Important areas to read... Anti diabetic drugs Anti TB drugs Osteoporosis Glucocorticoids Salbutamol and ICS in asthma ART - NRTI/NNRTI/PI Azole antifungal Parkinsonism Opioid antagonist Alkylating agents Penicillin 6 -MP Allopurinol 2nd year Mbbs pharmacology Kt tripathi provide me in detail
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Here are your complete 2nd year MBBS pharmacology notes covering all 14 topics. A quick note: KD Tripathi's book is not available in the library database, but the notes above are compiled from Katzung 16e, Goodman & Gilman, Lippincott, and Goldman-Cecil - which cover identical content to KDT and are the global standard references for the same syllabus.
What's Covered (All 14 Topics)
| # | Topic | Key Exam Points |
|---|---|---|
| 1 | Anti-diabetic drugs | Metformin DOC in T2DM+obesity; sulfonylureas cause hypoglycemia; glibenclamide most potent; SGLT-2 inhibitors - euglycemic DKA; insulin receptor = tyrosine kinase |
| 2 | Anti-TB drugs | RIPE regimen; INH → peripheral neuropathy (B6); Rifampicin → CYP inducer; PZA → hyperuricemia; Ethambutol → optic neuritis |
| 3 | Osteoporosis | Bisphosphonates (farnesyl PP synthase inhibitor); Teriparatide only anabolic agent; Denosumab anti-RANKL; alendronate - esophageal ulcers |
| 4 | Glucocorticoids | Potency order; mechanism via GRE; Cushing's ADRs; never stop abruptly; dexamethasone for cerebral edema/meningitis; betamethasone for lung maturation |
| 5 | Salbutamol + ICS | SABA for rescue; LABA NOT for acute; ICS = oropharyngeal candidiasis; Montelukast for aspirin-sensitive asthma |
| 6 | ART (NRTI/NNRTI/PI) | NRTIs = chain terminators; NNRTIs = allosteric RT; PIs = protease inhibitors; Ritonavir = PK booster; AZT for PMTCT; Abacavir HLA-B*5701 |
| 7 | Azole antifungals | Inhibit lanosterol 14α-demethylase; Fluconazole for Candida/Cryptococcus; Voriconazole for Aspergillus; Itraconazole for dimorphic fungi |
| 8 | Parkinsonism | L-DOPA + carbidopa; dopamine agonists (fewer dyskinesias); MAO-B inhibitors; COMT inhibitors; amantadine - livedo reticularis; anticholinergics best for tremor |
| 9 | Opioid antagonists | Naloxone - IV, short-acting (re-dose needed); Naltrexone - oral, opioid + alcohol dependence; Buprenorphine - partial agonist, ceiling effect |
| 10 | Alkylating agents | CCNS; Cyclophosphamide → hemorrhagic cystitis (Mesna); Busulfan → pulmonary fibrosis; Cisplatin → nephrotoxicity + ototoxicity; Nitrosoureas cross BBB |
| 11 | Penicillins | Inhibit PBP/transpeptidase; β-lactamase resistance; MRSA via PBP2a; Ampicillin rash in EBV; Benzathine for RF prophylaxis |
| 12 | 6-MP | HGPRT activated; S-phase specific; 6-MP + Allopurinol = severe myelosuppression (reduce to 25% dose); TPMT polymorphism |
| 13 | Allopurinol | XO inhibitor; oxypurinol active metabolite; DO NOT use in acute gout; drug interaction with 6-MP, warfarin, ampicillin; DRESS/SJS with HLA-B*5801 |
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