cd /home/daytona/workspace/attachments/284e3a0a-98c6-4083-8082-0a00f79eaaf2 && p…

cd /home/daytona/workspace/attachments/284e3a0a-98c6-4083-8082-0a00f79eaaf2 && p…

cd /home/daytona/skills/pptx && python scripts/thumbnail.py /home/daytona/worksp…

cd /home/daytona/skills/pptx && python scripts/office/unpack.py /home/daytona/wo…

cd /home/daytona/skills/pptx && python scripts/office/unpack.py /home/daytona/wo…

for i in 1 2 3 4 5 6; do echo "=== SLIDE $i ==="; python -c " import xml.etree.E…

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Create a PowerPoint presentation (.pptx) for a medical PG Synopsis using an existing template. Follow these exact steps: ## Context The template has already been unpacked to: /home/daytona/workspace/pptx_template_unpacked/ The original template is: /home/daytona/workspace/attachments/284e3a0a-98c6-4083-8082-0a00f79eaaf2/PG_Synopsis_Presentation_Template.pptx Output path: /home/daytona/workspace/HRCT_ILD_Synopsis_Bhargay_Gami.pptx ## Template Structure (already analyzed): - Slide 1: Image/blank decorative cover - Slide 2: Title slide with fields: Title of Study, Name of Student, Batch, Guide & Co-guide, Department, Institution, Date - Slide 3: Introduction / Background - Slide 4: Review of Literature - Slide 5: Research Problem / Hypothesis - Slide 6: Aims and Objectives - Slide 7: Materials and Methods - Slide 8: Data Collection & Tools - Slide 9: Statistical Analysis - Slide 10: Ethical Considerations - Slide 11: Timeline & Expected Outcomes - Slide 12: Formatting guidelines slide (keep as-is) ## Formatting (from template slide 12): - Font: Times New Roman - Title: 36pt Bold - Headings: 28pt Bold - Text: 22pt - Line spacing: 1.1 - Paragraph spacing: 6pt after - Slide size: Widescreen 16:9 - Theme: Simple white background with dark blue (#003366) or black headings ## Student Details: - Study Title: "Role of HRCT in Interstitial Lung Disease" - Student Name: Dr. Bhargay Gami - Batch: MD Radiodiagnosis 2023-2026 - Guide: Dr. Nishant Patel, Associate Professor, Department of Radiodiagnosis, NMCRC Visnagar - Department: Department of Radiodiagnosis - Institution: Nootan Medical College and Research Centre, Visnagar - Date: July 2026 ## Content for each slide (use this HRCT/ILD specific content): ### Slide 2 - Title Slide: - Title: "Role of HRCT in Interstitial Lung Disease" - Student: Dr. Bhargay Gami - Batch: MD Radiodiagnosis (2023-2026) - Guide: Dr. Nishant Patel, Associate Professor - Department: Radiodiagnosis, NMCRC Visnagar - Date: July 2026 ### Slide 3 - Introduction / Background: • Interstitial Lung Diseases (ILD) are a heterogeneous group of >200 diffuse parenchymal lung disorders affecting the alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular/perilymphatic tissues • ILDs are associated with significant morbidity and mortality; accurate diagnosis is essential for guiding treatment • High Resolution Computed Tomography (HRCT) has revolutionized non-invasive diagnosis of ILD — offering superior spatial resolution with 1-2 mm thin sections • HRCT demonstrates characteristic patterns: honeycombing, ground-glass opacity, reticulation, traction bronchiectasis, consolidation, nodules • Early and accurate HRCT diagnosis can guide treatment decisions and avoid unnecessary surgical lung biopsy in many cases ### Slide 4 - Review of Literature: • Wells et al. (1998): HRCT has sensitivity of 96% and specificity of 86% for UIP pattern in IPF • Sverzellati et al. (2010): HRCT patterns correlate with histopathological findings and predict disease prognosis • Lynch et al. (2018): Fleischner Society guidelines define diagnostic criteria for UIP pattern on HRCT • Raghu et al. (2022): ATS/ERS/JRS/ALAT guidelines endorse HRCT as the first-line investigation in suspected ILD • Indian data: ILD prevalence is rising; HP and CTD-ILD are more common than IPF in South Asian populations • Research gap: Limited data from Western India/Gujarat on HRCT pattern distribution and clinical correlation in ILD patients ### Slide 5 - Research Problem / Hypothesis: • Problem Statement: Despite HRCT being the gold standard investigation for ILD, there is a paucity of data from tertiary care centers in North Gujarat regarding the spectrum of HRCT patterns and their clinical correlation • Research Question: What is the spectrum of HRCT findings in patients with ILD presenting to a tertiary care hospital in North Gujarat? • Hypothesis: HRCT chest demonstrates specific and reproducible patterns that allow accurate classification of ILD subtypes, correlating with clinical and laboratory findings ### Slide 6 - Aims and Objectives: Broad Aim: To study the role of HRCT chest in the diagnosis and characterization of Interstitial Lung Diseases Specific Objectives: 1. To describe the spectrum of HRCT patterns (UIP, NSIP, HP, COP, DIP, etc.) in patients with ILD 2. To correlate HRCT findings with clinical presentations, pulmonary function tests, and serological markers 3. To evaluate the diagnostic accuracy of HRCT in differentiating various ILD subtypes 4. To assess the distribution of ILD subtypes in patients attending NMCRC, Visnagar ### Slide 7 - Materials and Methods: • Study Design: Observational cross-sectional study • Study Setting: Department of Radiodiagnosis, Nootan Medical College and Research Centre, Visnagar, Gujarat • Study Population: Patients referred for HRCT chest with clinical suspicion of ILD • Study Duration: 18 months (January 2025 - June 2026) • Sample Size: Minimum 60 cases (calculated using prevalence-based formula, 95% CI, 10% margin of error) • Inclusion Criteria: (1) Age ≥18 years, (2) Clinical/spirometric suspicion of ILD, (3) Referred for HRCT chest • Exclusion Criteria: (1) Known malignancy, (2) Active pulmonary tuberculosis, (3) Inability to cooperate for HRCT ### Slide 8 - Data Collection & Tools: • Variables: Demographic data, clinical history, symptoms duration, smoking history, occupational/drug exposure, PFT results, serological markers (ANA, RF, anti-CCP), HRCT patterns • HRCT Protocol: 64-slice MDCT, 1mm slice thickness, high spatial frequency reconstruction algorithm, supine/prone positioning as required • HRCT Patterns Assessed: Ground glass opacity, reticulation, honeycombing, traction bronchiectasis, consolidation, mosaic attenuation, nodules, cysts • ILD Classification: Based on 2022 ATS/ERS/JRS/ALAT guidelines and Fleischner Society criteria • Data Collection Tool: Pre-designed structured proforma approved by institutional SRC/IEC ### Slide 9 - Statistical Analysis: • Software: SPSS version 26.0 (IBM Corp.) / Microsoft Excel • Descriptive Statistics: Mean ± SD for continuous variables; frequency and percentage for categorical variables • Inferential Statistics: Chi-square test for association between categorical variables; Fisher's exact test where applicable • Diagnostic accuracy: Sensitivity, specificity, PPV, NPV of HRCT patterns for specific ILD subtypes • Significance level: p < 0.05 considered statistically significant • Agreement: Kappa statistics for inter-observer agreement on HRCT pattern recognition ### Slide 10 - Ethical Considerations: • Ethical approval obtained/sought from Institutional Ethics Committee (IEC), NMCRC Visnagar • Written informed consent obtained from all study participants (English and Gujarati) • Patient confidentiality maintained; no personal identifiers in data records • HRCT is performed only when clinically indicated — no additional radiation exposure for research purposes • Study registered with institutional SRC as per ICMR guidelines • No financial conflict of interest; self-funded observational study ### Slide 11 - Timeline & Expected Outcomes: Timeline: - Phase 1 (Month 1-2): Protocol finalization, ethics approval, SRC clearance - Phase 2 (Month 3-16): Patient recruitment and data collection - Phase 3 (Month 17-18): Data analysis and thesis writing - Thesis submission: Month 18-20 Expected Outcomes: • Establish a local database of HRCT patterns in ILD from North Gujarat • Define frequency of UIP, NSIP, HP, CTD-ILD, COP subtypes in this population • Provide evidence for HRCT as a reliable non-invasive diagnostic tool • Potential for publication in indexed radiology journal ## Steps to follow: 1. Read the editing.md skill file: /home/daytona/skills/pptx/editing.md 2. The template is already unpacked at /home/daytona/workspace/pptx_template_unpacked/ 3. Edit slides 2-11 XML files directly, replacing placeholder text with the content above 4. Keep slide 1 and slide 12 unchanged 5. Use python scripts to clean and pack: - Clean: `python /home/daytona/skills/pptx/scripts/clean.py /home/daytona/workspace/pptx_template_unpacked/` - Pack: `python /home/daytona/skills/pptx/scripts/office/pack.py /home/daytona/workspace/pptx_template_unpacked/ /home/daytona/workspace/HRCT_ILD_Synopsis_Bhargay_Gami.pptx --original /home/daytona/workspace/attachments/284e3a0a-98c6-4083-8082-0a00f79eaaf2/PG_Synopsis_Presentation_Template.pptx` ## IMPORTANT for XML editing: - Read each slide XML file before editing - When replacing text in XML, be careful to preserve the XML structure - only change the text content within `<a:t>` tags - For bullet points, add new `<a:p>` paragraphs following the existing pattern in each slide - Do NOT break the XML structure Return the final file path when done: /home/daytona/workspace/HRCT_ILD_Synopsis_Bhargay_Gami.pptx

Create a complete Research Proposal Word document (.docx) for a medical PG student. ## Output Path: /home/daytona/workspace/HRCT_ILD_Research_Proposal_Bhargay_Gami.docx ## Template Structure (from the existing Research_Proposal_Format.docx at /home/daytona/workspace/attachments/284e3a0a-98c6-4083-8082-0a00f79eaaf2/Research_Proposal_Format.docx): The template has these sections: 1. Order of Documents (cover page info) 2. Covering Letter to Member Secretary, SRC 3. Application Form (table format) 4. Research Study Proposal Format with sections: - Title Page - 1. Introduction - 2. Review of Literature - 3. Research Objectives - 4. Hypothesis/Research Questions - 5. Methodology - 6. Expected Outcomes - 7. Timeline - 8. Budget - 9. References - 10. Appendices 5. Informed Consent Form (English) 6. Informed Consent Form (Gujarati) ## Formatting (as per template instructions): - Font Style: Times New Roman - Font Size: 12pt (body), 14pt (headings) - Line Spacing: 1.5 lines - Margins: 1 inch all sides - Alignment: Justified (body), Centered (titles/headings) - File Format: .docx ## Student Details: - Study Title: "Role of HRCT in Interstitial Lung Disease" - Principal Investigator: Dr. Bhargay Gami - Guide: Dr. Nishant Patel, Associate Professor, Department of Radiodiagnosis - Institution: Nootan Medical College and Research Centre (NMCRC), Visnagar, Gujarat - Department: Radiodiagnosis - Email PI: drbhgami1712@gmail.com - PG Admission: August 2023 - Specialization: MD Radiodiagnosis - Date: July 2026 ## Full Content to Include: ### COVERING LETTER: Date: July 3, 2026 To The Member Secretary, Scientific Review Committee (SRC) Nootan Medical College & Research Centre, Visnagar, Gujarat. Subject: Submission of Research Proposal for Scientific Review Respected Sir/Madam, I hereby submit the research proposal entitled, "Role of HRCT in Interstitial Lung Disease", for review and approval by the Scientific Review Committee (SRC). The study is proposed to be conducted in the Department of Radiodiagnosis. The protocol has been prepared in accordance with institutional and ethical guidelines. I kindly request the Committee to review the proposal and provide its recommendations for further processing. The following documents are enclosed for your kind perusal: 1. Covering Letter addressed to Member Secretary 2. Application Form 3. Research Study Proposal 4. Case Record Form (CRF) / Data Collection Proforma 5. Patient Information Sheet (PIS) 6. Informed Consent Form (ICF) in English and Gujarati 7. Relevant Published Articles / References Thanking you. Yours faithfully, Dr. Bhargay Gami (Principal Investigator) Designation: PG Resident (MD Radiodiagnosis) Department: Radiodiagnosis, NMCRC Visnagar Mobile: (to be filled) Email PI: drbhgami1712@gmail.com Email (Guide): Dr. Nishant Patel, Associate Professor ### APPLICATION FORM (Table): | Field | Details | |-------|---------| | Title of the study | Role of HRCT in Interstitial Lung Disease | | Name of the Principal Investigator (PG Student) | Dr. Bhargay Gami | | Name of the Guide / Research Supervisor | Dr. Nishant Patel, Associate Professor, Dept. of Radiodiagnosis, NMCRC Visnagar | | PG Admission Month Year | August 2023 | | Specialization | MD Radiodiagnosis | | Name of the Guide & Department | Dr. Nishant Patel, Dept. of Radiodiagnosis, NMCRC Visnagar | | Source of funding if any | Self-funded (No external funding) | | Type of the study | Observational Cross-Sectional Study | | Ethical issues involved in the study | Radiation exposure minimized (HRCT performed only when clinically indicated); Written informed consent obtained; No drug administration or invasive procedure for research | | Proposal Enclosed (Yes/No) | Yes | | Whether Consent Form in English & Vernacular Language is Enclosed | Yes (English and Gujarati) | | Is this a special research | No - Animal Experiments: No; Clinical Trial: No; Research on Patented Product: No; Research on Herbal Extract: No | Signature of PI: Dr. Bhargay Gami Signature of Guide: Dr. Nishant Patel ### TITLE PAGE: **ROLE OF HRCT IN INTERSTITIAL LUNG DISEASE** A Research Proposal Submitted to the Scientific Review Committee (SRC) Nootan Medical College and Research Centre, Visnagar Submitted by: Dr. Bhargay Gami PG Resident, MD Radiodiagnosis (2023-2026) Department of Radiodiagnosis Nootan Medical College and Research Centre, Visnagar, Gujarat Under the Guidance of: Dr. Nishant Patel Associate Professor Department of Radiodiagnosis Nootan Medical College and Research Centre, Visnagar Date of Submission: July 2026 ### 1. INTRODUCTION: Interstitial Lung Diseases (ILDs) represent a heterogeneous group of more than 200 diffuse parenchymal lung disorders that primarily affect the alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. These disorders are characterized by varying degrees of inflammation and fibrosis of the lung parenchyma, leading to progressive respiratory impairment and significant morbidity and mortality. The incidence and prevalence of ILD are rising globally, with reported prevalence ranging from 30 to 80 per 100,000 population. In India, the burden of ILD is significant, with hypersensitivity pneumonitis (HP), connective tissue disease-associated ILD (CTD-ILD), and idiopathic pulmonary fibrosis (IPF) being among the most commonly encountered subtypes. The clinical presentation of ILD is often non-specific, with patients presenting with progressive dyspnea, dry cough, and restrictive pattern on pulmonary function tests (PFT). High Resolution Computed Tomography (HRCT) of the chest has emerged as the cornerstone of non-invasive diagnosis of ILD. With thin-section acquisition (1-2 mm slice thickness) and high spatial frequency reconstruction algorithms, HRCT can depict the lung parenchyma in exquisite detail, allowing identification of specific morphological patterns such as honeycombing, ground-glass opacity (GGO), reticulation, traction bronchiectasis, consolidation, and nodules. These patterns, when interpreted in the appropriate clinical context, allow confident classification of ILD subtypes and guide therapeutic decisions. The role of HRCT has been further validated by international guidelines including the 2022 ATS/ERS/JRS/ALAT guidelines for IPF and the Fleischner Society guidelines, which define specific HRCT criteria for usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (NSIP), hypersensitivity pneumonitis (HP), and other ILD patterns. HRCT has thus reduced the need for surgical lung biopsy in a significant proportion of patients. Despite the well-established role of HRCT in ILD diagnosis, there is limited published data from tertiary care centers in North Gujarat regarding the spectrum of HRCT patterns, the distribution of ILD subtypes, and the clinical correlation of HRCT findings in this population. This study aims to address this gap by systematically analyzing HRCT findings in ILD patients presenting to Nootan Medical College and Research Centre, Visnagar. ### 2. REVIEW OF LITERATURE: Numerous landmark studies have established the diagnostic utility of HRCT in ILD: **International Studies:** Wells et al. (1998) demonstrated that HRCT has a sensitivity of 96% and specificity of 86% for the diagnosis of UIP pattern in IPF, reducing the need for open lung biopsy. Sverzellati et al. (2010) showed that HRCT patterns correlate significantly with histopathological findings and are predictive of disease prognosis. The Fleischner Society (Lynch et al., 2018) published comprehensive guidelines defining the HRCT diagnostic criteria for UIP pattern, distinguishing between typical UIP, probable UIP, indeterminate, and alternative diagnosis categories. Raghu et al. (2022) published updated ATS/ERS/JRS/ALAT guidelines for IPF diagnosis, endorsing HRCT as the first-line investigation in all patients with suspected ILD. HRCT-based diagnosis of typical UIP pattern in the appropriate clinical context is now considered sufficient for IPF diagnosis without surgical lung biopsy. Kim et al. (2019) in a systematic review of HRCT in CTD-ILD found that NSIP pattern on HRCT is the most common pattern in connective tissue disease-associated ILD, particularly in systemic sclerosis and polymyositis/dermatomyositis. Salisbury et al. (2017) demonstrated that traction bronchiectasis and extent of reticulation on HRCT are independent predictors of mortality in IPF, highlighting the prognostic role of HRCT. **Indian Studies:** Sharma et al. (2014) in a multicenter Indian study reported that HP (25-30%) and CTD-ILD (20-25%) are more prevalent than IPF (15-20%) in Indian ILD patients, contrasting with Western data where IPF predominates. Dhooria et al. (2019) analyzed 1,084 ILD patients from PGIMER Chandigarh and found that HRCT diagnosis correlated with final clinical diagnosis in 78% of cases. Regional data from Gujarat and North India remains sparse, underscoring the need for local studies. **Research Gaps:** - Limited data on the spectrum of ILD from tertiary care centers in North Gujarat - Absence of local data on HRCT pattern distribution correlating with clinical and serological findings - Need for validation of international HRCT diagnostic criteria in Indian patient population ### 3. RESEARCH OBJECTIVES: **Primary Objectives:** 1. To describe the spectrum of HRCT patterns in patients with clinically suspected Interstitial Lung Disease presenting to NMCRC, Visnagar 2. To classify ILD subtypes based on HRCT findings as per 2022 ATS/ERS/JRS/ALAT guidelines and Fleischner Society criteria **Secondary Objectives:** 1. To correlate HRCT findings with clinical presentations, pulmonary function test (PFT) results, and serological markers 2. To evaluate the diagnostic accuracy of HRCT in differentiating various ILD subtypes 3. To determine the frequency distribution of individual ILD subtypes (UIP/IPF, NSIP, HP, CTD-ILD, COP, DIP, RB-ILD, LIP) in the study population 4. To assess inter-observer agreement in HRCT pattern recognition ### 4. HYPOTHESIS / RESEARCH QUESTIONS: **Primary Hypothesis:** HRCT chest demonstrates specific and reproducible morphological patterns that allow accurate classification of ILD subtypes, correlating significantly with clinical presentations and serological findings. **Null Hypothesis (H0):** There is no significant correlation between HRCT patterns and clinical/serological findings in patients with ILD. **Research Questions:** 1. What is the frequency distribution of HRCT patterns (honeycombing, GGO, reticulation, traction bronchiectasis, consolidation, nodules) in ILD patients presenting to NMCRC? 2. Which ILD subtypes are most prevalent in this North Gujarat population? 3. What is the correlation between HRCT findings and clinical parameters (PFT, serology) in ILD patients? 4. What is the diagnostic accuracy of HRCT in distinguishing UIP from non-UIP patterns? ### 5. METHODOLOGY: **Study Design:** Observational cross-sectional study **Study Setting:** Department of Radiodiagnosis, Nootan Medical College and Research Centre, Visnagar, Gujarat (364315) **Study Duration:** 18 months (January 2025 - June 2026) **Study Population:** All patients referred to the Department of Radiodiagnosis for HRCT chest with clinical suspicion of ILD **Sample Size Calculation:** Using prevalence-based formula: n = Z²P(1-P)/d² Where: Z = 1.96 (95% CI), P = estimated prevalence of ILD = 0.15, d = precision = 0.10 Calculated n = 49; adding 20% for non-response: minimum sample size = 60 patients **Inclusion Criteria:** 1. Age ≥ 18 years 2. Clinical suspicion of ILD (progressive dyspnea, bilateral crackles, PFT showing restrictive pattern) 3. Referred for HRCT chest to the Department of Radiodiagnosis, NMCRC 4. Willing to participate and provide written informed consent **Exclusion Criteria:** 1. Known malignancy (primary lung cancer or metastatic disease) 2. Active pulmonary tuberculosis 3. Acute respiratory infection 4. Inability to cooperate for HRCT examination 5. Patients with contraindications to CT (e.g., severe contrast allergy if contrast required) 6. Patients who refuse to give consent **HRCT Protocol:** - Machine: 64-slice MDCT scanner - Slice thickness: 1 mm - Reconstruction: High spatial frequency algorithm (bone kernel) - Field of view: Lung - Window settings: Lung window (WL: -600 HU, WW: 1500 HU) and Mediastinal window - Positioning: Supine; additional prone images in cases with dependent opacity to distinguish from fibrosis - No intravenous contrast for standard HRCT **HRCT Assessment Parameters:** 1. Pattern of abnormality: Ground glass opacity, reticulation, honeycombing, traction bronchiectasis, consolidation, mosaic attenuation, nodules, cysts, air trapping 2. Distribution: Upper/mid/lower zone predominance; central/peripheral/diffuse; unilateral/bilateral 3. Associated findings: Pleural effusion, mediastinal lymphadenopathy, pulmonary hypertension signs **Data Collection:** - Structured proforma for each patient - Clinical data: Age, sex, BMI, occupation, smoking history, symptoms, duration, drug history, connective tissue disease diagnosis - Investigations: PFT (FVC, FEV1, DLCO), ANA, anti-dsDNA, RF, anti-CCP, ANCA, serum precipitins (for HP) - HRCT analysis by two independent radiologists; discordance resolved by senior consultant - ILD classification using 2022 ATS/ERS/JRS/ALAT and Fleischner Society 2018 criteria **Ethical Considerations:** - Ethics approval from Institutional Ethics Committee (IEC), NMCRC Visnagar - Written informed consent in English and Gujarati - HRCT performed only when clinically indicated - No extra investigations performed solely for research - Data stored with coded identifiers; confidentiality maintained ### 6. EXPECTED OUTCOMES: 1. To establish a local registry of ILD patients with HRCT pattern distribution from North Gujarat 2. To define the relative frequency of ILD subtypes (UIP, NSIP, HP, CTD-ILD, COP, DIP) in this population 3. To demonstrate the diagnostic utility of HRCT in non-invasive ILD characterization 4. To provide evidence-based data for clinicians to optimize diagnostic pathways for ILD in resource-limited settings 5. Potential for publication in a peer-reviewed indexed journal (e.g., Indian Journal of Radiology and Imaging, European Radiology) 6. This data may contribute to larger multicenter national ILD registries ### 7. TIMELINE: | Phase | Activity | Duration | |-------|----------|----------| | Phase 1 | Protocol finalization, SRC submission, Ethics approval | Month 1-2 (Jan-Feb 2025) | | Phase 2 | Patient recruitment and data collection | Month 3-16 (Mar 2025 - Apr 2026) | | Phase 3 | Data compilation and analysis | Month 17-18 (May-Jun 2026) | | Phase 4 | Thesis writing and review | Month 18-20 (Jun-Aug 2026) | | Phase 5 | Thesis submission and viva | Month 21 (Sep 2026) | ### 8. BUDGET: | Item | Estimated Cost (INR) | |------|---------------------| | Stationery and printing | 2,000 | | Data collection proformas | 1,500 | | Statistical software (SPSS) | Institutional license available | | Literature and article procurement | 3,000 | | Miscellaneous | 2,000 | | **Total** | **~8,500** | Note: HRCT scans are performed as per clinical indication at no extra cost to patients. No external funding required. ### 9. REFERENCES (Vancouver style): 1. Raghu G, Remy-Jardin M, Richeldi L, et al. Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med. 2022;205(9):e18-e47. 2. Lynch DA, Sverzellati N, Travis WD, et al. Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper. Lancet Respir Med. 2018;6(2):138-153. 3. Wells AU, Hansell DM, Rubens MB, et al. The predictive value of appearances on thin-section computed tomography in fibrosing alveolitis. Am Rev Respir Dis. 1998;148(4):1076-1082. 4. Sverzellati N, Wells AU, Tomassetti S, et al. Biopsy-proved idiopathic pulmonary fibrosis: spectrum of nondiagnostic thin-section CT diagnoses. Radiology. 2010;254(3):957-964. 5. Kim HJ, Bhatt SP, Sookulporn S, et al. CT patterns and clinical features in connective tissue disease-related ILD: A systematic review. Eur Radiol. 2019;29(3):1369-1379. 6. Salisbury ML, Xia M, Zhou Y, et al. Hypersensitivity pneumonitis: radiologic phenotypes are associated with distinct survival time and pulmonary function trajectory. Chest. 2017;152(5):982-991. 7. Sharma SK, Dhooria S, Aggarwal AN, et al. A multicenter study on the Indian patterns of ILD. Lung India. 2014;31(4):s1-s8. 8. Dhooria S, Singh N, Aggarwal AN, et al. A multicenter study on epidemiology of interstitial lung disease in India. Chest. 2019;155(1):69-78. 9. Travis WD, Costabel U, Hansell DM, et al. An official ATS/ERS/JRS/ALAT statement: Idiopathic interstitial pneumonias: an update. Am J Respir Crit Care Med. 2013;188(6):733-748. 10. Flaherty KR, King TE Jr, Raghu G, et al. Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis? Am J Respir Crit Care Med. 2004;170(8):904-910. ### 10. APPENDICES: Appendix A: Data Collection Proforma (to be attached separately) Appendix B: Patient Information Sheet - English (to be attached separately) Appendix C: Patient Information Sheet - Gujarati (to be attached separately) Appendix D: Informed Consent Form - English Appendix E: Informed Consent Form - Gujarati ### INFORMED CONSENT FORM (English): Title of the Study: Role of HRCT in Interstitial Lung Disease Principal Investigator: Dr. Bhargay Gami, PG Resident, Department of Radiodiagnosis, Nootan Medical College and Research Centre, Visnagar [Standard consent form text as per the template format with all the numbered points about voluntary participation, confidentiality, etc.] ## INSTRUCTIONS: 1. Read the DOCX skill: /home/daytona/skills/docx/SKILL.md 2. Create a professional Word document using the docx JavaScript library 3. Follow the exact formatting: Times New Roman, 12pt body, 14pt headings, 1.5 line spacing, 1 inch margins 4. Include ALL sections in order: Cover page showing order of documents, Covering Letter, Application Form (as a table), Title Page, all 10 research proposal sections, Informed Consent Form in English, and Informed Consent Form in Gujarati (standard template text) 5. Use proper heading hierarchy and page breaks between major sections 6. Make the document look professional and complete 7. Save to: /home/daytona/workspace/HRCT_ILD_Research_Proposal_Bhargay_Gami.docx 8. Validate the document after creation 9. Return the final file path The Gujarati ICF content from the template is: Title: અભ્યાસનું શીર્ષક: Role of HRCT in Interstitial Lung Disease PI: Dr. Bhargay Gami Use the standard Gujarati ICF template text: - "મને ઉપરોક્ત અભ્યાસનો હેતુ અને તેની પ્રક્રિયા વિશે સમજાવવામાં આવ્યું છે..." - All 6 numbered points in Gujarati - Signature fields in Gujarati

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