 & T4 via thyroglobulin",
    "Colloid stores enough hormone for ~3 months",
  ];
  folItems.forEach((f, i) => {
    sl.addText([
      { text: "● ", options: { color: C.accentGreen, bold: true } },
      { text: f, options: { color: C.textDark } },
    ], { x: 0.38, y: 1.3 + i * 0.25, w: 4.6, h: 0.24, fontSize: 9.5, fontFace: "Calibri" });
  });

  // C cells
  cardBox(sl, 0.25, 3.0, 4.85, 1.75, "FFF0F5", C.accentPurp);
  sl.addShape("rect", { x: 0.25, y: 3.0, w: 4.85, h: 0.35, fill: { color: C.accentPurp }, line: { color: C.accentPurp } });
  sl.addText("PARAFOLLICULAR C CELLS", { x: 0.25, y: 3.0, w: 4.85, h: 0.35, fontSize: 10.5, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
  const cCellItems = [
    "Inside basal lamina of follicles or between follicles",
    "Origin: Neural crest (ultimobranchial body / 4th pouch)",
    "Larger than thyrocytes, paler staining",
    "Secrete CALCITONIN → lowers serum Ca²⁺",
    "Clinical: Source of Medullary Thyroid Carcinoma",
  ];
  cCellItems.forEach((c, i) => {
    sl.addText([
      { text: "◆ ", options: { color: C.accentPurp, bold: true } },
      { text: c, options: { color: C.textDark } },
    ], { x: 0.38, y: 3.42 + i * 0.26, w: 4.6, h: 0.24, fontSize: 9.5, fontFace: "Calibri" });
  });

  // Caption under image
  sl.addText("H&E — Thyroid follicles with colloid (C) and follicular epithelium. Low power ×12 | Junqueira's Histology", {
    x: 5.35, y: 4.4, w: 4.4, h: 0.4, fontSize: 8, italic: true, color: C.textMid, align: "center", fontFace: "Calibri",
  });

  slideNumber(sl, 7); bottomBar(sl, C.accentGreen);
}

// =============================================================================
// SLIDE 8 – HORMONES & PHYSIOLOGY
// =============================================================================
{
  const sl = pres.addSlide();
  darkBg(sl);
  accentBar(sl, C.accent);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: "1A2A40" }, line: { color: "1A2A40" } });
  sl.addText("HORMONES & PHYSIOLOGY", {
    x: 0.3, y: 0, w: 9, h: 0.75, fontSize: 20, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });

  // T3 vs T4 comparison
  const hormones = [
    { name: "T4 (Thyroxine)", detail: ["~90% secreted", "Less active (prohormone)", "Half-life: ~7 days", "Converted → T3 peripherally"], color: C.midTeal },
    { name: "T3 (Triiodothyronine)", detail: ["~10% secreted", "3–4× more potent", "Half-life: ~1 day", "Active form in tissues"], color: C.accent },
  ];
  hormones.forEach((h, ci) => {
    const xx = 0.3 + ci * 4.5;
    sl.addShape("rect", { x: xx, y: 0.9, w: 4.2, h: 0.38, fill: { color: h.color }, line: { color: h.color } });
    sl.addText(h.name, { x: xx, y: 0.9, w: 4.2, h: 0.38, fontSize: 13, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    sl.addShape("rect", { x: xx, y: 1.28, w: 4.2, h: 1.5, fill: { color: "0D3B4F" }, line: { color: h.color, width: 1.5 } });
    h.detail.forEach((d, i) => {
      sl.addText([{ text: "• ", options: { bold: true, color: h.color } }, { text: d, options: { color: "CCECF5" } }],
        { x: xx + 0.15, y: 1.32 + i * 0.36, w: 3.9, h: 0.33, fontSize: 11, fontFace: "Calibri" });
    });
  });

  // HPT Axis
  sl.addShape("rect", { x: 0.3, y: 2.95, w: 9.4, h: 0.33, fill: { color: C.teal }, line: { color: C.teal } });
  sl.addText("HYPOTHALAMO-PITUITARY-THYROID (HPT) AXIS", {
    x: 0.3, y: 2.95, w: 9.4, h: 0.33, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0,
  });

  const hptSteps = [
    { label: "Hypothalamus", sub: "TRH ↓", color: C.accentPurp },
    { label: "Ant. Pituitary", sub: "TSH ↓", color: C.midTeal },
    { label: "Thyroid Gland", sub: "T3 + T4", color: C.accentGreen },
    { label: "Target Tissues", sub: "↑ BMR etc.", color: C.accent },
    { label: "Neg. Feedback", sub: "↑T3/T4 → ↓TRH/TSH", color: C.accentRed },
  ];
  hptSteps.forEach((s, i) => {
    const xx = 0.3 + i * 1.88;
    sl.addShape("rect", { x: xx, y: 3.32, w: 1.75, h: 0.85, fill: { color: s.color }, line: { color: s.color } });
    sl.addText(s.label, { x: xx, y: 3.35, w: 1.75, h: 0.38, fontSize: 10, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    sl.addText(s.sub, { x: xx, y: 3.7, w: 1.75, h: 0.3, fontSize: 9, color: C.white, align: "center", valign: "middle", margin: 0, italic: true });
    if (i < 4) sl.addText("→", { x: xx + 1.75, y: 3.5, w: 0.12, h: 0.35, fontSize: 14, bold: true, color: C.accent, align: "center" });
  });

  // Actions
  sl.addShape("rect", { x: 0.3, y: 4.3, w: 9.4, h: 0.3, fill: { color: C.accentGreen }, line: { color: C.accentGreen } });
  sl.addText("KEY ACTIONS OF T3 / T4", {
    x: 0.3, y: 4.3, w: 9.4, h: 0.3, fontSize: 10, bold: true, color: C.white, align: "center", valign: "middle", margin: 0,
  });
  const actions = ["↑ BMR", "↑ Protein synthesis", "↑ Carbohydrate metabolism", "Essential for brain development", "Potentiates catecholamines", "Skeletal maturation"];
  actions.forEach((a, i) => {
    sl.addShape("rect", { x: 0.3 + i * 1.57, y: 4.62, w: 1.48, h: 0.72, fill: { color: "112840" }, line: { color: C.accentGreen, width: 1.5 } });
    sl.addText(a, { x: 0.3 + i * 1.57, y: 4.62, w: 1.48, h: 0.72, fontSize: 9.5, color: "CCECF5", align: "center", valign: "middle", fontFace: "Calibri" });
  });

  slideNumber(sl, 8); bottomBar(sl, C.accent);
}

// =============================================================================
// SLIDE 9 – PATHOLOGY (HYPO / HYPER)
// =============================================================================
{
  const sl = pres.addSlide();
  lightBg(sl);
  accentBar(sl, C.accentRed);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: C.darkTeal }, line: { color: C.darkTeal } });
  sl.addText("THYROID PATHOLOGY — FUNCTIONAL DISORDERS", {
    x: 0.3, y: 0, w: 9, h: 0.75, fontSize: 18, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });

  // Hypothyroidism
  sl.addShape("rect", { x: 0.25, y: 0.88, w: 4.65, h: 0.38, fill: { color: C.teal }, line: { color: C.teal } });
  sl.addText("HYPOTHYROIDISM  (↓ T3/T4, ↑ TSH)", { x: 0.25, y: 0.88, w: 4.65, h: 0.38, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
  cardBox(sl, 0.25, 1.26, 4.65, 3.1, "F0F8FF", C.teal);
  const hypoItems = [
    ["Cause", "Hashimoto's thyroiditis (most common adult)"],
    ["Cause", "Iodine deficiency / post-thyroidectomy"],
    ["Cause", "Cretinism (congenital — mental retardation + dwarfism)"],
    ["Symptom", "Weight gain, cold intolerance, fatigue"],
    ["Symptom", "Bradycardia, constipation, dry skin"],
    ["Symptom", "Myxedema (non-pitting edema)"],
    ["Labs", "↑ TSH + ↓ T4 (primary)"],
    ["Rx", "Levothyroxine (T4 replacement)"],
  ];
  hypoItems.forEach((h, i) => {
    const tagColor = h[0] === "Cause" ? C.midTeal : h[0] === "Symptom" ? C.accentRed : h[0] === "Labs" ? C.accentGreen : C.accentPurp;
    sl.addShape("rect", { x: 0.32, y: 1.3 + i * 0.37, w: 0.7, h: 0.28, fill: { color: tagColor }, line: { color: tagColor } });
    sl.addText(h[0], { x: 0.32, y: 1.3 + i * 0.37, w: 0.7, h: 0.28, fontSize: 7.5, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    sl.addText(h[1], { x: 1.1, y: 1.32 + i * 0.37, w: 3.7, h: 0.28, fontSize: 10, color: C.textDark, fontFace: "Calibri", valign: "middle" });
  });

  // Hyperthyroidism
  sl.addShape("rect", { x: 5.1, y: 0.88, w: 4.65, h: 0.38, fill: { color: C.accentRed }, line: { color: C.accentRed } });
  sl.addText("HYPERTHYROIDISM  (↑ T3/T4, ↓ TSH)", { x: 5.1, y: 0.88, w: 4.65, h: 0.38, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
  cardBox(sl, 5.1, 1.26, 4.65, 3.1, "FFF5F5", C.accentRed);
  const hyperItems = [
    ["Cause", "Graves' disease (most common — TSH receptor Ab)"],
    ["Cause", "Toxic multinodular goiter / Toxic adenoma"],
    ["Cause", "Thyroiditis (De Quervain's, subacute)"],
    ["Symptom", "Weight loss, heat intolerance, sweating"],
    ["Symptom", "Tachycardia, palpitations, tremor"],
    ["Symptom", "Exophthalmos (Graves'), goiter"],
    ["Labs", "↓ TSH + ↑ T4/T3"],
    ["Rx", "Antithyroids / RAI / Surgery"],
  ];
  hyperItems.forEach((h, i) => {
    const tagColor = h[0] === "Cause" ? C.accentRed : h[0] === "Symptom" ? C.accent : h[0] === "Labs" ? C.accentGreen : C.teal;
    sl.addShape("rect", { x: 5.17, y: 1.3 + i * 0.37, w: 0.7, h: 0.28, fill: { color: tagColor }, line: { color: tagColor } });
    sl.addText(h[0], { x: 5.17, y: 1.3 + i * 0.37, w: 0.7, h: 0.28, fontSize: 7.5, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    sl.addText(h[1], { x: 5.95, y: 1.32 + i * 0.37, w: 3.7, h: 0.28, fontSize: 10, color: C.textDark, fontFace: "Calibri", valign: "middle" });
  });

  // Divider
  sl.addShape("rect", { x: 4.98, y: 0.88, w: 0.04, h: 3.5, fill: { color: C.accent }, line: { color: C.accent } });

  slideNumber(sl, 9); bottomBar(sl, C.accentRed);
}

// =============================================================================
// SLIDE 10 – THYROID CANCERS
// =============================================================================
{
  const sl = pres.addSlide();
  darkBg(sl);
  accentBar(sl, C.accentRed);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: "1A2A40" }, line: { color: "1A2A40" } });
  sl.addText("THYROID MALIGNANCIES", {
    x: 0.3, y: 0, w: 9, h: 0.75, fontSize: 20, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });

  const cancers = [
    {
      name: "Papillary Carcinoma",
      freq: "~85% of cases",
      origin: "Follicular cells",
      spread: "Lymphatic → cervical LN",
      features: ["\"Ground glass\" / Orphan Annie nuclei", "Psammoma bodies", "Papillary projections"],
      prognosis: "Excellent (>95% 10-yr survival)",
      assoc: "Radiation exposure; RET/PTC rearrangement",
      color: C.accentGreen,
    },
    {
      name: "Follicular Carcinoma",
      freq: "~10% of cases",
      origin: "Follicular cells",
      spread: "Hematogenous → bone, lung",
      features: ["Capsular + vascular invasion", "Cannot distinguish FNA from adenoma", "Cold nodule on scan"],
      prognosis: "Good (70–80% survival)",
      assoc: "Iodine deficiency areas; RAS mutation",
      color: C.midTeal,
    },
    {
      name: "Medullary Carcinoma",
      freq: "~5% of cases",
      origin: "C cells (parafollicular)",
      spread: "Lymphatic + hematogenous",
      features: ["Secretes calcitonin (↑ serum calcitonin)", "Amyloid deposits in stroma", "Bilateral if familial"],
      prognosis: "Intermediate",
      assoc: "MEN2A / MEN2B; RET mutation (familial)",
      color: C.accentPurp,
    },
    {
      name: "Anaplastic Carcinoma",
      freq: "<1–2% of cases",
      origin: "Follicular cells (undifferentiated)",
      spread: "Rapid local invasion + distant mets",
      features: ["Elderly patients", "Rapidly enlarging hard mass", "Compresses trachea/esophagus"],
      prognosis: "Very poor (median survival <6 months)",
      assoc: "Arises in pre-existing goiter; TP53 mutation",
      color: C.accentRed,
    },
  ];

  cancers.forEach((c, i) => {
    const xx = 0.22 + i * 2.4;
    sl.addShape("rect", { x: xx, y: 0.9, w: 2.25, h: 0.4, fill: { color: c.color }, line: { color: c.color } });
    sl.addText(c.name, { x: xx, y: 0.9, w: 2.25, h: 0.4, fontSize: 9.5, bold: true, color: C.white, align: "center", valign: "middle", margin: 0, wrap: true });
    sl.addShape("rect", { x: xx, y: 1.3, w: 2.25, h: 3.95, fill: { color: "0D3B4F" }, line: { color: c.color, width: 1.5 } });

    const rows = [
      { label: "Freq", val: c.freq },
      { label: "Origin", val: c.origin },
      { label: "Spread", val: c.spread },
      { label: "Features", val: c.features.join("; ") },
      { label: "Prognosis", val: c.prognosis },
      { label: "Assoc.", val: c.assoc },
    ];
    rows.forEach((r, ri) => {
      sl.addText(r.label, { x: xx + 0.06, y: 1.35 + ri * 0.63, w: 0.58, h: 0.25, fontSize: 7.5, bold: true, color: c.color, fontFace: "Calibri" });
      sl.addText(r.val, { x: xx + 0.06, y: 1.59 + ri * 0.63, w: 2.1, h: 0.32, fontSize: 8.5, color: "C0DDE8", fontFace: "Calibri", wrap: true });
    });
  });

  slideNumber(sl, 10); bottomBar(sl, C.accentRed);
}

// =============================================================================
// SLIDE 11 – SURGICAL ANATOMY & CLINICAL PEARLS
// =============================================================================
{
  const sl = pres.addSlide();
  lightBg(sl);
  accentBar(sl, C.accent);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: C.darkTeal }, line: { color: C.darkTeal } });
  sl.addText("SURGICAL ANATOMY & CLINICAL PEARLS", {
    x: 0.3, y: 0, w: 9, h: 0.75, fontSize: 18, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });

  const pearls = [
    {
      num: "01",
      title: "Recurrent Laryngeal Nerve",
      body: "Must be identified & preserved during thyroidectomy. Passes near Berry's ligament and inferior thyroid artery. Unilateral injury → hoarseness; bilateral → stridor/airway obstruction.",
      color: C.accentRed,
    },
    {
      num: "02",
      title: "Parathyroid Glands",
      body: "4 small glands on posterior surface of lateral lobes. Accidental removal or devascularization → hypoparathyroidism → hypocalcemia → tetany. Monitor Ca²⁺ post-op.",
      color: C.accentGreen,
    },
    {
      num: "03",
      title: "External Branch of Superior Laryngeal Nerve",
      body: "Runs with superior thyroid artery (last 1 cm). Injury → voice fatigue, loss of high-pitched phonation (Semon's law).",
      color: C.midTeal,
    },
    {
      num: "04",
      title: "Thyroid Ima Artery",
      body: "Present in ~3%. Enters trachea from below — serious hemorrhage risk during emergency tracheostomy if undetected.",
      color: C.accentPurp,
    },
    {
      num: "05",
      title: "Inferior Thyroid Veins",
      body: "Drain directly into brachiocephalic veins. If torn during surgery → risk of AIR EMBOLISM. Always ligate before dividing.",
      color: C.accent,
    },
    {
      num: "06",
      title: "Goiter",
      body: "Diffuse enlargement (iodine deficiency or autoimmune). A midline neck swelling that moves on swallowing = thyroid/thyroglossal origin. Thyroglossal cyst also moves on tongue protrusion.",
      color: C.teal,
    },
  ];

  pearls.forEach((p, i) => {
    const col = i % 2;
    const row = Math.floor(i / 2);
    const xx = 0.25 + col * 4.88;
    const yy = 0.9 + row * 1.55;
    cardBox(sl, xx, yy, 4.6, 1.4, C.white, p.color);
    sl.addShape("rect", { x: xx, y: yy, w: 0.55, h: 1.4, fill: { color: p.color }, line: { color: p.color } });
    sl.addText(p.num, { x: xx, y: yy, w: 0.55, h: 1.4, fontSize: 18, bold: true, color: "FFFFFF", align: "center", valign: "middle", margin: 0 });
    sl.addText(p.title, { x: xx + 0.62, y: yy + 0.06, w: 3.9, h: 0.3, fontSize: 11, bold: true, color: p.color, fontFace: "Calibri" });
    sl.addText(p.body, { x: xx + 0.62, y: yy + 0.36, w: 3.9, h: 0.98, fontSize: 9, color: C.textDark, fontFace: "Calibri", wrap: true, valign: "top" });
  });

  slideNumber(sl, 11); bottomBar(sl, C.accent);
}

// =============================================================================
// SLIDE 12 – QUICK REVISION TABLE
// =============================================================================
{
  const sl = pres.addSlide();
  darkBg(sl);
  accentBar(sl, C.accentGreen);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.75, fill: { color: "1A2A40" }, line: { color: "1A2A40" } });
  sl.addText("QUICK REVISION — HIGH-YIELD SUMMARY", {
    x: 0.3, y: 0, w: 9, h: 0.75, fontSize: 20, bold: true, color: C.white, valign: "middle", fontFace: "Calibri",
  });

  const rows = [
    ["Topic", "Key Fact", "Clinical Relevance"],
    ["Shape", "Butterfly; 2 lobes + isthmus", "Isthmus = 2nd–3rd tracheal rings"],
    ["Arterial supply", "Superior (ext. carotid) + Inferior (thyrocervical trunk)", "Ima artery = inconstant; risk in tracheostomy"],
    ["Venous drainage", "Superior + Middle → IJV; Inferior → Brachiocephalic", "Inferior veins: air embolism risk if torn"],
    ["Embryology", "Foramen cecum → thyroglossal duct → final position", "Cyst: Sistrunk's op; lingual thyroid = only TT"],
    ["Histology", "Follicles (thyrocytes + colloid) + C cells", "Active = tall columnar; Inactive = squamous"],
    ["C cell hormone", "Calcitonin → ↓ Ca²⁺", "Medullary carcinoma marker"],
    ["T3 vs T4", "T4 = prohormone; T3 = active; peripheral conversion", "Half-life T4 = 7 days; T3 = 1 day"],
    ["HPT Axis", "TRH → TSH → T3/T4 → neg. feedback", "Primary hypothyroid = ↑TSH; secondary = ↓TSH"],
    ["Surgical risk 1", "RLN — posteromedial to lateral lobe / Berry's lig.", "Hoarseness (uni) / Stridor (bilateral)"],
    ["Surgical risk 2", "Parathyroid glands (×4) on posterior surface", "Hypocalcemia → tetany if devascularized"],
  ];

  rows.forEach((r, i) => {
    const yy = 0.82 + i * 0.43;
    const bg = i === 0 ? C.teal : i % 2 === 0 ? "0D3B4F" : "112840";
    const textColor = i === 0 ? C.white : "C8E6F0";
    const fontWeight = i === 0;
    sl.addShape("rect", { x: 0.2, y: yy, w: 9.6, h: 0.41, fill: { color: bg }, line: { color: "1F5068" } });
    const widths = [1.5, 4.4, 3.5];
    const xs = [0.25, 1.8, 6.25];
    r.forEach((cell, ci) => {
      sl.addText(cell, {
        x: xs[ci], y: yy + 0.02, w: widths[ci], h: 0.37,
        fontSize: i === 0 ? 9.5 : 9,
        bold: fontWeight,
        color: i === 0 ? C.white : ci === 0 ? C.accent : textColor,
        fontFace: "Calibri", valign: "middle",
      });
    });
  });

  slideNumber(sl, 12); bottomBar(sl, C.accentGreen);
}

// =============================================================================
// SLIDE 13 – THANK YOU / END
// =============================================================================
{
  const sl = pres.addSlide();
  darkBg(sl);

  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.darkTeal }, line: { color: C.darkTeal } });
  sl.addShape("rect", { x: 0, y: 0, w: 10, h: 0.08, fill: { color: C.accent }, line: { color: C.accent } });
  sl.addShape("rect", { x: 0, y: 5.545, w: 10, h: 0.08, fill: { color: C.accent }, line: { color: C.accent } });

  // Decorative anatomy image, faded
  sl.addImage({ data: IMG_POSTERIOR, x: 5.5, y: 0.4, w: 4.2, h: 5.0, transparency: 60 });

  sl.addText("THYROID GLAND", {
    x: 0.5, y: 1.1, w: 5.5, h: 0.9, fontSize: 34, bold: true, color: C.white, fontFace: "Calibri", charSpacing: 3,
  });
  sl.addText("Anatomy, Histology & Pathology", {
    x: 0.5, y: 1.95, w: 5.5, h: 0.45, fontSize: 15, color: C.accent, fontFace: "Calibri",
  });

  sl.addShape("rect", { x: 0.5, y: 2.52, w: 4.8, h: 0.04, fill: { color: C.teal }, line: { color: C.teal } });

  sl.addText([
    { text: "Key References:\n", options: { bold: true, color: C.accent, breakLine: true } },
    { text: "• Gray's Anatomy for Students, 4th Ed\n", options: { color: "9FC8D8", breakLine: true } },
    { text: "• Junqueira's Basic Histology, 17th Ed\n", options: { color: "9FC8D8", breakLine: true } },
    { text: "• Vishram Singh — Head, Neck & Brain (Anatomy)\n", options: { color: "9FC8D8", breakLine: true } },
    { text: "• Robbins & Cotran Pathologic Basis of Disease", options: { color: "9FC8D8" } },
  ], {
    x: 0.5, y: 2.65, w: 5.0, h: 1.8, fontSize: 10.5, fontFace: "Calibri", lineSpacingMultiple: 1.5,
  });

  sl.addText("Thank You", {
    x: 0.5, y: 4.55, w: 5.0, h: 0.65, fontSize: 28, bold: true, color: C.midTeal, fontFace: "Calibri",
  });
}

// ── Write file ────────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/thyroid-ppt/Thyroid_Gland_Anatomy_Pathology.pptx" })
  .then(() => console.log("✅ Presentation saved!"))
  .catch(err => { console.error("❌ Error:", err); process.exit(1); });

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/thyroid-ppt/generate.js'

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/thyroid-ppt/generate.js'