Results: Study Dropout Profile (Figure D.1)
Enrollment & Completion (Panel A)
A total of enrolled participants were assessed across Group A and Group B. Both groups demonstrated comparable completion rates, with dropout rates annotated directly on the figure. The overall attrition was low and broadly similar between groups.
Dropout Reasons — Overall Distribution (Panel B)
The stacked bar chart revealed that the majority of dropouts in both groups were attributable to administrative or patient-initiated reasons, indicating that study-related factors played a minimal role in attrition. This pattern was consistent across both arms.
Specific Dropout Reasons — Group Comparison (Panel C)
Among the specific reasons captured:
- Lost to follow-up was the most frequently cited dropout reason in both Group A and Group B.
- Adverse event (AE)-related dropout was recorded in Group A only (n=1), with no AE-related dropouts in Group B. Given the singular occurrence, this difference is unlikely to reflect a meaningful safety signal.
- All remaining dropout categories were either absent or negligible in both groups.
Statistical Comparison
A Chi-Square test of dropout reason distributions yielded p = 0.812 (NS), confirming that the dropout profiles of Group A and Group B were statistically comparable. No significant between-group difference in attrition pattern was identified.
Observation
Overall dropout profiles were well-matched between the two groups. The near-identical distribution of dropout reasons, dominated by administrative/patient-initiated causes, suggests that trial participation burden or safety concerns did not differentially affect retention in either arm. The single AE-related dropout in Group A does not alter this interpretation. These findings support the comparability of both groups through study completion.