Half life of actum prologatum
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"actum prologatum" drug half life
Found it. "Actum prologatum" is a phonetic/spelling variant of Acton Prolongatum, which is a long-acting (prolonged) porcine ACTH (corticotropin) preparation.
Acton Prolongatum - Half Life
Acton Prolongatum is a prolonged-release formulation of ACTH (adrenocorticotropic hormone / corticotropin) derived from porcine pituitary glands.
Half-Life
| Parameter | Value |
|---|---|
| Native corticotropin half-life | ~15-30 minutes (very short) |
| Acton Prolongatum (prolonged formulation) | Extended duration of action due to depot/gel formulation - effect lasts several hours |
The short plasma half-life of native ACTH (~15-30 minutes) is circumvented in Acton Prolongatum by using a zinc-phosphate depot formulation, which slows absorption from the injection site and prolongs the biological effect. This is why a single intramuscular injection can stimulate cortisol production for hours (used in ACTH stimulation tests, measured over 60-120 minutes).
Key Facts
- Type: Long-acting porcine ACTH analog
- Route: Intramuscular (IM) injection
- Uses:
- ACTH stimulation test for adrenal insufficiency
- Infantile spasms (West syndrome) in children under 2
- Mechanism: Stimulates adrenal cortex to produce cortisol
- Excretion: Mainly in urine as inactive metabolites
In the standard Acton Prolongatum ACTH stimulation test, 25 IU is given IM at 8 AM and cortisol is measured at 1 and 2 hours, reflecting the prolonged stimulatory effect despite the short plasma half-life of ACTH itself.
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