Dosage of rantac and ondan child dose
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ranitidine ondansetron pediatric dose mg/kg children 2024
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ranitidine Rantac pediatric dose children GERD mg/kg
Here is a complete pediatric dosing reference for both drugs:
Rantac (Ranitidine) - Pediatric Dose
Ranitidine is an H2 receptor antagonist used for GERD, peptic ulcer disease, and acid suppression.
Important note: Ranitidine (Zantac/Rantac) was withdrawn from many markets (including the US FDA in 2020) due to NDMA contamination concerns. It may still be available in India. Always confirm local availability and current guidelines before prescribing.
Oral Dose
| Indication | Age | Dose | Max |
|---|---|---|---|
| GERD / Erosive Esophagitis | 1 month - 16 years | 5-10 mg/kg/day in 2 divided doses (every 12 hrs) | 300 mg/day |
| Duodenal/Gastric Ulcer (treatment) | 1 month - 16 years | 2-4 mg/kg/dose twice daily | 300 mg/day |
| Duodenal/Gastric Ulcer (maintenance) | 1 month - 16 years | 2-4 mg/kg/dose once daily | 150 mg/day |
| Neonates | < 1 month | 2 mg/kg 3 times daily | - |
IV/Parenteral Dose
- 2-4 mg/kg/day IV, divided every 6-8 hours
- Max: 50 mg/dose or 200 mg/day
- Alternatively: continuous infusion at 0.08-0.17 mg/kg/hour
Ondan (Ondansetron) - Pediatric Dose
Ondansetron is a 5-HT3 antagonist used for nausea and vomiting.
Oral Dose (Weight-Based - Preferred for Gastroenteritis/Vomiting)
| Weight | Dose |
|---|---|
| 8-15 kg | 2 mg |
| 15-30 kg | 4 mg |
| > 30 kg | 6-8 mg |
- Standard: 0.15 mg/kg/dose PO (max 8 mg/dose)
- Frequency: every 6-8 hours (Q6-8H)
- For acute gastroenteritis: often a single dose is sufficient
IV Dose
- 0.15 mg/kg/dose IV every 6-8 hours (max 8 mg/dose)
- For post-op nausea (PONV): 0.1 mg/kg IV for children ≤ 40 kg; 4 mg for > 40 kg
- Administer over at least 30 seconds (slow IVP)
Age Restrictions
- Approved from 6 months of age for acute gastroenteritis
- For PONV: approved from 1 month of age (surgery)
Quick Reference Summary
| Drug | Route | Pediatric Dose | Max |
|---|---|---|---|
| Ranitidine (Rantac) | PO | 5-10 mg/kg/day ÷ BD | 300 mg/day |
| Ranitidine (Rantac) | IV | 2-4 mg/kg/day ÷ Q6-8H | 200 mg/day |
| Ondansetron (Ondan) | PO | 0.15 mg/kg/dose Q6-8H | 8 mg/dose |
| Ondansetron (Ondan) | IV | 0.15 mg/kg/dose Q6-8H | 8 mg/dose |
Sources: Drugs.com ranitidine pediatric dosing | CPS ondansetron guidelines | Harriet Lane Handbook 23rd Ed. | RxList
Eptoin dosage adult and paediatric
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phenytoin Eptoin adult pediatric dose mg/kg loading maintenance 2024
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I have comprehensive data from the textbook and web sources. Here is the full dosing reference:
Eptoin (Phenytoin) - Complete Dosage Guide
Eptoin is the brand name for Phenytoin Sodium, an antiepileptic drug (sodium channel blocker). It is used for focal seizures, tonic-clonic seizures, and status epilepticus. Not effective for absence seizures.
ADULT DOSAGE
Oral (Chronic Epilepsy - Maintenance)
| Regimen | Dose |
|---|---|
| Initial dose | 100 mg 3 times daily (300 mg/day) |
| Usual maintenance | 300-400 mg/day in 2-3 divided doses |
| Extended-release capsules | 300 mg once daily at night (after stabilization) |
| Maximum dose | 600 mg/day (in selected cases) |
IV - Status Epilepticus (Emergency)
| Parameter | Dose |
|---|---|
| Loading dose | 15-20 mg/kg IV (non-emergent: 10-15 mg/kg) |
| Rate | Not to exceed 50 mg/min |
| Maintenance after loading | 100 mg IV/oral every 6-8 hours |
ECG and BP monitoring mandatory during IV infusion. Do NOT give IM (erratic absorption).
PEDIATRIC DOSAGE
Oral (Chronic Maintenance)
| Age | Initial Dose | Maintenance Dose | Max |
|---|---|---|---|
| 1 month - 12 years | 3-5 mg/kg/day in 2-3 divided doses | 4-8 mg/kg/day in 2-3 divided doses | 300 mg/day |
| 12-18 years | 4-5 mg/kg/day in 1-2 doses | 200-500 mg/day in 2-3 divided doses | 600 mg/day |
IV - Status Epilepticus (Emergency)
| Age | Loading Dose | Rate |
|---|---|---|
| 1 month - 18 years | 15-20 mg/kg IV | Not to exceed 1-3 mg/kg/min or 50 mg/min (whichever is slower) |
Loading dose should be followed by maintenance dosing starting 12-24 hours later.
Therapeutic Drug Monitoring (TDM)
| Parameter | Value |
|---|---|
| Therapeutic range | 10-20 mg/L (mcg/mL) |
| Free (unbound) phenytoin | 1-2 mcg/mL |
| Sample timing | Trough (just before next dose) |
| Steady-state | 3-5 days after starting/changing dose |
In hypoalbuminemia, total levels are falsely low - correct using the Sheiner-Tozer formula or measure free phenytoin directly.
Available Formulations (Eptoin)
- Tablets: 50 mg, 100 mg
- Injection (Eptoin Inj): 50 mg/mL (2 mL vial = 100 mg)
- Suspension: 25 mg/5 mL
Key Adverse Effects & Precautions
- Dose-related: Nystagmus (10-20 mg/L), ataxia (20-30 mg/L), mental changes (>30 mg/L)
- Chronic: Gingival hyperplasia, hirsutism, coarsening of facial features, osteomalacia, folate deficiency
- Serious: Stevens-Johnson Syndrome (especially in HLA-B*1502 carriers - screen Asian patients), cardiovascular collapse with rapid IV infusion
- Drug interactions: Many - increases/decreases levels with carbamazepine, valproate, isoniazid, warfarin, OCP, and others
- Pregnancy: Category D - causes fetal hydantoin syndrome; use with caution
Sources: Drugs.com phenytoin dosing | FDA phenytoin labeling | Goodman & Gilman's Pharmacological Basis of Therapeutics | Perth Children's Hospital Phenytoin Monograph
Maintainance dose loading dise
Here is a clean, focused summary of Eptoin (Phenytoin) Loading and Maintenance Doses:
Eptoin (Phenytoin) - Loading & Maintenance Dose
LOADING DOSE
(Given to rapidly achieve therapeutic levels)
| Patient | Route | Dose | Rate |
|---|---|---|---|
| Adult | IV | 15-20 mg/kg | Max 50 mg/min |
| Adult (non-emergent) | IV/Oral | 10-15 mg/kg | Max 50 mg/min |
| Child (1 month - 18 yrs) | IV | 15-20 mg/kg | Max 1-3 mg/kg/min or 50 mg/min (whichever is slower) |
Example: 70 kg adult → Loading dose = 1000-1050 mg IV over ~20 min
MAINTENANCE DOSE
(Started 12-24 hours after loading dose)
| Patient | Route | Dose | Frequency |
|---|---|---|---|
| Adult | Oral/IV | 100 mg | Every 6-8 hours (300-400 mg/day) |
| Child 1 month - 12 yrs | Oral/IV | 4-8 mg/kg/day | In 2-3 divided doses (max 300 mg/day) |
| Child 12-18 yrs | Oral | 200-500 mg/day | In 2-3 divided doses |
Quick Memory Rule
Loading → 15-20 mg/kg IV (one time)
Maintenance → 5 mg/kg/day (children) | 300-400 mg/day (adults)
Therapeutic Target
- Serum level: 10-20 mg/L
- Check trough level 3-5 days after starting maintenance
- Adjust dose based on levels + clinical response
Never give IM - absorption is erratic. IV must be given slowly with cardiac monitoring.
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