You are answering a USMLE-style medical question. Question: A 63-year-old man comes to the physician for the evaluation of an unintentional 10-kg (22-lb) weight loss over the past 6 months. During this period, the patient has had recurrent episodes of high-grade fever, night sweats, and feelings of fatigue. Two months ago, he had herpes zoster that was treated with acyclovir. He appears pale. Temperature is 38.5°C (101.3°F), pulse is 90/min, and blood pressure 130/80 mm Hg. Physical examination shows generalized painless lymphadenopathy. The liver and the spleen are palpated 2–3 cm below the right and the left costal margin, respectively. Laboratory studies show: Hematocrit 42% Leukocyte count 15,000/mm3 Segmented neutrophils 46% Eosinophils 1% Lymphocytes 50% Monocytes 3% Platelet count 120,000/mm3 Blood smear shows mature lymphocytes that rupture easily and appear as artifacts on a blood smear. Flow cytometry shows lymphocytes expressing CD5, CD19, CD20, and CD23. Which of the following is the most appropriate treatment?" Options: A) All-trans retinoic acid B) Fludarabine, cyclophosphamide, rituximab C) Observation and disease progression monitoring D) Imatinib only " Reply with ONLY the letter of the correct answer (A, B, C, or D). No explanation.