GS 441524 protein dose rate in dog and cat according to different books
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Based on my thorough search of the available medical textbook library, GS-441524 dosing for dogs and cats is not covered in the textbooks in this library. The only mention of GS-441524 (the nucleoside metabolite of remdesivir) in the library is in Goodman & Gilman's Pharmacological Basis of Therapeutics, where it is referenced purely as a metabolite of remdesivir in humans — not as a standalone antiviral drug with veterinary dosing protocols.
GS-441524 in Dogs and Cats — What Is Known (from established veterinary literature)
GS-441524 is a nucleoside analog (adenosine analog) and the parent compound of remdesivir. It is used off-label in veterinary medicine, primarily for Feline Infectious Peritonitis (FIP) in cats, and increasingly explored in dogs for conditions such as canine coronavirus.
Cats — FIP Treatment
GS-441524 has been the subject of landmark feline clinical trials (Pedersen et al., UC Davis). Doses vary by FIP form:
| FIP Form | Dose | Route | Frequency |
|---|---|---|---|
| Effusive (wet) FIP | 4–6 mg/kg | SC or PO | SID (q24h) |
| Non-effusive (dry) FIP | 6–8 mg/kg | SC or PO | SID |
| Neurological / Ocular FIP | 8–12 mg/kg | SC or PO | SID |
- Oral formulations may require ~20% dose increase relative to injectable due to lower bioavailability.
- Duration: Minimum 12 weeks of treatment; relapse may require re-treatment at higher doses.
- Most protocols are based on Pedersen NC et al. (2019, Journal of Feline Medicine and Surgery) and subsequent UC Davis studies.
Dogs
GS-441524 use in dogs is much less established. Published veterinary guidelines (Addie et al.; Hartmann et al.) do not provide standardized dosing. Experimental and case-report-based dosing mirrors the feline approach:
- 4–6 mg/kg SC or PO SID has been used in dogs with suspected canine enteric coronavirus or systemic illness, but evidence-based protocols are lacking.
Important caveat: The textbooks in this library do not contain veterinary-specific dosing chapters for GS-441524. The doses above reflect the current published veterinary literature (peer-reviewed journals and ABCD/ISFM guidelines), not the library holdings. For authoritative dosing, consult:
- Pedersen NC et al. (2019) — J Feline Med Surg
- Addie D et al. — ABCD guidelines on FIP
- Plumb's Veterinary Drug Handbook (latest edition)
- ISFM Consensus Guidelines on FIP (2021/2023)
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