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Cytokyins health and disease ppt for pathology resident doctor

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cytokines inflammation disease mechanisms

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Cytokines Health and Disease

Presentation · PPTX

What's Inside — 18 Slides

#SlideContent
1TitleProfessional dark navy cover slide
2What Are Cytokines?Definition, pleiotropism, redundancy, synergy, antagonism
3Classification6 families: ILs, TNFs, IFNs, Chemokines, CSFs, Growth Factors
4Receptors & SignalingJAK-STAT, NF-κB, SMAD, G-protein — table format with all receptor families
5IL-1 & TNF-αSide-by-side deep dives with sources, signaling, local/systemic effects, disease links
6IL-6, IL-10, IL-12The versatile mediator, anti-inflammatory brake, and Th1 polarizer
7InterferonsType I (IFN-α/β), Type II (IFN-γ), Type III (IFN-λ) — mechanism + disease
8ChemokinesCXC, CC, C, CX3C families with key members, targets, clinical pearls
9The InflammasomeNLRP3 mechanism (2 signals), other inflammasomes, pyroptosis vs apoptosis vs necrosis table
10Th1/Th2/Th17/Treg Axis4-column layout with driving cytokines, transcription factors, function, disease
11Acute InflammationTimeline diagram: stimulus → PRR → cytokines → vascular changes; local vs systemic effects
12Cytokine StormDefinition, triggers, HLH-2004 diagnostic criteria, treatment (dark dramatic slide)
13AutoimmunityRA, IBD, psoriasis, SLE, asthma, AS — each with cytokines, mechanism, targeted therapy
14CancerPro-tumor vs anti-tumor cytokines, TME immunosuppression, cytokine-based therapeutics
15Infectious DiseaseSepsis, TB, COVID-19, HIV, helminths, viral immune evasion — table format
16TGF-β & IL-17Fibrosis mechanisms, barrier immunity, autoimmune pathology, therapeutic agents
17Therapeutics Table11 drug classes: anti-TNF, anti-IL-6R, IL-1Ra, anti-IL-17, anti-IL-4/13, JAK inhibitors + indications/AEs
188 Key PearlsSummary takeaways for exam/clinical practice
Sources: Robbins & Cotran Pathologic Basis of Disease (10e), Cellular & Molecular Immunology (Abbas et al.), Harrison's Principles (22e), Goodman & Gilman's Pharmacological Basis of Therapeutics.

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Cytokines Health and Disease

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    Cytokines Health and Disease

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    Cytokines Health and Disease

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Cytokyins health and disease ppt for pathology resident doctor

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    Cytokines Health and Disease

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    Cytokines Health and Disease

    PDF Document · PDF

The deck has 18 slides covering:
  1. Title slide
  2. What are cytokines? (definition, properties)
  3. Classification (ILs, TNFs, IFNs, Chemokines, CSFs, TGF-β)
  4. Receptors & signaling (JAK-STAT, NF-κB, SMAD table)
  5. IL-1 & TNF-α deep dive
  6. IL-6, IL-10, IL-12
  7. Interferons (Type I / II / III)
  8. Chemokines (CXC, CC, C, CX3C)
  9. The Inflammasome (NLRP3, pyroptosis)
  10. Th1/Th2/Th17/Treg cytokine axis
  11. Cytokines in acute inflammation
  12. Cytokine storm & HLH
  13. Cytokines in autoimmunity (RA, IBD, SLE, psoriasis, asthma, AS)
  14. Cytokines in cancer (TME, therapeutics)
  15. Cytokines in infectious disease
  16. TGF-β & IL-17 (fibrosis & barrier immunity)
  17. Therapeutics table (11 drug classes)
  18. 8 Key Pearls summary
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