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Bed Sores (Pressure Ulcers / Decubitus Ulcers) - Causes, Stages & Treatment

What Are Bed Sores?

Bed sores (also called pressure ulcers or decubitus ulcers) are wounds caused by ischemia of the skin, subcutaneous fat, and muscle from sustained, constant pressure - typically over bony prominences. They occur most often in chronically debilitated people who cannot reposition themselves. About 95% develop on the lower body: 65% in the pelvic area (sacrum, coccyx, ischium) and 30% on the legs (heels, ankles, lateral malleoli).

Staging

StageDescription
IPersistent non-blanchable redness; changes in skin temperature, tissue consistency, or sensation. Skin intact.
IISuperficial ulcer involving the epidermis and/or dermis only. Shallow open wound.
IIIFull-thickness skin loss; damage extends into subcutaneous fat.
IVFull-thickness loss reaching muscle, bone, tendon, or joint capsule.
An ulcer typically begins with erythema at the pressure point; a "punched-out" ulcer then develops. Untreated ulcers show necrosis with a grayish pseudomembrane. Complications include sepsis, local infection, osteomyelitis, fistulas, and squamous cell carcinoma (SCC).
Key risk factors: diabetes mellitus, peripheral vascular disease, cerebrovascular disease, sepsis, hypotension, traumatic spinal cord injury, immobility, malnutrition.

Treatment

1. Pressure Relief (the cornerstone)

  • Reposition every 2 hours - this is mandatory and the single most important measure
  • Mechanical kinetic beds, foam or gel overlays, air-filled mattresses, liquid-filled flotation devices
  • Padded orthotics for immobilized limbs
  • Avoid sheepskin mattresses - they do not prevent or treat pressure ulcers effectively
  • Do not perform therapeutic massage of high-risk areas - postmortem biopsies have found degenerated tissue in massaged areas

2. Wound Cleaning

  • Clean with normal saline at each dressing change - not hydrogen peroxide, povidone-iodine, hypochlorite, or acetic acid, as these inhibit wound healing
  • Use a gentle, non-traumatic technique

3. Debridement

At least once weekly. Four methods are available:
MethodDescription
Sharp (surgical)Scalpels, forceps, scissors; fastest; standard for non-coagulopathic patients
MechanicalWet-to-moist dressings, irrigation
EnzymaticTopical agents (e.g., collagenase) dissolve necrotic tissue
AutolyticSynthetic dressings allow devitalized tissue to self-digest using wound enzymes
BiosurgeryMaggot/larvae therapy for patients unable to tolerate surgical debridement
Exception: Stable heel ulcers with only dry eschar do NOT require debridement.

4. Dressings - Selection by Stage

The goal is to keep ulcer tissue moist while keeping surrounding skin dry.
Dressing TypeBest Use
Transparent filmsStage II only (light drainage)
Hydrocolloid dressingsStage II; speed healing, block bacteria, maintain moisture; stay in place several days
Gauze (saline-moistened)Clean Stage III and IV ulcers
HydrofibersStage III and IV full-thickness ulcers
Alginates / HydrogelsWounds with excessive drainage
Vacuum-assisted closure (VAC)After surgical debridement, once viable granulation base is established
More than 300 commercial dressing products exist across these categories (films, alginates, foams, hydrogels, hydrofibers, hydrocolloids).

5. Infection Control

  • At least once weekly: assess for bacterial colonization
  • Topical metronidazole eliminates the putrid odor from anaerobic colonization within 36 hours
  • Systemic antibiotics for confirmed cellulitis, osteomyelitis, or sepsis

6. Surgical Repair

Required for deep, non-healing wounds. Options include:
  • Formal operative debridement
  • Flap closure
  • Reconstructive procedures with skin substitutes or cultured keratinocyte grafts

7. Supportive & Adjunct Measures

  • Nutrition: 1.25-1.5 g protein/kg/day; correct vitamin and mineral deficiencies
  • Pain management
  • Psychosocial support
  • Education of all levels of caregivers and patients (multidisciplinary team approach significantly reduces incidence)
  • Investigational adjuncts being studied: ultrasound, laser, UV radiation, hyperbaric oxygen, electrical stimulation, radiant heat, growth factors

Prevention (Key Points)

  • Reposition minimum every 2 hours
  • Pressure-redistributing mattress/support surface
  • Moisture management (keep skin dry from incontinence, sweat)
  • Nutritional optimization
  • Skin inspection at every repositioning

Recent Evidence

A 2023-update Wound Healing Society guideline is the most current comprehensive treatment guide, and a 2025 umbrella review (PMID: 40437976) confirmed that prevention-focused interventions remain the most cost-effective strategy. A 2026 systematic review (PMID: 42466136) highlights that nutritional support - particularly protein supplementation - is a key and sometimes underutilized treatment component.

Sources: Andrews' Diseases of the Skin (Clinical Dermatology), p. 53 | Schwartz's Principles of Surgery, 11th ed. | Swanson's Family Medicine Review | Goldman-Cecil Medicine
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