Deriphylline dose per day
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Deriphylline dyphylline dose per day adults
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Here is a clear summary of Deriphylline dosing:
Deriphylline (Dyphylline/Etophylline) - Dose Per Day
Important note on the Indian brand "Deriphyllin": In India, Deriphyllin tablets are a combination of Theophylline + Etophylline (not pure dyphylline as sold in the US). The most common formulation is Theophylline 23 mg + Etophylline 77 mg per tablet (100 mg total) or the Retard (slow-release) versions.
Standard Adult Doses
| Formulation | Dose per tablet | Frequency | Total per day |
|---|---|---|---|
| Deriphyllin tablet (standard) | 100 mg (Theophylline 23 mg + Etophylline 77 mg) | 3-4 times/day | 300-400 mg/day |
| Deriphyllin Retard 150 | 150 mg | 1-2 times/day | 150-300 mg/day |
| Deriphyllin Retard 300 | 300 mg | 1-2 times/day | 300-600 mg/day |
Pure Dyphylline (US formulation, e.g. Dilor, Lufyllin)
- Dose: 15 mg/kg up to 4 times per day (per Mayo Clinic)
- For a 70 kg adult: ~1050 mg per dose, max ~2400-4000 mg/day (though typical clinical range is much lower: 200-400 mg/dose, 4x/day = 800-1600 mg/day)
Key Points
- Indication: Bronchospasm, asthma, COPD, chronic bronchitis, emphysema
- Take after food to reduce GI side effects
- Unlike theophylline, dyphylline is not converted to theophylline in the body and does not require serum level monitoring
- Reduce dose in renal impairment (dyphylline is renally excreted)
- Elderly and patients with heart failure or kidney disease may need lower doses
Contraindications/Cautions
- Active peptic ulcer
- Cardiac arrhythmias
- Hyperthyroidism
- Concurrent use with other xanthines
Always follow prescriber guidance - doses are individualized based on body weight, renal function, and clinical response.
Deriphylline single injection dose with dexona
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Deriphylline injection dose dexamethasone dexona acute bronchospasm IV
Here is the complete dosing reference for Deriphylline injection with Dexona (dexamethasone):
Deriphylline Injection + Dexona - Single Dose (Acute Bronchospasm/Asthma)
Deriphylline Injection (Etophylline 84.7 mg + Theophylline 25.3 mg per 2 mL ampoule)
| Patient | Single Injection Dose | Route | Duration |
|---|---|---|---|
| Adults | 2 mL - 4 mL (169.4-338.8 mg combined) | IV slow push or IM | Over 10-15 min |
| Children | 0.1 mL/kg body weight | IV slow | Over 10-15 min |
Standard clinical practice in India: 2 mL IV slowly (over 10-15 minutes) as a single dose for acute bronchospasm.
Dexona (Dexamethasone Sodium Phosphate) - Concurrent Dose
| Indication | Single IV Dose |
|---|---|
| Acute bronchospasm / status asthmaticus | 4 mg IV (1 mL of 4 mg/mL ampoule) |
| Severe/status asthmaticus | 8 mg IV (up to) |
| Children | 0.1-0.3 mg/kg IV |
How to Give (Practical Protocol)
- Deriphylline 2 mL + Dexona 4 mg (1 mL) diluted in 10-20 mL Normal Saline
- Administer IV slowly over 10-15 minutes (never bolus - risk of cardiac arrhythmia)
- Monitor heart rate and BP during administration
- Can repeat Deriphylline every 4-6 hours if needed
- Nebulization with salbutamol should run alongside for better bronchodilation
Important Safety Points
- Never give IV bolus - rapid injection causes palpitations, hypotension, arrhythmia, seizures
- Avoid in patients already on oral theophylline (risk of toxicity - narrow therapeutic index)
- Monitor for nausea, vomiting, tachycardia
- Dexona (corticosteroid) reduces airway inflammation and potentiates bronchodilator effect - works synergistically with deriphylline
- Reduce deriphylline dose in elderly, liver disease, heart failure
This combination (Deriphylline + Dexamethasone IV) is a widely used first-line injectable regimen for acute asthma/COPD exacerbations in Indian emergency and primary care settings.
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