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Left-sided heart failure
- Left ventricle fails to pump effectively.
- Blood backs up into the lungs.
- Causes breathlessness, cough, and pulmonary edema.
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Right-sided heart failure
- Right ventricle fails to pump effectively.
- Blood backs up into the body veins.
- Causes pedal edema, enlarged liver, abdominal swelling, and raised neck veins.
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Systolic heart failure (HFrEF)
- Heart muscle contracts weakly.
- Ejection fraction is reduced, usually 40% or less.
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Diastolic heart failure (HFpEF)
- Heart contracts but becomes stiff and does not relax/fill properly.
- Ejection fraction is preserved.
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Acute or chronic heart failure
- Acute: sudden worsening, often severe breathlessness and lung congestion.
- Chronic: long-term condition with repeated symptoms.
For HFrEF, modern guideline-directed treatment includes four main medicine groups: ARNI/ACE inhibitor/ARB, evidence-based beta-blocker, mineralocorticoid receptor antagonist, and SGLT2 inhibitor, as summarized in the
AHA heart-failure guideline.