Now I have rich, textbook-sourced content to generate high-quality, accurate NEET PG-style MCQs on RHD. Let me compile them:
🩺 10 NEET PG MCQs — Rheumatic Heart Disease (RHD)
Q1. Rheumatic fever (RF) is an immunologically mediated disease triggered by infection with which organism?
- A) Staphylococcus aureus
- B) Group A Streptococcus (S. pyogenes)
- C) Group B Streptococcus
- D) Streptococcus pneumoniae
✅ Answer & Explanation
Answer: B — Group A Streptococcus (S. pyogenes)
RF follows Group A streptococcal pharyngitis (2–3 weeks later). Molecular mimicry between streptococcal M proteins and cardiac antigens (cross-reactive antibodies and T cells) causes tissue damage. Importantly, streptococci are absent from the lesions themselves.
— Robbins Pathologic Basis of Disease
Q2. The pathognomonic histological lesion of acute rheumatic carditis is:
- A) Anitschkow cells in Aschoff bodies
- B) Lambl's excrescences
- C) Verocay bodies
- D) Russell bodies
✅ Answer & Explanation
Answer: A — Anitschkow cells in Aschoff bodies
Aschoff bodies are focal inflammatory lesions containing T lymphocytes, plasma cells, and Anitschkow cells (plump macrophages with central nuclei where chromatin condenses into a wavy ribbon — called "caterpillar cells"). They are pathognomonic of rheumatic carditis.
— Robbins Pathologic Basis of Disease
Q3. RHD is virtually the ONLY cause of which valvular lesion?
- A) Aortic regurgitation
- B) Tricuspid stenosis
- C) Mitral stenosis
- D) Pulmonary stenosis
✅ Answer & Explanation
Answer: C — Mitral stenosis
RHD is characterized principally by deforming fibrotic valvular disease, particularly the mitral valve. RHD is virtually the only cause of mitral stenosis. The mitral valve is affected in isolation in ~2/3 of cases, and along with the aortic valve in another ~25%.
— Robbins Pathologic Basis of Disease
Q4. In the Revised Jones Criteria (2015), which of the following is a MAJOR criterion for diagnosing acute rheumatic fever in HIGH-RISK populations but NOT in low-risk populations?
- A) Carditis
- B) Monoarthritis
- C) Chorea
- D) Subcutaneous nodules
✅ Answer & Explanation
Answer: B — Monoarthritis
In high-risk populations, monoarticular arthritis qualifies as a major criterion. In low-risk populations, only polyarticular arthritis is a major criterion (monoarthralgia is only a minor criterion). Carditis, chorea, erythema marginatum, and subcutaneous nodules are major criteria in both populations.
— Goldman-Cecil Medicine
Q5. Small vegetations (1–2 mm) seen along the line of closure of valves in acute rheumatic fever are called:
- A) MacCallum plaques
- B) Verrucae
- C) Libman-Sacks vegetations
- D) Janeway lesions
✅ Answer & Explanation
Answer: B — Verrucae
In acute RF, fibrinoid necrosis in valve cusps is overlaid by small (1–2 mm) vegetations called verrucae along the lines of closure. MacCallum plaques are subendocardial thickenings in the left atrium caused by regurgitant jets.
— Robbins Pathologic Basis of Disease
Q6. The "fish mouth" appearance of the mitral valve on gross examination is characteristic of:
- A) Mitral valve prolapse
- B) Infective endocarditis
- C) Chronic rheumatic mitral stenosis
- D) Calcific aortic stenosis
✅ Answer & Explanation
Answer: C — Chronic rheumatic mitral stenosis
Calcification and fibrous bridging across valvular commissures in chronic RHD create "fish mouth" stenoses of the mitral valve. This is a classic morphological feature tested repeatedly in NEET PG.
— Robbins Pathologic Basis of Disease
Q7. Secondary prophylaxis in rheumatic fever to prevent recurrence is best achieved with:
- A) Oral amoxicillin daily
- B) IM benzathine penicillin G 1.2 million units every 4 weeks
- C) IV vancomycin monthly
- D) Oral erythromycin twice daily
✅ Answer & Explanation
Answer: B — IM benzathine penicillin G 1.2 million units every 4 weeks
This is the drug of choice for secondary prophylaxis in RF, recommended for a minimum of 10 years (and in some cases indefinitely). It eradicates residual Group A streptococcus and prevents recurrent attacks, which cause cumulative valve damage.
— Goldman-Cecil Medicine
Q8. In acute rheumatic fever, Sydenham's chorea (St. Vitus' dance) is caused by:
- A) Immune complex deposition in joints
- B) Antibody binding to basal ganglia
- C) T-cell infiltration of the myocardium
- D) Delayed hypersensitivity in the skin
✅ Answer & Explanation
Answer: B — Antibody binding to basal ganglia
The various manifestations of RF have distinct immunopathological mechanisms:
- Carditis → antibody-binding + T-cell infiltration
- Arthritis → immune complexes in joints
- Chorea → antibody binding to basal ganglia
- Skin lesions → delayed hypersensitivity
— Goldman-Cecil Medicine
Q9. The most common valve affected in chronic RHD, in ISOLATION, is:
- A) Aortic valve
- B) Tricuspid valve
- C) Mitral valve
- D) Pulmonary valve
✅ Answer & Explanation
Answer: C — Mitral valve
The mitral valve is virtually always involved in chronic RHD — in isolation in ~2/3 of cases, and together with the aortic valve in ~25%. Tricuspid involvement is infrequent; pulmonary valve is only rarely affected.
— Robbins Pathologic Basis of Disease
Q10. A 12-year-old child presents 3 weeks after sore throat with fever, migratory large-joint polyarthritis, and a new pansystolic murmur. ESR is 70 mm/hr and PR interval is prolonged on ECG. According to Revised Jones Criteria, how many MAJOR criteria does this patient fulfill?
✅ Answer & Explanation
Answer: B — 2 Major criteria
Major criteria present:
- Carditis (new murmur = valvulitis)
- Polyarthritis (migratory large-joint)
Minor criteria present:
- Fever ≥38.5°C
- Elevated ESR (≥60 mm in low-risk; ≥30 mm in high-risk)
- Prolonged PR interval (Note: PR interval is NOT counted as a minor criterion when carditis is already a major criterion)
Diagnosis of initial ARF = 2 major OR 1 major + 2 minor criteria → This child satisfies diagnosis with 2 major criteria.
— Goldman-Cecil Medicine
📊 Quick Summary Table
| Topic | High-Yield Fact |
|---|
| Causative agent | Group A Streptococcus |
| Mechanism | Molecular mimicry (M protein ↔ cardiac antigens) |
| Pathognomonic lesion | Aschoff bodies with Anitschkow (caterpillar) cells |
| Only cause of mitral stenosis | RHD |
| Valve most commonly affected alone | Mitral (2/3 cases) |
| Chorea mechanism | Antibody → basal ganglia |
| Vegetations in acute RF | Verrucae (1–2 mm, along line of closure) |
| "Fish mouth" valve | Chronic rheumatic mitral stenosis |
| Secondary prophylaxis | IM Benzathine Penicillin G q4 weeks |
| Jones criteria (initial ARF) | 2 major OR 1 major + 2 minor |
Want MCQs on a specific subtopic of RHD (e.g., mitral stenosis management, Jones criteria edge cases, valvular surgery)? Or shall I move to another topic?