This report alone cannot distinguish B12 deficiency from folate deficiency, or exclude other causes such as hypothyroidism, liver disease, alcohol use, medications, hemolysis, or less commonly bone-marrow disorders. The usual next tests are peripheral smear, reticulocyte count, serum
vitamin B12, folate, bilirubin/LDH, thyroid and liver tests. Macro-ovalocytes and hypersegmented neutrophils on smear support megaloblastic anemia, as described in the
MSD diagnostic guidance.