There are some injections such as Slon-M Cortinol P Melonac Ketoject hepgan Dexamethasone Carasil cayonocob slevit give me proper dose rate in mg as well as in ml according to concentration and also guide me when should used give me indications also give me more details as veterinarian
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Slon-M Cortinol-P Melonac Ketoject Hepgan Dexamethasone Carasil Cyanocobalamin Slevit veterinary injection dose mg ml concentration
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Melonac meloxicam veterinary injection 5mg/ml dose Ketoject ketoprofen injection veterinary dose concentration
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Slon-M flunixin meglumine Cortinol-P cortisone prednisolone veterinary injection dose Hepgan heparin veterinary use
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Carasil carprofen injection veterinary dose cyanocobalamin B12 injection veterinary dose Slevit selenium vitamin E injection
Now I have sufficient data to compile a comprehensive veterinary reference. Let me put together the full detailed guide.
Veterinary Injectable Drug Reference Guide
Below is a detailed breakdown of all 9 injectable products you listed, covering their active ingredients, concentrations, dose rates (mg and mL), species, indications, routes, and clinical notes.
1. SLON-M (Flunixin Meglumine)
| Parameter | Details |
|---|---|
| Active Ingredient | Flunixin Meglumine |
| Concentration | 50 mg/mL (83 mg flunixin meglumine equivalent to 50 mg flunixin) |
| Drug Class | NSAID - Non-narcotic analgesic, anti-inflammatory, antipyretic |
Dose Rates
| Species | Dose (mg/kg) | Volume (mL/kg) | Route | Frequency |
|---|---|---|---|---|
| Cattle/Buffalo | 1.1-2.2 mg/kg | 1-2 mL per 45 kg BW | IV (slow) | Once daily or q12h x 3-5 days |
| Horse/Camel | 1.1 mg/kg | 1 mL per 45 kg BW | IV | Once daily x 3-5 days |
| Sheep/Goat | 1.1-2.2 mg/kg | 1-2 mL per 45 kg | Slow IV or IM | Once daily |
| Dog | 1.0 mg/kg | 0.02 mL/kg | Slow IV or IM | Once daily (max 3 days) |
| Pig | 1.0-2.0 mg/kg | 0.02-0.04 mL/kg | SC or slow IV | Once daily; MMA: 2.2 mg/kg IM q12h x 2 doses |
Formula: mL to give = (Body weight kg x dose mg/kg) / 50
Indications
- Pyrexia (fever) associated with bovine respiratory disease (BRD), pneumonia
- Endotoxemia and septicemia
- Acute mastitis (bovine)
- Musculoskeletal pain and lameness
- Visceral/colic pain in horses
- Post-surgical pain and inflammation
- MMA syndrome (metritis, mastitis, agalactia) in pigs
Clinical Notes
- CRITICAL: In cattle, administer IV ONLY. IM/SC use causes severe tissue necrosis, residue violations, and extended withdrawal times (>10 days slaughter; >96 hr milk)
- Do NOT use in dry cows, veal calves, or bulls for breeding (off-label)
- Withdrawal time (IV, cattle): 4 days slaughter, 36 hours milk
- Contraindicated with concurrent NSAID or corticosteroid use
2. CORTINOL-P (Prednisolone Sodium Succinate / Cortisone/Prednisolone Injection)
| Parameter | Details |
|---|---|
| Active Ingredient | Prednisolone sodium succinate (commonly 25 mg/mL or 50 mg/mL) |
| Drug Class | Glucocorticoid corticosteroid |
Dose Rates (Prednisolone Sodium Succinate)
| Species | Dose (mg/kg) | Volume (25 mg/mL) | Route | Frequency |
|---|---|---|---|---|
| Cattle/Horse | 0.5-2.0 mg/kg | 0.02-0.08 mL/kg | IV or IM | Once daily; taper over 3-5 days |
| Dog/Cat | 1.0-2.0 mg/kg (anti-inflam) | 0.04-0.08 mL/kg | IV, IM, SC | Once daily |
| Dog/Cat (shock) | 10-30 mg/kg | 0.4-1.2 mL/kg | IV rapid | Single dose emergency |
| Sheep/Goat | 0.5-1.0 mg/kg | 0.02-0.04 mL/kg | IM | Once daily |
Indications
- Allergic reactions and anaphylaxis
- Inflammatory conditions (arthritis, bursitis, tendinitis)
- Immune-mediated diseases (autoimmune hemolytic anemia, thrombocytopenia)
- Shock and trauma (emergency high-dose)
- Respiratory distress, pulmonary edema
- Ketosis and pregnancy toxemia support (cattle, sheep)
- Skin and dermatological conditions
Clinical Notes
- Immunosuppressive at higher doses - avoid in active infections unless life-threatening
- Can precipitate laminitis in horses (use with caution)
- Do NOT use in late pregnancy - can induce premature parturition in cattle
- Monitor blood glucose in diabetic animals
- Taper dose on discontinuation to avoid adrenal suppression
3. MELONAC (Meloxicam Injection)
| Parameter | Details |
|---|---|
| Active Ingredient | Meloxicam |
| Concentration | 5 mg/mL |
| Drug Class | NSAID - preferential COX-2 inhibitor, oxicam class |
Dose Rates
| Species | Dose (mg/kg) | Volume (5 mg/mL) | Route | Frequency |
|---|---|---|---|---|
| Dog (pain/OA) | 0.2 mg/kg initial | 0.04 mL/kg | IV or SC | Loading dose, then 0.1 mg/kg PO daily |
| Dog (post-op) | 0.2 mg/kg | 0.04 mL/kg | SC or IV pre-op | Single injection |
| Cat (post-op) | 0.3 mg/kg | 0.06 mL/kg | SC only | Single injection ONLY |
| Cattle/Horse | 0.5 mg/kg | 0.1 mL/kg | IV or SC | Once daily x 3-5 days |
| Pig | 0.4 mg/kg | 0.08 mL/kg | IM | Once; repeat after 24h if needed |
| Sheep/Goat | 0.5 mg/kg | 0.1 mL/kg | SC or IM | Once daily x 3 days |
Example calculation: 20 kg dog - 0.2 mg/kg = 4 mg - at 5 mg/mL = 0.8 mL
Indications
- Osteoarthritis pain and inflammation (dogs)
- Post-operative analgesia (soft tissue and orthopedic surgery)
- Musculoskeletal disorders
- Febrile conditions (cattle, pigs)
- Respiratory disease with fever
- Chronic pain management (long-term oral after initial injection)
Clinical Notes
- Preferred NSAID for cats due to COX-2 selectivity, but long-term use in cats is off-label in the US (approved in EU/Canada/Australia)
- Do NOT use in cats with renal disease or dehydration - risk of renal failure
- Safer GI profile than other NSAIDs due to COX-2 preference
- 97% plasma protein bound in dogs
- Do NOT combine with other NSAIDs or corticosteroids
4. KETOJECT (Ketoprofen Injection)
| Parameter | Details |
|---|---|
| Active Ingredient | Ketoprofen |
| Concentration | 100 mg/mL (most common veterinary formulation) |
| Drug Class | NSAID - propionic acid derivative, non-selective COX inhibitor |
Dose Rates
| Species | Dose (mg/kg) | Volume (100 mg/mL) | Route | Frequency |
|---|---|---|---|---|
| Horse | 2.2 mg/kg | 0.022 mL/kg | IV | Once daily x 5 days |
| Cattle/Buffalo | 3.0 mg/kg | 0.03 mL/kg | IV or IM | Once daily x 3-5 days |
| Dog | 1.0-2.0 mg/kg | 0.01-0.02 mL/kg | IV, IM, SC | Once daily x 3-5 days |
| Cat | 1.0 mg/kg | 0.01 mL/kg | SC | Once daily (max 1-3 days) |
| Sheep/Goat | 3.0 mg/kg | 0.03 mL/kg | IM or SC | Once daily x 3 days |
Example: 400 kg cattle @ 3 mg/kg = 1200 mg / 100 mg/mL = 12 mL
Indications
- Musculoskeletal inflammation and pain
- Colic pain (horses)
- Post-surgical analgesia
- Fever and pyrexia
- Respiratory disease associated inflammation
- Mastitis pain management (cattle)
- Acute lameness
Clinical Notes
- Non-selective COX-1/COX-2 inhibitor - higher GI risk than meloxicam
- Avoid concurrent NSAID or steroid use
- Use with caution in animals with GI ulceration history
- Cats are very sensitive - limit duration strictly
- Do NOT use with nephrotoxic drugs or in dehydrated animals
5. HEPGAN (Heparin Sodium Injection)
| Parameter | Details |
|---|---|
| Active Ingredient | Heparin Sodium |
| Concentration | 1,000 IU/mL or 5,000 IU/mL (varies by brand) |
| Drug Class | Anticoagulant - potentiates antithrombin III |
Dose Rates
| Species | Dose | Volume (5,000 IU/mL) | Route | Frequency |
|---|---|---|---|---|
| Dog/Cat (prophylaxis) | 75-100 IU/kg | 0.015-0.02 mL/kg | SC | q6-8 hours |
| Dog/Cat (treatment DIC) | 150-300 IU/kg | 0.03-0.06 mL/kg | SC | q6-8 hours |
| Horse | 100-150 IU/kg | 0.02-0.03 mL/kg | SC or IV | q8-12 hours |
| Cattle | 100-150 IU/kg | 0.02-0.03 mL/kg | IV slow | q8-12 hours |
| Flush dose (catheter) | 10-100 IU/mL | As needed | IV catheter flush | Each use |
Indications
- Disseminated intravascular coagulation (DIC) - prevention and treatment
- Thromboembolism (pulmonary, aortic, venous)
- Post-surgical thromboprophylaxis
- Snake envenomation with coagulopathy
- Feline aortic thromboembolism (FTE)
- Catheter patency maintenance
Clinical Notes
- Monitor activated clotting time (ACT) or aPTT - target 1.5-2x baseline
- Antidote: Protamine sulfate (1 mg neutralizes 100 IU heparin)
- Avoid in active hemorrhage, thrombocytopenia, or platelet dysfunction
- SC preferred over IM (less hematoma risk)
- Store at room temperature; do NOT freeze
- Heparin sodium and heparin calcium - same effect, both used SC
6. DEXAMETHASONE (Dexamethasone Sodium Phosphate)
| Parameter | Details |
|---|---|
| Active Ingredient | Dexamethasone sodium phosphate |
| Concentration | 2 mg/mL or 4 mg/mL |
| Drug Class | Potent synthetic glucocorticoid; 25x more potent than cortisol |
Dose Rates (using 4 mg/mL)
| Species | Dose (mg/kg) | Volume (4 mg/mL) | Route | Indication/Notes |
|---|---|---|---|---|
| Cattle | 0.02-0.06 mg/kg (anti-inflam) | 0.005-0.015 mL/kg | IV or IM | General anti-inflammatory |
| Cattle (parturition induction) | 20-30 mg TOTAL | 5-7.5 mL | IM | 3rd trimester, induces calving in 24-72h |
| Horse | 0.02-0.05 mg/kg | 0.005-0.013 mL/kg | IV or IM | Anti-inflammatory, allergy |
| Dog (anti-inflam) | 0.1-0.25 mg/kg | 0.025-0.063 mL/kg | IV, IM, SC | Once daily |
| Dog (shock) | 2.0-3.0 mg/kg | 0.5-0.75 mL/kg | IV rapid | Emergency single dose |
| Cat | 0.1-0.25 mg/kg | 0.025-0.063 mL/kg | IV, IM, SC | Anti-inflammatory |
| Sheep/Goat | 0.02-0.05 mg/kg | 0.005-0.013 mL/kg | IV or IM | Anti-inflammatory |
| Pig | 0.04-0.06 mg/kg | 0.01-0.015 mL/kg | IM | Anti-inflammatory |
Example: 30 kg dog, shock dose 2 mg/kg = 60 mg / 4 mg/mL = 15 mL (or use 2 mg/mL: 30 mL)
Indications
- Anaphylaxis and severe allergic reactions
- Cerebral edema and spinal cord trauma (high dose)
- Inflammatory conditions (arthritis, dermatitis, uveitis)
- Ketosis and acetonemia in dairy cattle
- Parturition induction (cattle, sheep)
- Immune-mediated diseases
- Equine heaves (recurrent airway obstruction)
- Adrenal insufficiency
- Anti-shock (high dose IV)
Clinical Notes
- NO mineralocorticoid activity - does NOT cause sodium retention
- Most potent commonly used veterinary glucocorticoid
- NEVER use in pregnancy except for planned parturition induction
- Risk of laminitis in horses with pre-existing Cushing's or metabolic syndrome
- Long-term use causes immunosuppression, muscle wasting, Cushing's-like syndrome
- In cattle with mastitis, use with antibiotic cover
- 4 mg/mL preferred for small animals; 2 mg/mL for large animals when large volumes needed
7. CARASIL (Carprofen Injection)
| Parameter | Details |
|---|---|
| Active Ingredient | Carprofen |
| Concentration | 50 mg/mL (injectable; Rimadyl injectable) |
| Drug Class | NSAID - arylpropionic acid class, preferential COX-2 inhibitor |
Dose Rates
| Species | Dose (mg/kg) | Volume (50 mg/mL) | Route | Frequency |
|---|---|---|---|---|
| Dog (surgery) | 4.4 mg/kg | 0.088 mL/kg | SC or IV | Pre-op single dose |
| Dog (chronic pain) | 4.4 mg/kg/day | 0.088 mL/kg | SC initially, then PO | Once daily or divided q12h |
| Cat (post-op) | 4.0 mg/kg | 0.08 mL/kg | SC | Single injection only |
| Cattle/Horse | 0.7-1.4 mg/kg | 0.014-0.028 mL/kg | IV or SC | Once daily x 3-5 days |
Example: 25 kg dog, 4.4 mg/kg = 110 mg / 50 mg/mL = 2.2 mL SC
Indications
- Post-operative pain and inflammation (soft tissue and orthopedic surgery)
- Osteoarthritis and degenerative joint disease (dogs)
- Acute musculoskeletal pain
- Dental pain and oral surgery recovery
- Cancer-associated pain
- Acute pain associated with trauma
Clinical Notes
- 90% oral bioavailability in dogs - injectable often just for perioperative use, then switch to tablets
- 99% plasma protein bound; hepatically metabolized
- Baseline and periodic liver enzyme monitoring recommended for long-term use
- Do NOT use in: hepatic disease, renal disease, bleeding disorders (von Willebrand disease), concurrent NSAIDs or corticosteroids
- Not approved for long-term use in cats in the US
8. CAYONOCOB / CYANOCOBALAMIN (Vitamin B12 Injection)
| Parameter | Details |
|---|---|
| Active Ingredient | Cyanocobalamin (Vitamin B12) |
| Concentration | 250 mcg/mL, 1,000 mcg/mL, or 5,000 mcg/mL depending on formulation |
| Drug Class | Water-soluble vitamin, essential coenzyme |
Dose Rates (using 1,000 mcg/mL = 1 mg/mL)
| Species | Dose | Volume (1 mg/mL) | Route | Frequency |
|---|---|---|---|---|
| Dog (small, <10 kg) | 250-500 mcg | 0.25-0.5 mL | SC or IM | Weekly x 6 weeks, then monthly |
| Dog (medium, 10-20 kg) | 500-750 mcg | 0.5-0.75 mL | SC or IM | Weekly x 6 weeks, then monthly |
| Dog (large, >20 kg) | 1,000 mcg (1 mg) | 1.0 mL | SC or IM | Weekly x 6 weeks, then monthly |
| Cat | 250 mcg | 0.25 mL | SC or IM | Weekly x 6 weeks, then monthly |
| Cattle/Buffalo | 3,000-5,000 mcg | 3-5 mL | IM or SC | Weekly or as needed |
| Sheep/Goat | 1,000-3,000 mcg | 1-3 mL | IM or SC | Weekly |
| Horse | 5,000-10,000 mcg | 5-10 mL | IM | Weekly |
Indications
- Inflammatory bowel disease (IBD) with B12 malabsorption
- Exocrine pancreatic insufficiency (EPI)
- Cobalamin deficiency (weight loss, poor appetite, lethargy, diarrhea)
- Anemia (megaloblastic or pernicious anemia)
- Liver disease support
- Recovery from debilitating illness
- Neonatal weakness (calves, lambs, foals)
- Nerve function support and neurological recovery
- Post-worm burden recovery in ruminants
Clinical Notes
- Very safe - no documented toxicity at veterinary doses
- Water-soluble; excess excreted in urine
- Use with caution with chloramphenicol (reduces B12 response)
- Long-term omeprazole use can reduce absorption (oral form)
- Injectable preferred when GI absorption is compromised
- SC injection may sting briefly but is well tolerated
9. SLEVIT (Selenium + Vitamin E Injection)
| Parameter | Details |
|---|---|
| Active Ingredients | Selenium (as sodium selenite) + Vitamin E (alpha-tocopherol acetate) |
| Concentration | Typically: Selenium 1 mg/mL + Vitamin E 50-68 mg/mL (varies by brand; e.g., BO-SE: Se 1 mg/mL + Vit E 50 IU/mL) |
| Drug Class | Antioxidant micronutrient supplement |
Dose Rates (based on BO-SE / Slevit equivalent: Se 1 mg/mL + Vit E 50 IU/mL)
| Species | Selenium Dose | Volume | Route | Frequency |
|---|---|---|---|---|
| Cattle (adult) | 2.5-3 mg Se (2.5-3 mL) | 2.5-3 mL | IM or SC | Every 4-6 weeks or as needed |
| Calves (newborn) | 1 mg Se (1 mL) | 1 mL | IM | At birth or within 24h |
| Calves (weaning) | 2 mg Se (2 mL) | 2 mL | IM | At weaning |
| Sheep/Goat (adult) | 0.5-1 mg Se (0.5-1 mL) | 0.5-1 mL | IM | Pre-breeding; late pregnancy |
| Lambs/Kids (newborn) | 0.25-0.5 mg Se (0.25-0.5 mL) | 0.25-0.5 mL | IM | At birth |
| Horse (adult) | 2.5-3 mg Se (2.5-3 mL) | 2.5-3 mL | IM | Monthly in deficient areas |
| Dog | 0.01-0.02 mg Se/kg | 0.01-0.02 mL/kg | IM | As directed (rarely used) |
| Pig (sow) | 1.5-2 mg Se | 1.5-2 mL | IM | 2-4 weeks pre-farrowing |
| Piglets | 0.5 mg Se | 0.5 mL | IM | At birth or within 3 days |
Indications
- White muscle disease (nutritional muscular dystrophy) - prevention and treatment
- Selenium and Vitamin E deficiency in selenium-poor soils
- Weak calf/lamb/foal syndrome
- Reproductive failure - repeat breeding, early embryonic death, poor conception
- Retained fetal membranes prevention
- Mastitis prevention (antioxidant support)
- Myopathy (stiff lamb disease, enzootic muscular dystrophy)
- Immune enhancement post-vaccination
- Poor growth and ill-thrift in ruminants
- Exertional rhabdomyolysis (tying-up) in horses
Clinical Notes
- TOXIC SAFETY MARGIN IS NARROW - selenium toxicity (blind staggers, alkali disease) can occur at just 3-5x the therapeutic dose
- Never exceed recommended dose; calculate carefully by body weight
- Selenium toxicity signs: hair/hoof loss, ataxia, respiratory distress, death
- IM injection site reactions possible - inject deep into muscle
- Give SC in small animals; IM preferred in large animals
- Areas with high dietary selenium (some US/Australian regions) - do NOT supplement blindly; test serum selenium first
- Pre-breeding Vitamin E/Se supplementation significantly improves reproductive outcomes in cattle and sheep
Quick Reference Summary Table
| Drug | Active Ingredient | Concentration | Class | Main Use |
|---|---|---|---|---|
| Slon-M | Flunixin Meglumine | 50 mg/mL | NSAID | Fever, colic, pain, endotoxemia |
| Cortinol-P | Prednisolone | 25-50 mg/mL | Glucocorticoid | Allergy, shock, inflammation, immune |
| Melonac | Meloxicam | 5 mg/mL | COX-2 NSAID | Arthritis, surgery, fever |
| Ketoject | Ketoprofen | 100 mg/mL | NSAID | Pain, lameness, colic |
| Hepgan | Heparin Sodium | 1,000-5,000 IU/mL | Anticoagulant | DIC, thromboembolism |
| Dexamethasone | Dexamethasone | 2-4 mg/mL | Potent GC | Shock, parturition, cerebral edema |
| Carasil | Carprofen | 50 mg/mL | COX-2 NSAID | Post-op pain, OA in dogs |
| Cayonocob | Cyanocobalamin (B12) | 1-5 mg/mL | Vitamin | Deficiency, IBD, EPI, anemia |
| Slevit | Se + Vitamin E | Se 1 mg/mL | Antioxidant | White muscle disease, reproduction |
Important General Clinical Rules
- Never combine two NSAIDs (e.g., Melonac + Ketoject + Slon-M) - risk of GI ulceration and renal failure
- Never combine an NSAID with a corticosteroid (Dexamethasone/Cortinol-P + any NSAID) without a washout period of at least 24-48 hours
- Observe withdrawal times in food animals before slaughter or milk collection
- Always dose by body weight - weigh animals where possible; estimate carefully in field conditions
- Monitor renal and hepatic function with long-term NSAID or steroid use
- Keep epinephrine available when using any injection in case of anaphylaxis
Disclaimer: These doses are general veterinary guidelines compiled from published literature and product inserts. Always verify against the specific product label available in your country, as concentrations and registered doses may vary by manufacturer and region. These drugs should be used under licensed veterinary supervision.
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