Is vancomycin compatible with d5
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vancomycin compatibility D5W dextrose 5% stability IV solution
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Based on well-established pharmaceutical compatibility data, here is a concise answer:
Yes, vancomycin is compatible with D5W (5% Dextrose in Water).
D5W is actually one of the two preferred diluents for vancomycin IV infusion, along with normal saline (0.9% NaCl).
Key Points
| Parameter | Details |
|---|---|
| Compatible diluents | D5W, NS (0.9% NaCl) |
| Recommended concentration | ≤5 mg/mL (to reduce infusion-related reactions) |
| Stability in D5W | 14 days refrigerated (2–8°C); ~7 days at room temperature |
| Infusion rate | ≥60 minutes for doses ≤1g; ≥90 min for doses >1g |
Clinical Notes
- Vancomycin must be adequately diluted regardless of diluent — concentrations >5 mg/mL increase the risk of Red Man Syndrome (histamine-mediated flushing, erythema, hypotension) if infused too rapidly.
- D5W is preferred over NS in some settings where sodium restriction is a concern.
- The solution should be inspected for particulates and discoloration before use; a slight yellow tint is acceptable, but do not use if markedly discolored or precipitate is present.
- Incompatibilities to note: vancomycin is incompatible with heparin, beta-lactam antibiotics (e.g., piperacillin-tazobactam), and several other drugs at certain concentrations — always check Y-site compatibility if co-infusing.
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