A 29-year-old heterosexual man presented in OPD with high-grade fever, headache and productive cough and rapid breathing. He gives history of chronic diarrhea, progressive fatigue and weight loss of about 13 kg during the last 6 months. On examination, he has generalised lymphadenopathy and mild hepatosplenomegaly. The skin shows many warts on neck, hands and genitals. On lung biopsy shows histoplasmosis granulomatous inflammation. CNS examination shows stiffness of neck, positive Kernig's sign. Fundus examination shows chorioretinitis. 1. What is the probable diagnosis? 2. Discuss the clinical pathological correlation with pathogenesis of the features. 3. What are clinical criteria to confirm the diagnosis? 4. How will you investigate the disease? 5. Which tumors can result after prolonged illness?