ls /home/daytona/workspace/ 2>/dev/null || echo "workspace empty"

~/copper-poisoning-ppt/copper_poisoning.js

const pptxgen = require("pptxgenjs");

const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Chronic Copper Poisoning – Seminar";
pres.author = "Toxicology Seminar";

// ─── PALETTE ────────────────────────────────────────────────────────────────
const C = {
  bg_dark:   "1A1A2E",  // deep navy (title / section slides)
  bg_mid:    "16213E",  // mid-navy (content)
  accent:    "E94560",  // vivid red-pink (headings accent)
  copper:    "B87333",  // authentic copper
  copper_lt: "D4956B",  // light copper
  gold:      "F5A623",  // warm gold (sub-headings)
  white:     "FFFFFF",
  off_white: "E8E8F0",
  grey:      "A0A0B8",
  green:     "27AE60",
  red:       "E74C3C",
  teal:      "1ABC9C",
  blue:      "3498DB",
  orange:    "E67E22",
  purple:    "9B59B6",
};

// ─── HELPERS ─────────────────────────────────────────────────────────────────
function darkBg(slide) {
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:"100%", h:"100%", fill:{color: C.bg_dark} });
}
function midBg(slide) {
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:"100%", h:"100%", fill:{color: C.bg_mid} });
}
function copperAccentBar(slide) {
  slide.addShape(pres.ShapeType.rect, { x:0, y:5.3, w:"100%", h:0.32, fill:{color: C.copper} });
}
function sectionTag(slide, label) {
  slide.addShape(pres.ShapeType.roundRect, { x:0.4, y:0.12, w:2.0, h:0.38, fill:{color: C.copper}, rectRadius:0.05, line:{color: C.copper} });
  slide.addText(label, { x:0.4, y:0.12, w:2.0, h:0.38, fontSize:11, bold:true, color:C.white, align:"center", valign:"middle", margin:0 });
}
function slideTitle(slide, title) {
  slide.addShape(pres.ShapeType.rect, { x:0, y:0.62, w:"100%", h:0.06, fill:{color: C.copper} });
  slide.addText(title, { x:0.5, y:0.7, w:9, h:0.65, fontSize:26, bold:true, color:C.white, fontFace:"Calibri" });
}
function bullet(text, level=0, color=C.off_white, size=15, bold=false) {
  return { text, options:{ bullet:{indent: level===0 ? 15:25}, indentLevel:level, fontSize:size, color, bold, breakLine:true, fontFace:"Calibri" }};
}
function lastBullet(text, level=0, color=C.off_white, size=15, bold=false) {
  return { text, options:{ bullet:{indent: level===0 ? 15:25}, indentLevel:level, fontSize:size, color, bold, fontFace:"Calibri" }};
}

// ════════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkBg(s);

  // decorative copper circle
  s.addShape(pres.ShapeType.ellipse, { x:7.8, y:-0.8, w:3.5, h:3.5, fill:{color: C.copper, transparency:80}, line:{color:C.copper, transparency:60, width:2} });
  s.addShape(pres.ShapeType.ellipse, { x:8.2, y:-0.4, w:2.5, h:2.5, fill:{color: C.copper_lt, transparency:85}, line:{color:C.copper_lt, transparency:50, width:1} });

  // top accent bar
  s.addShape(pres.ShapeType.rect, { x:0, y:0, w:4.5, h:0.08, fill:{color: C.copper} });

  // TOXICOLOGY SEMINAR label
  s.addShape(pres.ShapeType.roundRect, { x:0.5, y:0.4, w:2.8, h:0.42, fill:{color: C.accent}, rectRadius:0.04, line:{color:C.accent} });
  s.addText("TOXICOLOGY SEMINAR", { x:0.5, y:0.4, w:2.8, h:0.42, fontSize:10.5, bold:true, color:C.white, align:"center", valign:"middle", margin:0, charSpacing:1 });

  // Main title
  s.addText([
    { text:"COPPER", options:{ color:C.copper, fontSize:52, bold:true, breakLine:true, fontFace:"Calibri" }},
    { text:"POISONING", options:{ color:C.white, fontSize:52, bold:true, breakLine:true, fontFace:"Calibri" }},
  ], { x:0.5, y:1.05, w:8.5, h:2.0 });

  s.addText("Chronic Symptoms & Management", {
    x:0.5, y:2.95, w:8, h:0.55, fontSize:22, color:C.gold, italic:true, fontFace:"Calibri"
  });

  // divider line
  s.addShape(pres.ShapeType.line, { x:0.5, y:3.58, w:5, h:0, line:{color:C.copper, width:2} });

  s.addText("Department of Forensic Medicine & Toxicology", {
    x:0.5, y:3.72, w:8, h:0.38, fontSize:13, color:C.grey, fontFace:"Calibri"
  });

  // Cu atomic symbol
  s.addText("Cu", { x:8.5, y:4.6, w:1.2, h:0.8, fontSize:48, bold:true, color:C.copper, align:"center", fontFace:"Calibri" });
  s.addText("Atomic No. 29", { x:8.2, y:5.1, w:1.8, h:0.35, fontSize:10, color:C.grey, align:"center", fontFace:"Calibri" });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 2 — OUTLINE
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "OVERVIEW");
  slideTitle(s, "Seminar Outline");

  const topics = [
    ["01", "Introduction & Copper Biochemistry",       C.copper],
    ["02", "Sources of Chronic Exposure",              C.blue],
    ["03", "Pathophysiology of Chronic Toxicity",      C.purple],
    ["04", "Chronic Symptoms – Organ-by-Organ",        C.accent],
    ["05", "Wilson Disease – Copper Storage Disorder", C.teal],
    ["06", "Diagnosis & Investigations",               C.gold],
    ["07", "Management & Chelation Therapy",           C.green],
    ["08", "Autopsy Findings & Medicolegal Aspects",   C.orange],
    ["09", "Key Takeaways",                            C.copper],
  ];

  topics.forEach(([num, text, col], i) => {
    const row = i % 5;
    const col_x = i < 5 ? 0.45 : 5.3;
    const y_start = 1.65;
    const y = y_start + row * 0.72;

    s.addShape(pres.ShapeType.roundRect, { x: col_x, y, w:0.52, h:0.5, fill:{color:col}, rectRadius:0.06, line:{color:col} });
    s.addText(num, { x: col_x, y, w:0.52, h:0.5, fontSize:13, bold:true, color:C.white, align:"center", valign:"middle", margin:0 });
    s.addText(text, { x: col_x + 0.6, y: y + 0.06, w: 4.3, h:0.38, fontSize:13.5, color:C.off_white, fontFace:"Calibri", valign:"middle" });
  });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 3 — INTRODUCTION
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "INTRODUCTION");
  slideTitle(s, "Copper: An Essential Yet Toxic Element");

  // left column facts
  s.addShape(pres.ShapeType.roundRect, { x:0.4, y:1.6, w:4.4, h:3.45, fill:{color:"12183A"}, rectRadius:0.1, line:{color:C.copper, width:1.5} });
  s.addText("Key Facts", { x:0.6, y:1.68, w:4, h:0.42, fontSize:15, bold:true, color:C.copper, fontFace:"Calibri" });
  s.addText([
    bullet("Essential trace element for enzymatic function"),
    bullet("Normal body content: 70–80 mg total"),
    bullet("Daily requirement: 0.9 mg/day (adult)"),
    bullet("Stored mainly in liver, brain, kidney, heart"),
    bullet("Excreted via bile (primary route)"),
    bullet("Deficiency → hypochromic anemia, Menkes disease"),
    lastBullet("Excess → Wilson disease, toxic cirrhosis"),
  ], { x:0.55, y:2.2, w:4.1, h:2.7, fontFace:"Calibri" });

  // right column: role in body
  s.addShape(pres.ShapeType.roundRect, { x:5.2, y:1.6, w:4.4, h:3.45, fill:{color:"12183A"}, rectRadius:0.1, line:{color:C.teal, width:1.5} });
  s.addText("Physiological Roles", { x:5.4, y:1.68, w:4, h:0.42, fontSize:15, bold:true, color:C.teal, fontFace:"Calibri" });
  s.addText([
    bullet("Co-factor for cytochrome-c oxidase"),
    bullet("Superoxide dismutase (SOD1) activity"),
    bullet("Dopamine β-hydroxylase (catecholamine synthesis)"),
    bullet("Lysyl oxidase (collagen/elastin cross-linking)"),
    bullet("Ceruloplasmin: copper transport protein"),
    bullet("Melanin synthesis (tyrosinase)"),
    lastBullet("Iron metabolism – ferroxidase activity"),
  ], { x:5.35, y:2.2, w:4.15, h:2.7, fontFace:"Calibri" });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 4 — SOURCES OF CHRONIC EXPOSURE
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "EXPOSURE SOURCES");
  slideTitle(s, "Sources of Chronic Copper Exposure");

  const boxes = [
    { label:"Dietary",        icon:"🍽️", items:["Fruits & vegetables preserved with CuSO₄","Food cooked in unclean copper vessels","Contaminated drinking water (copper pipes)"], col:C.orange, x:0.4, y:1.6 },
    { label:"Occupational",   icon:"🏭", items:["Copper smelting & refining industry","Brass foundry workers (Brass-founder's ague)","Fungicide/pesticide manufacturing","Welding with copper oxide fumes"], col:C.blue, x:5.25, y:1.6 },
    { label:"Environmental",  icon:"🌍", items:["Inhalation of copper dust in mining","Skin absorption by copper-industry workers","Agricultural use of Bordeaux mixture","Metal fume fever (Cu + Zn inhalation)"], col:C.teal, x:0.4, y:3.52 },
    { label:"Iatrogenic",     icon:"💊", items:["Excess copper supplementation","Wilson disease (genetic accumulation)","Indian childhood cirrhosis (utensil-related)","Hemodialysis with copper-contaminated water"], col:C.purple, x:5.25, y:3.52 },
  ];

  boxes.forEach(b => {
    s.addShape(pres.ShapeType.roundRect, { x:b.x, y:b.y, w:4.4, h:1.85, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:b.col, width:1.5} });
    s.addShape(pres.ShapeType.rect, { x:b.x, y:b.y, w:4.4, h:0.46, fill:{color:b.col}, rectRadius:0 });
    s.addText(`${b.icon}  ${b.label}`, { x:b.x+0.1, y:b.y+0.03, w:4.2, h:0.4, fontSize:14, bold:true, color:C.white, fontFace:"Calibri", valign:"middle", margin:0 });
    const bullets_arr = b.items.map((txt, i) => i < b.items.length-1 ? bullet(txt, 0, C.off_white, 12.5) : lastBullet(txt, 0, C.off_white, 12.5));
    s.addText(bullets_arr, { x:b.x+0.1, y:b.y+0.52, w:4.2, h:1.28, fontFace:"Calibri" });
  });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 5 — PATHOPHYSIOLOGY
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "PATHOPHYSIOLOGY");
  slideTitle(s, "Mechanism of Chronic Copper Toxicity");

  // flow arrow chain
  const steps = [
    { label:"Chronic\nExposure", color:C.orange },
    { label:"Copper\nAccumulation", color:C.copper },
    { label:"Oxidative\nStress", color:C.accent },
    { label:"Enzyme\nInhibition", color:C.purple },
    { label:"Organ\nDamage", color:C.red },
  ];

  steps.forEach((st, i) => {
    const x = 0.35 + i * 1.9;
    s.addShape(pres.ShapeType.roundRect, { x, y:1.55, w:1.65, h:0.9, fill:{color:st.color}, rectRadius:0.1, line:{color:st.color} });
    s.addText(st.label, { x, y:1.55, w:1.65, h:0.9, fontSize:12.5, bold:true, color:C.white, align:"center", valign:"middle", fontFace:"Calibri" });
    if (i < steps.length - 1) {
      s.addShape(pres.ShapeType.line, { x: x+1.65, y:2.0, w:0.22, h:0, line:{color:C.gold, width:2.5} });
      s.addText("▶", { x: x+1.65, y:1.82, w:0.22, h:0.35, fontSize:11, color:C.gold, align:"center" });
    }
  });

  // mechanisms
  s.addShape(pres.ShapeType.roundRect, { x:0.4, y:2.72, w:4.25, h:2.45, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:C.copper, width:1.5} });
  s.addText("Cellular Mechanisms", { x:0.55, y:2.8, w:3.9, h:0.38, fontSize:14, bold:true, color:C.copper, fontFace:"Calibri" });
  s.addText([
    bullet("Fenton-like reaction → hydroxyl radical (·OH) generation"),
    bullet("Inhibits Na⁺-K⁺-ATPase, G6PD, glutathione reductase, catalase"),
    bullet("Lipid peroxidation → membrane damage"),
    bullet("Mitochondrial dysfunction & ATP depletion"),
    lastBullet("Direct hepatocyte necrosis – centrilobular pattern"),
  ], { x:0.55, y:3.25, w:3.95, h:1.8, fontFace:"Calibri", fontSize:13 });

  s.addShape(pres.ShapeType.roundRect, { x:5.25, y:2.72, w:4.35, h:2.45, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:C.teal, width:1.5} });
  s.addText("Target Organs", { x:5.4, y:2.8, w:4.1, h:0.38, fontSize:14, bold:true, color:C.teal, fontFace:"Calibri" });
  s.addText([
    bullet("Liver → fatty degeneration, necrosis, cirrhosis"),
    bullet("Kidney → proximal tubule damage, ATN"),
    bullet("Brain → basal ganglia degeneration (Wilson)"),
    bullet("Blood → hemolytic anemia"),
    bullet("Eyes → Kayser-Fleischer rings"),
    lastBullet("Peripheral nerves → peripheral neuritis"),
  ], { x:5.4, y:3.25, w:4.1, h:1.8, fontFace:"Calibri", fontSize:13 });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 6 — CHRONIC SYMPTOMS (GI + Neuro)
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "CHRONIC SYMPTOMS");
  slideTitle(s, "Chronic Symptoms – GI, Neurological & Oral");

  // GI symptoms
  s.addShape(pres.ShapeType.roundRect, { x:0.4, y:1.6, w:4.5, h:3.65, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:C.green, width:2} });
  s.addShape(pres.ShapeType.rect, { x:0.4, y:1.6, w:4.5, h:0.48, fill:{color:C.green} });
  s.addText("🫁  Gastrointestinal & Hepatic", { x:0.5, y:1.62, w:4.3, h:0.44, fontSize:14, bold:true, color:C.white, fontFace:"Calibri", valign:"middle", margin:0 });
  s.addText([
    bullet("Styptic metallic copper taste in mouth"),
    bullet("Nausea, chronic vomiting, indigestion, dyspepsia"),
    bullet("Occasional diarrhoea with colicky abdominal pain"),
    bullet("Laryngitis (from ingested/inhaled copper)"),
    bullet("Liver: fatty degeneration → cirrhosis (haematochromatosis)"),
    bullet("Jaundice (mild, chronic)"),
    lastBullet("Hepatomegaly – prominent in Wilson disease"),
  ], { x:0.55, y:2.17, w:4.2, h:3.0, fontFace:"Calibri", fontSize:13 });

  // Neuro symptoms
  s.addShape(pres.ShapeType.roundRect, { x:5.2, y:1.6, w:4.4, h:3.65, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:C.purple, width:2} });
  s.addShape(pres.ShapeType.rect, { x:5.2, y:1.6, w:4.4, h:0.48, fill:{color:C.purple} });
  s.addText("🧠  Neurological & Constitutional", { x:5.3, y:1.62, w:4.2, h:0.44, fontSize:14, bold:true, color:C.white, fontFace:"Calibri", valign:"middle", margin:0 });
  s.addText([
    bullet("Lassitude, giddiness and headache"),
    bullet("Peripheral neuritis"),
    bullet("Muscular weakness with atrophy → paralysis"),
    bullet("Bluish-green or purple gum line at tooth junction"),
    bullet("Hair: brownish-golden discolouration"),
    bullet("Neuropsychiatric changes (Wilson disease)"),
    lastBullet("Kayser-Fleischer rings (copper in Descemet's)"),
  ], { x:5.35, y:2.17, w:4.15, h:3.0, fontFace:"Calibri", fontSize:13 });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 7 — CHRONIC SYMPTOMS (Haematological, Renal, Dermal)
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "CHRONIC SYMPTOMS");
  slideTitle(s, "Chronic Symptoms – Blood, Kidney & Skin");

  const panels = [
    {
      title:"🩸  Haematological",
      color: C.accent,
      items:["Anaemia (haemolytic in nature)","Elevated serum copper / low ceruloplasmin (Wilson)","Haemoglobinuria with intravascular haemolysis","Sideroblastic anaemia (copper deficiency paradox)","Methaemoglobinaemia"],
      x:0.4, y:1.6, w:2.95, h:3.65
    },
    {
      title:"🫘  Renal",
      color: C.blue,
      items:["Cloudy swelling & degeneration of kidney","Albuminuria, oliguria","Proximal tubule damage (Fanconi-like syndrome)","Haemoglobin casts in tubules","Renal osteodystrophy (chronic)"],
      x:3.55, y:1.6, w:2.95, h:3.65
    },
    {
      title:"🖐️  Dermal & Ocular",
      color: C.teal,
      items:["Conjunctivitis & corneal ulceration (copper dust)","Contact dermatitis, skin ulcers","Green skin discolouration","Kayser–Fleischer rings on slit-lamp exam","Sunflower cataract (Wilson)"],
      x:6.65, y:1.6, w:2.95, h:3.65
    },
  ];

  panels.forEach(p => {
    s.addShape(pres.ShapeType.roundRect, { x:p.x, y:p.y, w:p.w, h:p.h, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:p.color, width:2} });
    s.addShape(pres.ShapeType.rect, { x:p.x, y:p.y, w:p.w, h:0.46, fill:{color:p.color} });
    s.addText(p.title, { x:p.x+0.08, y:p.y+0.03, w:p.w-0.1, h:0.4, fontSize:12.5, bold:true, color:C.white, fontFace:"Calibri", valign:"middle", margin:0 });
    const barr = p.items.map((t,i)=> i<p.items.length-1 ? bullet(t,0,C.off_white,12) : lastBullet(t,0,C.off_white,12));
    s.addText(barr, { x:p.x+0.12, y:p.y+0.56, w:p.w-0.2, h:2.98, fontFace:"Calibri" });
  });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 8 — WILSON DISEASE
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "WILSON DISEASE");
  slideTitle(s, "Wilson Disease – Chronic Copper Storage Disorder");

  s.addShape(pres.ShapeType.roundRect, { x:0.4, y:1.58, w:5.5, h:3.7, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:C.copper, width:2} });
  s.addText("Genetics & Pathogenesis", { x:0.6, y:1.66, w:5.1, h:0.42, fontSize:15, bold:true, color:C.copper, fontFace:"Calibri" });
  s.addText([
    bullet("Autosomal recessive – ATP7B gene mutation (chromosome 13)"),
    bullet("Defect in copper-transporting ATPase → impaired biliary excretion"),
    bullet("Copper accumulates in liver → spills into blood → deposits in brain, cornea, kidney"),
    bullet("Low serum ceruloplasmin (<20 mg/dL) is hallmark"),
    bullet("24-h urinary copper >100 µg/24 h (diagnostic)"),
    bullet("Liver biopsy: >250 µg copper/g dry weight"),
    bullet("KF rings: copper in Descemet's membrane of cornea"),
    lastBullet("Presents in 2nd–3rd decade; rare before age 5"),
  ], { x:0.55, y:2.17, w:5.25, h:3.0, fontFace:"Calibri", fontSize:13 });

  s.addShape(pres.ShapeType.roundRect, { x:6.15, y:1.58, w:3.5, h:3.7, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:C.teal, width:2} });
  s.addText("Clinical Presentations", { x:6.3, y:1.66, w:3.25, h:0.42, fontSize:15, bold:true, color:C.teal, fontFace:"Calibri" });
  s.addText([
    bullet("Acute hepatitis (mimics viral)"),
    bullet("Fulminant hepatic failure"),
    bullet("Chronic hepatitis → cirrhosis"),
    bullet("Steatohepatitis / gallstones"),
    bullet("Neuropsychiatric: tremor, dysarthria, ataxia, personality change"),
    bullet("Hemolytic anemia"),
    bullet("Fanconi syndrome (renal)"),
    lastBullet("Cardiomyopathy (rare)"),
  ], { x:6.3, y:2.17, w:3.25, h:3.0, fontFace:"Calibri", fontSize:12.5 });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 9 — DIAGNOSIS
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "DIAGNOSIS");
  slideTitle(s, "Diagnosis & Investigations");

  // table header
  s.addShape(pres.ShapeType.rect, { x:0.4, y:1.62, w:9.2, h:0.44, fill:{color:C.copper} });
  s.addText("Investigation", { x:0.4, y:1.62, w:2.8, h:0.44, fontSize:13, bold:true, color:C.white, align:"center", valign:"middle", fontFace:"Calibri", margin:0 });
  s.addText("Finding in Chronic Copper Poisoning", { x:3.2, y:1.62, w:4.0, h:0.44, fontSize:13, bold:true, color:C.white, align:"center", valign:"middle", fontFace:"Calibri", margin:0 });
  s.addText("Significance", { x:7.2, y:1.62, w:2.4, h:0.44, fontSize:13, bold:true, color:C.white, align:"center", valign:"middle", fontFace:"Calibri", margin:0 });

  const rows = [
    ["Serum ceruloplasmin", "↓ <20 mg/dL", "Wilson disease screening"],
    ["24-h urinary copper", ">100 µg/24h (diagnosis)\n>200-400 µg/24h (on chelation)", "Key monitoring marker"],
    ["Serum copper", "↑ Free copper (non-ceruloplasmin)", "Reflects toxic free copper"],
    ["LFT / Liver enzymes", "↑ AST, ALT, ALP; ↑ bilirubin", "Hepatocellular damage"],
    ["Liver biopsy", ">250 µg Cu/g dry weight; steatosis → fibrosis", "Gold standard for WD"],
    ["Slit-lamp examination", "Kayser-Fleischer rings", "Pathognomonic for WD"],
    ["Chemical test (vomitus)", "Deep blue with NH₄OH", "Acute/forensic identification"],
    ["CBC", "Haemolytic anaemia, ↓ Hb", "Haematological toxicity"],
    ["Kidney function tests", "↑ Creatinine, proteinuria, RBC casts", "Nephrotoxicity assessment"],
  ];

  rows.forEach((row, i) => {
    const y = 2.1 + i * 0.38;
    const bg = i % 2 === 0 ? "0D1533" : "121A3A";
    s.addShape(pres.ShapeType.rect, { x:0.4, y, w:9.2, h:0.38, fill:{color:bg} });
    s.addText(row[0], { x:0.45, y:y+0.04, w:2.7, h:0.3, fontSize:11.5, color:C.gold, bold:true, fontFace:"Calibri" });
    s.addText(row[1], { x:3.2, y:y+0.04, w:3.9, h:0.3, fontSize:11, color:C.off_white, fontFace:"Calibri" });
    s.addText(row[2], { x:7.2, y:y+0.04, w:2.35, h:0.3, fontSize:11, color:C.grey, fontFace:"Calibri" });
  });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 10 — MANAGEMENT
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "MANAGEMENT");
  slideTitle(s, "Management of Chronic Copper Poisoning");

  // General measures
  s.addShape(pres.ShapeType.roundRect, { x:0.4, y:1.6, w:9.2, h:0.95, fill:{color:"0D1533"}, rectRadius:0.08, line:{color:C.orange, width:1.5} });
  s.addText("General Supportive Measures", { x:0.55, y:1.66, w:3, h:0.34, fontSize:13.5, bold:true, color:C.orange, fontFace:"Calibri" });
  s.addText([
    { text:"• Remove patient from source of exposure  ", options:{fontSize:12.5, color:C.off_white} },
    { text:"• Correction of dyspepsia & nutritious diet  ", options:{fontSize:12.5, color:C.off_white} },
    { text:"• Multivitamins & IV fluids  ", options:{fontSize:12.5, color:C.off_white} },
    { text:"• Ensure copper utensils are clean & well-tinned", options:{fontSize:12.5, color:C.off_white} },
  ], { x:0.55, y:2.05, w:9.0, h:0.42, fontFace:"Calibri" });

  // Chelation table
  s.addShape(pres.ShapeType.rect, { x:0.4, y:2.72, w:9.2, h:0.44, fill:{color:C.copper} });
  ["Agent", "Dose / Route", "Mechanism", "Notes"].forEach((h, i) => {
    const ws = [2.1, 2.5, 2.7, 1.9];
    const xs = [0.4, 2.5, 5.0, 7.7];
    s.addText(h, { x:xs[i], y:2.72, w:ws[i], h:0.44, fontSize:13, bold:true, color:C.white, align:"center", valign:"middle", fontFace:"Calibri", margin:0 });
  });

  const chelRows = [
    ["D-Penicillamine", "250–500 mg QID orally\n(lifelong)", "Chelates copper → urinary excretion; also stimulates ceruloplasmin", "First-line WD; pyridoxine supplement required; many side effects"],
    ["Trientine (TETA)", "750–1500 mg/day orally", "Copper chelator; less toxic than penicillamine", "Preferred if penicillamine intolerance; similar efficacy"],
    ["Zinc salts", "50 mg elemental Zn TID", "Induces intestinal metallothionein → blocks copper absorption", "Maintenance therapy; safe in pregnancy & paediatrics"],
    ["EDTA", "IV infusion", "Non-specific heavy metal chelator", "Occupational/industrial exposure; less specific for copper"],
    ["Ammonium Tetrathiomolybdate", "Investigational", "Forms complex with albumin & copper", "Neurological WD; prevents neurological worsening"],
  ];

  chelRows.forEach((row, i) => {
    const y = 3.2 + i * 0.42;
    const bgc = i % 2 === 0 ? "0D1533" : "121A3A";
    s.addShape(pres.ShapeType.rect, { x:0.4, y, w:9.2, h:0.42, fill:{color:bgc} });
    const xs = [0.4, 2.5, 5.0, 7.7];
    const ws = [2.1, 2.5, 2.7, 1.9];
    const cols = [C.gold, C.off_white, C.off_white, C.grey];
    row.forEach((cell, j) => {
      s.addText(cell, { x:xs[j], y:y+0.04, w:ws[j]-0.05, h:0.34, fontSize:10.5, color:cols[j], fontFace:"Calibri", bold: j===0 });
    });
  });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 11 — MONITORING & FOLLOW-UP
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "MANAGEMENT");
  slideTitle(s, "Monitoring During Chelation Therapy");

  const cards = [
    { title:"Urinary Copper", items:["Target: 200–400 µg/24h on chelation","If consistently taking therapy, confirms compliance","Reduces to 20-50 µg/24h in remission","Monitor every 6 months once stable"], col:C.copper, x:0.4, y:1.62 },
    { title:"Serum Ceruloplasmin", items:["Should rise toward normal (20–35 mg/dL)","May remain low even on treatment in WD","Not a reliable treatment marker alone","Check alongside urine copper"], col:C.blue, x:5.25, y:1.62 },
    { title:"Liver Function", items:["AST/ALT should normalise within months","Bilirubin normalisation = hepatic recovery","Liver biopsy at 5 years (cirrhosis staging)","LFTs monthly for first year of treatment"], col:C.green, x:0.4, y:3.62 },
    { title:"Side Effects Watch", items:["Penicillamine: rash, proteinuria, SLE-like, bone marrow suppression","Trientine: iron deficiency anaemia","Zinc: gastritis (take between meals)","Stop drug if WBC < 3500 or platelets < 100k"], col:C.accent, x:5.25, y:3.62 },
  ];

  cards.forEach(c => {
    s.addShape(pres.ShapeType.roundRect, { x:c.x, y:c.y, w:4.4, h:1.82, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:c.col, width:1.5} });
    s.addShape(pres.ShapeType.rect, { x:c.x, y:c.y, w:4.4, h:0.44, fill:{color:c.col} });
    s.addText(c.title, { x:c.x+0.1, y:c.y+0.04, w:4.2, h:0.36, fontSize:14, bold:true, color:C.white, fontFace:"Calibri", valign:"middle", margin:0 });
    const ba = c.items.map((t,i)=> i<c.items.length-1 ? bullet(t,0,C.off_white,12) : lastBullet(t,0,C.off_white,12));
    s.addText(ba, { x:c.x+0.12, y:c.y+0.52, w:4.18, h:1.25, fontFace:"Calibri" });
  });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 12 — AUTOPSY & MEDICOLEGAL
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  midBg(s);
  sectionTag(s, "FORENSIC");
  slideTitle(s, "Autopsy Findings & Medicolegal Aspects");

  s.addShape(pres.ShapeType.roundRect, { x:0.4, y:1.6, w:4.5, h:3.65, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:C.orange, width:2} });
  s.addText("🔬  Autopsy Findings", { x:0.55, y:1.68, w:4.2, h:0.42, fontSize:15, bold:true, color:C.orange, fontFace:"Calibri" });
  s.addText([
    bullet("Liver: fatty degeneration, centrilobular necrosis"),
    bullet("Haematochromatosis (iron-copper pigment deposition)"),
    bullet("Biliary stasis; hepatic fibrosis → cirrhosis"),
    bullet("Kidney: cloudy swelling & degeneration of proximal tubules"),
    bullet("Acute tubular necrosis (severe cases)"),
    bullet("Haemoglobin casts in renal tubules"),
    bullet("Brain: basal ganglia cavitation (Wilson disease)"),
    lastBullet("Green discolouration of viscera in some cases"),
  ], { x:0.55, y:2.18, w:4.25, h:3.0, fontFace:"Calibri", fontSize:13 });

  s.addShape(pres.ShapeType.roundRect, { x:5.25, y:1.6, w:4.35, h:3.65, fill:{color:"0D1533"}, rectRadius:0.1, line:{color:C.accent, width:2} });
  s.addText("⚖️  Medicolegal Aspects", { x:5.4, y:1.68, w:4.1, h:0.42, fontSize:15, bold:true, color:C.accent, fontFace:"Calibri" });
  s.addText([
    bullet("Copper salts rarely used for suicide (self-emetic, blue colour, big lethal dose)"),
    bullet("May be used for homicide – disguised in food"),
    bullet("Occasionally used for cattle poisoning"),
    bullet("Accidental poisoning in copper-industry workers is most common"),
    bullet("Blue-green vomitus is a key post-mortem clue"),
    bullet("NH₄OH test on vomitus – deep blue = confirmatory"),
    bullet("Workplace exposure records are medicolegal evidence"),
    lastBullet("Fatal dose: 15–30 g (single); lower with repeated small doses"),
  ], { x:5.4, y:2.18, w:4.1, h:3.0, fontFace:"Calibri", fontSize:13 });

  copperAccentBar(s);
}

// ════════════════════════════════════════════════════════════════
// SLIDE 13 — KEY TAKEAWAYS
// ════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkBg(s);

  // big background circle decoration
  s.addShape(pres.ShapeType.ellipse, { x:7.5, y:0.5, w:4, h:4, fill:{color:C.copper, transparency:88}, line:{color:C.copper, transparency:70, width:1} });

  s.addShape(pres.ShapeType.roundRect, { x:0.4, y:0.12, w:2.5, h:0.42, fill:{color:C.copper}, rectRadius:0.05, line:{color:C.copper} });
  s.addText("KEY TAKEAWAYS", { x:0.4, y:0.12, w:2.5, h:0.42, fontSize:11, bold:true, color:C.white, align:"center", valign:"middle", margin:0, charSpacing:1 });

  s.addText("Summary Points", { x:0.5, y:0.7, w:8, h:0.58, fontSize:28, bold:true, color:C.white, fontFace:"Calibri" });
  s.addShape(pres.ShapeType.line, { x:0.5, y:1.36, w:4, h:0, line:{color:C.copper, width:2} });

  const points = [
    [C.copper,  "Chronic copper toxicity = prolonged low-dose exposure or impaired excretion (Wilson disease)"],
    [C.green,   "Liver & kidney are the primary targets; GI, neurological, haematological and ocular involvement common"],
    [C.blue,    "Kayser-Fleischer rings on slit-lamp + low ceruloplasmin are pathognomonic for Wilson disease"],
    [C.gold,    "24-hour urinary copper is the cornerstone of diagnosis and treatment monitoring"],
    [C.teal,    "D-Penicillamine / Trientine = first-line chelation; Zinc salts for maintenance"],
    [C.accent,  "Sudden discontinuation of chelation can precipitate acute liver failure – therapy is LIFELONG"],
    [C.orange,  "Occupational exposure (metal fumes, dust) is most common cause; PPE & workplace hygiene are preventive"],
    [C.purple,  "Blue-green vomitus + NH₄OH test = forensic identification clue in acute setting"],
  ];

  points.forEach(([col, text], i) => {
    const y = 1.5 + i * 0.5;
    s.addShape(pres.ShapeType.roundRect, { x:0.4, y:y+0.06, w:0.3, h:0.3, fill:{color:col}, rectRadius:0.04, line:{color:col} });
    s.addText(text, { x:0.82, y:y+0.04, w:8.7, h:0.34, fontSize:13, color:C.off_white, fontFace:"Calibri", valign:"middle" });
  });

  // bottom strip
  s.addShape(pres.ShapeType.rect, { x:0, y:5.3, w:"100%", h:0.32, fill:{color:C.copper} });
  s.addText("Thank you  |  Questions Welcome  |  Cu (Atomic No. 29)", {
    x:0, y:5.3, w:"100%", h:0.32, fontSize:12, color:C.white, align:"center", valign:"middle", fontFace:"Calibri", margin:0
  });
}

// ════════════════════════════════════════════════════════════════
// WRITE FILE
// ════════════════════════════════════════════════════════════════
pres.writeFile({ fileName: "/home/daytona/workspace/copper-poisoning-ppt/Copper_Poisoning_Seminar.pptx" })
  .then(() => console.log("✅  DONE: Copper_Poisoning_Seminar.pptx written"))
  .catch(e => { console.error("ERROR:", e); process.exit(1); });

cd /home/daytona/workspace/copper-poisoning-ppt && node copper_poisoning.js 2>&1