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Bed Sores (Pressure Ulcers / Decubitus Ulcers) - Causes, Stages & Treatment
What Are Bed Sores?
Bed sores (also called pressure ulcers or decubitus ulcers) are wounds caused by ischemia of the skin, subcutaneous fat, and muscle from sustained, constant pressure - typically over bony prominences. They occur most often in chronically debilitated people who cannot reposition themselves. About 95% develop on the lower body: 65% in the pelvic area (sacrum, coccyx, ischium) and 30% on the legs (heels, ankles, lateral malleoli).
Staging
| Stage | Description |
|---|
| I | Persistent non-blanchable redness; changes in skin temperature, tissue consistency, or sensation. Skin intact. |
| II | Superficial ulcer involving the epidermis and/or dermis only. Shallow open wound. |
| III | Full-thickness skin loss; damage extends into subcutaneous fat. |
| IV | Full-thickness loss reaching muscle, bone, tendon, or joint capsule. |
An ulcer typically begins with erythema at the pressure point; a "punched-out" ulcer then develops. Untreated ulcers show necrosis with a grayish pseudomembrane. Complications include sepsis, local infection, osteomyelitis, fistulas, and squamous cell carcinoma (SCC).
Key risk factors: diabetes mellitus, peripheral vascular disease, cerebrovascular disease, sepsis, hypotension, traumatic spinal cord injury, immobility, malnutrition.
Treatment
1. Pressure Relief (the cornerstone)
- Reposition every 2 hours - this is mandatory and the single most important measure
- Mechanical kinetic beds, foam or gel overlays, air-filled mattresses, liquid-filled flotation devices
- Padded orthotics for immobilized limbs
- Avoid sheepskin mattresses - they do not prevent or treat pressure ulcers effectively
- Do not perform therapeutic massage of high-risk areas - postmortem biopsies have found degenerated tissue in massaged areas
2. Wound Cleaning
- Clean with normal saline at each dressing change - not hydrogen peroxide, povidone-iodine, hypochlorite, or acetic acid, as these inhibit wound healing
- Use a gentle, non-traumatic technique
3. Debridement
At least once weekly. Four methods are available:
| Method | Description |
|---|
| Sharp (surgical) | Scalpels, forceps, scissors; fastest; standard for non-coagulopathic patients |
| Mechanical | Wet-to-moist dressings, irrigation |
| Enzymatic | Topical agents (e.g., collagenase) dissolve necrotic tissue |
| Autolytic | Synthetic dressings allow devitalized tissue to self-digest using wound enzymes |
| Biosurgery | Maggot/larvae therapy for patients unable to tolerate surgical debridement |
Exception: Stable heel ulcers with only dry eschar do NOT require debridement.
4. Dressings - Selection by Stage
The goal is to keep ulcer tissue moist while keeping surrounding skin dry.
| Dressing Type | Best Use |
|---|
| Transparent films | Stage II only (light drainage) |
| Hydrocolloid dressings | Stage II; speed healing, block bacteria, maintain moisture; stay in place several days |
| Gauze (saline-moistened) | Clean Stage III and IV ulcers |
| Hydrofibers | Stage III and IV full-thickness ulcers |
| Alginates / Hydrogels | Wounds with excessive drainage |
| Vacuum-assisted closure (VAC) | After surgical debridement, once viable granulation base is established |
More than 300 commercial dressing products exist across these categories (films, alginates, foams, hydrogels, hydrofibers, hydrocolloids).
5. Infection Control
- At least once weekly: assess for bacterial colonization
- Topical metronidazole eliminates the putrid odor from anaerobic colonization within 36 hours
- Systemic antibiotics for confirmed cellulitis, osteomyelitis, or sepsis
6. Surgical Repair
Required for deep, non-healing wounds. Options include:
- Formal operative debridement
- Flap closure
- Reconstructive procedures with skin substitutes or cultured keratinocyte grafts
7. Supportive & Adjunct Measures
- Nutrition: 1.25-1.5 g protein/kg/day; correct vitamin and mineral deficiencies
- Pain management
- Psychosocial support
- Education of all levels of caregivers and patients (multidisciplinary team approach significantly reduces incidence)
- Investigational adjuncts being studied: ultrasound, laser, UV radiation, hyperbaric oxygen, electrical stimulation, radiant heat, growth factors
Prevention (Key Points)
- Reposition minimum every 2 hours
- Pressure-redistributing mattress/support surface
- Moisture management (keep skin dry from incontinence, sweat)
- Nutritional optimization
- Skin inspection at every repositioning
Recent Evidence
A 2023-update
Wound Healing Society guideline is the most current comprehensive treatment guide, and a 2025 umbrella review (PMID: 40437976) confirmed that prevention-focused interventions remain the most cost-effective strategy. A 2026 systematic review (PMID: 42466136) highlights that
nutritional support - particularly protein supplementation - is a key and sometimes underutilized treatment component.
Sources: Andrews' Diseases of the Skin (Clinical Dermatology), p. 53 | Schwartz's Principles of Surgery, 11th ed. | Swanson's Family Medicine Review | Goldman-Cecil Medicine