vaxtang lagvilava shared a form Header profile photo vaxtang lagvilava (v.lagvilava@seu.edu.ge) has invited you to respond to the following form: Bio II (Lesson VIII) Snapshot of the item below: Google Forms Having trouble viewing or submitting this form? Fill out in Google Forms . Bio II (Lesson VIII) Acetylcholine (ACh) in the CNS is mainly involved in: A. Pain reflexes B. Cognitive processes C. Visual acuity D. Muscle hypertrophy after release into the synaptic cleft, ACh is rapidly degraded by: A. Monoamine oxidase B. Catechol-O-methyltransferase C. Acetylcholinesterase D. Choline acetyltransferase The high-affinity choline transporter responsible for choline reuptake into cholinergic terminals is: A. VAChT B. CHT1 C. DAT D. NET New evidence suggests that ACh can: A. Only act on plasma membrane receptors B. Be transported into postsynaptic neurons C. Be synthesized postsynaptically D. Inhibit dopamine release directly Intracellular M1 muscarinic receptors are prominently located in the: A. Nucleus only B. Golgi apparatus C. Lysosomes D. Synaptic vesicles Among muscarinic receptor subtypes, the most abundant in the CNS is: A. M1 B. M3 C. M2 D. M5 Surface M1 mAChRs primarily mediate: A. ERK activation over minutes B. PIP2 hydrolysis and rapid Ca²⁺ increase C. Gene transcription D. Protein synthesis Intracellular M1 receptors mainly activate: A. PIP2 pathway B. cAMP pathway C. ERK1/2 pathway D. Dopamine signaling Early-phase LTP is mainly associated with: A. ERK activation B. Gene transcription C. Rapid Ca²⁺ elevation D. Protein degradation Late-phase LTP depends primarily on: A. Sodium influx B. MAPK/ERK cascade C. Immediate membrane depolarization D. Acetylcholine hydrolysis M1 knockout mice show deficits in: A. Vision B. Working memory C. Hearing D. Motor reflexes only The main nicotinic receptor subtype highly permeable to Ca²⁺ is: A. α1 B. M2 C. β1 D. α7 Intracellular nicotinic receptors have been identified in: A. Lysosomes B. Mitochondria C. Ribosomes D. Microtubules ACh uptake into postsynaptic neurons is: A. Passive diffusion B. Mediated by a proposed ACh transporter C. Voltage-gated D. Dependent on dopamine ACh uptake is temperature-dependent, suggesting: A. Diffusion B. Enzymatic degradation C. Active transport D. Vesicular exocytosis ACh uptake is inhibited by: A. Glutamate B. GABA C. Hemicholinium-3 (HC-3) D. Dopamine Clinically used AChE inhibitors include: A. Fluoxetine B. Donepezil C. Haloperidol D. Diazepam Presynaptic muscarinic autoreceptors mainly involved in autoinhibition are: A. M2 B. M1 C. M3 D. M5 Blocking presynaptic mAChRs with atropine results in: A. Reduced ACh release B. Increased ACh release C. No change D. Dopamine suppression HC-3 at low concentrations selectively inhibits: A. ACh uptake B. M2 receptors C. CHT1 D. AChE Physiological plasma choline concentration is approximately: A. 1–2 μM B. 5–7 μM C. 10–50 μM D. 100 μM The early facilitation of NMDAR-dependent LTP is mediated mainly by: A. Intracellular M1 B. Surface M1 C. M2 receptors D. α7 nAChRs Dopamine is converted to norepinephrine by: A. Tyrosine hydroxylase B. Monoamine oxidase C. Dopamine-β-hydroxylase D. PNMT Dopamine-β-hydroxylase (DBH) is located primarily in the: A. Cytoplasm only B. Synaptic vesicles C. Nucleus D. Mitochondria DBH requires which metal ions for activity? A. Iron B. Zinc C. Copper D. Magnesium DBH is also known as: A. Catechol-O-methyltransferase B. Dopamine β-monooxygenase C. Aromatic L-amino acid decarboxylase D. Aldehyde reductase The electron donor used by DBH during hydroxylation is: A. NADH B. FAD C. Ascorbic acid D. ATP PNMT catalyzes the conversion of norepinephrine to: A. Dopamine B. Epinephrine C. DHPG D. DOPAC PNMT uses which methyl donor? A. ATP B. NADPH C. S-adenosylmethionine (SAM) D. FAD PNMT is best described as a: A. Membrane-bound dimer B. 30 kDa soluble monomer C. Tetrameric enzyme D. Mitochondrial enzyme DAT and NET are located: A. Directly in the synaptic cleft B. On postsynaptic membranes C. Outside the synaptic cleft D. In the nucleus Dopamine is primarily metabolized by MAO into: A. DHPG B. MHPG C. DOPAC D. VMA Norepinephrine is primarily converted to: A. DOPAC B. DHPG C. Dopamine D. Epinephrine The β-hydroxyl group on norepinephrine favors metabolism via: A. MAO only B. COMT only C. Aldehyde reductase D. TH DHPG is further metabolized by COMT to: A. VMA B. MHPG C. DOPAC D. HVA The major urinary metabolite of norepinephrine and epinephrine in humans is: A. DOPAC B. MHPG C. VMA D. DHPG All adrenergic receptors belong to which receptor class? A. Ionotropic receptors B. GPCRs C. Nuclear receptors D. Enzyme-linked receptors Adrenergic receptors contain how many transmembrane domains? . 6 C. 7 D. 8 α1-adrenergic receptors are coupled to: A. Gi B. Gs C. Gq D. Gt α2-adrenergic receptors are coupled to: A. Gq B. Gi C. Gs D. Golf β1–3 adrenergic receptors are coupled to: A. Gi B. Gq C. Gs D. G12 Powered by Google Forms This form was created inside of Georgian National University SEU. Report Abuse - Terms of Service - Additional Terms Create your own Google Form Google LLC, 1600 Amphitheatre Parkway, Mountain View, CA 94043, USA You have received this email because v.lagvilava@seu.edu.ge shared a file or folder located in Google Drive with you. Google Answer the following with optins