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immunodeficiency AND live vaccines

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CDC contraindications live vaccines severe immunodeficiency MMR

Answer: B) Measles/MMR
Recurrent candidiasis and respiratory viral infections from early infancy suggest a significant T-cell immunodeficiency, such as severe combined immunodeficiency. MMR is a live-attenuated viral vaccine and is contraindicated in severe immunodeficiency because vaccine-virus replication can cause serious infection.
Killed IPV, DPT, and TT/Td are non-live vaccines, so they are not contraindicated, although the immune response may be suboptimal. The CDC immunization guidance similarly states that live vaccines are generally contraindicated in severely immunocompromised people.
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cataract surgery AND endophthalmitis prevention

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ESCRS cataract surgery endophthalmitis prevention povidone iodine intracameral antibiotics guideline

Answer: A) Preoperative preparation with povidone-iodine
Topical 5% povidone-iodine to the conjunctival sac and periocular skin is the single most important, standard measure to reduce the patient’s own ocular-surface flora, the main source of organisms causing postoperative endophthalmitis.
  • One-week preoperative antibiotics: not routinely required.
  • Trimming eyelashes: not recommended.
  • Intravitreal antibiotics: used mainly for treatment of established endophthalmitis, not routine prevention.
Note: Current guidelines also support intracameral antibiotic prophylaxis at the end of surgery, but the option says intravitreal, so A is the best answer. The ESCRS cataract recommendations advise povidone-iodine antisepsis and intracameral antibiotics.
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