GYN-001: Genitourinary Development

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm, mm
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.platypus import (
    SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle,
    HRFlowable, Image, KeepTogether, PageBreak
)
from reportlab.platypus.flowables import Flowable
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY
from reportlab.graphics.shapes import Drawing, Rect, String, Line, Arrow
from reportlab.graphics import renderPDF
import os

# ── paths ────────────────────────────────────────────────────────────────────
OUT = "/tmp/workspace/gyn001-pdf/GYN001_Genitourinary_Development.pdf"
IMG1 = "/tmp/workspace/gyn001-pdf/unicornuate_hsg.jpg"
IMG2 = "/tmp/workspace/gyn001-pdf/bicornuate_mri.jpg"

# ── colour palette ────────────────────────────────────────────────────────────
NAVY   = colors.HexColor("#1a3a5c")
TEAL   = colors.HexColor("#0d6e8a")
MINT   = colors.HexColor("#e8f7f9")
AMBER  = colors.HexColor("#f5a623")
LGREY  = colors.HexColor("#f2f4f6")
WHITE  = colors.white
BLACK  = colors.HexColor("#1a1a1a")
RED    = colors.HexColor("#c0392b")
GREEN  = colors.HexColor("#27ae60")

# ── document ──────────────────────────────────────────────────────────────────
doc = SimpleDocTemplate(
    OUT, pagesize=A4,
    leftMargin=1.8*cm, rightMargin=1.8*cm,
    topMargin=2*cm, bottomMargin=2*cm
)
W = A4[0] - 3.6*cm   # usable width

# ── styles ────────────────────────────────────────────────────────────────────
ss = getSampleStyleSheet()

def S(name, **kw):
    return ParagraphStyle(name, **kw)

title_sty   = S("Title2",   fontName="Helvetica-Bold", fontSize=20,
                textColor=WHITE, alignment=TA_CENTER, spaceAfter=4)
sub_sty     = S("Sub",      fontName="Helvetica", fontSize=10,
                textColor=colors.HexColor("#d0e8f0"), alignment=TA_CENTER)
h1_sty      = S("H1",       fontName="Helvetica-Bold", fontSize=13,
                textColor=WHITE, spaceBefore=6, spaceAfter=2, leading=16)
h2_sty      = S("H2",       fontName="Helvetica-Bold", fontSize=11,
                textColor=NAVY, spaceBefore=8, spaceAfter=3)
h3_sty      = S("H3",       fontName="Helvetica-BoldOblique", fontSize=10,
                textColor=TEAL, spaceBefore=5, spaceAfter=2)
body_sty    = S("Body2",    fontName="Helvetica", fontSize=9,
                textColor=BLACK, leading=13, spaceAfter=3, alignment=TA_JUSTIFY)
bullet_sty  = S("Bullet2",  fontName="Helvetica", fontSize=9,
                textColor=BLACK, leading=13, leftIndent=12,
                bulletIndent=0, spaceAfter=2)
note_sty    = S("Note",     fontName="Helvetica-Oblique", fontSize=8,
                textColor=colors.HexColor("#555555"), spaceAfter=4)
caption_sty = S("Cap",      fontName="Helvetica-Oblique", fontSize=8,
                textColor=TEAL, alignment=TA_CENTER, spaceAfter=6)

def b(t): return f"<b>{t}</b>"
def i(t): return f"<i>{t}</i>"
def c(t, col): return f'<font color="{col}">{t}</font>'

# ── helper flowables ──────────────────────────────────────────────────────────
def section_header(title, lo=None):
    """Coloured section header band."""
    data = [[Paragraph(title, h1_sty)]]
    if lo:
        data[0].append(Paragraph(lo, S("LO", fontName="Helvetica",
                                        fontSize=8, textColor=colors.HexColor("#a8d8ea"))))
    t = Table([[Paragraph(title, h1_sty)]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0), (-1,-1), NAVY),
        ("TOPPADDING",  (0,0), (-1,-1), 6),
        ("BOTTOMPADDING",(0,0),(-1,-1), 6),
        ("LEFTPADDING", (0,0), (-1,-1), 10),
    ]))
    return t

def lo_badge(text):
    """Small teal learning-objective badge."""
    t = Table([[Paragraph(text, S("LO2", fontName="Helvetica-Bold", fontSize=8,
                                   textColor=WHITE))]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0), (-1,-1), TEAL),
        ("TOPPADDING",  (0,0), (-1,-1), 4),
        ("BOTTOMPADDING",(0,0),(-1,-1), 4),
        ("LEFTPADDING", (0,0), (-1,-1), 8),
    ]))
    return t

def box_table(rows, col_w, header=True):
    """Styled data table."""
    t = Table(rows, colWidths=col_w)
    style = [
        ("FONTNAME",    (0,0), (-1,-1), "Helvetica"),
        ("FONTSIZE",    (0,0), (-1,-1), 8.5),
        ("GRID",        (0,0), (-1,-1), 0.4, colors.HexColor("#b0c4d4")),
        ("ROWBACKGROUNDS",(0,1),(-1,-1),[WHITE, LGREY]),
        ("TOPPADDING",  (0,0), (-1,-1), 4),
        ("BOTTOMPADDING",(0,0),(-1,-1), 4),
        ("LEFTPADDING", (0,0), (-1,-1), 6),
        ("VALIGN",      (0,0), (-1,-1), "MIDDLE"),
    ]
    if header:
        style += [
            ("BACKGROUND",  (0,0), (-1,0), TEAL),
            ("TEXTCOLOR",   (0,0), (-1,0), WHITE),
            ("FONTNAME",    (0,0), (-1,0), "Helvetica-Bold"),
        ]
    t.setStyle(TableStyle(style))
    return t

def highlight_box(text, bg=MINT):
    t = Table([[Paragraph(text, S("HB", fontName="Helvetica", fontSize=9,
                                   textColor=NAVY, leading=13))]],
              colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND",    (0,0),(-1,-1), bg),
        ("LEFTPADDING",   (0,0),(-1,-1), 10),
        ("RIGHTPADDING",  (0,0),(-1,-1), 10),
        ("TOPPADDING",    (0,0),(-1,-1), 6),
        ("BOTTOMPADDING", (0,0),(-1,-1), 6),
        ("BOX",           (0,0),(-1,-1), 1, TEAL),
    ]))
    return t

def warn_box(text):
    return highlight_box(text, bg=colors.HexColor("#fff3cd"))

# ─────────────────────────────────────────────────────────────────────────────
# FLOWCHART helper  (pure ReportLab Drawing – no external libs)
# ─────────────────────────────────────────────────────────────────────────────
class FlowchartDrawing(Flowable):
    """
    Renders a vertical flowchart from a list of (label, colour) tuples.
    Arrows connect boxes.
    """
    BOX_W = 300
    BOX_H = 28
    GAP   = 14   # space between boxes
    ARR_H = GAP

    def __init__(self, items, width=None):
        Flowable.__init__(self)
        self.items = items   # list of (text, bg_color, text_color)
        self._w = width or self.BOX_W
        n = len(items)
        self._h = n * self.BOX_H + (n-1) * self.GAP + 10

    def wrap(self, availW, availH):
        self._w = min(self._w, availW)
        return (self._w, self._h)

    def draw(self):
        from reportlab.graphics.shapes import Drawing as D, Rect as R, String as St, Line as L
        from reportlab.pdfgen import canvas as cnv_mod
        c = self.canv
        bw = self._w * 0.78
        bx = (self._w - bw) / 2
        y = self._h - 5

        for idx, (text, bg, tc) in enumerate(self.items):
            y -= self.BOX_H
            # box
            c.setFillColor(bg)
            c.setStrokeColor(colors.HexColor("#0d6e8a"))
            c.setLineWidth(0.8)
            c.roundRect(bx, y, bw, self.BOX_H, 4, fill=1, stroke=1)
            # text
            c.setFillColor(tc)
            c.setFont("Helvetica-Bold", 9)
            c.drawCentredString(self._w/2, y + self.BOX_H/2 - 4, text)
            # arrow down (not after last)
            if idx < len(self.items) - 1:
                ax = self._w / 2
                ay_top = y
                ay_bot = y - self.GAP
                c.setStrokeColor(TEAL)
                c.setLineWidth(1.5)
                c.line(ax, ay_top, ax, ay_bot + 6)
                # arrowhead
                c.setFillColor(TEAL)
                c.beginPath()
                c.moveTo(ax, ay_bot)
                c.lineTo(ax-5, ay_bot+7)
                c.lineTo(ax+5, ay_bot+7)
                c.closePath()
                c.fill()
            y -= self.GAP


def embryo_timeline_chart():
    """Returns a Table showing the embryological timeline."""
    rows = [
        [b("Week"), b("Event")],
        ["3-4", "Pronephros forms → regresses (non-functional)"],
        ["4-6", "Mesonephros forms; Wolffian duct appears"],
        ["6",   "Müllerian duct appears; indifferent gonad present in both sexes"],
        ["6-7", "SRY activated → Testis determination (46,XY only)"],
        ["8-9", "AMH produced by Sertoli cells → Müllerian regression in males"],
        ["8-10","Testosterone → Wolffian duct development in males;\nFemales: Wolffian degenerates; Müllerian persists"],
        ["10",  "Only one duct system survives per sex"],
        ["20",  "Female internal genitalia fully formed from Müllerian ducts"],
    ]
    # wrap as Paragraphs
    prows = []
    for i2, row in enumerate(rows):
        sty = S("TCell", fontName="Helvetica-Bold" if i2==0 else "Helvetica",
                fontSize=8.5, leading=12, textColor=WHITE if i2==0 else BLACK)
        prows.append([Paragraph(str(row[0]), sty), Paragraph(str(row[1]), sty)])
    return box_table(prows, [2.2*cm, W-2.2*cm])


# ══════════════════════════════════════════════════════════════════════════════
# BUILD STORY
# ══════════════════════════════════════════════════════════════════════════════
story = []

# ── COVER BAND ────────────────────────────────────────────────────────────────
cover = Table(
    [[Paragraph("GYN-001", S("CT", fontName="Helvetica-Bold", fontSize=28,
                              textColor=WHITE, alignment=TA_CENTER))],
     [Paragraph("Genitourinary Development", title_sty)],
     [Paragraph("MBBS Year-5 | UHS | Academic Year 2025-2026", sub_sty)],
     [Paragraph("Based on: Ten Teachers • Arshad Chohan • Irfan Masood", sub_sty)],
    ], colWidths=[W]
)
cover.setStyle(TableStyle([
    ("BACKGROUND",    (0,0),(-1,-1), NAVY),
    ("TOPPADDING",    (0,0),(-1,-1), 14),
    ("BOTTOMPADDING", (0,0),(-1,-1), 14),
    ("LEFTPADDING",   (0,0),(-1,-1), 14),
]))
story.append(cover)
story.append(Spacer(1, 0.4*cm))

# ── LO LIST ──────────────────────────────────────────────────────────────────
lo_items = [
    "LO1 — Embryological development of female genitourinary structures",
    "LO2 — Sexual differentiation in early embryonic life",
    "LO3 — Congenital anomalies from Müllerian tract disorders",
    "LO4 — Layers & boundaries of abdominal and pelvic cavity",
]
lo_rows = [[Paragraph(b("Learning Objectives"), S("LH", fontName="Helvetica-Bold",
             fontSize=9, textColor=WHITE))]]
for lo in lo_items:
    lo_rows.append([Paragraph("● " + lo, S("LI", fontName="Helvetica",
                    fontSize=8.5, textColor=NAVY, leading=13))])
lo_t = Table(lo_rows, colWidths=[W])
lo_t.setStyle(TableStyle([
    ("BACKGROUND",    (0,0),(0,0), TEAL),
    ("BACKGROUND",    (0,1),(-1,-1), MINT),
    ("TOPPADDING",    (0,0),(-1,-1), 4),
    ("BOTTOMPADDING", (0,0),(-1,-1), 4),
    ("LEFTPADDING",   (0,0),(-1,-1), 10),
    ("BOX",           (0,0),(-1,-1), 1, TEAL),
]))
story.append(lo_t)
story.append(Spacer(1, 0.5*cm))

# ══════════════════════════════════════════════════════════════════════════════
# LO 1 – EMBRYOLOGICAL DEVELOPMENT
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_header("LO1 — Embryological Development of Female Genitourinary Structures"))
story.append(Spacer(1, 0.25*cm))

story.append(Paragraph(b("Three Successive Kidneys (Indifferent Stage — Weeks 1-6)"), h2_sty))
kidney_rows = [
    [b("Kidney System"), b("Weeks"), b("Fate")],
    ["Pronephros",  "3-4", "Non-functional → completely regresses"],
    ["Mesonephros", "4-8", "Functions briefly; Wolffian duct formed; degenerates in females"],
    ["Metanephros", "5+",  "Permanent kidney; ureter is its duct"],
]
prows = []
for i2, r in enumerate(kidney_rows):
    sty = S("T", fontName="Helvetica-Bold" if i2==0 else "Helvetica",
            fontSize=8.5, leading=12, textColor=WHITE if i2==0 else BLACK)
    prows.append([Paragraph(r[0],sty), Paragraph(r[1],sty), Paragraph(r[2],sty)])
story.append(box_table(prows, [3.5*cm, 2*cm, W-5.5*cm]))
story.append(Spacer(1, 0.3*cm))

# Flowchart: Müllerian duct fate in females
story.append(Paragraph(b("Fate of Müllerian Duct in Females (Default Pathway)"), h2_sty))
story.append(Paragraph("Both duct systems coexist until week 7. In the female, Müllerian ducts persist; Wolffian ducts regress.", body_sty))
story.append(Spacer(1, 0.2*cm))

fc1_items = [
    ("WEEK 6 — Müllerian duct evaginates lateral to Wolffian duct", TEAL, WHITE),
    ("Caudal portions fuse in midline → Uterovaginal Canal", colors.HexColor("#1a6b8a"), WHITE),
    ("Cranial (unfused) → Fallopian Tubes + Fimbriae", NAVY, WHITE),
    ("Middle fused → Fundus & Corpus of Uterus", colors.HexColor("#0a4f6e"), WHITE),
    ("Distal fused → Cervix + Upper 1/3 Vagina", TEAL, WHITE),
    ("Urogenital Sinus → Lower 2/3 Vagina + External Genitalia", colors.HexColor("#145374"), WHITE),
]
story.append(FlowchartDrawing(fc1_items, width=W))
story.append(Spacer(1, 0.2*cm))

# Summary table
story.append(Paragraph(b("Müllerian Duct → Adult Structures"), h3_sty))
md_rows = [
    [b("Müllerian Region"), b("Adult Female Structure")],
    ["Cranial (unfused)", "Fallopian tubes (fimbriae from müllerian tunnels)"],
    ["Middle fused", "Fundus & Corpus of Uterus"],
    ["Distal fused (uterovaginal primordium)", "Cervix + upper 1/3 vagina"],
    ["Urogenital sinus", "Lower 2/3 vagina + external genitalia"],
]
pr = []
for i2,r in enumerate(md_rows):
    sty = S("T", fontName="Helvetica-Bold" if i2==0 else "Helvetica",
            fontSize=8.5, leading=12, textColor=WHITE if i2==0 else BLACK)
    pr.append([Paragraph(r[0],sty), Paragraph(r[1],sty)])
story.append(box_table(pr, [6*cm, W-6*cm]))
story.append(Spacer(1, 0.15*cm))
story.append(note_sty and Paragraph(
    i("Source: Medical Physiology (Boron & Boulpaep) p.1578; Berek & Novak's Gynecology"), note_sty))
story.append(Spacer(1, 0.4*cm))

# ══════════════════════════════════════════════════════════════════════════════
# LO 2 – SEXUAL DIFFERENTIATION
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_header("LO2 — Sexual Differentiation in Early Embryonic Life"))
story.append(Spacer(1, 0.25*cm))

story.append(highlight_box(
    b("KEY PRINCIPLE: ") + "The default developmental pathway is FEMALE. "
    "Male differentiation requires active hormonal input from the testes. "
    "(Jost's castration experiments, 1953)"))
story.append(Spacer(1, 0.3*cm))

# Flowchart: differentiation pathway
story.append(Paragraph(b("Sexual Differentiation Flowchart"), h2_sty))

fc2 = [
    ("FERTILIZATION — Genetic Sex Determined (46,XX or 46,XY)", NAVY, WHITE),
    ("Indifferent Gonad (same in both sexes up to wk 6)", colors.HexColor("#555"), WHITE),
    ("46,XY → SRY gene → TDF → TESTIS forms", RED, WHITE),
    ("Sertoli Cells → AMH/MIS → Müllerian ducts REGRESS", colors.HexColor("#8e1a0e"), WHITE),
    ("Leydig Cells → Testosterone → Wolffian ducts DEVELOP", colors.HexColor("#a04000"), WHITE),
    ("46,XX → No SRY → No AMH → Müllerian ducts PERSIST", GREEN, WHITE),
    ("No Testosterone → Wolffian ducts DEGENERATE", colors.HexColor("#1a6b3a"), WHITE),
    ("FEMALE internal genitalia formed (default)", TEAL, WHITE),
]
story.append(FlowchartDrawing(fc2, width=W))
story.append(Spacer(1, 0.25*cm))

story.append(Paragraph(b("AMH (Anti-Müllerian Hormone)"), h2_sty))
amh_rows = [
    [b("Feature"), b("Detail")],
    ["Source",     "Sertoli cells of fetal testis"],
    ["Gene locus", "Chromosome 19"],
    ["Structure",  "140 kDa glycoprotein dimer; member of TGF-β superfamily"],
    ["Action",     "Causes regression of Müllerian ducts in male embryos"],
    ["Target",     "Mesenchymal cells of Müllerian duct"],
    ["Trigger",    "Transcription factor SRY may initiate AMH transcription"],
    ["Note",       "Testosterone CANNOT cause Müllerian regression (Jost experiment)"],
]
pr2 = []
for i2,r in enumerate(amh_rows):
    sty = S("T", fontName="Helvetica-Bold" if i2==0 else "Helvetica",
            fontSize=8.5, leading=12, textColor=WHITE if i2==0 else BLACK)
    pr2.append([Paragraph(r[0],sty), Paragraph(r[1],sty)])
story.append(box_table(pr2, [4*cm, W-4*cm]))
story.append(Spacer(1, 0.15*cm))
story.append(Paragraph(i("Source: Medical Physiology p.1580"), note_sty))
story.append(Spacer(1, 0.4*cm))

# Embryological Timeline
story.append(Paragraph(b("Embryological Timeline"), h2_sty))
story.append(embryo_timeline_chart())
story.append(Spacer(1, 0.4*cm))

# ══════════════════════════════════════════════════════════════════════════════
# LO 3 – CONGENITAL ANOMALIES
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_header("LO3 — Congenital Anomalies from Müllerian Tract Disorders"))
story.append(Spacer(1, 0.25*cm))

story.append(warn_box(
    b("Incidence: ") + "3-4% of all women; 5-10% in early pregnancy loss; "
    "up to 25% in second/third trimester losses. "
    "Renal imaging is MANDATORY when a Müllerian anomaly is diagnosed."))
story.append(Spacer(1, 0.3*cm))

# Flowchart: mechanism of anomalies
story.append(Paragraph(b("Mechanism of Müllerian Anomalies"), h2_sty))
fc3 = [
    ("Müllerian duct elongation toward each other", TEAL, WHITE),
    ("Fusion in the midline (by week 20)", colors.HexColor("#1a6b8a"), WHITE),
    ("Resorption of intervening septum", NAVY, WHITE),
    ("Normal uterus, cervix, fallopian tubes, upper vagina", GREEN, WHITE),
]
story.append(FlowchartDrawing(fc3, width=W))

fail_rows = [
    [b("Failure At"), b("Anomaly")],
    ["Duct formation failure", "Agenesis/Hypoplasia → MRKH Syndrome"],
    ["One duct fails to develop", "Unicornuate uterus ± rudimentary horn"],
    ["Complete fusion failure", "Uterus didelphys (double uterus, cervix, vagina)"],
    ["Partial fusion failure", "Bicornuate uterus"],
    ["Septal resorption failure", "Septate uterus (most common anomaly)"],
    ["Mild resorption failure", "Arcuate uterus (mildest form)"],
]
pr3 = []
for i2,r in enumerate(fail_rows):
    sty = S("T", fontName="Helvetica-Bold" if i2==0 else "Helvetica",
            fontSize=8.5, leading=12, textColor=WHITE if i2==0 else BLACK)
    pr3.append([Paragraph(r[0],sty), Paragraph(r[1],sty)])
story.append(Spacer(1, 0.2*cm))
story.append(box_table(pr3, [5.5*cm, W-5.5*cm]))
story.append(Spacer(1, 0.35*cm))

# MRKH box
story.append(Paragraph(b("MRKH Syndrome (Mayer-Rokitansky-Küster-Hauser)"), h2_sty))
mrkh_data = [
    ["Karyotype", "46,XX (genetically normal female)"],
    ["Features",  "Vaginal agenesis + variable uterine development"],
    ["Primary amenorrhea", "10-15% of all cases"],
    ["Associated anomalies", "Renal (absent/horseshoe kidney), skeletal, cardiac, hearing"],
    ["Fertility", "Only via IVF + gestational carrier"],
]
pr4 = []
for r in mrkh_data:
    pr4.append([Paragraph(b(r[0]), S("T", fontName="Helvetica-Bold", fontSize=8.5,
                               leading=12, textColor=NAVY)),
                Paragraph(r[1], S("T", fontName="Helvetica", fontSize=8.5,
                                   leading=12, textColor=BLACK))])
mrkh_t = Table(pr4, colWidths=[4.5*cm, W-4.5*cm])
mrkh_t.setStyle(TableStyle([
    ("BACKGROUND",    (0,0),(-1,-1), MINT),
    ("BOX",           (0,0),(-1,-1), 1.2, TEAL),
    ("INNERGRID",     (0,0),(-1,-1), 0.4, colors.HexColor("#b0d8e0")),
    ("TOPPADDING",    (0,0),(-1,-1), 4),
    ("BOTTOMPADDING", (0,0),(-1,-1), 4),
    ("LEFTPADDING",   (0,0),(-1,-1), 8),
    ("VALIGN",        (0,0),(-1,-1), "TOP"),
]))
story.append(mrkh_t)
story.append(Spacer(1, 0.3*cm))

# Transverse blockages
story.append(Paragraph(b("Transverse Blockages of the Müllerian System"), h2_sty))
story.append(Paragraph(
    "Cause <b>cyclic pain without menstrual bleeding</b> (cryptomenorrhoea) in adolescents.",
    body_sty))
block_rows = [
    [b("Blockage"), b("Consequence")],
    ["Imperforate hymen", "Hematocolpos (most common)"],
    ["Transverse vaginal septum", "Hematocolpos → Hematometra"],
    ["Cervical agenesis", "Hematometra → Hemoperitoneum → Endometriosis"],
]
pr5 = []
for i2,r in enumerate(block_rows):
    sty = S("T", fontName="Helvetica-Bold" if i2==0 else "Helvetica",
            fontSize=8.5, leading=12, textColor=WHITE if i2==0 else BLACK)
    pr5.append([Paragraph(r[0],sty), Paragraph(r[1],sty)])
story.append(box_table(pr5, [5*cm, W-5*cm]))
story.append(Spacer(1, 0.3*cm))

# Exam tips
exam_rows = [
    [b("Anomaly"), b("Key Clinical Fact")],
    ["Septate uterus",    "Most COMMON Müllerian anomaly; most associated with recurrent pregnancy loss"],
    ["Unicornuate uterus","Highest risk of ECTOPIC pregnancy (rudimentary horn)"],
    ["MRKH",             "Primary amenorrhea + normal 2° sex characteristics + normal karyotype 46,XX"],
    ["Any Müllerian anomaly", "Always co-investigate for RENAL anomaly"],
    ["Imaging gold standard", "MRI of pelvis (best sensitivity/specificity)"],
]
pr6 = []
for i2,r in enumerate(exam_rows):
    sty = S("T", fontName="Helvetica-Bold" if i2==0 else "Helvetica",
            fontSize=8.5, leading=12, textColor=WHITE if i2==0 else BLACK)
    pr6.append([Paragraph(r[0],sty), Paragraph(r[1],sty)])
exam_t = box_table(pr6, [4.8*cm, W-4.8*cm])
story.append(Paragraph(b("UHS Exam High-Yield Points"), h3_sty))
story.append(exam_t)
story.append(Spacer(1, 0.3*cm))
story.append(Paragraph(i("Source: Berek & Novak's Gynecology pp.2063-2064"), note_sty))

# ── Clinical images ───────────────────────────────────────────────────────────
story.append(Spacer(1, 0.3*cm))
story.append(Paragraph(b("Clinical Images"), h2_sty))

img_data = [
    [Image(IMG1, width=8*cm, height=6*cm),
     Image(IMG2, width=8*cm, height=6*cm)],
    [Paragraph("Fig 1. HSG showing unicornuate uterus — single elongated cavity with one tube visible. "
               "Class II Müllerian anomaly.", caption_sty),
     Paragraph("Fig 2. MRI showing bicornuate uterus — two distinct uterine horns. "
               "Müllerian partial fusion anomaly.", caption_sty)],
]
img_t = Table(img_data, colWidths=[W/2-0.3*cm, W/2-0.3*cm], hAlign="CENTER")
img_t.setStyle(TableStyle([
    ("ALIGN",        (0,0),(-1,-1), "CENTER"),
    ("VALIGN",       (0,0),(-1,-1), "MIDDLE"),
    ("TOPPADDING",   (0,0),(-1,-1), 4),
    ("BOTTOMPADDING",(0,0),(-1,-1), 4),
]))
story.append(img_t)
story.append(Spacer(1, 0.4*cm))

# ══════════════════════════════════════════════════════════════════════════════
# LO 4 – ABDOMINAL & PELVIC LAYERS
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_header("LO4 — Layers & Boundaries of Abdominal and Pelvic Cavity"))
story.append(Spacer(1, 0.25*cm))

story.append(Paragraph(b("Layers of the Anterior Abdominal Wall (Superficial → Deep)"), h2_sty))
fc4 = [
    ("1. Skin", colors.HexColor("#d4a574"), BLACK),
    ("2. Superficial Fascia — Camper's fascia (fatty)", colors.HexColor("#e8c49a"), BLACK),
    ("3. Deep Fascia — Scarpa's fascia (membranous)", colors.HexColor("#c4956a"), WHITE),
    ("4. Muscles: Ext. Oblique → Int. Oblique → Transversus Abdominis", TEAL, WHITE),
    ("5. Transversalis Fascia", NAVY, WHITE),
    ("6. Extraperitoneal (Preperitoneal) Fat", colors.HexColor("#4a7c59"), WHITE),
    ("7. Parietal Peritoneum", colors.HexColor("#2c5f3f"), WHITE),
]
story.append(FlowchartDrawing(fc4, width=W))
story.append(Spacer(1, 0.2*cm))
story.append(Paragraph(i("Source: Gray's Anatomy for Students"), note_sty))
story.append(Spacer(1, 0.3*cm))

story.append(Paragraph(b("Boundaries of the Abdomino-Pelvic Cavity"), h2_sty))
bound_rows = [
    [b("Boundary"), b("Structure")],
    ["Superior",  "Diaphragm"],
    ["Inferior",  "Pelvic floor (levator ani + coccygeus muscles)"],
    ["Anterior & lateral", "Abdominal wall muscles"],
    ["Posterior", "Vertebral column + posterior abdominal wall muscles\n(psoas, iliacus, quadratus lumborum)"],
]
pr7 = []
for i2,r in enumerate(bound_rows):
    sty = S("T", fontName="Helvetica-Bold" if i2==0 else "Helvetica",
            fontSize=8.5, leading=13, textColor=WHITE if i2==0 else BLACK)
    pr7.append([Paragraph(r[0],sty), Paragraph(r[1],sty)])
story.append(box_table(pr7, [5*cm, W-5*cm]))
story.append(Spacer(1, 0.15*cm))
story.append(Paragraph(i("Source: Gray's Anatomy for Students; Campbell-Walsh Urology"), note_sty))

# ── FOOTER line ───────────────────────────────────────────────────────────────
story.append(Spacer(1, 0.4*cm))
story.append(HRFlowable(width="100%", thickness=1, color=TEAL))
story.append(Spacer(1, 0.1*cm))
footer_t = Table([[
    Paragraph("GYN-001 | UHS MBBS Year-5 | 2025-2026",
              S("F", fontName="Helvetica", fontSize=7.5, textColor=TEAL)),
    Paragraph("Ten Teachers • Arshad Chohan • Irfan Masood",
              S("F2", fontName="Helvetica-Oblique", fontSize=7.5,
                textColor=colors.grey, alignment=TA_CENTER)),
    Paragraph("Medical Physiology • Berek & Novak • Gray's Anatomy",
              S("F3", fontName="Helvetica", fontSize=7.5, textColor=TEAL,
                alignment=TA_LEFT)),
]], colWidths=[W/3, W/3, W/3])
story.append(footer_t)

# ── BUILD ─────────────────────────────────────────────────────────────────────
doc.build(story)
print("PDF generated:", OUT)
print("File size:", os.path.getsize(OUT), "bytes")

Successfully replaced 1 instance(s) of the string in '/tmp/workspace/gyn001-pdf/generate_pdf.py'

Successfully replaced 1 instance(s) of the string in '/tmp/workspace/gyn001-pdf/generate_pdf.py'