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📋 NON-COMMUNICABLE DISEASES – PSM NOTES
MBBS 3rd Year | DUHS Chhattisgarh (Ayush University)
📊 PREVIOUS YEAR QUESTION ANALYSIS
Most Asked LAQs (12–15 Marks):
- Hypertension – epidemiology, risk factors, prevention (2015, S'16, S'09, S'13)
- CHD – risk factors + prevention (2012, S'16, S'09, S'13)
- Diabetes – epidemiology + primary prevention (2014)
- Cancer – types in India + warning signs + Ca Cervix prevention (2009, 2013)
- NPCDCS – components, objectives (S'16)
- RTA – measures as BMOH (2009)
Most Asked Short Notes (5 Marks):
- Risk factors/classification of Hypertension
- Screening for cancer cervix (Pap smear, VIA)
- Oral cancer
- Diabetes – diagnostic criteria
- Obesity – BMI, waist circumference
- Framingham Heart Study
- NPCDCS
- Metabolic syndrome
- Stroke – risk factors
- Cancer registration (PBCR, HBCR)
1. INTRODUCTION TO NCDs
- NCDs cause 74% of all deaths globally = 41 million/year
- 77% of NCD deaths in low/middle-income countries
- In India (2016): NCDs = 60% of all deaths
4 KEY MODIFIABLE RISK FACTORS – Mnemonic: TAPU
- T – Tobacco (~7 million deaths/year; 71% lung cancers)
- A – Alcohol (3.3 million deaths/year = 5.9% of global deaths)
- P – Physical inactivity (1.6 million deaths/year; 20–30% increased mortality)
- U – Unhealthy diet (high salt → HTN; 4.1M CVD deaths from excess sodium)
Other metabolic risk factors:
- Raised blood pressure – 9.4 million deaths/year (12.8% all deaths)
- Overweight/Obesity – 2.8 million+ deaths/year
- Raised blood glucose
2. CORONARY HEART DISEASE (CHD) ⭐⭐⭐
Definition: Disease of heart from inadequate oxygenated blood supply due to atherosclerosis of coronary arteries. Also called Ischaemic Heart Disease (IHD).
Risk Factors
A. Non-Modifiable:
- Age (risk rises after 50 years)
- Sex (males at higher risk; post-menopausal women catch up)
- Family history/Genetics (polygenic)
B. Modifiable – THE BIG FOUR ⭐
| Risk Factor | Key Point | Threshold |
|---|
| Hypertension | Single most useful test; accelerates atherosclerosis | SBP >140 / DBP >90 |
| Hypercholesterolaemia | CHD rare if cholesterol <200 mg/dl | >200 mg/dl |
| Cigarette Smoking | Dose-response; synergistic with other RFs | >10 cigs/day |
| Physical Inactivity | Sedentary life = 1.9x increased risk | <150 min/week |
C. Other Modifiable:
- Diabetes mellitus (2–4x CHD risk)
- Obesity (BMI >30)
- Unhealthy diet (high saturated fat, salt)
- Type A personality (competitive, aggressive, time-pressured)
- Heavy alcohol use
- Oral contraceptives (especially in smokers)
Prevention – 3 Strategies
- Population Strategy – Target whole community; health education, dietary changes, anti-smoking, physical activity promotion. Greatest potential (Geoffrey Rose)
- High-Risk Strategy – Target individuals with risk factors; screen, treat HTN/dyslipidaemia/DM, smoking cessation
- Secondary Prevention – Established CHD patients; aspirin, statins, beta-blockers, ACE inhibitors, PTCA/CABG
Framingham Heart Study – Short Note
- Started 1951, Framingham, Massachusetts, USA
- Best-known prospective cohort study on CHD
- Established 4 major CHD risk factors: elevated cholesterol, smoking, hypertension, sedentary habits
- Coined the term "risk factor"
- Still ongoing – multiple generations enrolled
3. HYPERTENSION ⭐⭐⭐
Classification (JNC 7)
| Category | Systolic (mmHg) | Diastolic (mmHg) |
|---|
| Normal | < 120 | < 80 |
| Pre-hypertension | 120–129 | < 80 |
| Stage 1 HTN | 130–139 | 80–89 |
| Stage 2 HTN | ≥ 140 | ≥ 90 |
| Hypertensive Crisis | > 180 | > 120 |
Problem Statement
- Global: ~22% of adults have raised BP (2015)
- Causes 9.4 million deaths/year (12.8% of all deaths)
- India: 20–40% urban, 12–17% rural adults
Risk Factors
A. Non-Modifiable:
- Age: BP rises with age. Children of 2 hypertensive parents → 45% risk (vs 3% if both normotensive)
- Sex: Males higher in young adults
- Genetics: Polygenic – confirmed by twin & family studies
- Race: Higher in Black populations
B. Modifiable ⭐:
- Salt (Sodium): WHO recommends <5g/day; INTERSALT study confirmed the link
- Obesity: 10 kg weight loss → lowers SBP by 5–20 mmHg
- Alcohol: Limit <2 drinks/day men, <1 drink/day women
- Physical inactivity: Regular aerobic exercise lowers SBP by 4–9 mmHg
- Low potassium/calcium, high saturated fat
- Stress/Psychosocial factors
- Oral contraceptives (oestrogen-containing OCP raises BP)
Tracking of Blood Pressure
KEY CONCEPT: Individuals with relatively high BP in childhood tend to maintain that higher rank as they grow older. Helps identify children "at risk" of future hypertension.
Prevention
| Level | Measures |
|---|
| Primordial | Prevent risk factors from emerging – healthy diet in children, active lifestyle, no-tobacco policies |
| Primary | Reduce salt <5g/day (DASH diet), weight reduction (BMI <25), exercise 30 min/day, reduce alcohol, stop smoking, stress management |
| Secondary | Screening >30 yrs (NPCDCS), regular BP monitoring, antihypertensive drugs |
| Tertiary | Manage complications: stroke, renal failure, heart failure, retinopathy |
DASH Diet = Dietary Approaches to Stop Hypertension – rich in fruits, vegetables, low-fat dairy; low in saturated fats and sodium.
4. DIABETES MELLITUS ⭐⭐⭐
Classification (WHO 2019)
| Type | Description |
|---|
| Type 1 DM | β-cell destruction (immune-mediated); absolute insulin deficiency; onset in childhood |
| Type 2 DM | Most common; β-cell dysfunction + insulin resistance; associated with obesity |
| Hybrid Forms | LADA (slowly evolving immune-mediated); Ketosis-prone Type 2 |
| Other Specific | MODY, pancreatic disease, drug-induced |
| Gestational DM | Hyperglycaemia in 2nd/3rd trimester |
Diagnostic Criteria (WHO)
| Test | Diabetic | Pre-diabetic | Normal |
|---|
| Fasting Plasma Glucose | ≥ 126 mg/dL | 110–125 (IFG) | < 110 mg/dL |
| 2-hr OGTT | ≥ 200 mg/dL | 140–199 (IGT) | < 140 mg/dL |
| HbA1c | ≥ 6.5% | 5.7–6.4% | < 5.7% |
| Random PG + symptoms | ≥ 200 mg/dL | – | – |
Risk Factors / Epidemiological Determinants
A. Non-Modifiable:
- Age: Type 2 DM rises after 40 years
- Genetics: Monozygotic twin concordance ~90% for Type 2
- Ethnicity: Higher in South Asians, Pima Indians
- Gestational history: GDM, macrosomic babies
B. Modifiable (Environmental) ⭐:
- Obesity (especially abdominal): MOST IMPORTANT – 44% of global diabetes burden
- Physical inactivity – alters insulin-receptor interaction
- Unhealthy diet – high saturated fat, low fibre; fibre >20g/day is protective
- Alcohol – damages pancreas, promotes obesity
- Viral infections – Rubella, mumps, Coxsackie B4 trigger Type 1 DM
- Malnutrition – PEM in early infancy → β-cell damage
- Stress – cortisol → insulin resistance
Primary Prevention of Type 2 DM
| Intervention | Evidence |
|---|
| Weight reduction | 5–7% weight loss → reduces T2DM risk by 58% (DPP Trial) |
| Physical activity | 150 min/week moderate activity; increases insulin sensitivity |
| Dietary modification | High fibre >20g/day, low GI foods, Mediterranean diet |
| Avoid tobacco & alcohol | Both increase insulin resistance |
| Screen high-risk groups | Obese, family history, GDM, age >40 yrs |
| Metformin | Reduces progression by 31% in high-risk individuals (DPP trial) |
KEY FACT: India has ~77 million diabetics – 2nd worldwide after China. Always mention in exam answers!
5. CANCER ⭐⭐⭐
Global & India Burden (2020)
| Parameter | Global | India |
|---|
| New cases | 19.29 million | 1.39 million |
| Deaths | 9.96 million | 0.92 million |
| Most common (Males) | Lung cancer | Lip/Oral cavity cancer |
| Most common (Females) | Breast cancer | Breast cancer |
7 Danger Signals of Cancer – Mnemonic: CAUTION ⭐
- C – Change in bowel or bladder habits
- A – A sore that does not heal
- U – Unusual bleeding or discharge
- T – Thickening or lump in breast or elsewhere
- I – Indigestion or difficulty in swallowing
- O – Obvious change in wart or mole
- N – Nagging cough or hoarseness of voice
Oral Cancer ⭐
- Most common cancer in males in India!
- Risk factors: Tobacco (smoking + smokeless), Alcohol, Betel nut chewing, HPV, poor oral hygiene, OSMF
- Precancerous lesions: Leukoplakia, Erythroplakia, OSMF
- Prevention: Tobacco cessation programs, early detection
Cancer Cervix & Screening ⭐
- 2nd most common cancer in women in India
- Risk factors: Early sex, multiple partners, HPV 16 & 18 (70% cases), multiparity, low SES, smoking
Screening Methods:
| Method | Details |
|---|
| Pap Smear | Detects cancer in situ; every 3 years after onset of sexual activity |
| VIA | 5% acetic acid → acetowhite lesion = positive. Simple, cheap, suitable for India |
| VIAM | VIA with magnification |
| VILI | Visual Inspection with Lugol's Iodine |
| HPV DNA test | High sensitivity; co-testing with Pap smear |
Prevention of Ca Cervix:
- Primary: HPV vaccination (Gardasil/Cervarix) for girls 9–26 yrs; delay sexual debut; safe sex; tobacco cessation
- Secondary: Pap smear / VIA screening programs
- Tertiary: Cryotherapy, LEEP, cone biopsy for early lesions
Cancer Registration in India
- Cancer is NOT a notifiable disease in India
- PBCR (Population-Based Cancer Registry): Incidence & mortality data
- HBCR (Hospital-Based Cancer Registry): Hospital patient data
- NCRP (National Cancer Registry Programme): Under ICMR, started 1981
- India has 30+ PBCRs covering ~15% of population
6. STROKE ⭐⭐
Types
- Ischaemic Stroke – Thrombotic/embolic occlusion of cerebral artery (~80–85%)
- Haemorrhagic Stroke – Rupture of cerebral blood vessel (~15–20%)
- TIA – Symptoms <24 hours; "mini-stroke"; warning sign
Risk Factors
- Hypertension: SINGLE MOST IMPORTANT modifiable risk factor
- Diabetes mellitus (2–3x risk)
- Smoking (doubles stroke risk)
- Atrial fibrillation (5x embolic stroke risk)
- Dyslipidaemia, Obesity, Physical inactivity
Prevention
- Control HTN (reduces stroke by 35–40%)
- Anti-platelet therapy (aspirin) for high-risk
- Anticoagulation for atrial fibrillation
- Statins for dyslipidaemia
- Lifestyle: stop smoking, exercise, healthy diet, weight control
7. OBESITY ⭐⭐
BMI Classification
| Category | BMI (WHO) | Asian BMI |
|---|
| Underweight | < 18.5 | < 18.5 |
| Normal | 18.5–24.9 | 18.5–22.9 |
| Overweight | 25–29.9 | 23–24.9 |
| Obese Class I | 30–34.9 | 25–29.9 |
| Obese Class II | 35–39.9 | ≥ 30 |
| Morbid Obesity | ≥ 40 | – |
Waist Circumference (Abdominal Obesity):
- Males: >102 cm (global) / >90 cm (Asian)
- Females: >88 cm (global) / >80 cm (Asian)
- Android (apple-shaped) obesity is more dangerous than gynoid (pear-shaped)
Health Consequences
- CVD: Hypertension, CHD, Stroke
- Metabolic: Type 2 DM, dyslipidaemia, metabolic syndrome
- Cancers: Breast, colorectal, endometrium, kidney, oesophagus
- Musculoskeletal: Osteoarthritis, gout
- Respiratory: Sleep apnoea
- GI: GERD, gallstones, fatty liver (NAFLD)
- Psychosocial: Depression, low self-esteem
Global stats: >1.9 billion overweight; >650 million obese (2016). Obesity has doubled since 1980.
8. NPCDCS ⭐⭐
Full Name: National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke
Background:
- NCDs = 60% of all deaths in India (2016)
- 11th Five Year Plan: 100 districts in 21 states
- 12th Five Year Plan: All districts covered
Objectives
- Prevent and control NCDs through behaviour and lifestyle changes
- Provide early diagnosis and management of common NCDs
- Build capacity at various levels of health care
- Train human resources (doctors, paramedics, nurses)
- Establish capacity for palliative and rehabilitative care
Implementation Strategy
- Opportunistic screening of persons above 30 years
- NCD Clinic established at CHC and District level
- Implementation through 20,000 sub-centres and 700 CHCs in 100 districts
- BCC messages: Healthy food, physical activity, avoid tobacco/alcohol, stress management
KEY POINTS to remember: Covers 4 conditions – Cancer, Diabetes, CVD, Stroke. Screening from age 30 years. NCD clinic at CHC level.
9. ROAD TRAFFIC ACCIDENTS (RTA) ⭐
- ~1.35 million deaths/year globally (2018)
- India: ~1.5 lakh RTA deaths/year
- Leading cause of death in 5–29 year age group
- 50% involve pedestrians, cyclists, motorcyclists
Role of BMOH in Reducing RTA
- Health education on drunk driving, speeding, helmet/seatbelt use
- Trauma care preparedness – first aid training, stabilization room at BPHC
- Coordination with police, PWD, transport department
- Establish referral system to district hospital
- Maintain RTA surveillance data
- Community involvement – VHCs, NGOs
- Golden hour concept – treatment within 1 hour of injury
10. MENTAL HEALTH ⭐
- Mental disorders affect 1 in 4 people globally
- Depression is the leading cause of disability worldwide
- ~800,000 suicides/year; 2nd leading cause of death in 15–29 yr age
- India NMHS 2015–16: 10.6% prevalence of mental disorders
National Mental Health Programme (NMHP)
- Launched in 1982 in India
- District Mental Health Programme (DMHP) – integration at district level
- Mental Healthcare Act 2017 – Right to access mental health care
⚡ QUICK REVISION – KEY NUMBERS
| Topic | Key Fact |
|---|
| NCD deaths globally | 41 million/year = 74% of all deaths |
| Tobacco deaths/year | ~7 million; 71% lung cancer |
| Alcohol deaths/year | 3.3 million = 5.9% of global deaths |
| Hypertension deaths | 9.4 million/year; 12.8% all deaths |
| Obesity global (2016) | >1.9 billion overweight; >650 million obese |
| Global cancer (2020) | 19.29 million new cases; 9.96 million deaths |
| India cancer – Males | Lip/Oral cavity (most common) |
| India cancer – Females | Breast cancer (most common) |
| India diabetes | ~77 million = 2nd worldwide after China |
| DM – FPG cutoff | ≥ 126 mg/dL |
| DM – 2hr OGTT cutoff | ≥ 200 mg/dL |
| DPP Trial | 5–7% weight loss → 58% risk reduction for T2DM |
| NPCDCS screening | From age > 30 years |
| Ca cervix screening | Pap smear every 3 years OR VIA |
| HPV types (cervix) | HPV 16 & 18 → ~70% cervical cancers |
| Danger signals of cancer | CAUTION (7 signs) |
| Framingham Study | 1951 – Prospective cohort, coined "risk factor" |
| RTA deaths – India | ~1.5 lakh/year |
| Salt – WHO | < 5 g/day |
| BMI overweight (Asian) | ≥ 23 kg/m² |
| BMI obese (Asian) | ≥ 25 kg/m² |
| NMHP launched | 1982 in India |
| NCRP (cancer registry) | Under ICMR, started 1981 |
📝 MODEL ANSWER FRAMEWORKS
Hypertension LAQ (12–15 marks)
- Introduction + Definition (JNC 7) — 1–2 marks
- Problem statement – Prevalence India & globally — 2 marks
- Classification table — 2 marks
- Risk factors – Non-modifiable + Modifiable (table) — 3–4 marks
- Prevention – Primordial, Primary, Secondary, Tertiary — 3–4 marks
- NPCDCS mention — 1 mark
- Conclusion — 1 mark
Diabetes LAQ (12 marks)
- Introduction + WHO 2019 Classification — 2 marks
- Problem statement – India 77 million, 2nd worldwide — 1 mark
- Diagnostic criteria table — 2 marks
- Epidemiological determinants – Non-modifiable + Modifiable — 3 marks
- Primary prevention – Weight, Diet, Exercise, Metformin, Screening — 4 marks
Cancer LAQ (12 marks)
- Introduction + magnitude in India — 2 marks
- Common cancers in India – Males & Females (table) — 2 marks
- Early warning signs – CAUTION mnemonic — 3 marks
- Prevention of Ca Cervix – HPV vaccine, Pap smear, VIA — 4 marks
- Cancer control in community — 1 mark
CHD LAQ (12 marks)
- Definition of CHD/IHD — 1 mark
- Problem statement + Framingham Study — 1 mark
- Risk factors – Non-modifiable + Big 4 + Other modifiable (table) — 6 marks
- Prevention – 3 strategies — 4 marks
All content based on Park's PSM Textbook | DUHS Chhattisgarh Syllabus | June 2026