Here is a complete structured guide to clinical examinations in general medicine, compiled from Harrison's Principles of Internal Medicine 22E, Goldman-Cecil Medicine, and Daroff's Neurology in Clinical Practice.
Clinical Examinations in General Medicine
The Universal Sequence (for any system)
Every clinical examination follows: Inspection → Palpation → Percussion → Auscultation
(Exception: the abdomen - always auscultate before palpating/percussing to avoid altering bowel sounds.)
1. GENERAL / SYSTEMIC EXAMINATION
Before going system-by-system, every patient gets a general survey.
1a. Overall Inspection
- Build: thin/obese, nutritional status, hydration
- Conscious level: alert, drowsy, confused (GCS if needed)
- Appearance: distressed, comfortable, jaundiced, pale, cyanosed
- Posture and gait (briefly, walking into the room)
- Speech: dysarthria, aphasia, hoarseness
1b. Vital Signs
| Parameter | Technique | Key Notes |
|---|
| Temperature | Oral/axillary/tympanic | >38°C = fever; <36°C = hypothermia |
| Pulse | Radial - rate, rhythm, volume, character | Normal 60-100 bpm; regular/irregular |
| Blood Pressure | Seated, arm at heart level, 5-10 min rest, correct cuff size | Both arms (>10 mmHg diff is abnormal). Korotkoff I = systolic, V = diastolic |
| Respiratory Rate | Count breaths for 60 seconds | Normal 12-20/min; most underrecorded vital sign |
| SpO2 | Pulse oximetry | Normal ≥95%; finger vs toe gap >2% = peripheral arterial disease |
| BMI / Weight | Scale + height | Document at every admission |
Blood pressure pearls (Harrison's):
- Systolic leg pressure is normally up to 20 mmHg higher than arm - reversed = coarctation or aortic dissection
- "White coat hypertension": BP >130/80 in clinic but <130/80 out of clinic, no end-organ damage
- Ankle-Brachial Index (ABI): ankle systolic ÷ higher brachial pressure. Low ABI = peripheral arterial disease; powerful predictor of cardiovascular mortality
1c. Hands
- Clubbing: loss of nail-fold angle; 5 causes per system (lung cancer, fibrosis, bronchiectasis, cyanotic heart disease, liver cirrhosis, IBD)
- Peripheral cyanosis: blue/cold fingers (low flow)
- Koilonychia: spoon-shaped nails - iron deficiency anaemia
- Leukonychia: white nails - hypoalbuminaemia
- Pallor: palmar crease pallor = Hb <9 g/dL roughly
- Asterixis (flap): outstretched hands, wrists extended - hepatic, uraemic, or CO2 retention encephalopathy
- Dupuytren's contracture: palmar fibrosis - liver disease, diabetes, familial
- Splinter haemorrhages: infective endocarditis, vasculitis
- Osler's nodes / Janeway lesions: endocarditis
- Tremor (resting, postural, intention): see Neurology section
1d. Face
- Eyes: jaundice (sclerae), anaemia (conjunctivae), Horner's (ptosis + miosis + anhidrosis), exophthalmos (thyroid), xanthelasma, arcus cornealis
- Mouth: angular stomatitis (B12/iron def), central cyanosis (tongue and lips), leukoplakia, oral candidiasis, gum hypertrophy (phenytoin, CCBs, leukaemia)
- Parotid enlargement: alcoholic liver disease
- Malar flush: mitral stenosis
- Facies: myxoedema, Cushingoid, acromegaly, Parkinsonism (hypomimia), progressive supranuclear palsy (worried expression)
1e. Neck
- JVP: see CVS section (very important bedside venous pressure measure)
- Lymph nodes: anterior/posterior cervical, supraclavicular (Virchow's node = gastric/lung cancer), axillary, inguinal
- Thyroid: palpate from behind, swallows on swallowing; auscultate for bruit
- Carotid bruit: auscultate at angle of mandible
1f. Oedema
- Peripheral: pitting oedema at ankles/sacrum - cardiac, hepatic, nephrotic, nutritional
- Non-pitting: lymphoedema, myxoedema
- Press firmly for 10-15 seconds - depth of pit correlates roughly with severity
2. CARDIOVASCULAR SYSTEM (CVS) EXAMINATION
(Based on Harrison's Principles of Internal Medicine 22E, Chapter 246)
Sequence: Position patient at 45°, adequately exposed from waist up.
2a. Jugular Venous Pressure (JVP)
The JVP is the single most important bedside measurement of volume status.
- Use the internal jugular vein (preferred - direct line to RA; external JV is valved)
- Measure the vertical height of venous pulsation above the sternal angle (angle of Louis) at 45°
- Normal: <4.5 cm above sternal angle at 45°
- Tip: pulsations above the clavicle in the sitting position are always abnormal (RA is ≥10 cm below clavicle)
Distinguishing JVP from carotid pulse:
| Feature | JVP | Carotid |
|---|
| Obliterable by pressure | Yes | No |
| Waveform | Biphasic (a and v waves) | Monophasic |
| Changes with posture | Yes | No |
| Changes with inspiration | Yes | No |
JVP waveform components:
- a wave - RA presystolic contraction (after P wave on ECG); absent in AF; cannon a wave = AV dissociation (VT!)
- x descent - RA pressure fall after tricuspid opening
- c wave - tricuspid bulging into RA during early systole
- v wave - atrial filling during ventricular systole; giant v wave = tricuspid regurgitation
- y descent - tricuspid opens, RA empties
- Prominent y descent + pericardial knock = constrictive pericarditis
Clinical meanings:
- Elevated JVP: fluid overload, right heart failure, tamponade, SVC obstruction
- Elevated JVP with elevated JVP rising on inspiration (Kussmaul's sign): constrictive pericarditis, restrictive cardiomyopathy
- Elevated JVP (>10 mmHg) predicts pulmonary wedge pressure >22 mmHg (PPV 88%)
2b. Arterial Pulse
- Best assessed at the carotid for character; radial for rate and rhythm
- Rate, rhythm, volume, character, radio-radial/radio-femoral delay, vessel wall
Pulse character:
| Pulse Type | Character | Cause |
|---|
| Pulsus parvus et tardus | Weak, slow upstroke | Severe aortic stenosis |
| Corrigan's/water-hammer | Sharp rise, rapid collapse | Severe aortic regurgitation |
| Bisferiens | Two systolic peaks | HOCM, AR |
| Pulsus paradoxus | >10 mmHg fall in systolic on inspiration | Cardiac tamponade, massive PE, severe obstructive lung disease, tension pneumothorax |
| Pulsus alternans | Beat-to-beat amplitude variation (regular rhythm) | Severe LV systolic dysfunction |
| Anacrotic | Slow notched upstroke | Severe AS |
Pulsus paradoxus measurement: inflate BP cuff above systolic; slowly deflate; note the pressure at which Korotkoff sounds are heard only in expiration, then the pressure at which heard in every beat. Difference >10 mmHg = positive.
2c. Blood Pressure
- Both arms; >10 mmHg difference = subclavian/atherosclerotic disease, coarctation, dissection
- Systolic legs > arms normally; reversed = coarctation
- Measure ABI in peripheral arterial disease
2d. Precordial Examination
Inspection:
- Visible apex beat: midclavicular line, 5th ICS in thin adults
- Visible pulsations elsewhere = abnormal
- Right parasternal pulsation = ascending aortic aneurysm
Palpation:
- Patient supine 30°, enhanced in left lateral decubitus
- Apex beat: location (normally ≤5th ICS, midclavicular line), size (<2 cm), character
- Heaving/sustained = LV hypertrophy (pressure overload: AS, hypertension)
- Hyperdynamic/thrusting = LV volume overload (MR, AR)
- Displaced/diffuse = dilated cardiomyopathy
- Parasternal heave: RV enlargement (pressure or volume overload)
- Thrills (palpable murmurs): grade 4+ murmurs; location identifies origin
- Loud P2 palpable at left upper sternal border = pulmonary hypertension
2e. Cardiac Auscultation
Areas:
- Aortic: 2nd right ICS
- Pulmonary: 2nd left ICS
- Tricuspid: left lower sternal border (4th/5th ICS)
- Mitral: apex (5th ICS, midclavicular line) - listen with bell for low-pitched sounds
First Heart Sound (S1):
- Mitral + tricuspid closure
- Loud S1: early rheumatic mitral stenosis, short PR interval, hyperkinetic states
- Soft S1: late rheumatic MS (calcified leaflets), long PR interval, LV systolic dysfunction, beta-blockers
- Splitting: heard in young patients and RBBB (delayed tricuspid closure)
Second Heart Sound (S2):
- Aortic (A2) + pulmonary (P2) closure
- Physiologic splitting: widens on inspiration (more right-sided filling), narrows on expiration
- Wide splitting: RBBB, severe MR (early aortic closure)
- Fixed splitting: ASD (no respiratory variation) - classic sign
- Reversed/paradoxical splitting: components audible at end-expiration, narrow on inspiration - LBBB, RV pacing, severe AS, HOCM, acute MI
- Loud P2: pulmonary hypertension (may be palpable)
- Narrow single S2: pulmonary hypertension
S3 (Third Heart Sound):
- Low-pitched, early diastolic; heard at apex with bell
- In adults: always pathological - LV failure, dilated cardiomyopathy
- In children/young adults: can be normal ("physiologic S3")
- Sounds like "Ken-TUCK-y"
S4 (Fourth Heart Sound):
- Low-pitched, late diastolic (pre-systolic); heard at apex
- Reflects stiff ventricle (LVH, ischaemia, hypertrophic cardiomyopathy)
- Sounds like "TEN-nes-see"
- Never normal in adults
Heart Murmur Grading:
| Grade | Description |
|---|
| 1 | Barely audible (only heard in ideal conditions) |
| 2 | Faint but clearly audible |
| 3 | Moderate, no thrill |
| 4 | Loud + palpable thrill |
| 5 | Very loud, heard with stethoscope partially off chest |
| 6 | Heard without stethoscope |
Systolic Murmurs:
| Murmur | Timing | Best Heard | Radiation | Quality |
|---|
| MR (chronic) | Holosystolic | Apex | Axilla | Blowing |
| AS | Midsystolic (ejection) | Aortic area | Carotids | Harsh, crescendo-decrescendo |
| TR | Holosystolic | Left lower sternal border | Increases with inspiration (Carvallo's sign) | Blowing |
| VSD | Holosystolic | Left sternal border | Radiates all over | Harsh |
| HOCM | Midsystolic | Left lower sternal border | Increases with Valsalva/standing, decreases with squatting | Harsh |
| Pulmonary stenosis | Midsystolic | Pulmonary area | Ejection click | Harsh |
Severe AS signs: parvus et tardus carotid pulse, late-peaking grade ≥3 murmur, soft or absent A2, S4 at apex, sustained LV impulse
Diastolic Murmurs (always pathological):
| Murmur | Timing | Best Heard | Radiation |
|---|
| AR | Early diastolic decrescendo | Left sternal border (lean forward, expiration) | - |
| MS | Mid-diastolic, low-pitched rumble | Apex (bell, left lateral decubitus, expiration) | - |
Manoeuvres:
- Valsalva: decreases preload - most murmurs softer; HOCM and MVP murmur louder
- Squatting: increases preload and afterload - HOCM murmur softer
- Standing: decreases preload - HOCM murmur louder
- Handgrip: increases afterload - MR/AR louder, AS softer
Heart sound splitting patterns - Harrison's 22E
Carotid pulse character waveforms - Harrison's 22E
2f. Peripheral Vascular Examination
- Palpate all peripheral pulses: radial, brachial, carotid, femoral, popliteal, dorsalis pedis, posterior tibial
- Auscultate for bruits: carotid, subclavian, renal (epigastric), femoral
- Bruit extending into diastole or with thrill = severe obstruction
- Check for lower limb oedema, skin changes (lipodermatosclerosis, venous ulcers), temperature asymmetry
3. RESPIRATORY SYSTEM EXAMINATION
(Harrison's Principles of Internal Medicine 22E, Chapter 262)
Position: Patient sitting, examine posterior chest first, then anterior.
3a. Inspection
- Rate and pattern: tachypnoea (>20/min), bradypnoea, Cheyne-Stokes (central apnoeic cycles - heart failure, CNS disease), Kussmaul (deep, sighing - metabolic acidosis), Biot's (irregular - brainstem damage)
- Accessory muscle use: sternocleidomastoid, scalenes - respiratory distress
- Intercostal recession: severe obstruction in children
- Barrel chest: AP diameter equal to transverse; COPD/emphysema
- Kyphoscoliosis: can cause restrictive defect
- Asymmetric expansion: collapse, pneumothorax, effusion on affected side
- Tracheal position: midline? Deviation away from effusion/tension pneumothorax; towards collapse
3b. Palpation
- Tracheal position (finger in sternal notch)
- Chest expansion: thumbs meet at midline over lower posterior chest; should expand symmetrically ≥5 cm
- Tactile (vocal) fremitus: place ulnar aspect of hand or palm on chest; say "99"
- Increased = consolidation (fluid-filled alveoli transmit better)
- Decreased/absent = effusion, pneumothorax, thick chest wall
3c. Percussion
- Middle finger of non-dominant hand as pleximeter; tap with middle finger of dominant hand
- Percuss comparing side to side symmetrically
- Normal: resonant
- Dull: consolidation, collapse, pleural effusion, mass
- Stony dull: pleural effusion (classically)
- Hyper-resonant: pneumothorax, emphysema
- Diaphragm excursion: mark dullness at end-expiration and end-inspiration (normal excursion ~5 cm)
3d. Auscultation
- Use diaphragm; compare sides methodically
- Breath sound character:
| Sound | Normal? | Cause when abnormal |
|---|
| Vesicular | Normal peripheral lung | - |
| Bronchial | Normal only over trachea | Consolidation (pneumonia) when heard peripherally |
| Bronchovesicular | Normal over main bronchi | Mild consolidation when elsewhere |
| Diminished/absent | Abnormal | Emphysema (diffuse), pneumothorax, effusion (unilateral) |
| Sound | Description | Cause |
|---|
| Crackles (rales) | Discontinuous, popping sounds | Fine: pulmonary oedema (bases), IPF (Velcro-like, bilateral bases); Coarse: pneumonia, bronchiectasis |
| Wheezes | Continuous, musical, usually expiratory | Asthma (polyphonic), COPD, tumour (monophonic, fixed) |
| Rhonchi | Low-pitched continuous, like snoring | Secretions in medium airways; bronchitis, COPD |
| Stridor | High-pitched inspiratory wheeze over neck | Upper airway obstruction (epiglottitis, foreign body, tumour) |
| Pleural rub | Creaking, leathery; both phases | Pleuritis (pneumonia, PE, malignancy) |
Vocal resonance tests:
- Whispered pectoriloquy: ask patient to whisper "1-2-3"; if clearly heard = consolidation
- Bronchophony: say "99"; louder than normal = consolidation
- Egophony: say "EEE"; if you hear "AHH" = consolidation (pneumonia); not heard in fibrosis
Summary of clinical signs by diagnosis:
| Condition | Expansion | Percussion | Breath sounds | Vocal fremitus | Added |
|---|
| Consolidation | Reduced (affected) | Dull | Bronchial | Increased | Crackles, egophony |
| Effusion | Reduced (affected) | Stony dull | Absent/reduced | Absent | Pleural rub (edge) |
| Pneumothorax | Reduced (affected) | Hyper-resonant | Absent | Absent | - |
| Collapse | Reduced (affected) | Dull | Reduced/absent | Reduced | - |
| Emphysema | Reduced (both, barrel) | Hyper-resonant | Reduced (both) | Reduced | Prolonged expiration |
| Fibrosis | Reduced (both) | Normal | Vesicular reduced | Normal | Fine basal crackles (Velcro) |
| Asthma (acute) | Reduced (both) | Normal/hyper | Reduced | Normal | Polyphonic wheeze |
4. ABDOMINAL EXAMINATION
(Goldman-Cecil Medicine, International Edition)
Position: Patient supine, one pillow, adequately exposed from xiphisternum to pubic symphysis. Ask them to keep arms at sides and legs flat.
4a. Inspection
Survey for:
- Scars: location suggests prior surgery (RIF appendicectomy, midline laparotomy, RUQ cholecystectomy)
- Distension: generalised (the 5 Fs: Fat, Fluid/ascites, Faeces, Flatus, Fetus/mass) vs localised
- Prominent veins: periumbilical - portal hypertension (caput medusae); inferior epigastric collaterals - IVC obstruction
- Visible peristalsis: small bowel obstruction, pyloric stenosis (epigastric, left to right)
- Hernias: umbilical, epigastric, inguinal (ask patient to cough/stand)
- Skin: striae (purple = Cushing's; white = pregnancy/obesity), spider naevi (>5 = liver disease), jaundice, Grey-Turner's/Cullen's sign (bruising in flanks/periumbilical = retroperitoneal haemorrhage, severe pancreatitis)
- Asymmetry: organomegaly, mass
4b. Auscultation (before palpation/percussion in the abdomen)
- Bowel sounds: listen in one spot (e.g., right iliac fossa) for 15-30 seconds
- Normal: intermittent gurgles
- Increased/hyperactive: early obstruction, gastroenteritis, after eating
- Absent (>3 min silence): paralytic ileus, peritonitis, late obstruction
- Tinkling/high-pitched: mechanical obstruction
- Bruits: renal arteries (lateral to umbilicus - renovascular hypertension); aortic (epigastric - aneurysm/stenosis); hepatic bruit (hepatocellular carcinoma)
- Note: routine auscultation for bowel sounds has limited value in patients without abdominal pain
4c. Percussion
- Cursory light percussion across all 9 regions first - dullness, tympany, unexpected tenderness
- Liver size: upper border of dullness in midclavicular line (MCL) on full expiration, lower border dullness in MCL on full inspiration; normal span 6-12 cm
- Splenomegaly: percussion in left upper quadrant near 10th rib posterior to midaxillary line - dullness distinct from gastric tympany suggests spleen
- Ascites: percuss for flank dullness (flanks dull, central tympany); if dull, test for shifting dullness: percuss flank to mark dullness, keep finger there, roll patient away - if line of dullness shifts upward = positive (most sensitive bedside sign for ascites)
- Fluid thrill (for massive ascites): flick one flank while pressing midline with other hand's edge, second hand on opposite flank detects impulse
4d. Palpation
Always start away from the site of pain. Begin with light palpation, then deep.
Light palpation:
- Watch the patient's face, not the abdomen
- Detect guarding (voluntary or involuntary muscle spasm), tenderness, superficial masses
- Involuntary guarding + rigidity = peritonism
Deep palpation - organ assessment:
Liver: start in RIF, hand flat, ask patient to breathe in and out; edge moves down on inspiration; palpate upward on each inspiration, feel for the edge. Assess: size (cm below costal margin), consistency (hard = malignancy, fibrosis; soft = congestive), tenderness, surface (smooth vs nodular), pulsatility (TR)
Spleen: start in RIF, move toward LUQ; use bimanual technique (left hand posteriorly supporting left costal margin, right hand palpating below); asks patient to breathe in. Cannot get above it (contrast with enlarged left kidney). Tip of enlarged spleen = splenomegaly:
- Grade I: just palpable
- Grade II: to umbilicus
- Grade III: into RIF (massive)
Kidneys: bimanual palpation (ballot technique); right kidney easier to feel than left; kidneys ballottable (unlike spleen). Polycystic kidneys can be massive bilateral.
Aorta: palpate in epigastrium, expansile pulsation (width >3 cm = aneurysm). In thin patients normal aorta felt easily.
Bladder: dull to percussion, arises from pelvis, cannot get below it.
Renal angle tenderness: fist percussion over costovertebral angle (CVA) - positive in pyelonephritis, renal stones.
Special signs:
- Murphy's sign: 2 fingers in RUQ, patient takes deep breath; arrest of inspiration due to pain = positive = acute cholecystitis (false positive: hepatitis)
- McBurney's sign: tenderness at McBurney's point (1/3 from ASIS to umbilicus) = appendicitis
- Rebound tenderness (Blumberg's): press slowly, release rapidly - pain worse on release = peritoneal irritation
- Rovsing's sign: pressure in LIF causes pain in RIF = appendicitis
- Obturator test: flex and internally rotate right hip - pain in RIF = inflamed appendix/pelvic abscess
- Psoas sign: extend right hip (patient left lateral) - pain in RIF = retrocaecal appendicitis
- Carnett's test: patient tenses abdominal wall (head lift) - if tenderness worse = abdominal wall source; if less = intra-abdominal source
4e. Rectal Examination
Indicated in: rectal/perianal symptoms, suspected GI bleeding, incontinence, acute abdomen.
- Inspect perianal area: fissures, fistulas, haemorrhoids, skin tags
- Digital: assess anal tone, rectal wall circumferentially for masses, prostate in males (size, consistency, tenderness), cervix in females
5. NEUROLOGICAL EXAMINATION
(Bradley and Daroff's Neurology in Clinical Practice)
5a. Philosophy: Start During the Interview
- Hypomimia (expressionless face) = Parkinsonism or depression
- Worried/astonished expression = progressive supranuclear palsy
- Ptosis = myasthenia gravis or brainstem lesion
- Speech = dysarthria, aphasia, spasmodic dysphonia
- Involuntary movements during history-taking
5b. Mental Status
- Orientation: time, place, person
- Attention: months backwards, serial 7s
- Memory: 3-word recall (immediate and 5-minute)
- Language: naming, repetition, comprehension, reading, writing
- Calculation, visuospatial function, executive function (frontal lobe)
- Validated tools: MMSE (30 points), MoCA (for mild cognitive impairment, 30 points)
5c. Cranial Nerves (CNs)
| CN | Test | Key Findings |
|---|
| I - Olfactory | Test each nostril (coffee, vanilla - not pungent) | Anosmia: head injury, Parkinson's, olfactory groove meningioma |
| II - Optic | Visual acuity (Snellen), visual fields (confrontation), pupil reactions (RAPD = swinging flashlight test), fundoscopy | Papilloedema = raised ICP; optic atrophy; RAPD = optic nerve lesion |
| III, IV, VI | Eye movements (horizontal and vertical), nystagmus, pupil shape/size/reactivity, ptosis | CN III palsy: ptosis, "down and out", dilated pupil; CN VI: failure to abduct |
| V - Trigeminal | Facial sensation (all 3 divisions), corneal reflex, jaw opening/deviation, masseter/temporalis power | Corneal reflex absent = V or early VII lesion |
| VII - Facial | Raise eyebrows, close eyes tight, show teeth, puff cheeks | UMN VII (stroke): forehead spared (bilateral cortical supply); LMN VII (Bell's): forehead involved, complete weakness |
| VIII - Vestibulocochlear | Whisper test, tuning fork (Rinne and Weber) | Rinne positive = normal or SNHL; Weber lateralises to better ear in SNHL, worse ear in conductive |
| IX, X | Palatal movement (say "ahhh"), gag reflex, voice quality | Unilateral palate deviation away from lesion |
| XI - Accessory | Trapezius (shrug against resistance), sternocleidomastoid (turn head against resistance) | Lesion: ipsilateral trapezius + contralateral SCM weakness |
| XII - Hypoglossal | Protrude tongue | Deviation toward side of LMN lesion |
5d. Motor System
Inspection:
- Wasting, fasciculations (LMN)
- Involuntary movements: tremor, chorea, dystonia, myoclonus, hemiballismus
Tone:
- Spasticity (velocity-dependent resistance, clasp-knife): UMN - stroke, MS, cord lesion
- Rigidity (equal resistance throughout range): extrapyramidal - Parkinson's (lead-pipe or cog-wheel with tremor)
- Hypotonia/flaccidity: LMN, cerebellar, acute UMN shock
- Test: flex/extend limbs passively at each joint
Power (MRC Grading):
| Grade | Description |
|---|
| 0 | No movement |
| 1 | Flicker of movement |
| 2 | Movement with gravity eliminated |
| 3 | Movement against gravity only |
| 4 | Movement against some resistance (4-, 4, 4+) |
| 5 | Normal full power |
Upper vs Lower Motor Neuron:
| Feature | UMN | LMN |
|---|
| Tone | Increased (spastic) | Decreased (flaccid) |
| Power | Weakness (pyramidal distribution) | Weakness (focal/radicular) |
| Reflexes | Hyperreflexia | Hyporeflexia/absent |
| Plantars | Extensor (Babinski) | Flexor |
| Fasciculations | Absent | Present |
| Wasting | Late/mild | Early/prominent |
Practical tests (save time):
- Pushup from floor, rising from chair without arms = proximal power
- Walk on toes (S1/gastrocnemius), walk on heels (L4-5/tibialis anterior)
- Pronator drift: arms outstretched, palms up, eyes closed; weak arm drifts down and pronates
5e. Reflexes
| Reflex | Test | Root Level |
|---|
| Biceps jerk | Tap biceps tendon | C5-C6 |
| Supinator/brachioradialis jerk | Tap distal radius | C5-C6 |
| Triceps jerk | Tap triceps tendon | C7-C8 |
| Finger jerk | Tap flexed fingers | C8 |
| Knee jerk (patellar) | Tap patellar tendon | L3-L4 |
| Ankle jerk (Achilles) | Tap Achilles tendon | S1-S2 |
| Plantar response | Stroke lateral sole with key | L5-S1 |
- Grading: 0 (absent), 1+ (reduced), 2+ (normal), 3+ (brisk), 4+ (clonus)
- Clonus: >5 beats = UMN lesion
- Hoffman's reflex: flick distal middle finger = thumb flexion; UMN sign in upper limb
- Plantar (Babinski): extensor (big toe extends, toes fan) = UMN lesion
Superficial reflexes (absent in UMN lesion):
- Abdominal reflexes: stroke toward umbilicus in each quadrant (T8-T12)
- Cremasteric reflex: stroke inner thigh = testis rises (L1-L2)
5f. Coordination
Cerebellar signs (mnemonic: DANISH):
- Dysdiadochokinesis - rapidly alternating movements (forearm pronation/supination)
- Ataxia - gait (broad-based, staggering), Romberg's negative (cerebellar)
- Nystagmus - fast phase to side of lesion (horizontal)
- Intention tremor - finger-nose test (tremor increases approaching target), heel-shin test
- Scanning speech - dysarthric, monotone, staccato
- Hypotonia - reduced tone
Romberg's test: stand feet together, arms outstretched, eyes open then closed. Falls with eyes closed but not open = proprioceptive ataxia (posterior column/dorsal root lesion). Cerebellar ataxia = falls with eyes open AND closed.
5g. Sensory Examination
Test in a dermatomal pattern; compare left vs right; distal vs proximal.
Primary modalities:
- Pain/temperature (spinothalamic tract): pinprick; temperature
- Light touch: cotton wool
- Vibration sense (posterior column): 128 Hz tuning fork on bony prominences (great toe, malleolus, knee, anterior iliac spine, sternum - go distal to proximal)
- Proprioception (joint position sense, JPS) (posterior column): grip the toe/finger at the sides, move up or down; patient identifies direction with eyes closed
Higher cortical sensory tests (parietal lobe):
- Graphesthesia: write number on palm
- Stereognosis: identify object in hand
- Sensory extinction: stimulate both sides simultaneously; parietal lesion extinguishes contralateral stimulus
5h. Gait Assessment
Examine every neurological patient walking:
| Gait Type | Description | Cause |
|---|
| Spastic (hemiplegic) | Circumduction of extended leg, arm flexed | Stroke, UMN lesion |
| Scissor gait | Both legs spastic, adducted, cross over | Bilateral UMN (cerebral palsy, bilateral stroke) |
| Parkinsonian | Stooped, shuffling, small steps, reduced arm swing, festination, en bloc turns | Parkinson's disease |
| Cerebellar (ataxic) | Wide-based, staggering, titubation | Cerebellar lesion (alcohol, MS, tumor) |
| High-stepping (foot drop) | Exaggerated hip and knee flexion, steppage | L4-5 lesion, peroneal nerve palsy |
| Waddling | Side-to-side swaying | Proximal myopathy, hip disease |
| Sensory ataxia | Wide-based, stamps feet, worse in dark, Romberg positive | Posterior column lesion (B12 def, tabes dorsalis) |
| Apraxic | Feet appear glued to floor, shuffling, normal in bed | Normal-pressure hydrocephalus, frontal lesion |
6. THYROID EXAMINATION
- Inspection: neck swelling? Moves on swallowing (thyroid tissue) vs protrusion of tongue (thyroglossal cyst)
- Palpation: stand behind patient; use 2-3 fingers bilaterally to palpate lobes and isthmus; ask patient to swallow sip of water; feel for size, consistency, tenderness, nodules, tracheal deviation
- Percussion: retrosternal extension? Percuss over sternum
- Auscultation: thyroid bruit = hyperthyroidism (increased vascularity)
- Signs of hyper/hypothyroidism: pulse rate, AF, tremor, eye signs (exophthalmos, lid lag, lid retraction, ophthalmoplegia in Graves'), proximal myopathy, pretibial myxoedema, onycholysis, reflexes (brisk in hyper, delayed relaxation in hypo)
- Pemberton's sign: raise both arms above head; facial plethora/congestion = SVC obstruction from retrosternal goitre
7. MUSCULOSKELETAL EXAMINATION
"GALS" Screening (Gait, Arms, Legs, Spine)
Quick screen; then go system/joint-specific if abnormal.
| Component | What to assess |
|---|
| Gait | Smooth, symmetric, arm swing, turns |
| Arms | Hands (squeeze MCP joints), wrists, elbows, shoulders (behind head, behind back), cervical spine |
| Legs | Hip (passive flexion/rotation), knees (effusion - ballottement, bulge sign), ankles, subtalar joint |
| Spine | Cervical (rotation, flexion), lumbar (forward flexion - Schober's test), SI joints (sacral pressure) |
Joint Examination Sequence (any joint):
- Look (swelling, deformity, erythema, wasting, rash)
- Feel (temperature, tenderness, swelling type: bony/synovial/effusion, crepitus)
- Move (active then passive range of motion; end-feel)
- Special tests (joint-specific)
- Function (grip strength, gait, ADLs)
8. QUICK REFERENCE: BEDSIDE DIAGNOSTIC TESTS ACROSS SYSTEMS
| Test | System | Positive Finding | Meaning |
|---|
| Shifting dullness | Abdomen | Dullness shifts | Ascites |
| Murphy's sign | Abdomen | Inspiratory arrest in RUQ | Acute cholecystitis |
| Babinski sign | Neurology | Extensor plantar | UMN lesion |
| Romberg's test | Neurology | Falls with eyes closed | Posterior column/sensory ataxia |
| Kernig's sign | Neurology | Pain/resistance to knee extension with hip flexed 90° | Meningism |
| Brudzinski's sign | Neurology | Hips flex on neck flexion | Meningism |
| Pulsus paradoxus | CVS | >10 mmHg fall in systolic on inspiration | Cardiac tamponade, severe asthma, PE |
| Kussmaul's sign | CVS | JVP rises on inspiration | Constrictive pericarditis |
| Hepatojugular reflux | CVS | JVP rises with sustained RUQ pressure | RV failure |
| Egophony | Respiratory | "EEE" heard as "AHH" | Consolidation |
| Whispered pectoriloquy | Respiratory | Whisper clearly audible | Consolidation |
| Tactile fremitus | Respiratory | Increased vs decreased | Consolidation vs effusion/pneumothorax |
9. ORDER OF A COMPLETE GENERAL MEDICINE WARD ROUND EXAMINATION
A structured approach at the bedside:
- End of bed inspection: general appearance, IV lines, O2, monitoring
- Hands: nails, palms, asterixis, temperature, pulses
- Face/neck: eyes, mouth, JVP, lymph nodes, thyroid
- Vital signs: BP (both arms if needed), pulse, RR, SpO2, temperature
- CVS: precordium, heart sounds, peripheral pulses, oedema
- Respiratory: trachea, chest expansion, percussion, auscultation
- Abdomen: inspection, auscultation, percussion, palpation; offer PR
- Neurology (if indicated): conscious level, cranial nerves, motor, reflexes, sensation, cerebellar, gait
- Lymph nodes, skin: full body skin check if relevant
- Genitalia/hernias: if clinically indicated
- Fundoscopy: HTN, diabetes, raised ICP, endocarditis
- Urine dipstick: routine in most medical patients
Sources:
- Harrison's Principles of Internal Medicine 22E (2025, McGraw Hill Medical) - Chapter 246 (Cardiovascular Examination), Chapter 262 (Respiratory Examination)
- Goldman-Cecil Medicine, International Edition - Chapter on Abdominal Examination
- Bradley and Daroff's Neurology in Clinical Practice - Chapter 1 (Neurological Examination)