No. A Widal titre of 1:160 alone does not mean IV antibiotics are required, and it does not by itself confirm typhoid. Interpretation depends on the local laboratory cutoff, whether it is O or H antibody, symptoms, prior vaccination/infection, and background titres in your area. A blood culture with antibiotic sensitivity, ideally before antibiotics, is much more useful.

IV antibiotics are usually considered when the person is severely unwell, vomiting or unable to take oral medicine, dehydrated/low blood pressure, confused, has abdominal complications, or needs hospital observation. Stable patients with suspected uncomplicated enteric fever can often be treated with an appropriate oral antibiotic selected by a clinician and local resistance patterns. The WHO-linked guidance notes that Widal is not sufficiently sensitive or specific to confirm or exclude typhoid, and IV fluids are for those who are very sick, dehydrated, or hypotensive (WHO guidance excerpt).

Please get evaluated today by a clinician rather than deciding from the titre. Seek urgent care now for persistent high fever with marked weakness, repeated vomiting, severe abdominal pain/distension, bleeding or black stools, confusion, fainting, low urine output, or inability to drink.