Here is a comprehensive guide to ECG interpretation, drawn from authoritative textbook sources and current guidelines:
ECG Interpretation Guidelines
Sources: Harrison's Principles of Internal Medicine 22E (2025), Tintinalli's Emergency Medicine, AHA/ACCF/HRS Scientific Statements
The 14-Step Systematic Approach
(Harrison's Principles of Internal Medicine, 22nd Ed, 2025)
Every ECG must be analysed in this order — errors of omission are the most common mistake:
| # | Parameter | What to Assess |
|---|
| 1 | Standardisation & Technical | Calibration (1 mV = 10 mm), paper speed (25 mm/s), lead placement, artefacts |
| 2 | Rhythm | Sinus vs non-sinus; regular vs irregular |
| 3 | Heart Rate | 60–100 bpm normal; calculate from RR interval |
| 4 | PR Interval / AV Conduction | Normal 120–200 ms; look for blocks |
| 5 | QRS Duration | Normal < 120 ms; widened in BBB, pacing |
| 6 | QT / QTc Interval | QTc < 440 ms (men), < 460 ms (women) |
| 7 | Mean QRS Electrical Axis | Normal −30° to +90°; LAD or RAD |
| 8 | P Waves | Morphology, duration, axis (normal upright in I, II) |
| 9 | QRS Voltages | LVH / RVH criteria |
| 10 | Precordial R-Wave Progression | Normal R grows V1→V5; poor progression suggests old anterior MI |
| 11 | Abnormal Q Waves | Pathological Q ≥ 40 ms wide or ≥ 25% of R height |
| 12 | ST Segments | Elevation, depression, morphology |
| 13 | T Waves | Inversion, peaking, symmetry |
| 14 | U Waves | Prominent U = hypokalaemia, bradycardia |
"Comparison with any previous ECGs is invaluable." — Harrison's, 22E
Normal Values Reference
| Parameter | Normal Range |
|---|
| HR | 60–100 bpm |
| PR interval | 120–200 ms |
| QRS duration | < 120 ms |
| QTc (men) | < 440 ms |
| QTc (women) | < 460 ms |
| QRS axis | −30° to +90° |
| R-wave progression | Transition V3–V4 |
Rhythm Interpretation
Sinus Rhythm criteria:
- P wave before every QRS
- P upright in I, II; inverted in aVR
- Constant PR interval
- Rate 60–100 bpm
Key Arrhythmias to Identify:
| Arrhythmia | Key Feature |
|---|
| Sinus tachycardia | Rate > 100, normal P waves |
| Sinus bradycardia | Rate < 60, normal P waves |
| AF | Absent P waves, irregularly irregular |
| AFL | Sawtooth flutter waves ~300/min, regular |
| SVT | Narrow QRS, rate 150–250, P waves hidden |
| VT | Wide QRS > 120 ms, rate > 100, AV dissociation |
| AV blocks | PR prolonged (1°), dropped beats (2°), no conduction (3°) |
| LBBB | Wide QRS, negative V1, broad notched R in I, V5–V6 |
| RBBB | Wide QRS, RSR' in V1 ("M" pattern), broad S in I, V6 |
ST-Segment & Ischaemia Patterns
STEMI Criteria (elevation in ≥2 contiguous leads):
- ≥ 1 mm in limb leads
- ≥ 2 mm in V1–V3 (men); ≥ 1.5 mm in V1–V3 (women)
- New LBBB with concordant ST changes
Localisation of MI:
| Territory | Leads | Artery |
|---|
| Inferior | II, III, aVF | RCA |
| Anterior | V1–V4 | LAD |
| Lateral | I, aVL, V5–V6 | LCx |
| Posterior | ST depression V1–V3 + tall R V1 | RCA / LCx |
| RV | ST elevation V1 + V4R | Proximal RCA |
Conditions Where ECG Interpretation is Difficult
(Tintinalli's Emergency Medicine)
Can Mimic ST Elevation (without AMI):
- Early repolarisation
- Left ventricular hypertrophy
- Pericarditis / Myocarditis
- LV aneurysm
- LBBB / Ventricular paced rhythm
- Takotsubo cardiomyopathy
- Hypothermia (Osborn J-waves)
- Hypertrophic cardiomyopathy
ST Depression WITHOUT Ischaemia:
- Hypokalaemia
- Digoxin effect
- Cor pulmonale / right heart strain
- Early repolarisation
T-Wave Inversions WITHOUT Ischaemia:
- Persistent juvenile pattern (V1–V3 in young women)
- Post-tachycardia T-wave inversion
- CNS haemorrhage / intracranial pathology
- Pulmonary embolism
- RBBB
- Myocardial contusion
LVH Voltage Criteria
| Criterion | Threshold |
|---|
| Sokolow-Lyon | SV1 + RV5 (or RV6) ≥ 3.5 mV |
| Cornell | RaVL + SV3 > 2.8 mV (men), > 2.0 mV (women) |
| Limb lead | R in aVL > 1.2 mV |
LVH with repolarisation changes ("strain pattern") = ST depression and T-wave inversion in lateral leads.
Special Patterns to Recognise
| Pattern | ECG Features | Significance |
|---|
| Wellens' Syndrome | Biphasic / deep T-wave inversion V2–V3, pain-free | Critical LAD stenosis |
| de Winter T-waves | Upsloping ST depression + tall peaked T V1–V6 | Proximal LAD occlusion, STEMI equivalent |
| Brugada Type 1 | Coved ST elevation ≥ 2 mm, T inversion V1–V2 | SCD risk |
| Long QT | QTc > 440 ms (men) / 460 ms (women) | Torsades de Pointes risk |
| Hyperkalaemia | Tall peaked T → wide QRS → sine wave | Life-threatening |
| Digoxin toxicity | Scooped ST "Salvador Dali" depression | Drug toxicity |
| PE | S1Q3T3, sinus tach, RBBB, T inversion V1–V4 | Pulmonary embolism |
Key Guideline References
- AHA/ACCF/HRS Scientific Statement — Standardization and Interpretation of the ECG (Parts I–VI) — the definitive reference
- International Recommendations for ECG in Athletes — Sharma S et al., Eur Heart J 39:1466, 2018 [PMID 29029207]
- 2024 ACC/AHA Perioperative Guideline — guidance on preoperative ECG use
- Goldberger's Clinical Electrocardiography, 10th Ed, 2024 — standard clinical reference text
- ECG Wave-Maven (Harvard) — free self-assessment tool at ecg.bidmc.harvard.edu
⚠️ Automated computerised ECG analyses have major limitations and should never be accepted without careful clinician review. — Harrison's, 22E