Treatment depends on the cause. If this is acanthosis nigricans or friction-related darkening, it usually improves gradually after treating the underlying trigger. It is not something that can safely be scrubbed off.
Please see a dermatologist or general physician before starting medicated creams. They may:
Dermatology texts report that creams such as urea, salicylic acid, glycolic acid, and retinoids have been used, but results are variable and managing insulin resistance or another cause is more important.
Fitzpatrick's Dermatology, p. 2524. The
AAD treatment guidance similarly advises checking for an underlying condition and notes that prescription topical treatments may help appearance.
Do not buy strong peeling solutions or laser treatments without a dermatologist. They can cause burns and darker marks, especially on neck skin.
Please seek review sooner if it appeared suddenly, is spreading quickly, becomes very thick, or you have unexplained weight loss. Recent reviews also confirm that topical-treatment evidence is limited and variable, so be cautious about promises of a fast cure (PMIDs: 41140645, 38904687).