const pptxgen = require("pptxgenjs");

const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Infectious Diseases: Transmission, Risk & Antibiotics";

// ─────────────────────────────────────────────
// THEME
// ─────────────────────────────────────────────
const DARK_BG    = "0D1B2A";   // deep navy
const MID_BG     = "1B2A3B";   // navy mid
const ACCENT1    = "00B4D8";   // vivid cyan (headings / accents)
const ACCENT2    = "90E0EF";   // light cyan (sub-text)
const DANGER_RED = "E63946";   // danger / antibiotics slides
const GREEN_SAFE = "2EC4B6";   // prevention / advantages
const WHITE      = "FFFFFF";
const LIGHT_GRAY = "C9D6DF";
const CARD_BG    = "162233";   // card background

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function addHeader(slide, text, y, color) {
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    wrap: true
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}

// ══════════════════════════════════════════════
// SLIDE 1 – TITLE
// ══════════════════════════════════════════════
{
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  sl.addText("INFECTIOUS DISEASES", {
    x: 0.5, y: 0.2, w: 9, h: 0.7,
    fontSize: 36, bold: true, color: DARK_BG,
    fontFace: "Calibri", align: "left", margin: 0
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  sl.addText("Transmission · Risk Factors · Antibiotics", {
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    { text: "How infectious diseases spread — two key transmission routes", options: { bullet: { code: "2022" }, breakLine: true } },
    { text: "Three risk factors and how to reduce them in care settings", options: { bullet: { code: "2022" }, breakLine: true } },
    { text: "Advantages and dangers of antibiotic therapy", options: { bullet: { code: "2022" } } }
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}

// ══════════════════════════════════════════════
// SLIDE 2 – WHAT ARE INFECTIOUS DISEASES?
// ══════════════════════════════════════════════
{
  const sl = pres.addSlide();
  addSlideBackground(sl);
  addHeader(sl, "What Are Infectious Diseases?");
  addDividerLine(sl);

  addBodyText(sl,
    "Infectious diseases are disorders caused by organisms such as bacteria, viruses, fungi, or parasites that invade the body, multiply, and disrupt normal function. They can be spread from person to person, via animals, insects, or contaminated environments.",
    0.5, 1.0, 9, 1.1, LIGHT_GRAY, 15);

  // 3 boxes: Bacteria, Viruses, Parasites
  const categories = [
    { label: "BACTERIA", detail: "Single-celled organisms. Cause TB, cholera, MRSA. Treatable with antibiotics." },
    { label: "VIRUSES", detail: "Non-living particles. Cause influenza, HIV, COVID-19. Antibiotics ineffective." },
    { label: "PARASITES / FUNGI", detail: "Multi- or single-celled. Cause malaria, tinea. Require specific treatments." }
  ];

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      align: "center", valign: "top", wrap: true
    });
  });
}

// ══════════════════════════════════════════════
// SLIDE 3 – SECTION DIVIDER: TRANSMISSION
// ══════════════════════════════════════════════
{
  const sl = pres.addSlide();
  addSlideBackground(sl, MID_BG);

  sl.addShape(pres.ShapeType.rect, {
    x: 0, y: 1.8, w: "100%", h: 2.1,
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    x: 0.5, y: 1.88, w: 9, h: 0.4,
    fontSize: 13, bold: true, color: DARK_BG,
    fontFace: "Calibri", align: "center", italic: true
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  sl.addText("How Infectious Diseases\nAre Transmitted", {
    x: 0.5, y: 2.25, w: 9, h: 1.4,
    fontSize: 34, bold: true, color: DARK_BG,
    fontFace: "Calibri", align: "center"
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    x: 0.5, y: 4.2, w: 9, h: 0.5,
    fontSize: 16, color: ACCENT2, fontFace: "Calibri", align: "center", italic: true
  });
}

// ══════════════════════════════════════════════
// SLIDE 4 – TRANSMISSION ROUTE 1: AIRBORNE
// ══════════════════════════════════════════════
{
  const sl = pres.addSlide();
  addSlideBackground(sl);

  // Coloured top badge
  sl.addShape(pres.ShapeType.rect, {
    x: 0, y: 0, w: "100%", h: 0.5,
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    x: 0.5, y: 0.05, w: 9, h: 0.4,
    fontSize: 12, bold: true, color: DARK_BG,
    fontFace: "Calibri", align: "left"
  });

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  addDividerLine(sl, 1.3);

  addBodyText(sl,
    "Airborne transmission occurs when infectious agents are carried by tiny airborne droplets or droplet nuclei (particles <5 µm) and inhaled by a susceptible host. These particles can remain suspended in the air for extended periods and travel further than 1 metre from the source.",
    0.5, 1.45, 9, 1.0, LIGHT_GRAY, 14);

  // Example box – TB
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    x: 0.4, y: 2.6, w: 4.3, h: 2.6,
    fill: { color: CARD_BG }, line: { color: ACCENT1, pt: 1.5 }
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  sl.addText("🦠  Example: Tuberculosis (TB)", {
    x: 0.5, y: 2.7, w: 4.1, h: 0.45,
    fontSize: 13, bold: true, color: ACCENT1, fontFace: "Calibri"
  });
  sl.addText([
    { text: "Pathogen: ", options: { bold: true, breakLine: false } },
    { text: "Mycobacterium tuberculosis\n", options: { breakLine: true } },
    { text: "Transmission: ", options: { bold: true, breakLine: false } },
    { text: "Infectious aerosols released when an infected person coughs, sneezes or speaks. Inhaled by a susceptible host.\n", options: { breakLine: true } },
    { text: "Impact: ", options: { bold: true, breakLine: false } },
    { text: "Was the leading infectious disease cause of death worldwide before SARS-CoV-2.", options: {} }
  ], {
    x: 0.5, y: 3.2, w: 4.1, h: 1.9,
    fontSize: 12, color: LIGHT_GRAY, fontFace: "Calibri", valign: "top", wrap: true
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    x: 5.1, y: 2.6, w: 4.3, h: 2.6,
    fill: { color: CARD_BG }, line: { color: ACCENT2, pt: 1.5 }
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    { text: "Pathogen: ", options: { bold: true, breakLine: false } },
    { text: "Influenza A/B virus\n", options: { breakLine: true } },
    { text: "Transmission: ", options: { bold: true, breakLine: false } },
    { text: "Droplets expelled by coughing/sneezing travel through the air and are inhaled, or land on mucous membranes.\n", options: { breakLine: true } },
    { text: "Note: ", options: { bold: true, breakLine: false } },
    { text: "Larger respiratory droplets (>5 µm) are sometimes called droplet rather than airborne; both are aerosol-based routes.", options: {} }
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    x: 5.2, y: 3.2, w: 4.1, h: 1.9,
    fontSize: 12, color: LIGHT_GRAY, fontFace: "Calibri", valign: "top", wrap: true
  });
}

// ══════════════════════════════════════════════
// SLIDE 5 – TRANSMISSION ROUTE 2: DIRECT CONTACT
// ══════════════════════════════════════════════
{
  const sl = pres.addSlide();
  addSlideBackground(sl);

  sl.addShape(pres.ShapeType.rect, {
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    fill: { color: GREEN_SAFE }, line: { color: GREEN_SAFE }
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    fontSize: 12, bold: true, color: DARK_BG, fontFace: "Calibri", align: "left"
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  addBodyText(sl,
    "Direct contact transmission occurs when an infectious organism is transferred through physical contact between an infected source and a susceptible host — either person-to-person, or via contaminated surfaces (fomites) and body fluids.",
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  const types = [
    { label: "Skin-to-Skin", desc: "Direct touching of infected skin or lesions (e.g. MRSA, herpes simplex)." },
    { label: "Body Fluids", desc: "Blood, sexual fluids or breast milk carrying HIV, Hepatitis B/C." },
    { label: "Fomites", desc: "Contaminated surfaces (door handles, instruments) harbouring pathogens." }
  ];
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    const x = 0.4 + i * 3.1;
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      x, y: 2.55, w: 2.8, h: 1.2,
      fill: { color: CARD_BG }, line: { color: GREEN_SAFE, pt: 1 }
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      x: x + 0.05, y: 2.6, w: 2.7, h: 0.35,
      fontSize: 12, bold: true, color: GREEN_SAFE, fontFace: "Calibri", align: "center"
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      x: x + 0.05, y: 2.98, w: 2.7, h: 0.7,
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    x: 0.4, y: 3.9, w: 9.1, h: 1.5,
    fill: { color: CARD_BG }, line: { color: GREEN_SAFE, pt: 1.5 }
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    x: 0.55, y: 3.97, w: 8.8, h: 0.4,
    fontSize: 13, bold: true, color: GREEN_SAFE, fontFace: "Calibri"
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  sl.addText(
    "MRSA spreads primarily through direct skin-to-skin contact or via contaminated hands of healthcare workers. It colonises wounds, surgical sites and skin abrasions. Shared equipment and unwashed hands are the principal vehicles. MRSA is a leading cause of healthcare-associated infections (HAIs) worldwide.",
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  );
}

// ══════════════════════════════════════════════
// SLIDE 6 – SECTION DIVIDER: RISK FACTORS
// ══════════════════════════════════════════════
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    x: 0.5, y: 1.88, w: 9, h: 0.4,
    fontSize: 13, bold: true, color: DARK_BG, fontFace: "Calibri", align: "center", italic: true
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  sl.addText("Risk Factors & Prevention\nin Care Settings", {
    x: 0.5, y: 2.25, w: 9, h: 1.4,
    fontSize: 34, bold: true, color: DARK_BG, fontFace: "Calibri", align: "center"
  });
  sl.addText("Three key factors that increase — and how to reduce — infection risk", {
    x: 0.5, y: 4.2, w: 9, h: 0.5,
    fontSize: 15, color: ACCENT2, fontFace: "Calibri", align: "center", italic: true
  });
}

// ══════════════════════════════════════════════
// SLIDE 7 – RISK FACTOR 1: POOR HAND HYGIENE
// ══════════════════════════════════════════════
{
  const sl = pres.addSlide();
  addSlideBackground(sl);

  sl.addShape(pres.ShapeType.rect, {
    x: 0, y: 0, w: 0.25, h: "100%",
    fill: { color: GREEN_SAFE }, line: { color: GREEN_SAFE }
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    x: 0.45, y: 0.25, w: 9, h: 0.55,
    fontSize: 22, bold: true, color: GREEN_SAFE, fontFace: "Calibri", margin: 0
  });
  addDividerLine(sl, 0.92);

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  // LEFT – the risk
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    x: 0.4, y: 1.1, w: 4.3, h: 4.1,
    fill: { color: CARD_BG }, line: { color: DANGER_RED, pt: 1.5 }
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  sl.addText("⚠  The Risk", {
    x: 0.55, y: 1.18, w: 4.0, h: 0.4,
    fontSize: 14, bold: true, color: DANGER_RED, fontFace: "Calibri"
  });
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    { text: "Poor hand hygiene is the single most important risk factor for healthcare-associated infections (HAIs).\n\n", options: { breakLine: true } },
    { text: "Pathogens are transferred from contaminated surfaces or patients to hands, then to other patients, wounds, catheters or IV lines.\n\n", options: { breakLine: true } },
    { text: "MRSA, Clostridioides difficile and gram-negative bacteria are commonly spread this way in clinical settings.", options: {} }
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    x: 0.55, y: 1.62, w: 4.0, h: 3.4,
    fontSize: 12.5, color: LIGHT_GRAY, fontFace: "Calibri", valign: "top", wrap: true
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    x: 5.1, y: 1.1, w: 4.3, h: 4.1,
    fill: { color: CARD_BG }, line: { color: GREEN_SAFE, pt: 1.5 }
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  sl.addText("✔  How to Reduce the Risk", {
    x: 5.25, y: 1.18, w: 4.0, h: 0.4,
    fontSize: 14, bold: true, color: GREEN_SAFE, fontFace: "Calibri"
  });
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    { text: "Use the WHO 5 Moments for Hand Hygiene — before/after patient contact, before aseptic procedures, after body fluid exposure, after touching patient surroundings.", options: { bullet: { code: "2022" }, breakLine: true, paraSpaceAfter: 4 } },
    { text: "Apply alcohol-based hand rub (ABHR) or soap and water — ABHR is preferred for most clinical interactions.", options: { bullet: { code: "2022" }, breakLine: true, paraSpaceAfter: 4 } },
    { text: "Promote visible, audited hand hygiene compliance programmes. Compliance increases with audit feedback.", options: { bullet: { code: "2022" } } }
  ];
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    x: 5.25, y: 1.62, w: 4.0, h: 3.4,
    fontSize: 12, color: LIGHT_GRAY, fontFace: "Calibri", valign: "top", wrap: true,
    lineSpacingMultiple: 1.3
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}

// ══════════════════════════════════════════════
// SLIDE 8 – RISK FACTOR 2: COMPROMISED IMMUNITY
// ══════════════════════════════════════════════
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    x: 0.4, y: 1.1, w: 4.3, h: 4.1,
    fill: { color: CARD_BG }, line: { color: DANGER_RED, pt: 1.5 }
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  sl.addText("⚠  The Risk", {
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    fontSize: 14, bold: true, color: DANGER_RED, fontFace: "Calibri"
  });
  sl.addText([
    { text: "Patients with weakened immune systems — due to HIV, diabetes, chemotherapy, organ transplant, or extremes of age — have reduced capacity to fight pathogens.\n\n", options: { breakLine: true } },
    { text: "Opportunistic infections (e.g. Pneumocystis pneumonia, CMV, fungal infections) occur at much higher rates.\n\n", options: { breakLine: true } },
    { text: "Neonates and elderly patients in care homes are at especially high risk from common organisms that healthy adults resist easily.", options: {} }
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    x: 0.55, y: 1.62, w: 4.0, h: 3.4,
    fontSize: 12.5, color: LIGHT_GRAY, fontFace: "Calibri", valign: "top", wrap: true
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  sl.addShape(pres.ShapeType.rect, {
    x: 5.1, y: 1.1, w: 4.3, h: 4.1,
    fill: { color: CARD_BG }, line: { color: ACCENT1, pt: 1.5 }
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    fontSize: 14, bold: true, color: ACCENT1, fontFace: "Calibri"
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    { text: "Ensure up-to-date vaccination programmes — including seasonal flu and pneumococcal vaccines for immunocompromised groups.", options: { bullet: { code: "2022" }, breakLine: true, paraSpaceAfter: 4 } },
    { text: "Use protective (reverse) isolation for highly immunocompromised patients (e.g. post-bone-marrow transplant) — HEPA-filtered, positive pressure rooms.", options: { bullet: { code: "2022" }, breakLine: true, paraSpaceAfter: 4 } },
    { text: "Monitor and manage underlying conditions (e.g. glycaemic control in diabetes) to optimise immune function.", options: { bullet: { code: "2022" } } }
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    lineSpacingMultiple: 1.3
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// ══════════════════════════════════════════════
// SLIDE 9 – RISK FACTOR 3: CROWDED / POOR ENVIRONMENTS
// ══════════════════════════════════════════════
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  addSlideBackground(sl);

  sl.addShape(pres.ShapeType.rect, {
    x: 0, y: 0, w: 0.25, h: "100%",
    fill: { color: ACCENT2 }, line: { color: ACCENT2 }
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  sl.addText("RISK FACTOR 3  |  Environment & Overcrowding", {
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    fontSize: 22, bold: true, color: ACCENT2, fontFace: "Calibri", margin: 0
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  sl.addShape(pres.ShapeType.rect, {
    x: 0.4, y: 1.1, w: 4.3, h: 4.1,
    fill: { color: CARD_BG }, line: { color: DANGER_RED, pt: 1.5 }
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    fontSize: 14, bold: true, color: DANGER_RED, fontFace: "Calibri"
  });
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    { text: "Overcrowded care settings and poor ventilation increase the concentration of airborne particles and the likelihood of contact with contaminated surfaces.\n\n", options: { breakLine: true } },
    { text: "Congregate settings — care homes, wards, ICUs — allow rapid transmission of respiratory pathogens (e.g. TB, COVID-19, influenza).\n\n", options: { breakLine: true } },
    { text: "Poor sanitation and inadequate cleaning of clinical surfaces also allows pathogens to persist and colonise new hosts.", options: {} }
  ], {
    x: 0.55, y: 1.62, w: 4.0, h: 3.4,
    fontSize: 12.5, color: LIGHT_GRAY, fontFace: "Calibri", valign: "top", wrap: true
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    x: 5.1, y: 1.1, w: 4.3, h: 4.1,
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    { text: "Apply transmission-based precautions: contact, droplet, and airborne isolation as dictated by the specific pathogen (CDC/HICPAC tiered precautions).", options: { bullet: { code: "2022" }, breakLine: true, paraSpaceAfter: 4 } },
    { text: "Regular environmental decontamination with appropriate disinfectants; cohorting of infected patients to prevent cross-transmission.", options: { bullet: { code: "2022" } } }
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}

// ══════════════════════════════════════════════
// SLIDE 10 – SECTION DIVIDER: ANTIBIOTICS
// ══════════════════════════════════════════════
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// ══════════════════════════════════════════════
// SLIDE 11 – ANTIBIOTICS: ADVANTAGES
// ══════════════════════════════════════════════
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      title: "Prophylaxis",
      body: "Pre- and peri-operative antibiotic prophylaxis dramatically reduces the risk of post-surgical infections, protecting patients undergoing invasive procedures."
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      title: "Reduced Mortality & Morbidity",
      body: "Since their introduction in the 1940s, antibiotics have reduced mortality from bacterial diseases worldwide and enabled modern medicine (surgery, transplants, cancer chemotherapy) which all rely on effective infection control."
    },
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      title: "Targeted Spectrum",
      body: "Narrow-spectrum agents (e.g. penicillin for streptococcal infection) allow treatment with minimal disruption to the normal microbiome; broad-spectrum agents cover polymicrobial infections when causative organisms are unknown."
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// ══════════════════════════════════════════════
// SLIDE 12 – ANTIBIOTICS: DANGERS
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      body: "Broad-spectrum antibiotics destroy beneficial gut bacteria, allowing opportunistic pathogens such as Clostridioides difficile to overgrow, causing severe, potentially fatal colitis."
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    {
      title: "Adverse Drug Reactions",
      body: "Side effects include allergic reactions (anaphylaxis with penicillins), nephrotoxicity (aminoglycosides), hepatotoxicity, QT prolongation (fluoroquinolones), and photosensitivity (tetracyclines)."
    },
    {
      title: "Ineffective Against Viruses",
      body: "Antibiotics have no effect on viruses (e.g. influenza, COVID-19). Inappropriate prescription accelerates resistance without patient benefit — a key driver of the AMR crisis."
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// ══════════════════════════════════════════════
// SLIDE 13 – ANTIBIOTICS: BALANCED OVERVIEW TABLE
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    ["Side Effects", "Well-tolerated in most patients at standard doses", "Allergy (anaphylaxis), nephrotoxicity, QT prolongation, hepatotoxicity"],
    ["Resistance", "Stewardship programmes can slow resistance emergence", "AMR is a global emergency; threatens modern surgical/oncological care"]
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// ══════════════════════════════════════════════
// SLIDE 14 – ANTIBIOTIC STEWARDSHIP
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    { icon: "📏", label: "Right Dose & Duration", detail: "Avoid under-dosing (drives resistance) and over-duration (harms microbiome)." },
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// ══════════════════════════════════════════════
// SLIDE 15 – SUMMARY
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// ─────────────────────────────────────────────
// WRITE FILE
// ─────────────────────────────────────────────
const outputPath = "/home/daytona/workspace/infectious-diseases-ppt/Infectious_Diseases.pptx";
pres.writeFile({ fileName: outputPath })
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