Classification of dyspepsia and differences between the functional and organic forms. The main reasons for the development of dyspeptic syndrome. Diagnostic criteria for gastric dyspepsia. Diagnostic criteria for intestinal dyspepsia. Diagnostic criteria for pancreatic dyspepsia. Diagnostic criteria for hepatic dyspepsia. Diagnostic criteria for biliary dyspensia The main aggressive and protective factors of the gastric mucosa. Diagnostic criteria for chronic cholecystitis. Diagnostic criteria for chronic pancreatitis. Diagnostic criteria for enteritis. or Diagnostic criteria for colitis. Differential diagnosis of Crohn's disease and ulcerative colitis. Laboratory and instrumental methods for diagnosing pancreatitis. Complications of gastric ulcer and duodenal ulcer. Basic methods of instrumental diagnostics of peptic ulcer disease. Basic approaches to the treatment of gastric dyspepsia. Basic approaches to the treatment of intestinal dyspepsia. Principles of treatment of dyspeptic syndrome in pancreatitis and cholecystitis.

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#TopicKey Points
1Classification of dyspepsiaUninvestigated → Organic vs. Functional; Rome IV (PDS/EPS)
2Causes of dyspeptic syndromePUD, GERD, cancer, biliary/pancreatic, drugs, H. pylori; functional mechanisms
3Gastric dyspepsia criteriaRome IV: postprandial fullness, early satiation, epigastric pain/burning ≥6 months
4Intestinal dyspepsia criteriaLower abdominal bloating, altered bowel habits, flatulence, steatorrhea
5Pancreatic dyspepsia criteriaBack-radiating pain, steatorrhea, weight loss, postprandial aggravation, new DM
6Hepatic dyspepsia criteriaRUQ heaviness, anorexia, fat intolerance, jaundice, signs of liver disease
7Biliary dyspepsia criteriaEpisodic RUQ biliary colic, fat intolerance, nausea, Murphy's sign
8Aggressive vs. protective factorsHCl/pepsin/H. pylori/NSAIDs vs. mucus/bicarbonate/prostaglandins/blood flow
9Chronic cholecystitisRecurrent biliary colic, US showing stones + thickening, HIDA ejection fraction
10Chronic pancreatitisPain + steatorrhea + DM; calcifications/ductal changes on CT; ↓ fecal elastase
11Enteritis criteriaPeriumbilical pain, watery diarrhea, malabsorption; biopsy for definitive diagnosis
12Colitis criteriaBloody mucoid diarrhea, tenesmus, elevated CRP/fecal calprotectin; colonoscopy
13Crohn's vs. UCSkip lesions/transmural/ileocolonic/fistulas vs. continuous/mucosal/rectal/bloody
14Pancreatitis diagnosticsLipase ≥3×ULN, CT severity index, MRCP, EUS (Rosemont), fecal elastase
15PUD complicationsHemorrhage, perforation, penetration, obstruction, malignant transformation
16PUD instrumental diagnosisEGD (gold standard), barium series, H. pylori tests, CT, gastrin/pH-metry
17Treatment of gastric dyspepsiaTest-and-treat H. pylori; PPI (EPS); prokinetics (PDS); TCAs; CBT
18Treatment of intestinal dyspepsiaTarget cause (diet/gluten-free/antibiotics/enzymes); antispasmodics, probiotics
19Treatment in pancreatitis/cholecystitisPERT + PPI; analgesics; alcohol cessation; UDCA; cholecystectomy; low-fat diet
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