Create an Anki card for [Necrosis, Mechanism, Morphology, Types, Coagulative versus Liquefactive Necrosis, Caseous Necrosis, Fat Necrosis, Fibrinoid Necrosis, Gangrenous Necrosis. Then, Apoptosis, Physiological and Pathological Examples, Morphology of Apoptosis, Mechanism, Phases, Enzymes, Regulators, the Intrinsic and Extrinsic Pathway, Necrosis versus Apoptosis. Then, Necroptosis, Ferroptosis, and Autophagy.] for NEET PG 2026 exam (pathology focus). Output a downloadable .txt file with exactly one line in this format: Front[TAB]Back. The Front should contain only the topic name. The Back should contain a comprehensive summary covering 100% of exam-relevant content, formatted using HTML bold tags for section headings and <br><br> between sections for spacing and readability. Do not use any newlines, pipes, or semicolons in the file — only commas, colons, dashes, and HTML tags. Confirm the file is exactly 1 line using wc -l before delivering it.
cell death pathology
Text File · TXT
Cell Death Pathology (Necrosis, Apoptosis, Necroptosis, Ferroptosis, Autophagy) - NEET PG 2026<br><br> separated):| Section | Key Points |
|---|---|
| Necrosis - Definition/Mechanism | DAMPs, irreversibility criteria (mitochondrial failure + membrane disruption), inflammation |
| Necrosis - Morphology | Eosinophilia, 3 nuclear changes (pyknosis/karyorrhexis/karyolysis), EM features, myelin figures |
| Coagulative Necrosis | Architecture preserved, firm, ghost cells, all solid organs except brain, infarcts |
| Liquefactive Necrosis | Bacterial/fungal infections + CNS ischemia, pus, abscess |
| Caseous Necrosis | TB, cheese-like, no architecture, granuloma, epithelioid macrophages |
| Fat Necrosis | Pancreatitis/trauma, saponification (calcium soap), chalky white deposits |
| Fibrinoid Necrosis | Vasculitis, immune complexes, bright pink vessels, malignant hypertension |
| Gangrenous Necrosis | Dry vs. wet vs. gas gangrene, lower limb, Clostridium |
| Apoptosis - Definition/Morphology | 1972 discovery, membrane intact, apoptotic bodies, efferocytosis, no inflammation, phosphatidylserine flip |
| Physiologic/Pathologic Examples | Embryogenesis, thymic clonal deletion, endometrial cycling, DNA damage, viral infections, CTL killing |
| Intrinsic Pathway | BCL-2 family (BCL-2/BCL-XL/MCL-1 anti, BAX/BAK pro, BH3-only sensors), cytochrome c, APAF-1, apoptosome, caspase-9, caspase-3 |
| Extrinsic Pathway | Fas/FasL, TNFR1, FADD, caspase-8/10, FLIP inhibitor, CTL mechanism |
| Regulators | p53, BCL-2, IAPs, Smac/DIABLO, FLIP, MCL-1, survivin |
| Necrosis vs. Apoptosis Table | 10-parameter comparison including size, nucleus, membrane, inflammation, caspases, DNA pattern |
| Necroptosis | RIPK1-RIPK3-MLKL, caspase-independent, programmed necrosis, CMV backup defense |
| Ferroptosis | Iron-dependent, lipid peroxidation, GPX4 defense, EM = lost mitochondrial cristae, cancer/neurodegeneration |
| Autophagy | Phagophore-autophagosome-autophagolysosome, LC3-PE marker, ATG genes, mTOR/Beclin-1, xenophagy, disease dysregulation |
| Quick Comparison Table | Necroptosis vs. Ferroptosis vs. Autophagy side-by-side |
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cell death pathology
Text File · TXT
wc -l = 1 line, 18,166 bytes, single tab separating Front from Back, zero pipes/semicolons/newlines..txt file